公开(公告)号：EP2463643A4

公开(公告)日：2014-02-19

申请号：EP10806508

申请日：2010-08-05

Applicant: UNIVERSAL BIO RESEARCH CO LTD

Inventor： TAJIMA HIDEJI

IPC: G01N21/64 ,  B01J19/00 ,  G01J3/02 ,  G01J3/10 ,  G01N21/25 ,  G01N35/02 ,  G02B6/42

CPC classification number: G01N21/6452 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/024 ,  G01J3/0291 ,  G01J3/08 ,  G01J3/10 ,  G01J3/32 ,  G01J3/4406 ,  G01J2003/1213 ,  G01N21/253 ,  G01N35/028 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833 ,  G02B6/4298

Abstract: Disclosed is a highly reliable optical fiber measurement device and measurement method having a simple and compact structure. The device includes a planar liquid holder having a plurality of liquid holding portions arranged along a flat face; a plurality of light receiving optical fibers for transmitting fluorescence generated in the liquid holding portions; a plurality of light emitting optical fibers for transmitting excitation light into the liquid holding portions; a measurement head capable of being positioned in the each liquid holding portion while supporting a plurality of measurement ends having a bundle of one light receiving end of the light receiving optical fibers and one light emitting end of light emitting optical fibers; a light reception selecting element that, by sequentially selecting one by one from plural the light receiving optical fibers and sequentially selecting one by one from plural kinds of wavelength or wavelength bands, sequentially guides the light of the selected wavelength or wavelength band of the fluorescence received by the selected light receiving optical fibers to one photoelectric element; and a photoelectric element for sequentially conducting photoelectric conversion on the guided fluorescence.

公开(公告)号：EP2533033A4

公开(公告)日：2013-07-10

申请号：EP10845340

申请日：2010-02-03

Applicant: UCHREZHDENIE ROSSIISKOI AKADEMII NAUK INST MOLEKULYARNOI BIOLOG IM V A ENGELGARDTA RAN IMB RAN

Inventor： BARSKY VIKTOR EVGENIEVICH ,  EGOROV EGOR EVGENIEVICH ,  ZASEDATELEV ALEXANDR SERGEEVICH

IPC: G01N21/64 ,  G01N33/483

CPC classification number: G01N21/6452 ,  G01N2021/6419 ,  G01N2201/0826

公开(公告)号：EP2605002A1

公开(公告)日：2013-06-19

申请号：EP12197003.2

申请日：2012-12-13

Applicant: Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Inventor： Herve, Lionel

IPC: G01N21/64 ,  A61B5/00 ,  G01N21/47 ,  G01N21/49

CPC classification number: G01N21/59 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/4064 ,  A61B5/4255 ,  A61B5/4312 ,  A61B5/4381 ,  A61B5/7253 ,  G01N21/4795 ,  G01N21/49 ,  G01N21/64 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6456 ,  G01N2021/1787 ,  G01N2021/6413 ,  G01N2021/6484 ,  G01N2201/0697 ,  G01N2201/0826 ,  G01N2201/0833 ,  G06T11/003 ,  G09B23/286

Abstract: Ce procédé de reconstruction de propriétés optiques d'un milieu est mis en oeuvre à l'aide d'un système de reconstruction comportant une source de rayonnement éclairant le milieu et un détecteur recevant un signal émis par le milieu.
Ce procédé comprend les étapes suivantes :
- l'éclairement (100) du milieu par la source de rayonnement,
- la réception par le détecteur d'un signal émis par le milieu, et
- l'élaboration (110), pour un couple source-détecteur, d'une première distribution du signal reçu par le détecteur (16, d) correspondant,
- le calcul (130) de la transformée de Mellin-Laplace, pour un ordre et une variable donnés, d'une grandeur comportant la première distribution, l'ordre étant un nombre entier, la variable étant un nombre réel, et
- la reconstruction (140) de propriétés optiques du milieu à l'aide de la transformée de Mellin-Laplace de ladite grandeur.
L'étape de calcul (130) comporte le calcul de transformées de Mellin-Laplace de ladite grandeur pour des valeurs distinctes de l'ordre, et l'étape de reconstruction (140) est effectuée à partir d'une combinaison desdites transformées de Mellin-Laplace.

Abstract translation: 该方法包括使用辐射源照明的介质，并且接收由检测器由介质mitted反式的信号。 由检测器接收到的信号的分布进行处理（110）。 甲梅林-拉普拉斯变换计算对于给定的顺序和给定的大小（130）的一个变量。 的介质的光学性质被重建（140）使用所述梅林-Laplace变换的幅度，其中该重建处理从多个梅林 - 拉普拉斯变换的组合来进行的。 因此独立claimsoft被包括为用于重建介质的光学特性的系统。

公开(公告)号：EP2459987A1

公开(公告)日：2012-06-06

申请号：EP10737515.6

申请日：2010-07-23

Applicant: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)

Inventor： RAZANSKY, Daniel ,  NTZIACHRISTOS, Vasilis

IPC: G01N21/17 ,  A61B5/00 ,  A61B5/1455

CPC classification number: A61B5/0073 ,  A61B5/0095 ,  A61B6/508 ,  A61B8/13 ,  A61B2503/40 ,  G01N21/1702 ,  G01N21/39 ,  G01N2021/1787 ,  G01N2201/0826

Abstract: An imaging device (100) being configured for optoacoustic imaging of an object (1) comprises an illumination device (10) including optical components arranged for illuminating the object (1), a detector device (20) arranged for detecting acoustic signals created in the object (1), and a container device (50) including a tank (51) arranged for accommodating the detector device (20), the object (1) and a matching transmission medium (53), wherein the container device (50) further includes a holding device (55) being adapted for positioning and moving the object (1) relative to the illumination device (10) and the detector device (20), the optical components are arranged in the tank (51) for illuminating the object (1) from different directions, and the detector device (20) comprises an array (21) of detector elements (22) which is arranged in the tank (51). According to a preferred embodiment, the holding device comprises a membrane (55) arranged for accommodating the object (1), wherein the membrane separates the object (1) and the matching transmission medium (53) from each other. Furthermore, an imaging method of optoacoustic imaging of an object (1) using the imaging device (100) is described.

Abstract translation: 一种被配置为用于物体的光声成像的成像装置，包括包括布置成照射物体的光学部件的照明装置，包括布置在罐中并被布置成检测在物体中产生的声信号的检测器元件阵列的检测器装置， 容器装置，包括布置成容纳检测器装置的容器，物体和匹配的传输介质，适于相对于照明装置和检测器装置定位和移动物体的保持装置，其中光学部件布置在罐中 从不同的方向照亮物体。

公开(公告)号：EP2376896A2

公开(公告)日：2011-10-19

申请号：EP10726151.3

申请日：2010-01-08

Applicant: IT-IS International Ltd

Inventor： HOWELL, James, Richard ,  WEBSTER, Benjamin, Masterman ,  CLARK, Mark, Quentin ,  HOWELL, Richard, Alfred

IPC: G01N21/25 ,  G01N21/64

CPC classification number: B01J19/0046 ,  G01N21/253 ,  G01N21/6452 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An apparatus for detecting spectra in light emanating from chemical or biochemical reactions occurring in at least one reaction vessel (3) of a plurality of reaction vessels is disclosed. Each reaction vessel (3) has a receptacle portion having an emitting area from which light can emanate. The apparatus may include a masking element (5) having an array of apertures (6) through which light from each reaction vessel (3) can escape. A plurality of light waveguides (7) are arranged to guide light from the apertures (6) in the masking element (5) to a light dispersing device (8) for dispersing the light from each waveguide (7) into a dispersed spectrum. A light detecting device (10) detects specific spectra in the dispersed spectra of light substantially simultaneously. In one embodiment, the apertures (6) are substantially smaller in size than the emitting area of the reaction vessel, but in another embodiment, the apertures (6) are substantially similar in size to the emitting area of the reaction vessel and the light waveguides (7) have a diameter that tapers from a first end substantially similar in diameter to the area of the top of the reaction vessel to a second end that is substantially smaller in diameter. In an alternative embodiment, the light waveguides are not used, when light from the small apertures is directed straight at the light dispersing device. In a further alternative embodiment, several light waveguides are provided for each reaction vessel, each waveguide directing light to a different detector for detecting a different specific spectrum.

公开(公告)号：EP0910791B1

公开(公告)日：2010-09-08

申请号：EP97930638.8

申请日：1997-07-04

Applicant: Perkinelmer Singapore PTE Ltd.

Inventor： RUSHBROOKE, John, Gordon ,  HOOPER, Claire, Elizabeth ,  NEALE, William, Wray

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An imaging system for fluorescence assays includes a fibre optic coupling plate (20, 24, 26) for transmitting radiation emitted by a sample (18) towards a camera. This is combined with an interference filter (22) so as to enable highly sensitive transmission of radiation to the camera, according to wavelength. The interference filter may be combined with a fibre optic coupling plate in which sample sites or wells of an array are viewed by separate fibre optic bundles, each bundle transmitting emitted light from a one sample or well to a discrete region of the field of view of the camera.

公开(公告)号：EP2203107A1

公开(公告)日：2010-07-07

申请号：EP08807971.0

申请日：2008-10-13

Applicant: Koninklijke Philips Electronics N.V. ,  Philips Intellectual Property & Standards GmbH

Inventor： KOEHLER, Thomas ,  NIELSEN, Tim ,  BRENDEL, Bernhard, J. ,  ZIEGLER, Andy ,  ZIEGLER, Ronny ,  BAKKER, Levinus, P. ,  VAN DER MARK, Martinus, B.

IPC: A61B5/00 ,  G01N21/47

CPC classification number: G01N21/4795 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/4312 ,  A61B2562/146 ,  G01N2021/1787 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.

公开(公告)号：EP1890142A3

公开(公告)日：2009-12-23

申请号：EP07015685.6

申请日：2007-08-09

Applicant: SYSMEX CORPORATION

Inventor： Yamamoto, Norimasa ,  Tokunaga, Kazutoshi

IPC: G01N21/27 ,  G01N21/31 ,  G01N21/82 ,  G01N33/487 ,  G01N33/49 ,  G01N33/557 ,  G01J3/42 ,  G01N35/02 ,  G01N33/53

CPC classification number: G01N33/4905 ,  G01N21/272 ,  G01N21/314 ,  G01N21/82 ,  G01N35/025 ,  G01N2021/3133 ,  G01N2021/3137 ,  G01N2021/3148 ,  G01N2021/3174 ,  G01N2021/825 ,  G01N2201/0618 ,  G01N2201/0826

Abstract: A blood coagulation analyzer and analyzing method perform following: (a) preparing a measurement specimen by dispensing a blood specimen and a reagent into a reaction container; (b) emitting light of a plurality of wavelengths to the measurement specimen in the reaction container, the wavelengths comprising a first wavelength for use in a measurement by a blood coagulation time method, and at least one of a second wavelength for use in a measurement by a synthetic substrate method and a third wavelength for use in a measurement by an immunoturbidimetric method; (c) detecting light of a plurality of wavelengths corresponding to the light emitted in (b), from the measurement specimen, by a light receiving element, and acquiring data corresponding to each wavelength; and (d) conducting an analysis based on the data corresponding to one of the wavelengths among the acquired data, and acquiring a result of the analysis.

公开(公告)号：EP1099107B1

公开(公告)日：2009-01-07

申请号：EP99934902.0

申请日：1999-07-20

Applicant: PACKARD INSTRUMENT COMPANY

Inventor： RUSHBROOKE, John Gordon ,  HOOPER, Claire, Elizabeth

IPC: G01N21/64 ,  G01N21/76

CPC classification number: G01N21/6452 ,  G01N21/76 ,  G01N2021/6421 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833 ,  G01N2201/0866

Abstract: Apparatus for detecting light emitted by assay samples is provided, in which light emitted by the sample is collected for transmission to a charge coupled device camera (74) by an optical fibre bundle. The cross-sectional area of the optical fibre bundle corresponds to the area of the sample, the end of which is located close to the sample for detecting any light emitted therefrom, and selected fibres (30) of those making up the bundle are separated from the remainder and extend to a source of excitation radiation (76) and serve to convey excitation radiation (if required) directly to a corresponding plurality of points distributed over the area of the end face of the bundle and therefore over the area of the sample. The remaining fibres (32, 38) of the bundle serve to collect emitted light (whether generated by fluorescence caused by excitation or otherwise) and provide a light path to the charge coupled device camera, wherein the ends of the excitation fibres and the ends of the emitted light collecting fibres are distributed uniformly over the area of the fibre bundle presented to the reaction site.

公开(公告)号：EP1913520A2

公开(公告)日：2008-04-23

申请号：EP06813265.3

申请日：2006-07-31

Applicant: OG Technologies, Inc.

Inventor： CHANG, Tzyy-Shuh ,  GUTCHESS, Daniel ,  HUANG, Hsun-Hau

IPC: G06K9/00

CPC classification number: G01N21/952 ,  G01N2201/0826 ,  G01N2201/084 ,  H04N7/18

Abstract: The present invention is directed to solving the problems associated with the detection of surface defects on metal bars as well as the problems associated with applying metal flat inspection systems to metal bars for non-destructive surface defects detection. A specially designed imaging system, which is comprised of a computing unit, line lights and high data rate line scan cameras, is developed for the aforementioned purpose. The target application is the metal bars (1) that have a circumference/cross-section-area ratio equal to or smaller than 4.25 when the cross section area is unity for the given shape, (2) whose cross-sections are round, oval, or in the shape of a polygon, and (3) are manufactured by mechanically cross-section reduction processes. The said metal can be steel, stainless steel, aluminum, copper, bronze, titanium, nickel, and so forth, and/or their alloys. The said metal bars can be at the temperature when they are being manufactured. A removable cassette includes various mirrors. A protection tube isolates the moving metal bar from the line light assembly and image acquisition camera. assembly and image acquisition camera. A contaminant reduction mechanism applies a vacuum to remove airborne contaminants.