公开(公告)号：WO2016127043A1

公开(公告)日：2016-08-11

申请号：PCT/US2016/016753

申请日：2016-02-05

Applicant: STC.UNM ,  WILSON, Bridget, S. ,  WINTER, Stuart, S. ,  ERASMUS, Michael, Frank ,  HOROWITZ, Michael

Inventor： WILSON, Bridget, S. ,  WINTER, Stuart, S. ,  ERASMUS, Michael, Frank ,  HOROWITZ, Michael

IPC: A61K39/00 ,  A61P35/02

CPC classification number: C07K16/2803 ,  A61K39/3955 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/35 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

Abstract: This disclosure describes the identification of pre-B Cell Receptor (pre-BCR) antagonists and the use of pre-BCR antagonists as a targeted therapy. The compositions and methods generally involve a composition that includes a pre-B cell receptor (pre-BCR) antagonist and is engineered for expression as a T cell chimeric receptor. In some embodiments, the pre-BCR antagonists can include an anti-pre-BCR antibody.

Abstract translation: 本公开描述了B细胞前受体（前BCR）拮抗剂的鉴定以及使用前BCR拮抗剂作为靶向治疗。 组合物和方法通常涉及包含前B细胞受体（前BCR）拮抗剂的组合物，并且被工程化以用作T细胞嵌合受体的表达。 在一些实施方案中，前BCR拮抗剂可以包括抗前BCR抗体。

公开(公告)号：WO2016086034A1

公开(公告)日：2016-06-02

申请号：PCT/US2015/062500

申请日：2015-11-24

Applicant: STC.UNM

Inventor： HAYAT, Majeed, M. ,  KRISHNA, Sanjay ,  GODOY, Sebastian, Eugenio ,  RAMIREZ, David, A

IPC: A61B5/00

CPC classification number: A61B5/7275 ,  A61B5/015 ,  A61B5/489 ,  A61B5/7264 ,  G06F19/00

Abstract: A technique for classifying lesions as malignant or benign is disclosed. The technique can include: cooling an area of skin including a lesion of a patient to initiate a warm-up process; receiving a temporal sequence of thermal images of the area of skin representing a thermal recovery of the area of skin, the temporal sequence of thermal images generated by an infrared camera; generating a temporal profile of the thermal recovery based on the temporal sequence of thermal images; analyzing temporal statistical properties of the temporal profile; determining a malignancy probability that the lesion is malignant based on an analysis of the temporal profile, wherein the determining includes extracting one or more statistical features based on continuous- time stochastic signals in the sequence of thermal images; and classifying the lesion based on the malignancy probability.

Abstract translation: 公开了一种将病变分类为恶性或良性的技术。 该技术可以包括：冷却包括患者病变的皮肤区域以启动预热过程; 接收代表皮肤区域的热恢复的皮肤区域的时间序列，由红外相机生成的热图像的时间序列; 基于热图像的时间序列产生热恢复的时间分布; 分析时间分布的时间统计特性; 基于所述时间分布的分析来确定所述病变是恶性的恶性概率，其中所述确定包括基于所述热图像序列中的连续时间随机信号提取一个或多个统计特征; 并根据恶性概率对病变进行分类。

公开(公告)号：WO2016081603A1

公开(公告)日：2016-05-26

申请号：PCT/US2015/061349

申请日：2015-11-18

Applicant: STC.UNM

Inventor： TRUJILLO, Kristina ,  GANNON, Nicholas, Patrick ,  VAUGHAN, Roger, Alan

IPC: A61K38/16 ,  A61P35/00

CPC classification number: A61K38/22 ,  A61K31/155 ,  A61K31/337 ,  A61K31/704 ,  A61K38/177 ,  A61K45/06 ,  G01N33/74 ,  G01N2800/7028 ,  A61K2300/00

Abstract: In one embodiment, the invention provides methods of treating or preventing cancer, in particular aspects breast and/or prostate cancer, by administering to a subject in need thereof a therapeutically-effective amount of irisin and, optionally, one or more adjuvant therapies (e.g. synergistic co-administration of an additional anti-cancer agent or chemotherapy). Related pharmaceutical compositions, assays and kits are also provided.

Abstract translation: 在一个实施方案中，本发明提供了治疗或预防癌症，特别是乳腺和/或前列腺癌方面的方法，其通过向有需要的受试者施用治疗有效量的虹啡肽和任选的一种或多种辅助疗法（例如， 协同共同施用另外的抗癌剂或化疗）。 还提供了相关的药物组合物，测定和试剂盒。

公开(公告)号：WO2016054129A1

公开(公告)日：2016-04-07

申请号：PCT/US2015/053074

申请日：2015-09-30

Applicant: STC.UNM ,  SEROV, Alexey ,  ATANASSOV, Plamen, B. ,  KALUGIN, Nikolai ,  FROLOVA, Liliya, V.

Inventor： SEROV, Alexey ,  ATANASSOV, Plamen, B. ,  KALUGIN, Nikolai ,  FROLOVA, Liliya, V.

IPC: C07C51/42 ,  C07C57/30 ,  C07D207/04 ,  C07D207/06 ,  A61K31/192 ,  A61K9/70

CPC classification number: B01D15/08 ,  C01B31/0438 ,  C01B31/0492 ,  C07B2200/09 ,  C07C51/47 ,  C07D207/08 ,  G01N30/02 ,  G01N30/14 ,  G01N30/62 ,  G01N2030/027 ,  G01N2030/143 ,  G01N2030/146 ,  G01N2030/621 ,  G01N2030/623 ,  C07C57/30

Abstract: A variety of inorganic-organic hybrid materials and various methods for preparing and using the same are described. The hybrid materials are graphene or graphitic materials populated with organic molecules and may have a variety of surface defects, pits or three- dimensional architecture, thereby increasing the surface area of the material. The hybrid materials may take the form of three dimensional graphene nanosheets (3D GNS). If the organic molecules are enantiospecific molecules, the hybrid materials can be used for chiral separation of racemic mixtures.

Abstract translation: 描述了各种无机 - 有机杂化材料及其制备和使用的各种方法。 混合材料是石墨烯或石墨材料，它们含有有机分子，并且可能具有各种表面缺陷，凹坑或三维结构，从而增加了材料的表面积。 混合材料可以采用三维石墨烯纳米片（3D GNS）的形式。 如果有机分子是对映体特异性分子，则杂化材料可用于外消旋混合物的手性分离。

公开(公告)号：WO2016032882A1

公开(公告)日：2016-03-03

申请号：PCT/US2015/046238

申请日：2015-08-21

Applicant: STC.UNM

Inventor： BESWICK, Ellen, Janine ,  MORRIS, Katherine, Theresa

IPC: A61K31/167 ,  A61K31/5517 ,  A61K31/437 ,  A61K31/47 ,  A61K31/497 ,  A61K31/4995 ,  A61P35/00

CPC classification number: A61K31/167 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/551 ,  A61K31/553 ,  A61K38/005 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to the discovery that MK2 is highly expressed in cancer tissue and the inhibition of MK2 using an MK2 inhibitor represents a viable approach to the treatment of cancer, including drug resistant cancers, metastatic cancers and recurrent cancers. MK2 inhibitors as described herein may be used alone or in combination with an at least one additional anti-cancer agent for the treatment of cancer.

Abstract translation: 本发明涉及MK2在癌组织中高度表达的发现，并且使用MK2抑制剂抑制MK2代表治疗癌症的可行方法，包括耐药性癌症，转移性癌症和复发性癌症。 本文所述的MK2抑制剂可以单独使用或与至少一种另外的抗癌剂组合用于治疗癌症。

公开(公告)号：WO2016019311A1

公开(公告)日：2016-02-04

申请号：PCT/US2015/043240

申请日：2015-07-31

Applicant: STC.UNM ,  BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

Inventor： SALAMEH, Ahmed ,  LEE, Alessandro ,  NUNES, Diana, N. ,  DIAD-NETO, Emmanuel ,  PASQUALINE, Renata ,  ARAP, Wadih

IPC: A61K31/7088

CPC classification number: A61K31/7088

Abstract: Methods for detecting and treating prostate cancers are provided. In some aspects, methods for detecting a prostate cancer comprise measuring a level of PRUNE2 expression and/or PCA3 expression in a sample from a subject. In further aspects, a method for treating prostate cancer is provided comprising administering a PRUNE2 tumor suppressor polypeptide or a nucleic acid molecule that inhibits expression of PC A3 RNA.

Abstract translation: 提供了检测和治疗前列腺癌的方法。 在一些方面，用于检测前列腺癌的方法包括测量来自受试者的样品中PRUNE2表达和/或PCA3表达的水平。 在另外的方面，提供了一种治疗前列腺癌的方法，包括施用PRUNE2肿瘤抑制多肽或抑制PC A3 RNA表达的核酸分子。

公开(公告)号：WO2015175961A1

公开(公告)日：2015-11-19

申请号：PCT/US2015/031124

申请日：2015-05-15

Applicant: STC.UNM ,  MUTTIL, Pavan ,  WAFULA, Denis ,  WU, Terry ,  KUNDA, Nitesh

Inventor： MUTTIL, Pavan ,  WAFULA, Denis ,  WU, Terry ,  KUNDA, Nitesh

IPC: A61K9/14 ,  A61K39/02

CPC classification number: A61K39/02 ,  A61K9/0075 ,  A61K9/1617 ,  A61K9/1623 ,  A61K2039/522 ,  A61K2039/545 ,  Y02A50/405

Abstract: This disclosure describes, generally, compositions and methods related to thermostable vaccine formulations, their storage, and their use. Generally, the thermostable vaccine formulations can be in the form of a dry powder. The dry powder formulations can increase the length of time that the vaccine remains viable under non-refrigerated, ambient temperature conditions.

Abstract translation: 本公开一般地描述了与耐热性疫苗制剂相关的组合物和方法，它们的储存及其用途。 通常，热稳定性疫苗制剂可以是干粉的形式。 干粉配方可以增加疫苗在非冷藏环境温度条件下保持活力的时间长度。

公开(公告)号：WO2015126930A2

公开(公告)日：2015-08-27

申请号：PCT/US2015/016359

申请日：2015-02-18

Applicant: STC.UNM

Inventor： TIMMINS, Graham ,  CHOI, Seong, Won

IPC: A61K31/425

CPC classification number: A61K31/16 ,  A61K9/0075 ,  A61K31/4965 ,  A61K45/06 ,  A61K2300/00

Abstract: In one embodiment, the invention provides a method of treating a subject who suffers from, or who is suspected of suffering from, a Mycobacterium infection, the method comprising administering to the subject a therapeutically effective amount of a urease inhibitor, optionally in combination with one or more anti-mycobacterial agents.

Abstract translation: 在一个实施方案中，本发明提供了治疗患有或被怀疑患有分枝杆菌感染的受试者的方法，所述方法包括向受试者施用治疗有效量的脲酶抑制剂，任选地与一种 或更多的抗分枝杆菌剂。

公开(公告)号：WO2015077763A1

公开(公告)日：2015-05-28

申请号：PCT/US2014/067356

申请日：2014-11-25

Applicant: STC.UNM

Inventor： HILL, Jeff, Wade

IPC: C07K14/00 ,  C07K5/10 ,  C07K7/06 ,  A61K38/03 ,  A61K38/07

CPC classification number: A61K38/06 ,  A61K38/00 ,  A61K45/06 ,  C07K5/0823 ,  C07K14/7158

Abstract: The present invention provides a novel class of medicament based on CXCR antagonistic peptides. Among other things, the present invention provides peptides, compositions and methods for treating diseases, disorders and conditions in which a CXCR mediated pathway is implicated. Compositions and methods for effective treatment of inflammation, stroke, traumatic brain injury, pancreatic cancer, and others are provided.

Abstract translation: 本发明提供了一种基于CXCR拮抗肽的新型药物。 除其他之外，本发明提供用于治疗涉及CXCR介导的途径的疾病，病症和病症的肽，组合物和方法。 提供了有效治疗炎症，中风，创伤性脑损伤，胰腺癌等的组合物和方法。

公开(公告)号：WO2015058105A1

公开(公告)日：2015-04-23

申请号：PCT/US2014/061178

申请日：2014-10-17

Applicant: STC.UNM

Inventor： HAN, Sang, Eon ,  HOARD, Brittany, R. ,  HAN, Sang, M. ,  GHOSH, Swapnadip

IPC: H01L31/0236 ,  H01L31/18

CPC classification number: H01L31/02363 ,  G02B1/005 ,  H01L31/0747 ,  H01L31/1804 ,  H01L31/202 ,  H01L31/208 ,  H03H9/10 ,  H03H9/145 ,  H03H9/25 ,  Y02E10/547 ,  Y02P70/521

Abstract: Provided is a method for fabricating a nanopatterned surface. The method includes forming a mask on a substrate, patterning the substrate to include a plurality of symmetry- breaking surface corrugations, and removing the mask. The mask includes a pattern defined by mask material portions that cover first surface portions of the substrate and a plurality of mask space portions that expose second surface portions of the substrate, wherein the plurality of mask space portions are arranged in a lattice arrangement having a row and column, and the row is not oriented parallel to a [110] direction of the substrate. The patterning the substrate includes anisotropically removing portions of the substrate exposed by the plurality of spaces.

Abstract translation: 提供了一种制造纳米图案表面的方法。 该方法包括在衬底上形成掩模，图案化衬底以包括多个对称破坏的表面波纹，以及去除掩模。 掩模包括由覆盖基板的第一表面部分的掩模材料部分限定的图案和暴露基板的第二表面部分的多个掩模空间部分，其中多个掩模空间部分布置成具有排的格子布置 和列，并且该行不平行于衬底的[110]方向取向。 图案化衬底包括由多个空间暴露的各向异性去除部分的衬底。