公开(公告)号：WO2013138929A1

公开(公告)日：2013-09-26

申请号：PCT/CA2013/050216

申请日：2013-03-15

Applicant: ORMECI BECKERS, Banu

Inventor： ORMECI BECKERS, Banu

IPC: G01N21/25 ,  C02F1/00 ,  C02F1/52 ,  C02F1/56

CPC classification number: G01N21/33 ,  C02F1/008 ,  C02F1/5209 ,  C02F1/5245 ,  C02F1/56 ,  C02F11/14 ,  C02F2103/06 ,  C02F2103/30 ,  C02F2103/32 ,  C02F2209/00 ,  C02F2209/001 ,  C02F2209/003 ,  G01J3/42 ,  G01N21/59 ,  G01N2201/105

Abstract: The present application provides a method of detecting an amount of a treatment agent, such as a flocculating agent, in a process stream comprising the step of measuring at least one absorption property of a sample obtained from the process stream at a wavelength of less than about 250 nm. Processes and systems for monitoring and regulating addition of treatment agents to process streams are also provided.

Abstract translation: 本申请提供了在工艺流中检测处理剂如絮凝剂的量的方法，该方法包括以下步骤：测量从工艺流中获得的样品的至少一种吸收性能，其波长小于约 250 nm。 还提供了用于监测和调节加工流程中处理剂添加的过程和系统。

公开(公告)号：WO2010041082A2

公开(公告)日：2010-04-15

申请号：PCT/GB2009051350

申请日：2009-10-09

Applicant: MALVERN INSTR LTD ,  WATSON FRASER MCNEIL

Inventor： WATSON FRASER MCNEIL

IPC: G01N27/447 ,  B01L3/00 ,  G01N15/02

CPC classification number: G01N21/253 ,  B01L3/5025 ,  B01L2300/0829 ,  B01L2400/0421 ,  G01N21/03 ,  G01N21/51 ,  G01N27/44721 ,  G01N2015/1493 ,  G01N2021/0346 ,  G01N2021/4707 ,  G01N2021/513 ,  G01N2201/103 ,  G01N2201/105

Abstract: In one general aspect, a high-throughput optical suspension characterization instrument is disclosed, which can include hydraulically separate and at least partially transparent sample containers. A selection mechanism is operative to selectively direct light from a light source through different ones of the sample containers along an optical axis, and an off-axis scattering detector(40)is responsive to scattered light from the light source after it has interacted with a sample.

Abstract translation: 在一个一般方面，公开了一种高通量光学悬浮表征仪器，其可以包括液压分离和至少部分透明的样品容器。 选择机构可操作以沿着光轴选择性地引导来自光源的光通过不同的样本容器，并且离轴散射检测器（40）在与光源相互作用后响应于来自光源的散射光 样品。

公开(公告)号：WO2009093050A1

公开(公告)日：2009-07-30

申请号：PCT/GB2009/000214

申请日：2009-01-26

Applicant: RENISHAW PLC ,  HAYWARD, Ian, Paul ,  SMITH, Brian, John, Edward

Inventor： HAYWARD, Ian, Paul ,  SMITH, Brian, John, Edward

IPC: G01J3/44 ,  G01J3/28 ,  G01N21/65 ,  G01J3/02

CPC classification number: G01J3/02 ,  G01J3/0289 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/656 ,  G01N2201/103 ,  G01N2201/105

Abstract: In a Raman spectroscopy apparatus, exciting light is focussed on a sample (26) as a line focus (38). Spectra from points in the line focus are dispersed in rows 46 on a CCD detector (34), having a two-dimensional array of pixels. The line focus moves longitudinally in a direction Y relative to the sample. Simultaneously and synchronously, charge is shifted in a parallel direction Y' within the CCD, so that data from a given point in the sample continues to accumulate, hi order to provide averaging in the X direction during fast, low resolution scanning, the line focus is swept across the sample in a zig-zag fashion, between boundary lines 60.

Abstract translation: 在拉曼光谱装置中，激发光聚焦在样品（26）上作为线焦点（38）。 来自线对焦中的点的光谱分散在具有二维像素阵列的CCD检测器（34）上的行46中。 线对焦相对于样品沿Y方向纵向移动。 同时同步地，电荷在CCD内的平行方向Y'上移动，使得来自样本中给定点的数据继续积累。为了在快速，低分辨率扫描期间在X方向上提供平均，线焦点 在边界线60之间以锯齿形的方式扫过样本。

公开(公告)号：WO2006066137A3

公开(公告)日：2009-04-16

申请号：PCT/US2005045784

申请日：2005-12-17

Applicant: ADE CORP

Inventor： JUDELL NEIL ,  KOHL IAN THOMAS ,  GOA SONGPING ,  BILLS RICHARD EARL

IPC: G01N21/88 ,  G01N21/00

CPC classification number: G01N21/9501 ,  G01N21/21 ,  G01N21/47 ,  G01N21/4738 ,  G01N21/474 ,  G01N21/55 ,  G01N21/88 ,  G01N21/8806 ,  G01N21/95 ,  G01N21/956 ,  G01N2021/4707 ,  G01N2021/4711 ,  G01N2021/4792 ,  G01N2021/556 ,  G01N2021/8809 ,  G01N2021/8848 ,  G01N2021/8864 ,  G01N2021/8877 ,  G01N2021/8896 ,  G01N2201/0612 ,  G01N2201/105 ,  G06T7/0004 ,  G06T2207/30148 ,  Y10T29/49826

Abstract: A surface inspection system, as well as related components and methods, are provided. The surface inspection system includes a beam source subsystem, a beam scanning subsystem, a workpiece movement subsystem, an optical collection and detection subsystem, and a processing subsystem. The system features a variable polarization a polarizing relay assembly arranged to selectively permit the scattered light having a selected polarization orientation to pass along a detector optical axis to a light detection unit in the detection subsystem. They system also features a collector output width varying subsystem for varying the width of an output slit in response to changes in the location of the location scanned on the workpiece.

Abstract translation: 提供了表面检查系统，以及相关的部件和方法。 表面检查系统包括光束源子系统，光束扫描子系统，工件运动子系统，光学收集和检测子系统以及处理子系统。 该系统具有可变极化，偏振继电器组件布置成选择性地允许具有选定的偏振取向的散射光沿着检测器光轴传递到检测子系统中的光检测单元。 它们还具有收集器输出宽度变化子系统，用于响应于在工件上扫描的位置的位置的改变而改变输出狭缝的宽度。

公开(公告)号：WO2009009081A2

公开(公告)日：2009-01-15

申请号：PCT/US2008/008447

申请日：2008-07-10

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  CHOI, Wonshik ,  DASARI, Ramachandra, Rao ,  FANG-YEN, Christopher, M. ,  FELD, Michael, S.

Inventor： CHOI, Wonshik ,  DASARI, Ramachandra, Rao ,  FANG-YEN, Christopher, M. ,  FELD, Michael, S.

IPC: G01N21/47 ,  A61B3/12 ,  A61B5/00

CPC classification number: G01N21/45 ,  G01N21/51 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2021/458 ,  G01N2201/061 ,  G01N2201/105 ,  G01N2201/12

Abstract: The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase- shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time -dependent changes in cell structure and the quantitative characterization of specimen- induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering.

Abstract translation: 本发明涉及使用具有可变照射角的相移激光干涉显微镜在活体或非活体细胞，组织或生物中定量三维绘制折射率的系统和方法。 一个优选的实施方案提供了细胞和多细胞生物体的层析成像，以及细胞结构的时间依赖性变化以及在组织光散射中具有多种应用的高分辨率显微镜中样本诱导的像差的定量表征。

公开(公告)号：WO2006066139A2

公开(公告)日：2006-06-22

申请号：PCT/US2005045786

申请日：2005-12-17

Applicant: ADE CORP

Inventor： BILLS RICHARD EARL ,  JUDELL NEIL ,  FREISCHLAD KLAUS REINHARD

IPC: G01N21/00

CPC classification number: G01N21/9501 ,  G01N21/21 ,  G01N21/47 ,  G01N21/4738 ,  G01N21/474 ,  G01N21/55 ,  G01N21/88 ,  G01N21/8806 ,  G01N21/95 ,  G01N21/956 ,  G01N2021/4707 ,  G01N2021/4711 ,  G01N2021/4792 ,  G01N2021/556 ,  G01N2021/8809 ,  G01N2021/8848 ,  G01N2021/8864 ,  G01N2021/8877 ,  G01N2021/8896 ,  G01N2201/0612 ,  G01N2201/105 ,  G06T7/0004 ,  G06T2207/30148 ,  Y10T29/49826

Abstract: A surface inspection system, as well as related components and methods, are provided. The surface inspection system includes a beam source subsystem, a beam scanning subsystem, a workpiece movement subsystem, an optical collection and detection subsystem, and a processing subsystem. The optical collection and detection system features, in the front quartersphere, a light channel assembly for collecting light reflected from the surface of the workpiece, and a front collector and wing collectors for collecting light scattered from the surface, to, greatly improve the measurement capabilities of the system. The light channel assembly has a switchable edge exclusion mask and a reflected light detection system for improved detection of the reflected light.

Abstract translation: 提供了表面检查系统，以及相关的部件和方法。 表面检查系统包括光束源子系统，光束扫描子系统，工件运动子系统，光学收集和检测子系统以及处理子系统。 光学收集和检测系统在前四分之一区域中具有用于收集从工件表面反射的光的光通道组件，以及用于收集从表面散射的光的前收集器和翼收集器，大大提高测量能力 的系统。 光通道组件具有可切换的边缘排除掩模和用于改进反射光检测的反射光检测系统。

公开(公告)号：WO2006066138A2

公开(公告)日：2006-06-22

申请号：PCT/US2005045785

申请日：2005-12-17

Applicant: ADE CORP

Inventor： BARAN BRUCE ,  GAO SONGPING ,  BILLS RICHARD EARL ,  MURPHREE MICHAEL ,  KOLIOPOULOS CHRIS L

IPC: A61M25/00

CPC classification number: G01N21/9501 ,  G01N21/21 ,  G01N21/47 ,  G01N21/4738 ,  G01N21/474 ,  G01N21/55 ,  G01N21/88 ,  G01N21/8806 ,  G01N21/95 ,  G01N21/956 ,  G01N2021/4707 ,  G01N2021/4711 ,  G01N2021/4792 ,  G01N2021/556 ,  G01N2021/8809 ,  G01N2021/8848 ,  G01N2021/8864 ,  G01N2021/8877 ,  G01N2021/8896 ,  G01N2201/0612 ,  G01N2201/105 ,  G06T7/0004 ,  G06T2207/30148 ,  Y10T29/49826

Abstract: A surface inspection system, as well as related components and methods, are provided. The surface inspection system includes a beam source subsystem, a beam scanning subsystem, a workpiece movement subsystem, an optical collection and detection subsystem, and a processing subsystem. The system features a variable scan speed beam scanning subsystem, preferably using an acousto-optic deflector, with beam compensation, so that variable scanning speeds can be achieved. Also included are methods and systems for improving the signal to noise ratio by use of scatter reducing complements, and a system and method for selectively and repeatedly scanning a region of interest on the surface in order to provide additional observations of the region of interest.

Abstract translation: 提供了表面检查系统，以及相关的部件和方法。 表面检查系统包括光束源子系统，光束扫描子系统，工件移动子系统，光学收集和检测子系统以及处理子系统。 该系统具有可变扫描速度波束扫描子系统，优选地使用声光偏转器，具有光束补偿，使得可以实现可变的扫描速度。 还包括用于通过使用散射减少补充来提高信噪比的方法和系统，以及用于选择性地和重复地扫描表面上的感兴趣区域以便提供感兴趣区域的附加观察的系统和方法。

公开(公告)号：WO2006066136A2

公开(公告)日：2006-06-22

申请号：PCT/US2005045783

申请日：2005-12-17

Applicant: ADE CORP

Inventor： BILLS RICHARD EARL ,  JUDELL NEIL

IPC: G01N21/00

CPC classification number: G01N21/9501 ,  G01N21/21 ,  G01N21/47 ,  G01N21/4738 ,  G01N21/474 ,  G01N21/55 ,  G01N21/88 ,  G01N21/8806 ,  G01N21/95 ,  G01N21/956 ,  G01N2021/4707 ,  G01N2021/4711 ,  G01N2021/4792 ,  G01N2021/556 ,  G01N2021/8809 ,  G01N2021/8848 ,  G01N2021/8864 ,  G01N2021/8877 ,  G01N2021/8896 ,  G01N2201/0612 ,  G01N2201/105 ,  G06T7/0004 ,  G06T2207/30148 ,  Y10T29/49826

Abstract: A surface inspection system includes a beam source subsystem, a beam scanning subsystem, a workpiece movement subsystem, an optical collection and detection subsystem, and a processing subsystem. The optical collection and detection system features back collectors disposed in the back quartersphere, outside the incident plane, for collecting light scattered from the surface of the workpiece. The back collectors are disposed at a relative minimum in the portion of scattered light attributable to haze relative to the portion of scattered light attributable to defect scatter portion, or, alternatively, at a relative minimum in the Rayleigh scatter.

Abstract translation: 表面检查系统包括光束源子系统，光束扫描子系统，工件运动子系统，光学收集和检测子系统以及处理子系统。 光学收集和检测系统具有设置在后四分之一圆周的入射平面外部的后收集器，用于收集从工件表面散射的光。 背部收集器相对于归因于缺陷散射部分的散射光部分的雾度部分的散射光部分相对最小设置，或者在瑞利散射中相对最小。

公开(公告)号：EP3256856A4

公开(公告)日：2018-06-06

申请号：EP15871090

申请日：2015-12-17

Applicant: SINGULEX INC

Inventor： LIVINGSTON RICHARD ,  GILBERT MICHELLE ,  FELBERG JACQUELINE ,  BISHOP JEFFREY

IPC: G01N33/58 ,  G01J3/44 ,  G01N21/62 ,  G01N21/64 ,  G01N33/53

CPC classification number: G01N21/6428 ,  G01J3/4406 ,  G01N21/645 ,  G01N21/6452 ,  G01N33/5302 ,  G01N33/536 ,  G01N33/58 ,  G01N33/6845 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/0612 ,  G01N2201/103 ,  G01N2201/104 ,  G01N2201/105

Abstract: Analyzers and analyzer systems that include an analyzer for determining multiple label species, methods of using the analyzer and analyzer systems to analyze samples, are disclosed herein. The analyzer includes one or more sources of electromagnetic radiation to provide electromagnetic radiation at wavelengths within the excitation bands of one or more fluorophore species to an interrogation space that is translated through the sample to detect the presence or absence of molecules of different target analytes. The analyzer may also include one or more detectors configured to detect electromagnetic radiation emitted from the one or more fluorophore species. The analyzer for determining multiple target molecule species provided herein is useful for diagnostics because the concentration of multiple species of target molecules may be determined in a single sample and with a single system.

公开(公告)号：EP3324173A1

公开(公告)日：2018-05-23

申请号：EP17382427.7

申请日：2017-07-03

Applicant: Fyla Laser, S.L.

Inventor： PÉREZ MILLÁN, Pere ,  TORRES PEIRÓ, Salvador ,  ABREU ALFONSO, Javier ,  MUÑOZ MARCO, Héctor ,  OTGON, Viorel

IPC: G01N21/47 ,  G01N21/49 ,  G01N21/64

CPC classification number: G01N21/474 ,  G01N21/49 ,  G01N2021/4742 ,  G01N2021/4747 ,  G01N2021/475 ,  G01N2021/4773 ,  G01N2201/105

Abstract: The system comprises a light source (10) generating a light beam (LB) to impinge on a sample (1); an imaging system (20) obtaining an image of said sample (1) and comprising a parabolic mirror (21) with a hole to allow the passage of the light beam (LB) towards the sample (1), the redirection of a scattered light component of the sample (1) towards a light capturing unit comprising a bundle of bifurcated fibers (15), and the elimination of the light coming from direct reflection at the sample (1); the bundle of fibers (15) having a central fiber (17) and at least one external fiber (16), said central fiber (17) receiving scattered light from the surface (1 S) and said external fiber (16) receiving scattered light from inside (11) the sample (1); and a measuring system (30) measuring a power and/or a spectrum collected independently in the central (17) and in the external fiber (16).