Abstract:
A process for producing a quinazolin-4-one compound having the formula: Äwherein R , R , R and R each represents a group not participating in the below-mentioned reaction, and R , R , R and R can be combined together to form a ringÜ which comprises reacting an anthranilic acid derivative having the formula: Äwherein R is a hydrogen atom or a hydrocarbyl groupÜ with a formic acid derivative in the presence of an ammonium carboxylate.
Abstract:
PROBLEM TO BE SOLVED: To improve a widely and generally usable method for cross coupling a carbon electrophile and a carbon nucleophile by using a catalyst, which method forms in-situ the carbon nucleophile by removing a carboxyl group from a metal carboxylate.SOLUTION: This method includes forming a carbon-carbon bonding by reacting a carboxylate and a carbon electrophile while decarboxylating them in the presence of a catalyst of a transition metal or transition metal compound. Also there is provided such a catalytic system for a carbon-carbon bonding involving a decarboxylation, namely a carbon-carbon bonding of a carboxylate and a carbon electrophile, as includes a palladium compound, a copper compound, and a chelatable cyclic amine or a substituted compound thereof selected from the group consisting of phenanthroline, dipyridine, and terpyridine.
Abstract:
In the invented process for producing a nitro compound, an organic substrate and nitrogen dioxide are reacted in the presence of oxygen or are reacted in a molar ratio of nitrogen dioxide to the organic substrate of less than 1 to yield a corresponding nitro compound. The reaction may be performed in the presence of N-hydroxyphthalimide or other imide compounds. Such organic substrates include (a) aliphatic hydrocarbons, (b) alicyclic hydrocarbons, (c) non-aromatic heterocyclic compounds each having a carbon atom on a ring, which carbon atom is bonded to a hydrogen atom, (d) compounds each having a carbon-hydrogen bond at the adjacent position to an aromatic ring, and (e) compounds each having a carbon-hydrogen bond at the adjacent position to a carbonyl group. This process can efficiently nitrate an organic substrate even under relatively mild conditions.
Abstract:
PROBLEM TO BE SOLVED: To provide a simple method for producing 1,5-dinitronaphthalene by reducing or eliminating existing problems. SOLUTION: This method for producing the 1,5-dinitronaphthalene comprises nitrating naphthalene with 72-87 mass% concentration nitric acid in the absence of sulfuric acid at 30-80°C, filtering the nitrated naphthalene at 5-20°C, washing the obtained solid precipitated material with water, and then washing with acetone to isolate the 1,5-dinitronaphthalene. COPYRIGHT: (C)2005,JPO&NCIPI