公开(公告)号：AT380054T

公开(公告)日：2007-12-15

申请号：AT01945236

申请日：2001-06-01

Applicant: PENTAPHARM LTD ,  EZAKI GLICO CO

Inventor： KURIKI TAKASHI ,  NAKAE TAKASHI ,  NISHIMURA TAKAHISA ,  NAKAYAMA HIROKI

IPC: A61Q19/02 ,  A61K8/00 ,  A61K8/19 ,  A61K8/23 ,  A61K8/30 ,  A61K8/33 ,  A61K8/34 ,  A61K8/35 ,  A61K8/36 ,  A61K8/362 ,  A61K8/365 ,  A61K8/368 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K8/44 ,  A61K8/46 ,  A61K8/49 ,  A61K8/60 ,  A61K8/64 ,  A61K8/67 ,  A61K8/68 ,  A61K8/72 ,  A61K8/73 ,  A61K8/86 ,  A61K8/96 ,  A61K8/97 ,  A61K8/98 ,  A61K31/198 ,  A61K31/355 ,  A61K31/375 ,  A61K31/70 ,  A61K31/7048 ,  A61K31/715 ,  A61K36/06 ,  A61Q5/00 ,  A61Q19/00 ,  C07D201/00

Abstract: The objective of the present invention was to enhance the skin whitening effects and blackening prevention effects and supply safe topical agents for dermatological use. For that purpose a topical composition comprising 4-hydroxyphenyl-alpha-D-glucopyranoside and UV absorber is manufactured.

公开(公告)号：EA008705B1

公开(公告)日：2007-06-29

申请号：EA200501582

申请日：2004-04-08

Applicant: ALGORX PHARMACEUTICALS INC

Inventor： MCINVAIN SHARON ,  CHEN WEI ,  RAMIYA PREMCHANDRAN H ,  BIRCH RONALD ,  CARTER RICHARD B ,  ANDERSON TIMOTHY A ,  ZHANG HEPING

IPC: A61K31/165 ,  A61K31/05 ,  A61K31/16 ,  A61K31/5415 ,  A61K31/551 ,  A61K45/06 ,  C07C51/36 ,  C07C231/02 ,  C07C233/20 ,  C07D201/00

Abstract: Внастоящемизобретениипредложенспособсинтезатранс-изомеракапсаицинаи/иликапсаициноподобныхсоединений, путемиспользованияпроцесса, вкоторомтранс-конфигурациюзадаютс самогоначалареакциисинтезаи сохраняютеенапротяжениивсегопроцессасинтеза.

公开(公告)号：ES2245594B1

公开(公告)日：2006-12-01

申请号：ES200401285

申请日：2004-05-27

Applicant: ESTEVE LABOR DR

Inventor： NOHEDA MARIN PEDRO ,  BERNABE PAJARES MANUEL ,  MAROTO QUINTANA SERGIO ,  TABARES CANTERO NURIA

IPC: C07D205/12 ,  C07D201/00

Abstract: La invención proporciona azetidinonas espirocondensadas sumamente funcionalizadas que tienen un resto ciclohexano con el número deseado de grupos hidroxilo protegidos o sin proteger, que se introducen con alta estereo y regioselectividad, así como procedimientos para su obtención.

公开(公告)号：BRPI0409748A

公开(公告)日：2006-10-24

申请号：BRPI0409748

申请日：2004-04-08

Applicant: ALGORX PHARMACEUTICALS INC

Inventor： MCIIVAIN SHARON ,  CHEN WEI ,  RAMIYA PREMCHANDRAN H ,  BURCH RONALD ,  CARTER RICHARD ,  ANDERSON TIMOTHY A

IPC: A61K31/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/5415 ,  A61K31/551 ,  A61K45/06 ,  C07C51/36 ,  C07C231/02 ,  C07C233/20 ,  C07D201/00

Abstract: The present invention provides methods for synthesizing the trans isomer of capsaicin and/or capsaicin-like compounds by utilizing a process wherein the trans geometry is set from the beginning of the synthesis reaction and carried through the entire synthesis process.

公开(公告)号：EA200501582A1

公开(公告)日：2006-06-30

申请号：EA200501582

申请日：2004-04-08

IPC: A61K31/165 ,  A61K31/05 ,  A61K31/16 ,  A61K31/5415 ,  A61K31/551 ,  A61K45/06 ,  C07C51/36 ,  C07C231/02 ,  C07C233/20 ,  C07D201/00

Abstract: Внастоящемизобретениипредложенспособсинтезатрансизомеракапсаицинаи/иликапсаициноподобныхсоединенийпутемиспользованияпроцесса, вкоторомтрансконфигурациюзадаютс самогоначалареакциисинтезаи сохраняютеенапротяжениивсегопроцессасинтеза.

公开(公告)号：DK1280757T3

公开(公告)日：2005-12-12

申请号：DK01947234

申请日：2001-04-23

Applicant: HOFFMANN LA ROCHE

Inventor： LAPIERRE JEAN-MARC ,  BELLONI PAULA NANETTE ,  JOLIDON SYNESE ,  KLAUS MICHAEL

IPC: A61K31/045 ,  A61K31/11 ,  A61K31/165 ,  A61K31/19 ,  A61K31/192 ,  A61K31/20 ,  A61K31/23 ,  A61K31/235 ,  A61K31/27 ,  A61K31/275 ,  A61K31/353 ,  A61K31/381 ,  A61K31/382 ,  A61K31/421 ,  A61K31/4704 ,  A61P3/02 ,  A61P11/00 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P17/16 ,  A61P35/00 ,  A61P43/00 ,  C07C63/49 ,  C07C63/64 ,  C07C63/66 ,  C07C63/74 ,  C07C65/26 ,  C07C65/28 ,  C07C69/616 ,  C07C69/635 ,  C07C69/734 ,  C07C69/76 ,  C07C69/80 ,  C07C69/82 ,  C07C69/90 ,  C07C69/94 ,  C07C255/33 ,  C07C271/58 ,  C07C323/56 ,  C07C403/20 ,  C07D213/30 ,  C07D215/12 ,  C07D215/14 ,  C07D215/22 ,  C07D261/08 ,  C07D263/00 ,  C07D263/38 ,  C07D271/06 ,  C07D277/24 ,  C07D307/42 ,  C07D311/00 ,  C07D311/58 ,  C07D333/40 ,  C07D335/06 ,  C07D201/00

Abstract: New compounds containing bicyclic fused rings, one of which being a phenyl moiety connected by an aliphatic chain to a cycloalkyl or aryl moiety, and pharmaceutically active salts thereof are useful as RAR selective retinoid agonists. Furthermore, such retinoic acid receptor agonists, particularly retinoic acid receptor gamma (RARgamma) selective agonists, are useful for the treatment of emphysema and associated pulmonary diseases, as well as for the therapy and prophylaxis of dermatological disorders, for the therapy and prophylaxis of malignant and premalignant epithelial lesions, tumors and precancerous changes of the mucous membrane in the mouth, tongue, larynx, esophagus, bladder, cervix and colon.

公开(公告)号：NO20053910D0

公开(公告)日：2005-08-22

申请号：NO20053910

申请日：2005-08-22

Applicant: UCB FARCHIM SA

Inventor： ATES CELAL ,  CAVOY EMILE ,  BOUVY DIDIER

IPC: C07D201/00 ,  C07D271/06 ,  C07D271/07 ,  C07D295/15 ,  C07D

Abstract: The present invention relates to new enantiomerically pure piperazine derivatives of formula (I) wherein Y represents hydroxy or a leaving group and n is 1, 2, 3, 4 or 5, and to their use as synthesis intermediates, especially for the preparation of pharmaceutically active compounds

公开(公告)号：DK1235831T3

公开(公告)日：2005-06-27

申请号：DK00971960

申请日：2000-10-13

Applicant: ASTRAZENECA AB

Inventor： BJOERE ANNIKA ,  STRANDLUND GERT ,  WILSTERMANN MICHAEL ,  PONTEN FRITIOF ,  BJOERSNE MAGNUS ,  CLADINGBOEL DAVID ,  HOFFMAN KURT-JUERGEN ,  PAVEY JOHN ,  SVENSSON PEDER ,  THOMSON COLIN

IPC: C07D303/36 ,  A61K20060101 ,  A61K31/535 ,  A61K31/537 ,  A61K31/538 ,  A61K31/5386 ,  A61P20060101 ,  A61P9/06 ,  C07B61/00 ,  C07D20060101 ,  C07D265/30 ,  C07D295/16 ,  C07D295/26 ,  C07D303/48 ,  C07D498/00 ,  C07D498/08 ,  C07D513/00 ,  C07D515/02 ,  C07D519/00 ,  C07D201/00

Abstract: The present invention relates to a combination comprising component (a) being a compound of formula I, and component (b), being, at least one other drug useful in the treatment of arrhythmias and / or at least one other drug useful in the treatment of a cardiovascular disorder.

公开(公告)号：HK1051046B

公开(公告)日：2005-04-29

申请号：HK03101833

申请日：2003-03-13

Applicant: ALLERGAN PHARMACEUTICALS INT LTD

Inventor： FREDRICK DANA CAZER ,  GREGORY EUGENE PERRY ,  DENNIS MICHAEL BILLINGS ,  NANCY LEE REDMAN-FUREY

IPC: A61K31/663 ,  C07F20060101 ,  A61K20060101 ,  A61K31/675 ,  A61P20060101 ,  A61P3/14 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  C07D201/00 ,  C07F9/58

公开(公告)号：TR200402435T4

公开(公告)日：2004-12-21

申请号：TR200402435

申请日：2001-02-01

Applicant: PROCTER & GAMBLE

Inventor： CAZER FREDRICK DANA ,  PERRY GREGORY EUGENE ,  BILLINGS DENNIS MICHEAL ,  FUREY NANCY LEE REDMAN

IPC: A61K31/663 ,  A61K31/675 ,  A61P3/14 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  C07D201/00 ,  C07F9/58

Abstract: The present invention discloses 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid sodium hemipentahydrate and monohydrate, methods of preparing the hemipentahydrate or monohydrate through control of the nucleation temperature and rate of crystallization and pharmaceutical compositions containing one or both of the hydrate forms.