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    Method for producing a polymer, using caprolactam
    271.
    发明申请
    Method for producing a polymer, using caprolactam 失效
    使用己内酰胺制造聚合物的方法

    公开(公告)号：US20030135019A1

    公开(公告)日：2003-07-17

    申请号：US10257876

    申请日：2002-10-17

    Inventor： Frank Ohlbach ,  Helmut Winterling ,  Andreas Ansmann ,  Rolf-Hartmuth Fischer ,  Johann-Peter Melder ,  Stefan Maixner ,  Peter Bassler ,  Hermann Luyken

    IPC: C08G069/08 ,  C07D201/02

    CPC classification number: C08G69/14 ,  C08G69/04 ,  C08G69/16 ,  Y10T428/29 ,  Y10T428/2969 ,  Y10T428/2971

    Abstract: A process for preparing a polymer, which comprises a) reacting a mixture (I) containing 6-aminocapronitrile and water in the presence of a catalyst to obtain a mixture (II) containing caprolactam, ammonia, water, high boilers and low boilers, then b) removing ammonia from mixture (II) to obtain a mixture (III) containing caprolactam, water, high boilers and low boilers, then c) removing all or some of the water from mixture (III) to obtain a mixture (IV) containing caprolactam, high boilers and low boilers and then d) feeding mixture (IV) to a polymerization reaction,and also the polymer obtainable by this process, the use of the polymer for producing fibers, sheetlike structures and moldings, and also fibers, sheetlike structures and moldings obtainable using such a polymer.

    Abstract translation: 一种制备聚合物的方法，其包括a）在催化剂存在下使含有6-氨基己腈和水的混合物（I）反应，得到含有己内酰胺，氨，水，高锅炉和低锅炉的混合物（II） b）从混合物（II）中除去氨以得到含有己内酰胺，水，高锅炉和低锅炉的混合物（III），然后c）从混合物（III）中除去全部或部分水，得到含有 己内酰胺，高锅炉和低锅炉，然后d）将混合物（IV）加入到聚合反应中，以及可通过该方法获得的聚合物，使用聚合物生产纤维，片状结构和模制品，以及纤维，片状结构 以及使用这种聚合物可获得的模制品。

    Method for producing caprolactam from 6-aminocapronitrile
    272.
    发明申请
    Method for producing caprolactam from 6-aminocapronitrile 有权
    从6-氨基己腈生产己内酰胺的方法

    公开(公告)号：US20030125546A1

    公开(公告)日：2003-07-03

    申请号：US10258942

    申请日：2002-10-29

    Inventor： Peter Bassler ,  Dieter Baumann ,  Rolf-Hartmuth Fischer ,  Eberhard Fuchs ,  Johann-Peter Melder ,  Frank Ohlbach

    IPC: C07D201/02

    CPC classification number: C07D201/08 ,  C07D201/16

    Abstract: A process for the preparation of caprolactam is provided, wherein a) a mixture (I) containing 6-aminocapronitrile and water is reacted in the liquid phase, in the presence of a catalyst, to give a mixture (II) containing caprolactam, ammonia, water, high-boiling components and low-boiling components, b) ammonia is then removed from the mixture (II) to give a mixture (III) containing caprolactam, water, high-boiling components and low-boiling components, c) water is then removed from the mixture (III) to give a mixture (IV) containing caprolactam, high-boiling components and low-boiling components, and d) a solid (V) containing caprolactam is then obtained from the mixture (IV) by crystallization, the proportion by weight of caprolactam in the solid (V) being greater than in the mixture (IV).

    Abstract translation: 提供了制备己内酰胺的方法，其中a）含有6-氨基己腈和水的混合物（I）在液相中在催化剂存在下反应，得到含有己内酰胺，氨， 水，高沸点组分和低沸点组分，b）然后从混合物（II）中除去氨，得到含有己内酰胺，水，高沸点组分和低沸点组分的混合物（III），c）水是 然后从混合物（III）中取出，得到含己内酰胺，高沸点成分和低沸点组分的混合物（Ⅳ），然后通过结晶从混合物（Ⅳ）中获得含有己内酰胺的固体（Ⅴ） 固体（V）中己内酰胺的重量比例大于混合物（IV）中的比例。

    Process for the preparation of a mixture of .epsilon.-caprolactam, 6-aminocaproic acid and 6-aminocaproic amide
    273.
    发明授权
    Process for the preparation of a mixture of .epsilon.-caprolactam, 6-aminocaproic acid and 6-aminocaproic amide 失效
    制备ε-己内酰胺，6-氨基己酸和6-氨基己酰胺的混合物的方法

    公开(公告)号：US6011153A

    公开(公告)日：2000-01-04

    申请号：US140896

    申请日：1998-08-21

    Applicant: Wim Buijs ,  Henricus F. W. Wolters

    Inventor： Wim Buijs ,  Henricus F. W. Wolters

    IPC: C07D201/12 ,  C07D201/02 ,  C07D201/08

    CPC classification number: C07D201/12

    Abstract: Process for the preparation of a mixture of .epsilon.-caprolactam, 6-aminocaproic acid and 6-aminocaproic amide by heating an aqueous mixture containing ammonia and oligomers of 6-aminocaproic acid and/or of 6-aminocaproic amide, the aqueous mixture containing 0.5-7 wt. % of equivalent ammonia (calculated as NH.sub.3) and the temperature lying between 280.degree. C. and 330.degree. C., in which by "equivalent ammonia" is meant free ammonia and ammonia present in the form of a terminal amide group of one of the compounds present in the aqueous mixture.

    Abstract translation: 通过加热含有氨和6-氨基己酸和/或6-氨基己酸酰胺的低聚物的含水混合物制备ε-己内酰胺，6-氨基己酸和6-氨基己酰胺的混合物的方法，含0.5- 7重量％ 相当于氨的百分比（以NH 3计算）和温度在280℃至330℃之间，其中“等效氨”是指游离氨和氨以其中之一的末端酰胺基团的形式存在 存在于含水混合物中的化合物。

    Processes for producing epsilon caprolactams
    274.
    发明授权
    Processes for producing epsilon caprolactams 失效
    生产ε己内酰胺的方法

    公开(公告)号：US5962680A

    公开(公告)日：1999-10-05

    申请号：US839576

    申请日：1997-04-15

    Applicant: Thomas Carl Eisenschmid ,  John Robert Briggs ,  Diane Lee Packett ,  Kurt Damar Olson ,  John Michael Maher

    Inventor： Thomas Carl Eisenschmid ,  John Robert Briggs ,  Diane Lee Packett ,  Kurt Damar Olson ,  John Michael Maher

    IPC: B01J31/24 ,  C07B61/00 ,  C07D201/02 ,  C07D201/08 ,  C07D223/10 ,  C08G69/02 ,  C08G69/14 ,  C08G69/36

    CPC classification number: C07D201/02 ,  C07D201/08 ,  C08G69/02 ,  C08G69/14 ,  C08G69/36 ,  Y02P20/582

    Abstract: This invention relates in part to processes for producing one or more substituted or unsubstituted epsilon caprolactams, e.g., epsilon caprolactam, which comprises: (a) subjecting one or more substituted or unsubstituted alkadienes to hydroxycarbonylation in the presence of a hydroxycarbonylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, and neutralization with a base to produce one or more substituted or unsubstituted pentenoic acid salts; (b) subjecting said one or more substituted or unsubstituted pentenoic acid salts to hydroformylation in the presence of a hydroformylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, to produce one or more substituted or unsubstituted formylvaleric acid salts and/or one or more substituted or unsubstituted epsilon caprolactam precursors; and (c) subjecting said one or more substituted or unsubstituted formylvaleric acid salts and/or said one or more substituted or unsubstituted epsilon caprolactam precursors to reductive amination in the presence of a reductive amination catalyst and cyclization optionally in the presence of a cyclization catalyst to produce said one or more substituted or unsubstituted epsilon caprolactams. This invention also relates in part to reaction mixtures containing one or more substituted or unsubstituted epsilon caprolactams as the principal product(s) of reaction.

    Abstract translation: 本发明部分地涉及用于制备一种或多种取代或未取代的ε-己内酰胺（例如ε-己内酰胺）的方法，其包括：（a）在羟基羰基化催化剂存在下使一种或多种取代或未取代的烷撑二醇进行羟基羰基化， 金属有机磷配体络合物催化剂，并用碱中和以产生一种或多种取代或未取代的戊烯酸盐; （b）使所述一种或多种取代或未取代的戊烯酸盐在加氢甲酰化催化剂（例如金属 - 有机磷配体配合物催化剂）存在下进行加氢甲酰化，以产生一种或多种取代或未取代的甲酰基戊酸盐和/或一种或多种 更多取代或未取代的ε己内酰胺前体; 和（c）在还原胺化催化剂存在下使所述一种或多种取代或未取代的甲酰基戊酸盐和/或所述一种或多种取代或未取代的己内酰胺前体进行还原胺化，任选地在环化催化剂存在下进行环化， 产生所述一种或多种取代或未取代的ε己内酰胺。 本发明还部分涉及含有一种或多种取代或未取代的ε-己内酰胺作为反应主要产物的反应混合物。

    Process for the preparation of 2-bromo- and 2-nitroxy derivatives of 3-bromo- and 3,3-dibromo-4-oxo-azetidines
    275.
    发明授权
    Process for the preparation of 2-bromo- and 2-nitroxy derivatives of 3-bromo- and 3,3-dibromo-4-oxo-azetidines 失效
    制备3-溴 - 和3,3-二溴-4-氧代 - 氮杂环丁烷的2-溴和2-硝基氧基衍生物的方法

    公开(公告)号：US5892036A

    公开(公告)日：1999-04-06

    申请号：US926449

    申请日：1997-09-10

    Applicant: Irena Lukic

    Inventor： Irena Lukic

    IPC: A61K31/395 ,  A61K31/397 ,  A61P31/04 ,  A61P35/00 ,  C07D201/02 ,  C07D205/08

    CPC classification number: A61K31/395 ,  C07D205/08 ,  Y02P20/55

    Abstract: The invention relates to novel 2-bromo- and 2-nitroxy derivatives of 3-,bromo- and 3-dibromo-4-oxo-azetidines, to processes for the preparation thereof and to the use thereof.According to the invention 2-bromo- and 2-nitroxy derivatives of 3-bromo- and 3-dibromo-4-oxo-azetidines are prepared by reacting derivatives of protected penicillanic lanic acid 1,1-dioxides with DBN reactant (1,5-diazabicyclo/3.4.0/non-5-ene) and then the obtained DBN salt of sulfinic acid or isolated sulfinic acid is treated with thionyl chloride and, after eliminating thionyl chloride by evaporation, the obtained residue is passed through a silica gel column with methylene chloride or some other solvent as eluant or the obtained residue is dissolved in tetrahydrofuran or some other suitable solvent and treated with tetrabutyl ammonium bromide and after the treatment a derivative of 2-bromo, 3-bromo or 2-bromo-3,3-dibromo-4oxo-azetidine is isolated, which derivative may be subjected to a reaction with silver nitrate in 2-propanol and, after the treatment of the reaction mixture, derivatives of 2-nitroxy-, 3-bromo- or 2-nitroxy-3,3-dibromo-4-oxo-azetidine are isolated.The obtained substances are useful intermediates in the syntheses of beta lactam analogons or as components in formulations having antibacterial, inhibitory, anti-tumour or antagonistic action.

    Abstract translation: 本发明涉及3-，溴 - 和3-二溴-4-氧代 - 氮杂环丁烷的新型2-溴 - 和2-硝基氧基衍生物，其制备方法及其用途。 根据本发明，3-溴 - 和3-二溴-4-氧代 - 氮杂环丁烷的2-溴 - 和2-硝基氧基衍生物是通过将受保护的青霉烷基酸兰酸1,1-二氧化物的衍生物与DBN反应物（1,5 - 二氮杂双环/ 3.4.0 /非-5-烯），然后将得到的亚磺酸DBI盐或分离的亚磺酸用亚硫酰氯处理，在通过蒸发除去亚硫酰氯后，将所得残余物通过硅胶柱 用二氯甲烷或一些其它溶剂作为洗脱剂，或将所得残余物溶于四氢呋喃或一些其它合适的溶剂中，并用四丁基溴化铵处理，处理后，将2-溴，3-溴或2-溴-3,3 分离出二溴-4-氧代 - 氮杂环丁烷，该衍生物可以与硝酸银在2-丙醇中进行反应，并且在处理反应混合物后，将2-硝基氧基，3-溴 - 或2-硝基氧基 - 分离出3,3-二溴-4-氧代 - 氮杂环丁烷。 获得的物质是合成β-内酰胺类似物或作为具有抗细菌，抑制，抗肿瘤或拮抗作用的制剂中的组分的有用中间体。

    2-bromo- and 2-nitroxy derivatives of 3-bromo- and 3,3-dibromo-4-oxo-azetidines, and preparation
    276.
    发明授权
    2-bromo- and 2-nitroxy derivatives of 3-bromo- and 3,3-dibromo-4-oxo-azetidines, and preparation 失效
    3-溴 - 和3,3-二溴-4-氧代 - 氮杂环丁烷的2-溴 - 和2-硝基氧基衍生物，以及制备

    公开(公告)号：US5670638A

    公开(公告)日：1997-09-23

    申请号：US272206

    申请日：1994-07-08

    Applicant: Irena Lukic

    Inventor： Irena Lukic

    IPC: A61K31/395 ,  A61K31/397 ,  A61P31/04 ,  A61P35/00 ,  C07D201/02 ,  C07D205/08

    CPC classification number: A61K31/395 ,  C07D205/08 ,  Y02P20/55

    Abstract: The azetidines of the present invention have the formula I ##STR1## wherein R.sup.1 is hydrogen or bromine, R.sup.2 is hydrogen or bromine, wherein at least one of R.sup.1 or R.sup.2 is bromine, R.sup.3 is hydrogen; Me.sub.2 --C.dbd.C--COOR.sup.4 wherein R.sup.4 is hydrogen, methyl, benzyl or some other carboxy-protective group, and X is bromine or nitroxy group (--ONO.sub.2). According to the invention 2-bromo- and 2-nitroxy derivatives of 3-bromo- and 3-dibromo-4-oxo-azetidines are prepared by reacting derivatives of protected penicillanic acid 1,1-dioxides with DBN reactant (1,5-diazabicyclo/3.4.0/non-5-ene) and then the obtained DBN salt of sulfinic acid or isolated sulfinic acid is treated with thionyl chloride and, after eliminating thionyl chloride by evaporation, the obtained residue is passed through a silica gel column with methylene chloride or some other solvent as eluant or the obtained residue is dissolved in tetrahydrofuran or some other suitable solvent and treated with tetrabutyl ammonium bromide and after the treatment a derivative of 2-bromo, 3-bromo or 2-bromo-3,3-dibromo-4-oxo-azetidine is isolated, which derivative may be subjected to a reaction with silver nitrate in 2-propanol and, after the treatment of the reaction mixture, derivatives of 2-nitroxy-, 3-bromo- or 2-nitroxy-3,3-dibromo-4-oxo-azetidine are isolated. The obtained substances are useful intermediates in the syntheses of beta lactam analogons or as components in formulations having antibacterial, inhibitory, antitumour or antagonistic action.

    Abstract translation: 本发明的氮杂环丁烷具有式I其中R 1是氢或溴，R 2是氢或溴，其中R 1或R 2中的至少一个是溴，R 3是氢; Me2-C = C-COOR4，其中R4是氢，甲基，苄基或一些其它羧基保护基，X是溴或硝基氧基（-ONO 2）。 根据本发明，3-溴 - 和3-二溴-4-氧代 - 氮杂环丁烷的2-溴 - 和2-硝基氧基衍生物是通过将受保护的青霉烷酸1,1-二氧化物的衍生物与DBN反应物（1,5- 二氮杂双环/ 3.4.0 /非-5-烯），然后将得到的亚磺酸的DBN盐或分离的亚磺酸用亚硫酰氯处理，通过蒸发除去亚硫酰氯后，将所得残余物通过硅胶柱， 二氯甲烷或一些其它溶剂作为洗脱剂，或将所得残余物溶于四氢呋喃或其它合适的溶剂中并用四丁基溴化铵处理，处理后，将2-溴，3-溴或2-溴-3,3- 分离出二溴-4-氧代 - 氮杂环丁烷，该衍生物可以与硝酸银在2-丙醇中进行反应，在处理反应混合物后，将2-硝基氧基，3-溴 - 或2-硝基氧基 分离出-3,3-二溴-4-氧代 - 氮杂环丁烷。 获得的物质是合成β-内酰胺类似物或作为具有抗菌，抑制，抗肿瘤或拮抗作用的制剂中的组分的有用中间体。

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