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    PHOTOACOUSTIC IMAGING DEVICES AND METHODS OF IMAGING
    281.
    发明专利
    PHOTOACOUSTIC IMAGING DEVICES AND METHODS OF IMAGING 未知

    公开(公告)号：CA2708743A1

    公开(公告)日：2009-06-18

    申请号：CA2708743

    申请日：2008-12-10

    Applicant: STC UNM

    Inventor： CHEN JINGKUANG

    IPC: A61B8/00

    Abstract: A photoacoustic medical imaging device may include a substrate, an array of ultrasonic transducers on the substrate, at least one groove etched on the substrate, at least one optical fiber, and at least one facet. Each optical fiber is disposed in one of the grooves. Each facet is etched in one of the grooves and coated with a layer of metal having high infrared reflectivity. Each optical fiber is configured to guide infrared light from a light source through the fiber and toward the respective facet. The facet is configured to reflect the infrared light toward a target.

    METODOS DE HIBRIDACION IN SITU SOBRE LAMINAS PORTAOBJETOS.
    282.
    发明专利
    METODOS DE HIBRIDACION IN SITU SOBRE LAMINAS PORTAOBJETOS. 未知

    公开(公告)号：ES2319135T3

    公开(公告)日：2009-05-04

    申请号：ES97910799

    申请日：1997-10-03

    Applicant: STC UNM

    Inventor： SARTO GLORIA E ,  THOMPSON DONALD M

    IPC: C12Q1/68 ,  G02B21/34

    Abstract: LA PRESENTE INVENCION SE REFIERE A UN PROCEDIMIENTO, TAL Y COMO SE MUESTRA EN EL DIBUJO, DE PREPARACION DE LAMINAS PORTAOBJETOS FLUORESCENTES PARA HIBRIDACION IN SITU, EL CUAL CONSISTE EN: PROPORCIONAR UNA LAMINA PORTAOBJETOS CON UN ANILLO SOBREELEVADO EN LA MISMA; SITUAR UNA SONDA DE ADN SOBRE LA MISMA; SITUAR A CONTINUACION CELULAS Y UN ADN DIANA SOBRE DICHA LAMINA; A CONTINUACION, DEPOSITAR SOBRE ESTA UNA MEZCLA EXENTA DE FORMAMIDA QUE CONTIENE 10 % +/- 2 % EN PESO DE SULFATO DE DEXTRANO, 15 % - 25 % DE GLICEROL Y 0,9 % EN PESO DE UNA SAL O UNA SOLUCION DE 10 % +/- 2 % EN PESO DE SULFATO DE DEXTRANO, 10-30 % EN VOLUMEN DE FORMAMIDA Y 0,9 % EN PESO DE SAL; COLOCAR UNA LAMINA CUBREOBJETOS SOBRE EL ANILLO; DESNATURALIZAR E HIBRIDAR LA LAMINA, Y LLEVAR A CABO UN LAVADO POSTERIOR DE LA MISMA.

    Swellable particles for drug delivery
    283.
    发明专利
    Swellable particles for drug delivery 未知

    公开(公告)号：AU2007240986A1

    公开(公告)日：2007-11-01

    申请号：AU2007240986

    申请日：2007-04-03

    Applicant: STC UNM

    Inventor： SMYTH HUGH D ,  DONOVAN MARTIN J

    IPC: A61K9/22 ,  A61K31/195

    Abstract: Swellable particles for delivering a working agent to the pulmonary system comprise a plurality of biodegradable particles each formed from a polymer network, each of the plurality of biodegradable particles having a mass mean aerodynamic diameter not exceeding 5 mum, the particles being swellable by hydration to a size that is greater than 6 mum volume mean diameter, and a working agent entrapped in the polymer network of each of the plurality of biodegradable particles.

    QUANTUM DASH DEVICES
    284.
    发明专利
    QUANTUM DASH DEVICES 未知

    公开(公告)号：IL154997A

    公开(公告)日：2006-08-01

    申请号：IL15499703

    申请日：2003-03-19

    Applicant: STC UNM

    IPC: H01L29/06 ,  H01S5/12 ,  H01S5/14 ,  H01S5/183 ,  H01S5/34 ,  H01S5/343 ,  H01S5/40

    Abstract: Quantum dot active region structures are disclosed. In a preferred embodiment, the distribution in dot size and the sequence of optical transition energy values associated with the quantum confined states of the dots are selected to facilitate forming a continuous optical gain spectrum over an extended wavelength range. In one embodiment, the quantum dots are self-assembled quantum dots with a length-to-width ratio of at least three along the growth plane. In one embodiment, the quantum dots are formed in quantum wells for improved carrier confinement. In other embodiments, the quantum dots are used as the active region in laser devices, including tunable lasers and monolithic multi-wavelength laser arrays.

    DISTANCE OF FLIGHT SPECTROMETER FOR MS AND SIMULTANEOUS SCANLESS MS/MS
    285.
    发明专利
    DISTANCE OF FLIGHT SPECTROMETER FOR MS AND SIMULTANEOUS SCANLESS MS/MS 未知

    公开(公告)号：CA2519601A1

    公开(公告)日：2004-10-07

    申请号：CA2519601

    申请日：2004-03-19

    Applicant: STC UNM

    Inventor： ENKE CHRISTIE G

    IPC: G01N20060101 ,  G01N27/64 ,  H01J49/00 ,  H01J49/40 ,  H01J49/42

    Abstract: A distance of flight (DOF) approach to mass spectroscopy in which the resolution among the various ion masses is accomplished in space rather than time. A separate detector is associated with each ion mass resolution elemen t. The DOF mass spectrometer can serve as one element in a tandem arrangement, which has the capability to produce a full two-dimensional precursor/product spectrum for each bunch of ions extracted from the source. A "distance-of- flight" (DOF) mass analyzer, having an ion storage device (21) means for applying an ion extraction voltage pulse to said storage device (22, 23), a field free region, and detectors (29), is used in combination with time-of- flight (TOF) mass analysis for precursor and product dispersion. All the precursor ions can undergo a mass changing reaction simultaneously, while still retaining the essential information about the particular precursor m/zvalue from which each product m/z value emanated. Through the use of a tw o- dimensional detector, all the products ions from all the precursors can be detected for each batch of ions analyzed.

    ISOTOPE ENHANCED AMBROXOL FOR LONG LASTING AUTOPHAGY INDUCTION
    289.
    发明专利
    ISOTOPE ENHANCED AMBROXOL FOR LONG LASTING AUTOPHAGY INDUCTION 未知

    公开(公告)号：CA3055311A1

    公开(公告)日：2018-08-16

    申请号：CA3055311

    申请日：2018-02-02

    Applicant: STC UNM

    Inventor： TIMMINS GRAHAM ,  DERETIC VOJO P

    IPC: C07B59/00 ,  A61K31/136 ,  A61K51/04 ,  A61P11/00 ,  A61P31/04 ,  C07C213/08 ,  C07C215/68

    Abstract: The present invention is directed to 13C and/or 2H isotope enhanced ambroxol ("isotope enhanced ambroxol") and its use in the treatment of autophagy infections, especially mycobacterial and other infections, disease states and/or conditions of the lung, such as tuberculosis, especially including drug resistant and multiple drag resistant tuberculosis. Pharmaceutical compositions comprising isotope enhanced amhroxol, alone or in combination with an additional bioactive agent, especially rifamycin antibiotics, including an additional autophagy modulator (an agent which is active to promote or inhibit autophagy), thus being useful against, an autophagy mediated disease state and/or condition), especially an antophagy mediated disease state and/or condition which occurs in the lungs, for example, a Mycobacterium infection. Chronic Obstructive Pulmonary Disease (COPD), asthma, pulmonary fibrosis, cystic fibrosis, Sjogren's disease and lung cancer (small cell and non-small cell lung cancer, among other disease states and/or conditions, especially of the lung. Methods of treating autophagy disease states and/or conditions, especially including autophagy disease states or conditions which occur principally in the lungs of a patient represent a further embodiment of the present invention. An additional embodiment includes methods of synthesizing compounds according to the present invention as otherwise disclosed herein.

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