公开(公告)号：WO2007123793A2

公开(公告)日：2007-11-01

申请号：PCT/US2007008058

申请日：2007-04-03

Applicant: STC UNM ,  SMYTH HUGH D ,  DONOVAN MARTIN J

Inventor： SMYTH HUGH D ,  DONOVAN MARTIN J

IPC: A61K9/16

CPC classification number: A61K9/0073 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/1641 ,  A61K47/60 ,  A61K47/6949 ,  A61K48/00 ,  B82Y5/00 ,  Y10T428/2982

Abstract: Swellable particles for delivery of a drug or other working agent to the pulmonary system are provided. The swellable particles include a dehydrated (dry) aerodynamic particle diameter of 5 µm or less to enable delivery to the respiratory tract, such as for example to the tracheo-bronchial airways of the upper respiratory tract and/or to the alveolic regions of the deep lung, and a hydrated particle diameter that is greater than 6 µm volume mean diameter to retard or prevent their phagocytosis by the macrophages present in airways of the respiratory tract.

Abstract translation: 提供了用于将药物或其它工作剂递送至肺部系统的可溶胀颗粒。 可溶胀颗粒包括5μm或更小的脱水（干燥）空气动力学粒径，以使得能够输送到呼吸道，例如向上呼吸道的气管支气管气道和/或深层的通气区域 肺，以及大于6μm体积平均直径的水合颗粒直径，以阻止或阻止其由呼吸道气道中的巨噬细胞吞噬。

公开(公告)号：AU2007240986A1

公开(公告)日：2007-11-01

申请号：AU2007240986

申请日：2007-04-03

Applicant: STC UNM

Inventor： SMYTH HUGH D ,  DONOVAN MARTIN J

IPC: A61K9/22 ,  A61K31/195

Abstract: Swellable particles for delivering a working agent to the pulmonary system comprise a plurality of biodegradable particles each formed from a polymer network, each of the plurality of biodegradable particles having a mass mean aerodynamic diameter not exceeding 5 mum, the particles being swellable by hydration to a size that is greater than 6 mum volume mean diameter, and a working agent entrapped in the polymer network of each of the plurality of biodegradable particles.

公开(公告)号：CA2648291A1

公开(公告)日：2007-11-01

申请号：CA2648291

申请日：2007-04-03

Applicant: STC UNM

Inventor： SMYTH HUGH D ,  DONOVAN MARTIN J

IPC: A61K9/22 ,  A61K31/195

Abstract: Swellable particles for delivering a working agent to the pulmonary system comprise a plurality of biodegradable particles each formed from a polymer network, each of the plurality of biodegradable particles having a mass mean aerodynamic diameter not exceeding 5 mum, the particles being swellable by hydration to a size that is greater than 6 mum volume mean diameter, and a working agent entrapped in the polymer network of each of the plurality of biodegradable particles.

公开(公告)号：EP2007358A4

公开(公告)日：2012-01-25

申请号：EP07754563

申请日：2007-04-03

Applicant: STC UNM

Inventor： SMYTH HUGH D ,  DONOVAN MARTIN J

IPC: A61K9/22 ,  A61K31/195

CPC classification number: A61K9/0073 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/1641 ,  A61K47/60 ,  A61K47/6949 ,  A61K48/00 ,  B82Y5/00 ,  Y10T428/2982