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    SWELLABLE PARTICLES FOR DRUG DELIVERY
    1.
    发明申请
    SWELLABLE PARTICLES FOR DRUG DELIVERY 审中-公开
    用于药物递送的易碎颗粒

    公开(公告)号：WO2007123793A2

    公开(公告)日：2007-11-01

    申请号：PCT/US2007008058

    申请日：2007-04-03

    Applicant: STC UNM ,  SMYTH HUGH D ,  DONOVAN MARTIN J

    Inventor： SMYTH HUGH D ,  DONOVAN MARTIN J

    IPC: A61K9/16

    CPC classification number: A61K9/0073 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/1641 ,  A61K47/60 ,  A61K47/6949 ,  A61K48/00 ,  B82Y5/00 ,  Y10T428/2982

    Abstract: Swellable particles for delivery of a drug or other working agent to the pulmonary system are provided. The swellable particles include a dehydrated (dry) aerodynamic particle diameter of 5 µm or less to enable delivery to the respiratory tract, such as for example to the tracheo-bronchial airways of the upper respiratory tract and/or to the alveolic regions of the deep lung, and a hydrated particle diameter that is greater than 6 µm volume mean diameter to retard or prevent their phagocytosis by the macrophages present in airways of the respiratory tract.

    Abstract translation: 提供了用于将药物或其它工作剂递送至肺部系统的可溶胀颗粒。 可溶胀颗粒包括5μm或更小的脱水（干燥）空气动力学粒径，以使得能够输送到呼吸道，例如向上呼吸道的气管支气管气道和/或深层的通气区域 肺，以及大于6μm体积平均直径的水合颗粒直径，以阻止或阻止其由呼吸道气道中的巨噬细胞吞噬。

    METHODS AND SYSTEMS FOR DOSING AND COATING INHALATION POWDERS ONTO CARRIER PARTICLES
    2.
    发明申请
    METHODS AND SYSTEMS FOR DOSING AND COATING INHALATION POWDERS ONTO CARRIER PARTICLES 审中-公开
    用于给载体吸入粉末并将载体吸入载体颗粒的方法和系统

    公开(公告)号：WO2011031564A3

    公开(公告)日：2011-07-14

    申请号：PCT/US2010047043

    申请日：2010-08-27

    Applicant: STC UNM ,  SMYTH HUGH D C ,  DONOVAN MARTIN J

    Inventor： SMYTH HUGH D C ,  DONOVAN MARTIN J

    IPC: A61K9/28 ,  A61K9/12 ,  A61K9/14

    CPC classification number: A61K9/0075 ,  A61K9/14 ,  A61K31/58

    Abstract: A method of method of coating powdered medical agent onto a carrier particle for use in a dry powder inhaler may include applying ultrasonic energy to agglomerated powdered medical agent to deaggregate and aerosolize particles of the medical agent into particles having a desired average particle size, and coating at least one carrier particle with a desired amount of the deaggregated and aerosolized particles of the medical agent.

    Abstract translation: 将粉末状药剂涂覆到用于干粉吸入器的载体颗粒上的方法可包括将超声波能量应用于聚集粉末药剂以将药剂颗粒解聚并雾化成具有期望平均粒度的颗粒， 至少一种载体颗粒与期望量的药物的解聚和雾化颗粒。

    SWELLABLE PARTICLES FOR DRUG DELIVERY
    3.
    发明专利
    SWELLABLE PARTICLES FOR DRUG DELIVERY 未知

    公开(公告)号：CA2648291A1

    公开(公告)日：2007-11-01

    申请号：CA2648291

    申请日：2007-04-03

    Applicant: STC UNM

    Inventor： SMYTH HUGH D ,  DONOVAN MARTIN J

    IPC: A61K9/22 ,  A61K31/195

    Abstract: Swellable particles for delivering a working agent to the pulmonary system comprise a plurality of biodegradable particles each formed from a polymer network, each of the plurality of biodegradable particles having a mass mean aerodynamic diameter not exceeding 5 mum, the particles being swellable by hydration to a size that is greater than 6 mum volume mean diameter, and a working agent entrapped in the polymer network of each of the plurality of biodegradable particles.

    Swellable particles for drug delivery
    5.
    发明专利
    Swellable particles for drug delivery 未知

    公开(公告)号：AU2007240986A1

    公开(公告)日：2007-11-01

    申请号：AU2007240986

    申请日：2007-04-03

    Applicant: STC UNM

    Inventor： SMYTH HUGH D ,  DONOVAN MARTIN J

    IPC: A61K9/22 ,  A61K31/195

    Abstract: Swellable particles for delivering a working agent to the pulmonary system comprise a plurality of biodegradable particles each formed from a polymer network, each of the plurality of biodegradable particles having a mass mean aerodynamic diameter not exceeding 5 mum, the particles being swellable by hydration to a size that is greater than 6 mum volume mean diameter, and a working agent entrapped in the polymer network of each of the plurality of biodegradable particles.

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