公开(公告)号：EP1329448A1

公开(公告)日：2003-07-23

申请号：EP03000846.0

申请日：2003-01-15

Applicant: Ube Industries, Ltd.

Inventor： Kuroda, Nobuyuki, c/oUbe Chemical Factory ,  Kawai, Joji, c/oUbe Chemical Factory ,  Shimomura, Hideo, c/oUbe Chemical Factory

IPC: C07D201/04 ,  C07D201/06

CPC classification number: C07D201/06 ,  C07D201/04

Abstract: Laurolactam having high quality is produced by reacting cyclododecanone with a hydroxylamine salt of a mineral acid, and converting the resultant cyclododecanoneoxime to laurolactam through the Beckmann rearrangement reaction, wherein a content of each of oxygen atom-containing C 12 organic compounds, for example, cyclododecenone or epoxycyclododecane, and cycloaliphatic unsaturated C 12 hydrocarbon compounds, contained, as an impurity, in the staring cyclododecanone material, is controlled to 1,000 ppm or less.

Abstract translation: 通过使环十二烷酮与无机酸的羟胺盐反应，通过贝克曼重排反应将所得的环十二烷酮肟转化成十二内酰胺，生成高品质的月桂内酰胺，其中含有氧原子的C12有机化合物，例如环十二酮或 环氧环十二烷和环脂肪族不饱和C12烃化合物被控制在1000ppm以下，作为杂质，作为起始环十二烷酮材料。

公开(公告)号：EP1013643A1

公开(公告)日：2000-06-28

申请号：EP99125632.2

申请日：1999-12-22

Applicant: PRAXAIR TECHNOLOGY, INC.

Inventor： Echegaray, Diego Fernandez ,  Velloso, Antonio Augusto M. ,  Wagner, Matthew Lincoln

IPC: C07D201/06 ,  C07D201/10

CPC classification number: C07D201/06 ,  C07D201/10

Abstract: An improvement in the conventional process for the production of caprolactam. The process involves:

(a) reacting air with ammonia gas in an ammonia conversion zone to produce nitric oxide;
(b) oxidizing a portion of the nitric oxide to nitrogen dioxide to produce an NO x -rich process gas stream;
(c) reacting the NO x -rich stream with ammonium carbonate in a nitriting zone to produce ammonium nitrite;
(d) reducing the ammonium nitrite to hydroxylamine diammonium sulfate;
(e) hydrolyzing the hydroxylamine diammonium sulfate to hydroxylamine sulfate;
(f) oximating the hydroxylamine sulfate with cyclohexanone to produce cyclohexanone oxime; and
(g) converting the cyclohexanone oxime to caprolactam.
The process is improved by adding supplemental oxygen downstream of the ammonia conversion zone to increase the quantity and rate of formation of nitrogen dioxide in the NO x -rich process gas stream.

Abstract translation: 在传统工艺的改进生产己内酰胺的。 该过程包括：（a）在氨转化区反应用氨气空气以产生一氧化氮; （B）氧化所述一氧化氮的一部分以二氧化氮以生产富含NOx的反应气流; （C）反应与碳酸铵在亚硝化区中，以产生亚硝酸铵的富含NOx的物流; （D）降低了亚硝酸盐对羟胺二硫酸铵; （E）水解所述羟胺硫酸二铵到硫酸羟胺; （F）的肟化的硫酸胲用环己酮，以产生环己酮肟; 及（g）将所述环己酮肟为己内酰胺。 该过程通过加入氨转化区，以增加富含NOx反应气流中形成的二氧化氮的量和速率的下游补充氧气改善。

公开(公告)号：KR100820763B1

公开(公告)日：2008-04-10

申请号：KR1020037009645

申请日：2001-12-21

Applicant: 메르크 파텐트 게엠베하

Inventor： 크라씨에헬렌느 ,  에케르트우베 ,  뵈트헤르헨닝 ,  바테,안드레아스 ,  엠메르트슈테펜

IPC: C07D201/06 ,  C07D211/78 ,  C07D211/72 ,  A61P25/18

CPC classification number: C07D209/42 ,  C07D209/14 ,  C07D209/30

Abstract: The present invention relates to a process for the preparation of (3-cyano-1H-indol-7-yl)[4-(4-fluorophenethyl)piperazin-1-yl]-methanone and salts thereof, characterised in that an indole ester of the formula II in which R is as defined in Claim 1, is converter into 3-cyano-1H-indole-7-carboxylic acid via steps (1) to (4) according to Claim 1, and this is reacted with 1-[2-(4-fluorophenyl)ethyl]piperazine of salts thereof to give the product.

公开(公告)号：KR1020070085836A

公开(公告)日：2007-08-27

申请号：KR1020077012801

申请日：2005-11-30

Applicant: 로디아 쉬미

Inventor： 르꽁뜨필리쁘 ,  베라치니세르쥐 ,  모렐필리쁘

IPC: C07C45/27 ,  C07C49/403 ,  C07D201/06

CPC classification number: C07C29/132 ,  C07C45/33 ,  C07C407/00 ,  C07C409/14 ,  C07C2601/14 ,  C07C49/403 ,  C07C35/08

Abstract: The invention relates to a method for the preparation of cyclohexanone from cyclohexane. The invention relates more particularly to a method for the production of cyclohexane whose impurity content enables cyclohexanone to be used as a raw material for the production of e-caprolactam. The inventive method consists in treating the mixture of cyclohexanol/cyclohexanone arising from oxidation of cyclohexane by oxygen in a dehydrogenation stage in order to transform cyclohexanol into cyclohexanone and the impurities present such as cyclopentenal. The inventive method makes it possible to obtain highly pure cyclohexanone which is compatible when used as a raw material in the synthesis of e-caprolactam.

Abstract translation: 本发明涉及从环己烷制备环己酮的方法。 本发明更具体地涉及一种生产环己烷的方法，其中杂质含量使得环己酮可用作生产ε-己内酰胺的原料。 本发明的方法是在脱氢阶段用氧处理由环己烷氧化产生的环己醇/环己酮的混合物，以便将环己醇转化成环己酮和存在的杂质如环戊烯醛。 本发明的方法使得可以获得在用作合成ε-己内酰胺的原料时相容的高纯度环己酮。

公开(公告)号：KR1020030068590A

公开(公告)日：2003-08-21

申请号：KR1020037009645

申请日：2001-12-21

Applicant: 메르크 파텐트 게엠베하

Inventor： 크라씨에헬렌느 ,  에케르트우베 ,  뵈트헤르헨닝 ,  바테,안드레아스 ,  엠메르트슈테펜

IPC: C07D201/06 ,  C07D211/78 ,  C07D211/72 ,  A61P25/18

CPC classification number: C07D209/42 ,  C07D209/14 ,  C07D209/30

Abstract: 본 발명은 특허청구범위 제 1항에 따른 단계 (1) 내지 (4)를 통해, R이 특허청구범위 제 1항에서 정의한 바와 같은 화학식 Ⅱ의 인돌 에스테르를 3-시아노-1H-인돌-7-카르복실산으로 전환하고, 이를 이의 염의 1-[2-(4-플루오로페닐)에틸]피페라진과 반응시켜 생성물을 얻는 것을 특징으로 하는, (3-시아노-1H-인돌-7-일)[4-(4-플루오로페닐)피페라진-1-일]-메타논 및 이의 염의 제조 방법에 관한 것이다.

公开(公告)号：KR1020170135373A

公开(公告)日：2017-12-08

申请号：KR1020160067178

申请日：2016-05-31

Applicant: 주식회사 제이앤씨사이언스

Inventor： 최종류 ,  최인영 ,  장지성

IPC: C07D201/04 ,  C07D201/06 ,  C07D225/02 ,  C07C49/413

Abstract: 본발명은라우로락탐(laurolactam)의제조방법에관한것으로, 좀더상세하게설명하자면, 출발물질인사이클로도데카논(cyclo dodecanone)에다아지드(azide) 화합물과반응용매, 그리고엑시드(acid) 화합물을순차적으로첨가하여원-포트반응(one-pot reaction)으로라우로락탐을제조하는방법에관한것이다.

Abstract translation: 本发明涉及一种用于在楼内酰胺（月桂内酰胺），砂砾的制备更具体地，起始原料，二环喔EDA十二烷基佳能（环十二碳酮）叠氮化物（叠氮化物）化合物和反应溶剂，并超越（酸）化合物 通过一锅反应制备月桂内酰胺的方法。

公开(公告)号：EP1329448B2

公开(公告)日：2021-08-04

申请号：EP03000846.0

申请日：2003-01-15

Inventor： Kuroda, Nobuyuki, c/oUbe Chemical Factory ,  Kawai, Joji, c/oUbe Chemical Factory ,  Shimomura, Hideo, c/oUbe Chemical Factory

IPC: C07D201/04 ,  C07D201/06

公开(公告)号：EP3277664A1

公开(公告)日：2018-02-07

申请号：EP15731711.6

申请日：2015-06-04

Applicant: Anthea Aromatics Private Limited

Inventor： MOHAPATRA, Manoj Kumar ,  BENDAPUDI, Ramamohanrao ,  MENACHERRY, Paul Vincent ,  PAUL, Vincent

IPC: C07D201/04 ,  C07B43/06 ,  C07D201/06

CPC classification number: C07D201/06 ,  B01D3/36 ,  C01B21/14 ,  C01G9/02 ,  C07D201/04 ,  C07D201/16 ,  C07D227/087

Abstract: Disclosed herein is an efficient, economical, industrially advantageous, straight-through process for the preparation of cyclic amides, also referred as lactams, in substantially pure form and high yield, from the corresponding cyclic ketones and a hydroxylammonium salt, using a combination of amphoteric metal oxide or amphoteric masked metal oxide and a base.

公开(公告)号：EP2098506A1

公开(公告)日：2009-09-09

申请号：EP08003291.5

申请日：2008-02-22

Applicant: Uhde Inventa-Fischer GmbH

Inventor： Hölderich, Wolfgang F. ,  Anilkumar, Mettu ,  Schaller, Rainer

IPC: C07D201/06

CPC classification number: C07D201/06 ,  C07D201/02 ,  C07D211/76

Abstract: Present invention describes the direct catalytic liquid phase synthesis of caprolactam from cyclohexanone, hydrogen peroxide and ammonia.
The invention can be carried out by using mesoporous materials amongst the MMS family (mesoporous molecular sieves) as catalysts, such as Ti-MCM-41, A1-MCM-41 and Ti-SBA-15 materials at temperatures between 20 and 120 °C.

Abstract translation: 本发明描述了来自环己酮，过氧化氢和氨的己内酰胺的直接催化液相合成。 本发明可以通过使用MMS系列（介孔分子筛）中的介孔材料作为催化剂，例如Ti-MCM-41，Al-MCM-41和Ti-SBA-15材料，在20〜120℃的温度下进行 。

公开(公告)号：EP0535455B1

公开(公告)日：1997-03-12

申请号：EP92115903.4

申请日：1992-09-17

Applicant: BASF Aktiengesellschaft

Inventor： Fuchs, Hugo, Dr. ,  Neubauer, Gerald, Dr. ,  Ritz, Josef, Dr.

IPC: C07D201/04 ,  C07D201/06

CPC classification number: C07D201/04 ,  C07D201/06