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    Method of and system for multiplexed analysis by spectral imaging
    21.
    发明申请
    Method of and system for multiplexed analysis by spectral imaging 审中-公开
    通过光谱成像进行多重分析的方法和系统

    公开(公告)号：US20030215791A1

    公开(公告)日：2003-11-20

    申请号：US10277916

    申请日：2002-10-23

    Applicant: Applied Spectral Imaging Ltd.

    Inventor： Yuval Garini ,  Nir Katzir ,  Irit Bar-Am ,  Uri Milman ,  Eli Horn ,  Yacov Malinovich ,  Terry Hammill ,  Vladimir Cherepakhin

    IPC: C12Q001/70 ,  C12Q001/68 ,  G01N033/53 ,  G01N033/554 ,  G01N033/569 ,  G06F019/00 ,  G01N033/48 ,  G01N033/50

    CPC classification number: B82Y5/00 ,  B82Y10/00 ,  G01N33/54306 ,  G01N33/54366 ,  G01N33/54373

    Abstract: A method of detecting the presence, absence and/or level of a plurality of analytes-of-interest in a sample, the method comprisES: (a) providing a plurality of objects, each of the plurality of objects having a predetermined, measurable and different imagery characteristic, and further having a predetermined and specific affinity to one analyte of the plurality of analytes-of-interest, each the imagery characteristic corresponding to one the predetermined specific affinity, hence each the imagery characteristic corresponds to one analyte of the plurality of analytes-of interest; (b) providing at least one affinity moiety having a predetermined and specific affinity or predetermined and specific affinities to the plurality of analytes-of-interest, each the affinity moiety having a predetermined, measurable response to light; (c) combining the objects, the at least one affinity moiety and the sample under conditions for affinity binding; and (d) simultaneously determining, for each object of the plurality of objects an imagery characteristic, and for at least a portion of the at least one affinity moiety a response to light, thereby detecting the presence, absence and/or level of the plurality of analytes-of-interest in the sample.

    Abstract translation: 一种检测样本中多个感兴趣分析物的存在，不存在和/或等级的方法，所述方法包括：（a）提供多个对象，所述多个对象中的每一个具有预定的，可测量的和 不同的图像特征，并且还对多个感兴趣分析物中的一个分析物具有预定和特异性的亲和力，每个图像特征对应于一个预定的特异亲和力，因此每个图像特征对应于多个 分析物 - 兴趣; （b）提供至少一个亲和部分，其具有对多个感兴趣分析物的预定和特异性亲和力或预定和特异性亲和力，每个亲和部分具有对光的预定的可测量响应; （c）在用于亲和结合的条件下将所述目标，所述至少一个亲和部分和所述样品组合; 以及（d）对于所述多个对象的每个对象同时确定图像特征，以及对所述至少一个亲和部分的至少一部分对光的响应，从而检测所述多个对象的存在，不存在和/或等级 的样品中感兴趣的分析物。

    Optical detection method for improved sensitivity
    22.
    发明申请
    Optical detection method for improved sensitivity 有权
    灵敏度提高的光学检测方法

    公开(公告)号：US20020176084A1

    公开(公告)日：2002-11-28

    申请号：US09824684

    申请日：2001-04-04

    Applicant: Applied Spectral Imaging Ltd.

    Inventor： Yuval Garini

    IPC: G01N021/55

    CPC classification number: G06K19/06046 ,  G06K7/10801

    Abstract: A light reflecting article is disclosed. The light reflecting article comprises a sample carrying article layered with a light reflecting layer. The light reflecting layer serves for allowing an optical collection and detection system to collect both luminescent light emitted from a sample positioned on the light reflecting article in a direction of the optical collection and detection system, as well as luminescent light emitted from the sample in a direction away from the optical collection and detection system and reflected in the direction of the optical collection and detection system via the light reflecting layer, thereby increasing a sensitivity of luminescent light detection.

    Abstract translation: 公开了一种光反射制品。 光反射制品包括层叠有光反射层的样品携带物品。 光反射层用于允许光学收集和检测系统从光学收集和检测系统的方向收集从位于光反射物品上的样品发射的发光，以及从样品中发出的发光 方向远离光学采集和检测系统，并通过光反射层在光学采集和检测系统的方向上反射，从而增加了发光光检测的灵敏度。

    Apparatus and method for synchronizing images from an object undergoing cyclic variations
    23.
    发明申请
    Apparatus and method for synchronizing images from an object undergoing cyclic variations 审中-公开
    用于使来自经历循环变化的对象的图像同步的装置和方法

    公开(公告)号：US20020141624A1

    公开(公告)日：2002-10-03

    申请号：US10155647

    申请日：2002-05-28

    Applicant: Applied Spectral Imaging Ltd.

    Inventor： Amir Gil ,  Tamir Gil ,  Eli Horn ,  Yuval Garini

    IPC: G06K009/00

    CPC classification number: A61B5/0084 ,  A61B5/0075 ,  A61B5/0456 ,  A61B5/14553 ,  A61B5/4064 ,  A61B5/7285 ,  A61B6/541

    Abstract: A synchronizing imaging apparatus to obtain images from an object undergoing variations according to a cycle with the apparatus comprising an acquisition device to acquire a plurality of pre-images at respective phases over each one of a plurality of cycles, and an image matcher to match together the pre-images from different ones of said cycles according to respective phases within said cycles, to create a representation of said cycle.

    Abstract translation: 一种同步成像装置，用于根据周期从经历变化的对象获得图像，该装置包括：采集装置，用于在多个周期中的每一个周期获取各个相位的多个预图像;以及图像匹配器，以一起匹配 根据所述循环内的各个相位，来自不同的所述循环的预图像，以创建所述周期的表示。

    System and method for functional brain mapping and an oxygen saturation difference map algorithm for effecting same
    24.
    发明申请
    System and method for functional brain mapping and an oxygen saturation difference map algorithm for effecting same 审中-公开
    功能脑映射的系统和方法以及影响相同的氧饱和度差分图算法

    公开(公告)号：US20020099295A1

    公开(公告)日：2002-07-25

    申请号：US09776871

    申请日：2001-02-06

    Applicant: Applied Spectral Imaging Ltd.

    Inventor： Amir Gil ,  Tamir Gil ,  Eli Horn ,  Yuval Garini

    IPC: A61B005/00

    CPC classification number: A61B5/14553 ,  A61B5/0042 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/4064 ,  A61B5/4094

    Abstract: A method of functional brain mapping of a subject is disclosed. The method is effected by (a) illuminating an exposed cortex of a brain or portion thereof of the subject with incident light; (b) acquiring a reflectance spectrum of each picture element of at least a portion of the exposed cortex of the subject; (c) stimulating the brain of the subject; (d) during or after step (c) acquiring at least one additional reflectance spectrum of each picture element of at least the portion of the exposed cortex of the subject; and (e) generating an image highlighting differences among spectra of the exposed cortex acquired in steps (b) and (d), so as to highlight functional brain regions. Algorithms for calculating oxygen saturation and blood volume maps which can be used to practice the method are also disclosed. Systems for practicing the method are also disclosed.

    Abstract translation: 公开了一种对象的功能性脑图谱的方法。 该方法通过以下方式实现：（a）用入射光照射受试者的大脑或其部分的暴露皮层; （b）获取被摄体的暴露皮质的至少一部分的每个图像元素的反射光谱; （c）刺激受试者的大脑; （d）在步骤（c）期间或之后（c）获取受试者暴露皮层的至少部分的每个图像元素的至少一个附加反射光谱; 和（e）产生突出显示在步骤（b）和（d）中获得的暴露皮质的光谱之间的差异的图像，以便突出功能性脑区域。 还公开了可用于实践该方法的用于计算氧饱和度和血容量图的算法。 还公开了用于实施该方法的系统。

    28.
    发明专利
    未知

    公开(公告)号：DE69813248D1

    公开(公告)日：2003-05-15

    申请号：DE69813248

    申请日：1998-06-29

    Applicant: APPLIED SPECTRAL IMAGING LTD

    Inventor： CABIB DARIO

    IPC: G01J3/28 ,  C12Q1/68 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/44 ,  G01J3/453 ,  G01N21/64 ,  G01N33/50 ,  G01N33/569 ,  G01N33/58 ,  G06K9/00 ,  G06K9/76 ,  G06T1/00 ,  G06K9/62 ,  G06T5/00

    Abstract: A method for remote scenes classification comprising the steps of (a) preparing a reference template for classification of the remote scenes via (i) classifying a set of reference scenes via a conventional classification technique for obtaining a set of preclassified reference scenes; (ii) using a first spectral imager for measuring a spectral cube of the preclassified reference scenes; (iii) employing a principal component analysis for extracting the spectral cube for decorrelated spectral data characterizing the reference scenes; and (vi) using at least a part of the decorrelated spectral data for the preparation of the reference template for remote scenes classification; (b) using a second spectral imager for measuring a spectral cube of analyzed remote scenes, such that a spectrum of each pixel in the remote scenes is obtained; (c) employing a decorrelation statistical method for extracting decorrelated spectral data characterizing the pixels; and (d) comparing at least a part of the decorrelated spectral data extracted from the pixels of the remote scenes with the reference template.

    29.
    发明专利
    未知

    公开(公告)号：DE69809161T2

    公开(公告)日：2003-03-20

    申请号：DE69809161

    申请日：1998-08-24

    Applicant: APPLIED SPECTRAL IMAGING LTD

    Inventor： KATZIR NIR ,  GARINI YUVAL ,  WINE DAVID ,  CABIB DARIO

    IPC: G01N21/64 ,  G01N15/14 ,  G01N21/78 ,  G01N33/533 ,  G01N33/566 ,  G01N33/58 ,  G02B21/06 ,  G01J3/28

    Abstract: Classification of pixels into groups of pixels according to their association with a single fluorophore or a combination of fluorophores, comprises: (a) providing a number of wide-band emission filters; (b) for each of the pixels, recording emitted light intensity as retrieved after passing through each one of the emission filters, such that each of the pixels is representable by a vector of a number of dimensions equal to the number of wide-band emission filters; and (c) using an algorithm for evaluating the presence of each of the fluorophores associated with each of the pixels, thus classifying each of the pixels into a group of pixels according to its association with the fluorophores. Each fluorophore has a characterising emission spectrum and a specifying emission peak.

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