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    Method of and composite for fluorescent (in situ) hybridization
    5.
    发明专利
    Method of and composite for fluorescent (in situ) hybridization 未知

    公开(公告)号：AU5123599A

    公开(公告)日：2000-02-21

    申请号：AU5123599

    申请日：1999-07-23

    Applicant: APPLIED SPECTRAL IMAGING LTD

    Inventor： BAR-AM IRIT ,  JANISH CATHY ,  GARINI YUVAL ,  CABIB DARIO ,  BUCKWALD ROBERT A

    IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/6841 ,  G01N33/533 ,  G01N33/566 ,  C07H21/04

    Abstract: A fluorescent in situ hybridization method including the steps of (a) obtaining a chromosome spread of a species; (b) preparing a hybridization composite containing a plurality of chromosomal paints each of the plurality of chromosomal paints being labeled with a different fluorophore-or-combination-of-fluorophores, such that an averaged specific activity of highly repetitive sequences in the hybridization composite substantially equals an averaged specific activity of unique sequences in the hybridization composite; (c) denaturing the hybridization composite and subjecting the hybridization composite to conditions for allowing at least a part of the highly repetitive sequences in the hybridization composite to reanneal while at least a part of the unique sequences in the hybridization composite remaining single stranded; (d) contacting under hybridization conditions the hybridization composite with the chromosome spread; (e) washing away excess of the hybridization composite; and (d) analyzing and presenting images of the now hybridized chromosome spread.

    7.
    发明专利
    未知

    公开(公告)号：DE69940270D1

    公开(公告)日：2009-02-26

    申请号：DE69940270

    申请日：1999-11-16

    Applicant: APPLIED SPECTRAL IMAGING LTD

    Inventor： GARINI YUVAL ,  MCNAMARA GEORGE ,  SOENKSEN DIRK G ,  CABIB DARIO ,  BUCKWALD ROBERT A

    IPC: G01N33/53 ,  C12Q1/00 ,  C12Q1/28 ,  C12Q1/42 ,  C12Q1/54 ,  C12Q1/68 ,  C12Q1/6841 ,  C12Q1/6883 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/453 ,  G01N1/30 ,  G01N21/64 ,  G01N21/78 ,  G01N33/50 ,  G01N33/533 ,  G01N33/535 ,  G01N33/569 ,  G01N33/58 ,  G06K9/00 ,  G06K9/76

    Abstract: A method of in situ analysis of a biological sample comprising the steps of (a) staining the biological sample with N stains of which a first stain is selected from the group consisting of a first immunohistochemical stain, a first histological stain and a first DNA ploidy stain, and a second stain is selected from the group consisting of a second immunohistochemical stain, a second histological stain and a second DNA ploidy stain, with provisions that N is an integer greater than three and further that (i) if the first stain is the first immunohistochemical stain then the second stain is either the second histological stain or the second DNA ploidy stain; (ii) if the first stain is the first histological stain then the second stain is either the second immunohistochemical stain or the second DNA ploidy stain; whereas (iii) if the first stain is the first DNA ploidy stain then the second stain is either the second immunohistochemical stain or the second histological stain; and (b) using a spectral data collection device for collecting spectral data from the biological sample, the spectral data collection device and the N stains are selected such that a spectral component associated with each of the N stains is collectable.

    Method and apparatus for spectral analysis
    9.
    发明专利
    Method and apparatus for spectral analysis 未知

    公开(公告)号：GR3033470T3

    公开(公告)日：2000-09-29

    申请号：GR20000401166

    申请日：2000-05-22

    Applicant: APPLIED SPECTRAL IMAGING LTD

    Inventor： CABIB DARIO ,  FRIEDMAN ZVI ,  LIPSON STEPHEN G ,  BUCKWALD ROBERT A

    IPC: C12Q1/68 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/453 ,  G01N21/64 ,  G06K9/00 ,  G06K9/76

    Abstract: A method of analyzing an optical image of a scene to determine the spectral intensity of each pixel of the scene, which includes collecting incident light from the scene; (b) passing the light through an interferometer which outputs modulated light corresponding to a predetermined set of linear combinations of the spectral intensity of the light emitted from each pixel; focusing the light outputted from the interferometer on a detector array; and processing the output of the detector array to determine the spectral intensity of each pixel thereof. If the interferometer is of the moving type scanning in one dimension is required where the detector array is one dimensional, and no scanning when the detector array is two-dimensional. If the interferometer is of the non-moving type scanning is required in one dimension when the detector array is two-dimensional, and in two dimensions when the detector array is one-dimensional.

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