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    SYSTEMS AND METHODS FOR ASSEMBLY VIA CONTACT ELECTRIFICATION
    25.
    发明申请
    SYSTEMS AND METHODS FOR ASSEMBLY VIA CONTACT ELECTRIFICATION 审中-公开
    通过接触电气组装的系统和方法

    公开(公告)号：WO2008127649A3

    公开(公告)日：2009-06-04

    申请号：PCT/US2008004704

    申请日：2008-04-11

    Applicant: HARVARD COLLEGE ,  WHITESIDES GEORGE M ,  MCCARTY LOGAN S ,  THOMAS SAMUEL W ,  RECHES MEITAL ,  KAUFMAN GEORGE K

    Inventor： WHITESIDES GEORGE M ,  MCCARTY LOGAN S ,  THOMAS SAMUEL W ,  RECHES MEITAL ,  KAUFMAN GEORGE K

    IPC: C08J5/12 ,  B05D1/04 ,  C08J7/00

    CPC classification number: C08J5/12 ,  B05D3/14 ,  B05D7/02 ,  B05D2401/32 ,  C08J7/047 ,  C08J2327/18 ,  C08J2433/12

    Abstract: The present invention generally relates to the charging of materials via contact electrification, including systems and methods of assembly using contact electrification. One aspect of the present invention is directed to systems and methods of identifying and synthesizing nonionic polymeric materials that can be charged using contact electrification. Another aspect of the present invention is directed to methods of localizing charged particles or other materials on such surfaces, for example, in the presence of a controlled humidity environment. Yet another aspect of the present invention is directed to a surface comprising positively and negatively charged regions. Oppositely charged materials may be attracted to those regions. Other aspects of the invention are directed to methods of making, using, and promoting such materials, or kits containing such materials.

    Abstract translation: 本发明一般涉及通过接触带电充电材料，包括使用接触带电装配的系统和组装方法。 本发明的一个方面涉及鉴定和合成可以使用接触带电充电的非离子聚合物材料的系统和方法。 本发明的另一方面涉及将带电粒子或其它材料定位在这些表面上的方法，例如在受控湿度环境的存在下。 本发明的另一方面涉及包括正带电和带负电荷的区域的表面。 对这些区域可能会吸引相反电荷的材料。 本发明的其它方面涉及制造，使用和促进这些材料或包含这种材料的试剂盒的方法。

    FORMING GEL STRUCTURES USING MICROFLUIDIC CHANNELS
    26.
    发明申请
    FORMING GEL STRUCTURES USING MICROFLUIDIC CHANNELS 审中-公开
    使用微流通道形成凝胶结构

    公开(公告)号：WO2009061392A1

    公开(公告)日：2009-05-14

    申请号：PCT/US2008/012445

    申请日：2008-11-04

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  WONG, Amy, P. ,  PEREZ-CASTILLEJOS, Raquel ,  LOVE, J., Christopher ,  WHITESIDES, George, M.

    Inventor： WONG, Amy, P. ,  PEREZ-CASTILLEJOS, Raquel ,  LOVE, J., Christopher ,  WHITESIDES, George, M.

    IPC: B01L3/00 ,  C12M3/00

    CPC classification number: C12N5/0062 ,  B01L3/502707 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2300/069 ,  C12M23/16 ,  C12M25/14 ,  C12N2533/90 ,  C12N2535/10

    Abstract: Articles and methods for forming structures in microfluidic channels are provided. Methods described herein may include the use of spatially-defined flows of fluid within microchannels to form portions of gel (e.g., gel structures) inside the microchannels. The gel structures may be formed by flowing, e.g., laminarly, one or more streams of fluid in a microfluidic channel, at least one of the streams including a gel precursor. The stream(s) of gel precursor can be polymerized to form one or more gel structures by various methods such as by application of heat. Advantageously, the dimensions of the gel structures may be varied, for example, by applying different flow rates to the fluid streams, choosing different viscosities of the fluids, and/or by varying the dimensions of the microchannel. Using such methods, different configurations of gel structures in microfluidic channels can be formed. Gel structures having different components encapsulated therein may also be formed. Articles and methods described herein may involve, in some embodiments, i) culturing cells within or on surfaces of the gel portions, ii) patterning different types of cells on or in adjacent gel structures, and/or iii) applying gradients of soluble factors across the cell-containing gel portions. Such structures may be used for studying intercellular communication between cells cultured within biologically-derived, 3-D matrices of microscopic size.

    Abstract translation: 提供了在微流体通道中形成结构的制品和方法。 本文描述的方法可以包括在微通道内使用空间限定的流体流，以在微通道内部形成凝胶（例如，凝胶结构）的部分。 凝胶结构可以通过在微流体通道中流动（例如，层流）一种或多种流体流而形成，至少一种流包括凝胶前体。 凝胶前体的流可以通过各种方法例如通过加热来聚合以形成一种或多种凝胶结构。 有利地，凝胶结构的尺寸可以例如通过对流体流施加不同的流速，选择不同的流体粘度和/或通过改变微通道的尺寸来改变。 使用这种方法，可以形成微流体通道中凝胶结构的不同构型。 也可以形成具有封装在其中的不同组分的凝胶结构。 在一些实施方案中，文章和方法可能涉及i）在凝胶部分内或表面上培养细胞，ii）在相邻凝胶结构上或相邻凝胶结构中构图不同类型的细胞，和/或iii）将可溶性因子的梯度跨越 含有细胞的凝胶部分。 这种结构可用于研究在微观尺寸的生物衍生的3-D基质内培养的细胞之间的细胞间通信。

    PATTERNING OF IONIC POLYMERS
    27.
    发明申请
    PATTERNING OF IONIC POLYMERS 审中-公开
    离子聚合物的构图

    公开(公告)号：WO2008051432A3

    公开(公告)日：2009-04-09

    申请号：PCT/US2007022219

    申请日：2007-10-18

    Applicant: HARVARD COLLEGE ,  LAHAV MICHAL ,  WINKLEMAN ADAM ,  NAROVLYANSKY MAX ,  PEREZ-CASTILLEJOS RAQUEL ,  WEISS EMILY A ,  RODRIGUEZ LEONARD N J ,  WHITESIDES GEORGE M

    Inventor： LAHAV MICHAL ,  WINKLEMAN ADAM ,  NAROVLYANSKY MAX ,  PEREZ-CASTILLEJOS RAQUEL ,  WEISS EMILY A ,  RODRIGUEZ LEONARD N J ,  WHITESIDES GEORGE M

    IPC: G03F7/00

    CPC classification number: G03F7/0002 ,  B82Y10/00 ,  B82Y40/00 ,  Y10T428/24479

    Abstract: In one aspect, methods of patterning of thin films of an ionotropic polymer (e.g., poly(acrylic acid)) are provided. These processes can create micron or sub-micron-scale patterns of ionotropic polymers such as cation crosslinked poly(acrylic acid) (CCL- PAA). In one embodiment, patterning may be performed within microfluidic channels by flowing a solution of crosslinking agent (e.g., metal cations such as Ag+, Ca2+, Pd2+, Al3+, La3+, and Ti4+) that can crosslink a portion of an ionotropic polymer in contact with the solution. In another embodiment, methods of patterning ionotropic polymers involve photolithography. Upon patterning a positive photoresist (e.g., diazonaphthoquinone- novolac resin) on a film of CCL-PAA, the exposed regions of CCL-PAA can be etched by an aqueous solution. Advantageously, the patterned, crosslinked polymer may also serve as both a reactant and a matrix for subsequent chemistry. For example, in some embodiments, the initial crosslinking cation can be exchanged for a second cation that could not be patterned photolithographically. Patterned films of CCL-PAA can also be used to host and template the reduction of metallic cations to metallic nanoparticles, and to fabricate porous, low-k dielectric substrates.

    Abstract translation: 一方面，提供了离子型聚合物（例如聚（丙烯酸））的薄膜图案化方法。 这些方法可以产生离子型聚合物如阳离子交联的聚（丙烯酸）（CCL-PAA）的微米级或亚微米级的图案。 在一个实施方案中，可以在微流体通道内通过使交联剂（例如金属阳离子如Ag +，Ca 2+，Pd 2+，Al 3+，La 3+和Ti 4+）的溶液流过微流体通道，所述溶液可以将部分离子型聚合物与 解决方案。 在另一个实施方案中，构图离子型聚合物的方法涉及光刻。 在CCL-PAA膜上形成正性光致抗蚀剂（例如重氮萘酚 - 酚醛清漆树脂）之后，CCL-PAA的曝光区域可以通过水溶液进行蚀刻。 有利地，图案化的交联聚合物也可以用作反应物和用于后续化学的基质。 例如，在一些实施方案中，可以将初始交联阳离子交换为不能光刻图案化的第二阳离子。 CCL-PAA的图案化膜也可用于将金属阳离子还原为金属纳米颗粒，并制备多孔，低k电介质基底。

    FABRICATION OF CONDUCTIVE PATHWAYS, MICROCIRCUITS AND MICROSTRUCTURES IN MICROFLUIDIC NETWORKS
    30.
    发明申请
    FABRICATION OF CONDUCTIVE PATHWAYS, MICROCIRCUITS AND MICROSTRUCTURES IN MICROFLUIDIC NETWORKS 审中-公开
    微流控网络中导电路径，微型计算机和微结构的制造

    公开(公告)号：WO2007061448A3

    公开(公告)日：2008-08-28

    申请号：PCT/US2006019787

    申请日：2006-05-18

    Applicant: HARVARD COLLEGE ,  BRUZEWICZ DEREK A ,  BONCHEVA-BETTEX MILA ,  WHITESIDES GEORGE M ,  SIEGEL ADAM ,  WEIBEL DOUGLAS B ,  SHEVKOPLYAS SERGEY ,  MARTINEZ ANDRES

    Inventor： BRUZEWICZ DEREK A ,  BONCHEVA-BETTEX MILA ,  WHITESIDES GEORGE M ,  SIEGEL ADAM ,  WEIBEL DOUGLAS B ,  SHEVKOPLYAS SERGEY ,  MARTINEZ ANDRES

    IPC: H05K3/10 ,  B01F13/00 ,  B01L3/00 ,  B29C39/12

    CPC classification number: H05K3/101 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2400/0415 ,  B33Y80/00 ,  H05K1/0272 ,  H05K1/032 ,  H05K3/389 ,  H05K2201/0162 ,  H05K2201/0305 ,  H05K2203/128 ,  Y10T29/49117

    Abstract: Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter referred to as "microsolidic" devices). In certain such devices, in which electrical connections can be formed and/or reformed between regions in a microfluidic structure; in some cases, the devices/circuits formed may be flexible and/or involve flexible electrical components. In certain embodiments, the solid metal wires/conductive pathways formed in microfluidic channel(s) may remain contained within the microfluidic structure. In certain such embodiments, the conductive pathways formed may be located in proximity to other microfluidic channel(s) of the structure that carry flowing fluid, such that the conductive pathway can create energy (e.g. electromagnetic and/or thermal energy) that interacts withy and/or affects the flowing fluid and/or a component contained therein or carried thereby. In other embodiments, a microsolidic structure may be removed from a microfluidic mold to form a stand-alone structure. In certain embodiments, the solid metal structures formed may interact with light energy incident upon a structure or may be used to fabricate a light-weight electrode. Another aspect of the invention relates to the formation of self-assembled structures that may comprise these electrically conductive pathways/connections.

    Abstract translation: 本文公开了各种微流体装置和可以使用诸如模具的装置形成的固体，通常导电的装置。 在某些实施方案中，形成的装置包括通过固化存在于一个或多个微流体通道（这种装置在下文中称为“微溶体”装置）中的液态金属形成的导电通路。 在某些这样的装置中，其中可以在微流体结构的区域之间形成和/或重组电连接; 在一些情况下，所形成的器件/电路可能是柔性的和/或涉及柔性电气部件。 在某些实施方案中，在微流体通道中形成的固体金属线/导电路径可以保持在微流体结构内。 在某些这样的实施例中，所形成的导电路径可以位于结构的其它微流体通道附近，其携带流动的流体，使得导电路径可以产生与...相互作用的能量（例如电磁和/或热能） /或影响流动的流体和/或其中所含的或由其携带的部件。 在其它实施方案中，微溶体结构可以从微流体模具中移除以形成独立结构。 在某些实施方案中，形成的固体金属结构可与入射到结构上的光能相互作用，或者可用于制造轻质电极。 本发明的另一方面涉及可以包括这些导电路径/连接的自组装结构的形成。

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