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    신규한 유사 세라마이드 화합물 및 그 제조방법
    26.
    发明公开
    신규한 유사 세라마이드 화합물 및 그 제조방법 审中-实审
    新型PSEUDO-CERAMIDE化合物及其制备方法

    公开(公告)号：KR1020140070474A

    公开(公告)日：2014-06-10

    申请号：KR1020130147705

    申请日：2013-11-29

    Applicant: (주)아모레퍼시픽

    Inventor： 우병영 ,  장원희 ,  주영협 ,  박양희 ,  이창근 ,  조영석 ,  백흥수 ,  신송석 ,  박영호

    IPC: C07C235/08 ,  A61K31/164 ,  A61P17/16

    CPC classification number: A61K8/42 ,  A61K8/68 ,  A61K2800/40 ,  A61Q19/007 ,  C07C233/18 ,  C07C235/08 ,  C07C235/28

    Abstract: The present invention provides a novel pseudo-ceramide compound represented by Chemical Formula 1, an isomer, a pharmaceutically allowable salt, a pro-drug, a hydroxide, or a solvated compound thereof. [Chemical Formula 1] (In Chemical Formula 1, R1 and R2 are independently non-substituted or hydroxyl group-substituted C 9 to 23 saturated or unsaturated aliphatic chains.) According to the present invention, the compound has excellent stability and dissolubility and is effective in moisturizing the skin so as to protect the skin from external stimuli without side effects and be used as an active ingredient for recovering damaged skin and preventing skin damage. Accordingly, the compound can be used as an external skin application composition for moisturizing the skin, as a cosmetic composition, or as a pharmaceutical composition.

    Abstract translation: 本发明提供由化学式1表示的新型假神经酰胺化合物，异构体，药学上可允许的盐，前药，氢氧化物或溶剂化物。 [化学式1] （在化学式1中，R1和R2分别为非 取代或羟基取代的C 9〜23饱和或不饱和脂肪链）根据本发明，该化合物具有优异的稳定性和溶解性，并且有效地保湿皮肤，从而保护皮肤免受外部刺激而没有副作用 并用作恢复受损皮肤并防止皮肤损伤的活性成分。 因此，该化合物可以用作皮肤保湿剂，化妆品组合物或作为药物组合物的外用皮肤施用组合物。

    카르노스산 또는 그 유도체를 함유하는 엘라스테이즈 활성 저해제
    27.
    发明公开
    카르노스산 또는 그 유도체를 함유하는 엘라스테이즈 활성 저해제 无效
    含有羧酸或其衍生物的弹性酶抑制剂

    公开(公告)号：KR1020130077953A

    公开(公告)日：2013-07-10

    申请号：KR1020110146636

    申请日：2011-12-30

    Applicant: (주)아모레퍼시픽

    Inventor： 최수정 ,  백흥수 ,  주영협 ,  신송석 ,  박영호

    IPC: A61K31/08 ,  A61K31/05 ,  A61K36/53 ,  A61P17/00

    Abstract: PURPOSE: Carnosic acid, a derivative thereof, or a pharmaceutically acceptable salt thereof is provided to suppress elastase activation or matrix metalloproteinase-9 (MMP) expression, and to basically inhibit vital reaction mediated by the suppression. CONSTITUTION: An elastase activation inhibitor contains carnosic acid of chemical formula 1, a derivative thereof, or a pharmaceutically acceptable salt thereof as an active ingredient. The carnosic acid derivative is carnosic acid methyl ester or carnosic methyl alcohol. The carnosic acid, the derivative, or the pharmaceutically acceptable salt is derived from rosemary and/or sage. The inhibitor contains 0.0001-20 wt% of the active ingredient. An MMP expression inhibitor contains the carnosic acid, the derivative, or the pharmaceutically acceptable salt as an active ingredient. A composition for skin anti-aging contains the carnosic acid, the derivative, or the pharmaceutically acceptable salt as an active ingredient.

    Abstract translation: 目的：为了抑制弹性蛋白酶活化或基质金属蛋白酶-9（MMP）的表达，基本上抑制由抑制介导的生物反应，提供鼠尾草衍生物或其药学上可接受的盐。 构成：弹性蛋白酶活化抑制剂含有化学式1的山梨酸，其衍生物或其药学上可接受的盐作为活性成分。 鼠尾草酸衍生物是鼠尾草酸甲酯或鼠尾草甲醇。 鼠尾草酸，衍生物或药学上可接受的盐衍生自迷迭香和/或鼠尾草。 抑制剂含有0.0001-20重量％的活性成分。 MMP表达抑制剂含有鼠尾草酸，衍生物或药学上可接受的盐作为活性成分。 用于皮肤抗衰老的组合物含有鼠尾草酸，衍生物或药学上可接受的盐作为活性成分。

    자외선 차단용 유무기 복합분체 및 이를 함유하는 화장료 조성물
    28.
    发明公开
    자외선 차단용 유무기 복합분체 및 이를 함유하는 화장료 조성물 审中-实审
    用于阻挡紫外线的有机无机复合粉末及其包含的化妆品组合物

    公开(公告)号：KR1020130047555A

    公开(公告)日：2013-05-08

    申请号：KR1020120065929

    申请日：2012-06-20

    Applicant: (주)아모레퍼시픽

    Inventor： 양영준 ,  이현석 ,  김준오 ,  최선경 ,  최경호 ,  주영협

    IPC: A61K8/27 ,  A61K8/29 ,  A61K47/48 ,  A61Q17/04

    Abstract: PURPOSE: Organic and inorganic composite powder for blocking UV rays and a cosmetic composition containing the same are provided to ensure excellent UV protection ability, dispersion property, softness, and a moisturizing effect. CONSTITUTION: Organic and/or inorganic composite powder for blocking UV rays is prepared by surface-treating inorganic powder with one or more phospholipids selected from 2-methacryloyloxyethyl phosphorylcholine and 2-methacryloyloxyethyl phosphatidylcholine. The inorganic powder is selected among titanium oxide and zinc oxide. The inorganic powder contains 0.1-8% of phospholipid. A cosmetic composition for blocking UV rays contains 0.1-25wt% of organic and inorganic composite powder. [Reference numerals] (AA,CC) Absorbance(AU); (BB) Absorbance average value comparison at 310nm; (DD) Wavelength(nm)

    Abstract translation: 目的：提供用于阻止紫外线的有机和无机复合粉末和含有它们的化妆品组合物，以确保优异的紫外线防护能力，分散性，柔软性和保湿效果。 构成：通过用选自2-甲基丙烯酰氧基乙基磷酰胆碱和2-甲基丙烯酰氧基乙基磷脂酰胆碱的一种或多种磷脂表面处理无机粉末制备用于阻断紫外线的有机和/或无机复合粉末。 无机粉末选自氧化钛和氧化锌。 无机粉末含有0.1-8％的磷脂。 用于阻挡紫外线的化妆品组合物含有0.1-25重量％的有机和无机复合粉末。 （标号）（AA，CC）吸光度（AU）; （BB）310nm下的吸光度平均值比较; （DD）波长（nm）

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