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公开(公告)号：KR101081424B1
公开(公告)日：2011-11-08
申请号：KR1020040097817
申请日：2004-11-26
Applicant: (주)아모레퍼시픽
Abstract: 본발명은지모(Anemarrhenae Rhizoma), 원지(Polygalae Radix), 쇄양(Cynomorii Herba) 및오수유(Evodiae Fructus) 중선택된 1종이상의추출물을함유하는피부외용제에관한것으로서, 인슐린유사성장인자-1 (Insulin-like Growth Factor-1; IGF-1)의생체내분비를촉진하여피부노화와관련된여러인자들을증진혹은억제하여피부주름및 탄력개선효과를나타내어궁극적으로피부노화를지연시킬수 있는부작용이없는조성물을제공한다.
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公开(公告)号：KR1020100026855A
公开(公告)日：2010-03-10
申请号：KR1020080086021
申请日：2008-09-01
Applicant: (주)아모레퍼시픽
CPC classification number: A61K36/82 , A61K36/21 , A61K36/232 , A61K36/234 , A61K36/48 , Y10S514/844 , Y10S514/857 , Y10S514/886
Abstract: PURPOSE: A skin external composition for preventing or treating inflammatory dermatitis containing natural products is provided to ensure anti-inflammation and skin moisturization. CONSTITUTION: A skin external composition for preventing or treating inflammatory dermatitis contains 0.001-20 weight% of green tea, 0.05-3 weight% of sophora root, 0.05-3 weight% of Portulaca oleracea L., and 0.5-30 weight% of Polygonatum officinale as active ingredient. The skin external composition additionally contains 1-50 weight% of starch, 1-10 weight% of cacao bean, 1-10 weight% of Cnidii Rhizoma or 0.5-5 weight% of Angelicae gigantis Radix. The composition is cosmetic composition or pharmaceutical composition.
Abstract translation: 目的：提供用于预防或治疗含有天然产物的炎性皮炎的皮肤外用组合物，以确保抗炎和皮肤保湿。 构成：用于预防或治疗炎症性皮炎的皮肤外用组合物含有绿茶的重量百分比为0.001-20重量％，槐根0.05-3重量％，马齿苋属0.05-3重量％，黄芪0.5-30重量％ 草药作为活性成分。 皮肤外用组合物另外含有1-50重量％的淀粉，1-10重量％的可可豆，1-10重量％的Cnidii Rhizoma或0.5-5重量％的Angelicae gigantis大戟。 组合物是化妆品组合物或药物组合物。
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公开(公告)号：KR1020100011226A
公开(公告)日：2010-02-03
申请号：KR1020080072355
申请日：2008-07-24
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A multilayer lamella granule and a skin external composition containing the same are provided to stably maintain lamella structure which is similar to the skin keratin layer and ensure moisturization effect and barrier healing effect. CONSTITUTION: A multilayer lamella granule contains nucleant, lipid lamella layer containing ceramide on the nucleant, and polymer layer on the lipid lamella layer. The nucleant is sugar, salt, hyaluronic acid, alginic acid, chondroitin sulfate, chitosan, chitin, polylysine, collagen, gelatin, stearic acid, cetyl alcohol, stearyl alcohol or their mixture. The ceramide is a natural ceramide 1-8 or similar ceramide of chemical formulas 1-6. A similar keratin lipid lamella layer is contained in 0.000001-99 weight% based on total weight. The similar keratin lipid lamella layer additionally contains fatty acid, cholesterol or its derivative or their mixture. The fatty acid is saturated or unsaturated fatty acid of 8-30 carbon atoms.
Abstract translation: 目的：提供多层薄片颗粒和含有它的皮肤外用组合物，以稳定地保持与皮肤角质层相似的薄片结构，并确保保湿效果和屏障愈合效果。 构成：多层薄片颗粒含有成核剂，成核剂上含有神经酰胺的脂质层层和脂质层层上的聚合物层。 成核剂是糖，盐，透明质酸，海藻酸，硫酸软骨素，壳聚糖，壳多糖，聚赖氨酸，胶原，明胶，硬脂酸，鲸蜡醇，硬脂醇或它们的混合物。 神经酰胺是天然神经酰胺1-8或类似化学式1-6的神经酰胺。 基于总重量，类似的角蛋白脂质层层含量为0.000001-99重量％。 类似的角蛋白脂质层层还含有脂肪酸，胆固醇或其衍生物或其混合物。 脂肪酸是8-30个碳原子的饱和或不饱和脂肪酸。
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公开(公告)号：KR1020090093245A
公开(公告)日：2009-09-02
申请号：KR1020080018672
申请日：2008-02-29
Applicant: (주)아모레퍼시픽 , 경상대학교산학협력단
CPC classification number: C07K14/47 , C12Q1/6876 , C12Q2600/136 , G01N33/5008 , G01N33/68
Abstract: A bio marker for diagnosing hyperpigmentation disposition of skin is provided to rapidly and sensitively predict the possibility of pigmentation. A bio marker for diagnosing skin of hyperpigmentation disposition comprises a gene of which expression is increased or decreased by UV irradiation. A kit for diagnosing hyperpigmentation disposition comprises a polynucleotide of the bio marker gene or its fragment and solid support in which one or more polynucleotide is conjugated on the surface. A method for screening an inhibitor of hyperpigmentation disposition comprises: a step of treating test material in the bio marker gene; and a step of confirming whether the test material suppresses or inhibits the expression of the gene.
Abstract translation: 提供用于诊断皮肤色素沉着过度的生物标记，以快速和敏感地预测色素沉着的可能性。 用于诊断色素沉着过度皮肤的生物标志物包括通过UV照射增加或减少表达的基因。 用于诊断色素沉着过度的试剂盒包括生物标记基因的多核苷酸或其片段和固体支持物，其中一个或多个多核苷酸在表面上缀合。 一种筛选色素沉着过度抑制剂的方法，包括：在生物标记基因中处理试验材料的步骤; 以及确认测试材料是否抑制或抑制基因表达的步骤。
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公开(公告)号：KR1020090052652A
公开(公告)日：2009-05-26
申请号：KR1020070119266
申请日：2007-11-21
Applicant: (주)아모레퍼시픽
IPC: A61K36/488 , A61K8/97 , A61Q7/00
CPC classification number: A61K36/488
Abstract: 본 발명은 갈근(칡)을 유효성분으로 함유하는 백모 방지용 및 백반증 치료용 조성물을 개시한다. 본 발명에 의한 백모 방지용 및 백반증 치료용 조성물은 멜라노사이트의 MITF 발현을 증가시켜 멜라노사이트를 활성화시키고 멜라닌 합성을 촉진함으로써 백모 방지와 백반증 치료를 도모한다.
갈근, 칡, 멜라노사이트, MITF, 멜라닌, 백모, 백반증-
Patent Agency Ranking
公开(公告)号：KR100837517B1
公开(公告)日：2008-06-12
申请号：KR1020020016298
申请日：2002-03-26
Applicant: (주)아모레퍼시픽
IPC: C07K5/10
Abstract: 본 발명은 티로시나제 저해 활성을 가지는 펩티드, 그 제조방법, 및 이를 함유하는 피부 외용제 조성물에 관한 것이다. 보다 상세하게는 화학적으로 합성된 펩티드 라이브러리(펩티드 무작위 서열 혼합물)로부터 선별되는 네개의 아미노산으로 이루어진 펩티드로서, 구체적으로 첫번째 아미노산 및 두번째 아미노산이 티로신 또는 트립토판에서 선택되고, 세번째 아미노산이 트립토판, 네번째 아미노산이 아르기닌으로 구성되는 서열을 가지는, 티로시나제 억제 작용을 가지는 펩티드 및 그 제조방법에 관한 것이다. 또한, 본 발명은 상기 펩티드를 유효 성분으로 함유한 피부 외용제 조성물에 관한 것이다. 본 발명에 의한 멜라닌 생성 억제 펩티드는 멜라닌 생성 세포에 존재하는 티로시나제의 활성을 억제하며, 세포에도 매우 안전하다. 따라서, 상기 펩티드를 유효 성분으로 함유하는 본 발명의 피부 외용제 조성물은, 멜라닌 생성의 효과적인 억제로 피부 미백 효과에 있어 탁월하며, 기미, 주근깨, 태양 광선에 의한 피부 그을림 등의 피부 색소 침착을 효과적으로 개선 및 방지할 수 있다.
미백, 멜라닌 생성 억제, 아미노산 서열, 펩티드, 티로시나제, 피부 외용제 조성물-
公开(公告)号：KR1020080044612A
公开(公告)日：2008-05-21
申请号：KR1020060113663
申请日：2006-11-17
Applicant: (주)아모레퍼시픽
IPC: A61K36/575 , A61P17/00
CPC classification number: A61K8/97 , A61Q19/02 , Y10S514/846 , Y10S514/847
Abstract: A composition comprising an extract of Magnolia Obovata bark is provided to inhibit melanogenesis by inhibiting the activity of c-kit protein expressed in melanocyte effectively, thereby showing excellent whitening effect. A composition for inhibiting c-kit protein activity comprises 0.0001-10 wt.% of an extract of Magnolia Obovata bark as an effective ingredient, wherein the extract controls function of melanocyte by inhibiting signalling of cells in a melanocyte participated by a C-kit protein.
Abstract translation: 通过抑制黑素细胞表达的c-kit蛋白的活性，提供含有木兰提取物的组合物，以抑制黑素生成，从而显示优异的美白效果。 用于抑制c-kit蛋白活性的组合物包含0.0001-10重量％的木兰木皮提取物作为有效成分，其中所述提取物通过抑制C-kit蛋白质参与的黑素细胞中细胞的信号传导来控制黑素细胞的功能 。
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公开(公告)号：KR100806162B1
公开(公告)日：2008-02-22
申请号：KR1020060119448
申请日：2006-11-30
Applicant: (주)아모레퍼시픽
CPC classification number: A61Q19/08 , A61K8/33 , A61K8/42 , A61K8/49 , A61K8/4926 , A61K8/498 , A61K2800/70
Abstract: A skin external composition comprising a PPARs(Peroxisome proliferator activated receptors) activator derived from a plant is provided to be able to promote the differentiation of skin keratinocytes and delay or improve the inflammation inhibition and skin aging through the activation and the expression increase of PPAR-gamma and PPAR-alpha. A skin external application composition for improving skin aging or skin wrinkle or inhibiting inflammatory reaction by promoting the activity of PPARs comprises 0.1-10 wt.% of at least one selected from the group consisting of galbulin, methylhalfordinol, brevicarine, 3-(4-methyl-thiazol-2-yl)-7-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-chromen-4-one, 9-dimethyl-3-(3-methoxyphenyl)-psolen-6-yl propionic acid and (N-(2-(2,3,4',5'-tetramethoxychalcon-2-yl)-ethyl)-acetamide) as an effective ingredient.
Abstract translation: 提供了包含来自植物的PPAR（过氧化物酶体增殖物激活受体）激活剂的皮肤外用组合物，以能够促进皮肤角质化细胞的分化，并延缓或改善炎症抑制和皮肤老化，通过激活和表达增加PPAR- γ和PPAR-α。 用于通过促进PPARs的活性来改善皮肤老化或皮肤皱纹或抑制炎性反应的皮肤外用施用组合物包含0.1-10重量％的选自以下的至少一种：姜黄素，甲基氟代醇，二乙醇胺，3-（4- 甲基 - 噻唑-2-基）-7-（3,4,5-三羟基-6-羟基甲基 - 四氢 - 吡喃-2-基氧基） - 色烯-4-酮，9-二甲基-3-（3-甲氧基苯基） （3-（2-（2,3,4'，5'-四甲氧基咔啉-2-基） - 乙基） - 乙酰胺）作为有效成分。
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公开(公告)号：KR1020080011543A
公开(公告)日：2008-02-05
申请号：KR1020060071985
申请日：2006-07-31
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/35 , A61K8/36 , A61K8/466 , A61K2800/78 , A61Q19/08
Abstract: A cosmetic composition is provided to promote collagen biosynthesis by comprising alpha-ketoglutarate increasing the prolidase activity involving with the supply of proline, a main constituent amino acid of the collagen, together with alpha-lipoic acid increasing the expression of prolyl-4-hydroxylase to make a generated pro-collagen form a right triple helix. A cosmetic composition for improving skin wrinkle comprises 0.001-10 wt.% of alpha-ketoglutarate as an effective ingredient. The composition further comprises 0.001-10 wt.% of alpha-lipoic acid.
Abstract translation: 提供化妆品组合物以通过包含α-酮戊二酸来增加胶原蛋白生物合成，所述α-酮戊二酸增加脯氨酸酶活性，其涉及脯氨酸的供应，胶原的主要成分氨基酸与α-硫辛酸一起增加脯氨酰-4-羟化酶的表达， 使生成的原胶原形成右三重螺旋。 用于改善皮肤皱纹的化妆品组合物包含0.001-10重量％的作为有效成分的α-酮戊二酸。 组合物还包含0.001-10重量％的α-硫辛酸。
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30.发明公开콜레스테릴 헤미숙신네이트 기반의 나노 전달체로 포집된상백피 추출물을 유효 성분으로 함유하는 피부 미백용조성물 无效用于皮肤白蛋白的组合物包含多糖根提取物包裹在胆固醇合成的基于脂质的纳米载体中
公开(公告)号：KR1020070089459A
公开(公告)日：2007-08-31
申请号：KR1020060019537
申请日：2006-02-28
Applicant: (주)아모레퍼시픽
Abstract: A lipid-based nano-carrier is provided to increase the whitening effect of an extract of Mori Cotex Radicis by encapsulating an extract of Mori Cortex Radicis in the lipid-based nano-carrier in which cholesteryl hemisuccinate is introduced, thereby effectively inhibiting the melanogenesis without side effects. The lipid-based nano-carrier is characterized in that it is in the form of a liposome dispersion or a nano-emulsion in which cholesteryl hemisuccinate encapsulating an extract of Mori Cortex Radicis or a salt thereof is introduced. Regarding the total weight of the total liposome dispersion or the nano-emulsion, the content of the lipid is 0.001-20 wt.% and the content of the extract is 0.001-30 wt.%. The skin whitening composition comprises the nano-carrier.
Abstract translation: 提供一种脂质纳米载体，通过将Mori Cortex Radicis的提取物包封在引入胆固醇基半琥珀酸酯的脂质纳米载体中，从而有效抑制黑素生成，从而有效抑制黑素生成，从而提高Mori Cotex Radicis提取物的美白效果， 副作用。 基于脂质的纳米载体的特征在于其为脂质体分散体或纳米乳剂的形式，其中引入了包封Mori Cortex Radicis提取物的胆固醇半琥珀酸盐或其盐。 关于总脂质体分散体或纳米乳液的总重量，脂质的含量为0.001-20重量％，提取物的含量为0.001-30重量％。 皮肤美白组合物包含纳米载体。
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