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    과색소침착성 피부 진단용 키트
    3.
    发明公开
    과색소침착성 피부 진단용 키트 无效
    用于预防高发病处理皮肤的工​​具包

    公开(公告)号：KR1020100058439A

    公开(公告)日：2010-06-03

    申请号：KR1020100038994

    申请日：2010-04-27

    Applicant: (주)아모레퍼시픽 ,  경상대학교산학협력단

    Inventor： 장희경 ,  김수정 ,  안수미 ,  황재성 ,  윤태진 ,  이증훈 ,  김진화

    IPC: C12Q1/68 ,  C12N15/12 ,  G01N33/53

    CPC classification number: C12Q1/6883 ,  C12Q2600/148 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5302 ,  G01N33/5308

    Abstract: PURPOSE: A kit for diagnosing hyperpigmentation is provided to sensitively and quickly predict pigmentation using a marker gene for pigmentation. CONSTITUTION: A kit for diagnosing hyperpigmentation contains a gene selected from gene. The gene expression is enhanced by UV irradiation. A marker for diagnosing hyperpigmentation contains a protein selected from proteins of table 1. The protein expression is also enhanced by UV irradiation. A diagnosis kit contains a polynucleotide having 10 polynucleotides or conplementary polynucleotide thereof, and a solid phase support coupled on the surface. A method for screening a hyperpigmentation inhibitor comprises: a step of treating a test material to the protein and a step of confirming promotion or suppression of protein activation.

    Abstract translation: 目的：提供一种用于诊断色素沉着过度的试剂盒，以便使用色素沉着标记基因敏感和快速地预测色素沉着。 构成：用于诊断色素沉着过度的试剂盒含有选自基因的基因。 通过UV照射增强基因表达。 用于诊断色素沉着过度的标记物含有选自表1蛋白质的蛋白质。蛋白质表达也通过UV照射增强。 诊断试剂盒含有具有10个多核苷酸或其互补多核苷酸的多核苷酸，以及耦合在该表面上的固相载体。 用于筛选色素沉着过度抑制剂的方法包括：将测试材料处理到蛋白质的步骤和确认促进或抑制蛋白质活化的步骤。

    과색소침착성 피부 진단용 바이오 마커
    4.
    发明公开
    과색소침착성 피부 진단용 바이오 마커 失效
    生物标记物用于预防高发病处理的皮肤

    公开(公告)号：KR1020090093245A

    公开(公告)日：2009-09-02

    申请号：KR1020080018672

    申请日：2008-02-29

    Applicant: (주)아모레퍼시픽 ,  경상대학교산학협력단

    Inventor： 장희경 ,  김수정 ,  안수미 ,  황재성 ,  윤태진 ,  이증훈 ,  김진화

    IPC: C12N15/12 ,  C12Q1/68

    CPC classification number: C07K14/47 ,  C12Q1/6876 ,  C12Q2600/136 ,  G01N33/5008 ,  G01N33/68

    Abstract: A bio marker for diagnosing hyperpigmentation disposition of skin is provided to rapidly and sensitively predict the possibility of pigmentation. A bio marker for diagnosing skin of hyperpigmentation disposition comprises a gene of which expression is increased or decreased by UV irradiation. A kit for diagnosing hyperpigmentation disposition comprises a polynucleotide of the bio marker gene or its fragment and solid support in which one or more polynucleotide is conjugated on the surface. A method for screening an inhibitor of hyperpigmentation disposition comprises: a step of treating test material in the bio marker gene; and a step of confirming whether the test material suppresses or inhibits the expression of the gene.

    Abstract translation: 提供用于诊断皮肤色素沉着过度的生物标记，以快速和敏感地预测色素沉着的可能性。 用于诊断色素沉着过度皮肤的生物标志物包括通过UV照射增加或减少表达的基因。 用于诊断色素沉着过度的试剂盒包括生物标记基因的多核苷酸或其片段和固体支持物，其中一个或多个多核苷酸在表面上缀合。 一种筛选色素沉着过度抑制剂的方法，包括：在生物标记基因中处理试验材料的步骤; 以及确认测试材料是否抑制或抑制基因表达的步骤。

    민감성 피부 진단용 바이오 마커 및 이를 이용한 진단 키트
    10.
    发明公开
    민감성 피부 진단용 바이오 마커 및 이를 이용한 진단 키트 有权
    用于预测敏感性皮肤和测试套件的生物标记

    公开(公告)号：KR1020140123035A

    公开(公告)日：2014-10-21

    申请号：KR1020140124122

    申请日：2014-09-18

    Applicant: (주)아모레퍼시픽 ,  서울대학교산학협력단

    Inventor： 안수선 ,  김수정 ,  이은영 ,  노민수 ,  이태룡 ,  문성준 ,  김한곤 ,  은희철 ,  정진호 ,  김은주 ,  최원우

    IPC: C12Q1/68 ,  G01N33/53

    CPC classification number: C12Q1/6844

    Abstract: Disclosed is a biomarker of which gene expression levels are specifically increased or reduced for sensitive skin. The biomarker specific to sensitive skin is used in such a diagnostic kit for sensitive skin and a screening method of an abirritant. The biomarker for diagnosis of sensitive skin according to the present invention includes one or more genes selected from a group consisting of HLA-C, TCEA1, IGHA1, TFRC, S100A8, LOC652128, SERPINB13, EHF, FLJ10781, TP63, CDH1, TNFRSF19, GM2A, FKBP5, PI3, PSPH, HORMAD1, SPRR2G, and ACTR2 or a group consisting of KBTBD10, TTN, ACTA1, MYBPC1, MB, MYOZ1, TPM1, CA3, CASQ1, ENO3, RBP4, GYG2, PPP1R1A, PYGM, G0S2, NEB, H19, LIPE, PLIN, H19, GPAM, FABP4, CIDEC, LPL, PCK1, ADIPOQ, PDE3B, ACVR1C, LPL, FABP4, DKFZP761N09121, TNMD, ATP6V1B1, C8orf22, and CRISP3.

    Abstract translation: 公开了一种生物标志物，其敏感性皮肤基因表达水平被特异地增加或降低。 敏感皮肤特异性的生物标志物用于敏感皮肤的诊断试剂盒和刺激物的筛选方法。 根据本发明的敏感性皮肤诊断用生物标志物包括选自HLA-C，TCEA1，IGHA1，TFRC，S100A8，LOC652128，SERPINB13，EHF，FLJ10781，TP63，CDH1，TNFRSF19，GM2A的一种或多种基因 ，FKBP5，PI3，PSPH，HORMAD1，SPRR2G和ACTR2或由KBTBD10，TTN，ACTA1，MYBPC1，MB，MYOZ1，TPM1，CA3，CASQ1，ENO3，RBP4，GYG2，PPP1R1A，PYGM，G0S2，NEB， H19，LIPE，PLIN，H19，GPAM，FABP4，CIDEC，LPL，PCK1，ADIPOQ，PDE3B，ACVR1C，LPL，FABP4，DKFZP761N09121，TNMD，ATP6V1B1，C8orf22和CRISP3。

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