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公开(公告)号：KR1020040067127A
公开(公告)日：2004-07-30
申请号：KR1020030004108
申请日：2003-01-21
Applicant: 삼성전자주식회사
IPC: G01N33/50
CPC classification number: B01F13/0076 , B01L3/50273 , B01L3/502769 , B01L2400/0418 , G01N27/44752 , Y10T436/11
Abstract: PURPOSE: A method for measuring zeta potential using alternation voltage and T-channel is provided to measure zeta potential between a solid wall and a solvent without track particles. CONSTITUTION: A steady state has come by injecting an electrolytic solution through a first injection port of a T-channel having a grounded output electrode, a first input electrode, and a second input electrode. Direct current is applied to the output electrode from the first and the second input electrodes so that a boundary is formed between the electrolytic solution and a mixed solution of fluorescence. Alternation current is applied to the grounded output electrode from any one of two input electrodes. Zeta potential is calculated by measuring the amplitude of the boundary.
Abstract translation: 目的：提供使用交变电压和T沟道测量ζ电位的方法，用于测量固体壁和无轨道颗粒的溶剂之间的ζ电位。 构成：通过具有接地输出电极，第一输入电极和第二输入电极的T沟道的第一注入口注入电解液来实现稳定状态。 从第一和第二输入电极向输出电极施加直流电流，使得在电解液和荧光的混合溶液之间形成边界。 交替电流从两个输入电极中的任何一个施加到接地的输出电极。 通过测量边界的振幅来计算ζ电位。
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公开(公告)号：KR100438828B1
公开(公告)日：2004-07-05
申请号：KR1020010069502
申请日：2001-11-08
Applicant: 삼성전자주식회사
IPC: B81C1/00
CPC classification number: G01N27/44791 , G01N27/226 , G01N27/4473
Abstract: A micro-electric detector for use in a micro-analysis system is provided. The micro-electric detector comprises a first substrate having a first surface, comprising at least one microchannel and at least one reservoir in fluid communication with the microchannel; a second substrate having a second surface disposed on the first surface of the first substrate; and a sensing portion comprising at least one pair of first electrodes for detection, which is disposed on the second surface of the second substrate along the microchannel, such that the first electrodes are positioned facing a bottom of the microchannel.
Abstract translation: 提供了用于微分析系统的微电探测器。 所述微电探测器包括具有第一表面的第一基底，所述第一基底包括至少一个微通道和与所述微通道流体连通的至少一个储存器; 具有设置在所述第一基板的所述第一表面上的第二表面的第二基板; 以及感测部分，所述感测部分包括至少一对用于检测的第一电极，所述感测部分沿着所述微通道设置在所述第二基板的所述第二表面上，使得所述第一电极定位成面向所述微通道的底部。 ＆lt;图像＆GT;
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公开(公告)号：KR1020030048178A
公开(公告)日：2003-06-19
申请号：KR1020010078010
申请日：2001-12-11
Applicant: 삼성전자주식회사
IPC: G01N33/53
Abstract: PURPOSE: A method for detecting immobilization of probes and a method for detecting binding degree between the probes and target samples are provided, thereby simultaneously and accurately detecting immobilization of probe DNA and hybridization of probe DNA with target DNA. CONSTITUTION: A method for detecting immobilization of probes comprises the steps of: (1) supplying probes to a biochip with an MOSFET type sensor; (2) combining the probes with the surface of a gate electrode of the MOSFET type sensor; and (3) measuring characteristics of voltage and current passed through the gate electrode. A method for detecting binding degree between probes and target samples comprises the steps of: (1) supplying probes to a biochip with a MOSFET type sensor to combine them with the surface of a gate electrode of the MOSFET type sensor; (2) measuring characteristics of voltage and current passed through the gate electrode; (3) combining target samples with the probes; and (4) measuring characteristics of voltage and current passed through the gate electrode.
Abstract translation: 目的：提供检测探针固定化的方法和检测探针与靶标结合度的方法，同时准确检测探针DNA的固定和探针DNA与靶DNA的杂交。 构成：用于检测探针固定的方法包括以下步骤：（1）用MOSFET型传感器将探针供应给生物芯片; （2）将探针与MOSFET型传感器的栅电极的表面组合; 和（3）测量通过栅电极的电压和电流的特性。 用于检测探针和目标样品之间的结合度的方法包括以下步骤：（1）向具有MOSFET型传感器的生物芯片供应探针，以将其与MOSFET型传感器的栅电极的表面组合; （2）测量通过栅电极的电压和电流的特性; （3）将目标样品与探针组合; 和（4）测量通过栅电极的电压和电流的特性。
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公开(公告)号：KR100366701B1
公开(公告)日：2003-01-06
申请号：KR1019990049531
申请日：1999-11-09
Applicant: 삼성전자주식회사
CPC classification number: G01Q60/30 , G11B9/02 , G11B9/149 , G11B11/007 , Y10S977/875
Abstract: 전계 효과 트랜지스터 채널(field effect transistor channel; FET channel) 구조가 형성된 스캐닝 프로브 마이크로스코프(scanning probe microscope; SPM)의 탐침(probe) 및 그 제작 방법이 개시되어 있다. 개시된 탐침은 테두리에 제1 불순물이 도핑된 채널영역과 제2 불순물이 도핑된 소오스 및 드레인이 존재하되, 상기 채널영역은 적어도 상기 테두리의 팁(tip)에 존재하고, 상기 소오스 및 드레인은 상기 채널영역 양측에 존재하는 반도체 팁(tip)부를 구비하되, 상기 테두리의 상기 채널 영역이 존재하는 부분과 상기 소오스 및 드레인이 존재하는 부분은 결정면이 서로 다른 경사면인 것을 특징으로 한다.
Abstract translation: 提供在探针尖端具有场效应晶体管（FET）结构的扫描探针显微镜（SPM）的探针，以及制造该探针的方法。 证明具有源极，沟道和漏极的SPM通过将单晶硅衬底蚀刻成V形凹槽并在V形凹槽的一端处用杂质掺杂蚀刻斜面来形成。
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公开(公告)号：KR100338810B1
公开(公告)日：2002-05-31
申请号：KR1019990049214
申请日：1999-11-08
Applicant: 삼성전자주식회사
IPC: F25B39/00
CPC classification number: F28D15/043 , H01L23/427 , H01L2224/29499
Abstract: 모세관력을응용한냉각장치에관해기술된다. 냉각장치는: 루우프형그루브가그 상면에형성된하판; 상기하판의상면에결합되어상기그루브를상부를폐쇄하여, 작동유체유동경로를제공하는상판; 상기유동경로상에마련되는것으로상기상판또는하판에일체적으로형성되는미세구조의증발핀을다수구비한증발부; 상기그루브상에상기증발부와소정거리를두고위치하는하는것으로상기상판또는하판에일체적으로형성되는미세구조의응축핀을다수구비한응축부를; 구비한다. 따라서, 이상과같은본 발명에의하면, 외부의동력이없이냉각을수행할수 있는소형및 박형의냉각장치를얻을수 있게된다. 또한, 증발부에부착된단순형태의미세채널의다양한변형에의해작동유체의상변화에의한비체적의증가에의한유로에서의저항을없애고급격한압력증가에의한역류를방지하여전체냉동시스템의수력학적안정성을구현할수 있다.
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Patent Agency Ranking
公开(公告)号：KR101059562B1
公开(公告)日：2011-08-26
申请号：KR1020040011321
申请日：2004-02-20
Applicant: 삼성전자주식회사
IPC: G01N27/327
CPC classification number: G01N27/4145
Abstract: There is provided a biomolecule eg DNA FET with enhanced sensitivity. The biomolecule FET includes a substrate (21), first and second impurity regions (22a,22b) formed on both sides of the substrate, and doped with impurities of a polarity opposite to that of the substrate, a gate (23) formed on the substrate and being in contact with the first and second impurity regions, and a probe biomolecule (18) attached to the gate. An annular channel region underneath the gate (23) surrounds the circular drain region (22b), and is in turn surrounded by the source region (22a). The density of the probe biomolecule attached to the surface of the gate is increased, and when detecting the level of hybridization of the probe biomolecule and the target biomolecule, its sensitivity is improved.
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公开(公告)号：KR100858080B1
公开(公告)日：2008-09-10
申请号：KR1020020070141
申请日：2002-11-12
Applicant: 삼성전자주식회사
IPC: C12Q1/68
CPC classification number: C12Q1/6825 , C12Q1/686 , G01N27/221 , C12Q2565/607 , C12Q2561/113 , C12Q2531/113
Abstract: 본 발명은 (a) PCR 반응 용기 내에 한 쌍 이상의 전극을 제공하는 단계; (b) PCR을 수행하는 단계; (c) 상기 전극 사이에 전기장을 발생시키는 단계; 및 (d) 상기 PCR 반응 용액의 유전적 특성의 변화를 측정하는 단계를 포함하는 PCR 증폭 산물을 검출하는 방법을 제공한다. 본 발명에 의하면, PCR 산물을 리얼타임으로 검출할 수 있다
전기적 신호, 임피던스, 리얼타임 PCR-
公开(公告)号：KR100601999B1
公开(公告)日：2006-07-19
申请号：KR1020050121130
申请日：2005-12-09
Applicant: 삼성전자주식회사
Abstract: 본 발명은 신규의 전도성 고분자에 관한 것으로, 구체적으로는 하기 일반식(I)으로 표시되는 전도성 고분자에 관한 것이다.
(I)
여기서，m은 1, 2, 또는 3이고, R은 히드록시숙신이미딜(hydroxysuccinimidyl)，히드록시프탈이미딜(hydroxyphthalimidyl) 또는 펜타플루오로페놀릴(pentafluorophenolyl) 그룹이다. 본 발명의 전도성 고분자는 혼성화에 의한 표적 분자를 검출하는 센서 및 방법에 효과적으로 이용될 수 있다.
티오펜, 전도성 고분자, 핵산, 단백질, 혼성화-
29.发明授权물질 유로의 측벽에 형성된 ＭＯＳＦＥＴ으로 이루어진물질 검출용 칩, 이를 포함하는 물질 검출 장치, 이의제조 방법 및 물질 검출 장치를 이용한 물질 검출 방법 失效으유로의측벽에형성된MOSFET으로이루어진물질검출용칩，이를포함하는물질검출장치，이의제조방법및물질검출장치를이용물질물질검출방물질
公开(公告)号：KR100455283B1
公开(公告)日：2004-11-08
申请号：KR1020010021752
申请日：2001-04-23
Applicant: 삼성전자주식회사
IPC: C12Q1/68
Abstract: PURPOSE: Provided are a chip for detecting material, a device for detecting material containing the same, a producing method thereof, and a method for detecting material using the same, thereby high integration of a sensor can be possible, a probe can be stably adhered on the chip, and the adherence of the probe can be easily confirmed in situ, so that various target materials can be detected using various probes. CONSTITUTION: The chip for detecting material comprises: a semi-conductive board(100); a microline(105) which is formed on the surface of the semi-conductive board(100) and is the pathway of a material; and MOSFET formed on the side wall of the microline, wherein the gate electrode(150G) of MOSFET is made from gold thin film; a material probe having thiol group is adhered on the surface of the gate electrode of MOSFET by a self assembled monolayer method; and the material is a nucleic acid, protein, an enzyme substrate, a supplemental factor or an oligosaccharide.
Abstract translation: 目的：提供一种用于检测材料的芯片，一种用于检测材料的装置，一种检测材料的装置，其制造方法以及使用该检测装置的材料检测方法，由此可以实现传感器的高度集成，探针可以稳定地粘附 在芯片上，并且可以容易地就地确认探针的粘附性，从而使用各种探针可以检测各种目标材料。 构成：用于检测材料的芯片包括：半导体板（100）; 形成在半导体板（100）的表面上并且是材料的路径的微型线（105） 以及形成在微切口侧壁上的MOSFET，其中MOSFET的栅电极（150G）由金薄膜制成; 通过自组装单层法将具有巯基的材料探针粘附在MOSFET的栅极表面上; 并且该材料是核酸，蛋白质，酶底物，补充因子或寡糖。
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公开(公告)号：KR1020040069063A
公开(公告)日：2004-08-04
申请号：KR1020030005486
申请日：2003-01-28
Applicant: 삼성전자주식회사
IPC: C12Q1/68
CPC classification number: B01L3/508 , B01L7/52 , B01L2300/163 , B05D1/62 , B05D2203/35 , C03C17/30
Abstract: PURPOSE: A method for treating the substrate surface of biochemical reaction devices is provided, thereby inhibiting adhesion of bio-materials on the substrate surface of a PCR chip, so that yield of PCR reaction can be improved. CONSTITUTION: The method for treating the substrate surface of biochemical reaction devices comprises depositing a compound of formula (1): (RO)3-Si-(CH2)n1-X, and a compound of formula (2): (RO)3-Si-(CH2)n2-(CF2)m-X, on the substrate surface of biochemical reaction devices at 60 to 140 deg. C, wherein R is methyl or ethyl; X is methyl or trifluoromethyl; n1 is an integer of 1 to 3; n2 is an integer of 1 to 10; m is an integer of 1 to 10; the substrate is silicone or glass; and the biochemical reaction device is PCR device. A composition for treating the substrate surface of biochemical reaction devices contains the compound of formula (1): (RO)3-Si-(CH2)n1-X, and the compound of formula (2): (RO)3-Si-(CH2)n2-(CF2)m-X.
Abstract translation: 目的：提供一种处理生物化学反应装置的底物表面的方法，从而抑制生物材料在PCR芯片的基材表面上的粘附，从而可以提高PCR反应的产率。 构成：用于处理生化反应装置的底物表面的方法包括沉积式（1）：（RO）3-Si-（CH 2）n1-X化合物和式（2）化合物：（RO）3 -Si-（CH2）n2-（CF2）mX，在生物化学反应装置的底物表面上在60至140度。 C，其中R是甲基或乙基; X是甲基或三氟甲基; n1为1〜3的整数， n2为1〜10的整数， m为1〜10的整数。 基材是硅胶或玻璃; 生化反应装置为PCR装置。 用于处理生化反应装置的底物表面的组合物含有式（1）化合物：（RO）3-Si-（CH 2）n1-X和式（2）化合物：（RO）3-Si- （CH 2）N 2 - （CF 2）MX。
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