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公开(公告)号：KR1020090068075A
公开(公告)日：2009-06-25
申请号：KR1020070135948
申请日：2007-12-22
Applicant: 서강대학교산학협력단
CPC classification number: G11C13/0014 , B82Y10/00 , G11C13/0009 , G11C13/0019 , H01L51/0093 , H01L51/0591
Abstract: A biomass base electronic device is provided, which makes excellent performance of the bio memory device possible by using the substrate formed of the self-assembled thin film. In a biomass base electronic device, the biomass having the redox potential is directly fixed to the substrate. The biomass is the recombinant protein having the redox potential. In the N-terminal or the C-terminal of the recombinant protein, the cystein residue is introduced. The recombinant protein is directly fixed to the substrate through the thiol group of the introduced cystein residue. The biomass base electronic device is the bio-memory device. The number of cystein residue introduced to the recombinant proteins are 1-10.
Abstract translation: 提供了一种生物质基础电子器件，通过使用由自组装薄膜形成的衬底，可以使生物存储器件具有优异的性能。 在生物质基础电子装置中，具有氧化还原电位的生物质直接固定在基板上。 生物质是具有氧化还原电位的重组蛋白。 在重组蛋白的N末端或C末端引入半胱氨酸残基。 重组蛋白通过导入的半胱氨酸残基的巯基直接固定在底物上。 生物质基础电子装置是生物记忆装置。 引入重组蛋白的半胱氨酸残基的数目是1-10。
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公开(公告)号：KR100894703B1
公开(公告)日：2009-04-24
申请号：KR1020070108720
申请日：2007-10-29
Applicant: 서강대학교산학협력단
IPC: C07K17/00
CPC classification number: C07K17/14
Abstract: A method for specifically immobilizing cells on a solid substrate is provided to immobilize the cells on a nanopattern which can be used for microenvironment cell chips without cytotoxin. A method for specifically immobilizing cells on a solid substrate comprises the following steps of: coating peptide represented by the formula 3 or 4 on a solid substrate; and contacting the coated peptide on the solid substrate to zooblast. In the formula 3 and 4, Xaa1 shows Gly or Ala; and n1-n8 are independently integers of 1 to 100. A microarray or a biosensor includes the solid substrate coated with the peptide.
Abstract translation: 提供了将细胞固定在固体基质上的方法，以将细胞固定在可用于微环境细胞芯片而不含细胞毒素的纳米图案上。 将细胞特异性固定在固体基质上的方法包括以下步骤：将由式3或4表示的肽包被在固体底物上; 并将固体基质上的包被的肽接触到成神经细胞。 在式3和4中，Xaa1表示Gly或Ala; n1-n8独立地为1〜100的整数。微阵列或生物传感器包括涂有肽的固体基质。
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公开(公告)号：KR102154351B1
公开(公告)日：2020-09-09
申请号：KR1020190040972
申请日：2019-04-08
Applicant: 서강대학교산학협력단
IPC: G01N33/483 , G01N27/417 , A61B5/00
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公开(公告)号：KR102086282B1
公开(公告)日：2020-03-06
申请号：KR1020190000361
申请日：2019-01-02
Applicant: 서강대학교산학협력단
IPC: G01N33/573 , C12Q1/37 , G01N33/543 , G01N33/553 , G01N33/68
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公开(公告)号：KR1020160150173A
公开(公告)日：2016-12-29
申请号：KR1020150086828
申请日：2015-06-18
Applicant: 서강대학교산학협력단
IPC: C12N5/0793 , C12N13/00 , C01G49/08 , C01G49/06
Abstract: 본발명은신경세포수상돌기의성장방향조절방법및 상기방법에의해쪼된신경세포배양물을제공한다. 본발명에따르면, 자성나노입자및 자기장을이용하여용이한방법으로신경세포의수상돌기성장방향을제어할수 있다.
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Patent Agency Ranking
公开(公告)号：KR101613604B1
公开(公告)日：2016-04-20
申请号：KR1020150020911
申请日：2015-02-11
Applicant: 서강대학교산학협력단
IPC: G01N27/26 , G01N27/416 , C12N5/074
CPC classification number: G01N27/3277 , G01N27/48 , G01N33/48728 , G01N27/416 , C12N5/0607 , C12N5/0696
Abstract: 본발명은미분화만능성줄기세포(undifferentiated pluripotent stem cells)의검출방법및 이를이용한세포칩에관한것이다. 본발명의세포칩기반의정량적분석방법은종래만능줄기세포의정량적분석을위해서이용하던유세포분석법또는실시간 PCR법과달리항체를사용하지않기때문에간편하고빠르게정량적분석이가능하며, 분석후에도세포의기능에영향이없어분석에사용한세포를회수하여사용가능하다는장점이있다. 본발명의검출방법은 hPSCs의특이적 E(-0.077 V)를이용한것으로서, 미분화 hPSCs의세포수에따라비례적으로증가하는신호강도(i)로부터미분화 hPSCs의세포수를정량적으로분석할수 있다. 본발명의세포칩기반의전기화학적평가는상대적으로단시간내에이루어져간편하고명확한선형성(선형성 0.99 이상)을가지는높은재현값을얻을수 있다.
Abstract translation: 本发明涉及基于未分化的人多能干细胞的细胞芯片的定量分析方法和使用其的细胞芯片。 基于细胞芯片的定量分析方法通过不使用与实时PCR方法不同的抗体或用于多能干细胞的现有定量分析的薄壁细胞分析方法来实现方便和快速的定量分析。 基于细胞芯片的定量分析方法可以收集用于分析的细胞，并且使用细胞作为细胞的功能在分析后不受影响。 本发明的检测方法使用hPSC_s的特定E_pc（-0.077V），并且可以基于根据未分化hPSC_s的细胞数按比例增加的信号强度（i_pc）来分析未分化hPSC_s的细胞数 。 根据本发明，在相对短的时间内进行基于单元芯片的电化学评价，从而可以获得具有简单且确定的线性度（线性度为0.99以上）的高表示值。
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公开(公告)号：KR1020150123373A
公开(公告)日：2015-11-04
申请号：KR1020140049260
申请日：2014-04-24
Applicant: 서강대학교산학협력단
IPC: G11C11/54
CPC classification number: G11C11/54
Abstract: 본발명은산화환원능(redox potential)을갖는융합단백질(fusion protein)이직접기판에고정화되어있는이중상(dual-level) 바이오메모리장치에관한것으로, 본발명의이중상바이오메모리장치는단일장치내 다양한정보를저장할수 있으며, 앞으로의단일분자-기반이중상정보저장시스템을개발하기위한강력한대안이될 것이다.
Abstract translation: 本发明涉及一种具有氧化还原电位的融合蛋白直接固定在基底上的双层生物记录装置。 双级生物仪器可以将各种信息存储在单个设备中，并且可以成为开发未来基于单一蛋白质的双水平生物记忆装置的有力替代方案。
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公开(公告)号：KR1020140066674A
公开(公告)日：2014-06-02
申请号：KR1020140035617
申请日：2014-03-26
Applicant: 서강대학교산학협력단
IPC: G01N33/573 , C12Q1/26 , C12Q1/68
Abstract: The present invention relates to a sensor for detecting tyrosine hydroxylase comprising; (a) a magnetic particle in which a first antibody for the tyrosine hydroxylase is conjugated; and (b) a gold nanoparticle in which a second antibody for the tyrosine hydroxylase and first oligonucleotide are conjugated and a barcode DNA having a complementary sequence with the first oligonucleotide is hybridized with the first oligonucleotide. According to the present invention, the sensor for detecting the tyrosine hydroxylase is a sensor for detecting the initial neurotransmission-related enzyme and provides high sensitivity to detect less than 0.2 ng/ml of the tyrosine hydroxylase. Therefore, the sensor for detecting the tyrosine hydroxylase of the present invention easily and rapidly detects the tyrosine hydroxylase and diagnoses nerve disorders such as Parkinson′s disease at an early stage.
Abstract translation: 本发明涉及一种检测酪氨酸羟化酶的传感器，包括： （a）其中结合有酪氨酸羟化酶的第一抗体的磁性颗粒; 和（b）金纳米颗粒，其中将酪氨酸羟化酶和第一寡核苷酸的第二抗体缀合，并且与第一寡核苷酸具有互补序列的条形码DNA与第一寡核苷酸杂交。 根据本发明，用于检测酪氨酸羟化酶的传感器是用于检测初始神经传递相关酶的传感器，并且提供高灵敏度以检测小于0.2ng / ml的酪氨酸羟化酶。 因此，用于检测本发明的酪氨酸羟化酶的传感器容易且快速地检测酪氨酸羟化酶，并且在早期阶段诊断诸如帕金森病的神经障碍。
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公开(公告)号：KR101390328B1
公开(公告)日：2014-05-02
申请号：KR1020110075570
申请日：2011-07-29
Applicant: 서강대학교산학협력단
IPC: G11C11/54
CPC classification number: C07K14/00 , C12N9/0004 , C12N11/00 , C12N11/14 , C12Y120/09001
Abstract: 본발명은치환된금속이온을포함하는산화환원능을갖는단백질이직접고정화된다기능성바이오-메모리칩에관한것이다. 본발명은단백질의산화환원능을이용하여인가전위에따라산화환원상태를조절하는것이가능하며, 세가지전위를인가하는방식의작동법을제시할수 있다. 또한, 본발명은금속단백질의금속이온을치환하여보다다양한특징을갖는바이오-메모리디바이스를제공할 수있다. 이로써, 본발명은생체분자가내재한자연계고유의전자전달원리를정보저장장치를이용하여새로운개념의바이오-메모리디바이스를제공할 수있다.
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公开(公告)号：KR1020130121550A
公开(公告)日：2013-11-06
申请号：KR1020120044853
申请日：2012-04-27
Applicant: 서강대학교산학협력단
IPC: G01N33/573 , C12Q1/26 , G01N33/551 , C12Q1/68
CPC classification number: G01N33/573 , C12Q1/26 , C12Q1/686 , C12Q2563/185 , G01N33/551
Abstract: The present invention relates to a sensor for detecting tyrosine hydrolase, comprising: a magnetic particle conjugated to a first antibody against tyrosine hydrolase; and gold nanoparticles which are conjugated to a second antibody against tyrosine hydrolase and a first oligonucleotide which is hybridized with a barcode DNA with a sequence complementary with the first oligonucleotide. According to the present invention, the sensor for detecting tyrosine hydrolase is used for detecting the first neurotransmission-related enzymes and has high sensitivity, capable of detecting 0.2 ng/ml or less of tyrosine hydrolase. Accordingly, the sensor quickly and easily detects tyrosine hydrolase, thereby early diagnosing neurological disorders such as Parkinson’s disease.
Abstract translation: 本发明涉及一种用于检测酪氨酸水解酶的传感器，包括：与抗酪氨酸水解酶的第一抗体缀合的磁性颗粒; 和与第二抗体相对抗酪氨酸水解酶的金纳米颗粒和第一寡核苷酸，其与条形码DNA与第一寡核苷酸互补的序列杂交。 根据本发明，用于检测酪氨酸水解酶的传感器用于检测第一神经传递相关酶，并且具有高灵敏度，能够检测0.2ng / ml或更少的酪氨酸水解酶。 因此，传感器快速且容易地检测酪氨酸水解酶，从而早期诊断诸如帕金森病的神经障碍。
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