公开(公告)号：KR1020160115039A

公开(公告)日：2016-10-06

申请号：KR1020150041691

申请日：2015-03-25

Applicant: 서울대학교산학협력단 ,  한국과학기술연구원

Inventor： 양현옥 ,  정병화 ,  박정일 ,  권성원 ,  이광진 ,  강건욱

IPC: A61K36/268

CPC classification number: A61K36/268 ,  A61K2236/30 ,  A61K2236/33

Abstract: 본발명은독성성분을제거한세신추출물의제조방법및 상기추출물을유효성분으로포함하는한약제제에관한것에관한것이다.

公开(公告)号：KR1020150088205A

公开(公告)日：2015-07-31

申请号：KR1020150010772

申请日：2015-01-22

Applicant: 동국대학교 산학협력단 ,  서울대학교산학협력단

Inventor： 이경 ,  강건욱 ,  최용문 ,  양진원

IPC: C07C235/24 ,  A61K31/165 ,  A61K31/166

CPC classification number: C07C235/24 ,  A61K31/165 ,  A61K31/166

Abstract: 본발명은페녹시아세틸유도체화합물및 이를유효성분으로포함하는비알콜성지방간질환의예방또는치료용약학적조성물에관한것이다. 본발명에따른화합물은 SREBP-1c의활성억제및 FAS 발현억제능이우수한바, 비알콜성지방간질환을예방, 개선또는치료하기위한약학적조성물또는기능성식품조성물의활성성분으로유용하게사용될수 있을것으로기대된다.

Abstract translation: 本发明涉及苯氧基丙烯酸衍生物和包含其作为预防或治疗非酒精性脂肪性肝病的活性成分的药物组合物。 根据本发明的化合物对SREBP-1c的活化和FAS的表达具有优异的抑制作用，因此预期有利地用作药物组合物或功能性食品组合物的活性成分，用于预防，缓解或 治疗非酒精性脂肪性肝病。

公开(公告)号：KR1020140109273A

公开(公告)日：2014-09-15

申请号：KR1020140022221

申请日：2014-02-25

Applicant: 서울대학교산학협력단

Inventor： 김상희 ,  강건욱 ,  임채민 ,  김수민

IPC: C07D307/52 ,  C07D307/36 ,  C07C233/11 ,  A61K31/341 ,  A61P3/04

CPC classification number: C07C233/22 ,  C07C233/09 ,  C07C233/11 ,  C07C235/34 ,  C07D295/192 ,  C07D307/54 ,  C07D317/60 ,  C07D319/18

Abstract: The present invention relates to a novel α,β-unsaturated amide compound expressed by following Chemical Formula 1, a method for preparing a composition for preventing or treating obesity; and a composition for preventing or treating obesity including the α,β-unsaturated amide compound, the method being characterized by comprising: screening a compound exhibiting the effect of treating or preventing obesity from a compound library including one or more of α,β-unsatruated amide compound(s); and preparing a composition for treating or preventing obesity containing the selected compound. [Chemical Formula 1]. Since the α,β-unsatruated amide compound of the present invention is a compound having a scaffold which mimics a natural substance, piper amide, showing various activity, the α,β-unsatruated amide compound would exhibit various pharmacological activities. Also, as an intermediate, soluble by-products are produced by using β-phosphono-N-hydroxysuccinimidyl ester, and thus a pure compound is obtainable without a need for performing the typically used purification process through column chromatography. Furthermore, pharmacological activity is tested from a chemical library thus synthesized to screen a compound which serves as an agonist against BRS-3a and thus this compound can be useful as a composition for treating or preventing obesity.

Abstract translation: 本发明涉及以下化学式1表示的新型α，β-不饱和酰胺化合物，用于预防或治疗肥胖症的组合物的制备方法。 以及用于预防或治疗包括α，β-不饱和酰胺化合物的肥胖症的组合物，所述方法的特征在于包括：从包含α，β-不饱和酰胺化合物中的一种或多种的化合物文库筛选显示出治疗或预防肥胖的作用的化合物 酰胺化合物; 以及制备用于治疗或预防含有所选化合物的肥胖症的组合物。 [化学式1]。 由于本发明的α，β-不饱和酰胺化合物是具有模仿具有各种活性的天然物质，哌啶酰胺的支架的化合物，所以α，β-不饱和酰胺化合物具有各种药理活性。 此外，作为中间体，通过使用β-膦酰基-N-羟基琥珀酰亚胺酯制备可溶性副产物，因此可以获得纯化合物，而不需要通过柱色谱法进行通常使用的纯化方法。 此外，从如此合成的化学文库中测试药理活性，筛选作为针对BRS-3a的激动剂的化合物，因此该化合物可用作治疗或预防肥胖症的组合物。