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公开(公告)号：KR1020130033938A
公开(公告)日：2013-04-04
申请号：KR1020120050142
申请日：2012-05-11
Applicant: 서울대학교산학협력단 , 동국대학교 산학협력단
Abstract: PURPOSE: A three dimensional cell culture device and a three dimensional cell culture method using the same are provided to form a floating spheroid in a culture medium without a separate treatment such as inoculation of cells on a cover part. CONSTITUTION: A three dimensional cell culture device comprises a culture plate part, a cover part, and a protrusion part(50). The culture plate part has wells for culturing cells. The cover part covers the culture plate part. The protrusion part is extended toward the inside of the well from the surface which touches the culture plate part.
Abstract translation: 目的：提供三维细胞培养装置和使用该三维细胞培养装置的三维细胞培养方法，以在培养基中形成浮球体，而无需单独处理，例如在盖部分上接种细胞。 构成：三维细胞培养装置包括培养板部分，盖部分和突出部分（50）。 培养板部分具有培养细胞的孔。 盖部覆盖培养板部。 突起部分从接触培养板部分的表面延伸到井的内部。
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Patent Agency Ranking
公开(公告)号：KR1020120025440A
公开(公告)日：2012-03-15
申请号：KR1020110090896
申请日：2011-09-07
Applicant: 서울대학교산학협력단
IPC: C07D493/10 , A61K31/352 , A61P3/10 , A61P9/00
CPC classification number: C07D493/10 , A61K31/352 , A61K31/4184 , A61K31/4192 , A61K31/422 , A61K31/453 , A61K31/496 , A61K31/541 , A61K31/665 , A61K31/7048 , A61K45/06 , C07D493/20 , C07F9/65615 , C07H17/04
Abstract: PURPOSE: A sesterterpen compound and a composition containing the same are provided to prevent and treat diabetes, fatty liver, and obesity. CONSTITUTION: A sesterterpen compound is denoted by chemical formula I. A pharmaceutical composition for preventing and treating diabetes, diabetes complication, cardiovascular diseases or obesity contains sesterterpen compounds, stereoisomer, enantiomer, hybridizable precursor, or pharmaceutically acceptable salt thereof. A pharmaceutical composition for preventing and treating cardiovascular diseases contains sesterterpen compounds of chemical formula I, stereoisomer, enantiomer, in vivo hybridizable precursor thereof, or pharmaceutically acceptable salt thereof, and LXR agonist.
Abstract translation: 目的：提供西酯化合物和含有它们的组合物以预防和治疗糖尿病，脂肪肝和肥胖。 构成：化学式I表示酯化合物。用于预防和治疗糖尿病，糖尿病并发症，心血管疾病或肥胖症的药物组合物含有酯化合物，立体异构体，对映异构体，可杂交前体或其药学上可接受的盐。 用于预防和治疗心血管疾病的药物组合物含有化学式I的酯化合物，立体异构体，对映异构体，体内可杂交的前体或其药学上可接受的盐和LXR激动剂。
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公开(公告)号：KR101061502B1
公开(公告)日：2011-09-02
申请号：KR1020090109348
申请日：2009-11-12
Applicant: 서울대학교산학협력단
Abstract: 본 발명은 자성 입자를 이용한 생물막의 불활성화 방법에 관한 것으로 더욱 상세하게는 자성 입자(magnetic particle,MP)에 교류 자기장을 인가하면 발열한다는 특성을 이용한 생물막의 불활성화 방법에 관한 것이다. 본 발명은 표면에 생물막(biofilm)이 형성되어 있는 대상체를 준비하는 단계; 상기 생물막에 자성 입자를 첨가하는 단계; 상기 자성 입자가 첨가된 생물막이 형성된 대상체 외부에서 교류 자기장을 인가하는 단계; 및 외부에서 인가된 교류 자기장에 의해 상기 자성 입자가 발열함으로써 상기 생물막을 불활성화하는 단계를 포함하는 자성 입자를 이용한 생물막의 불활성화 방법에 관한 것이다.
상기 자성 입자가 첨가된 생물막을 외부에서 교류 자기장을 인가함으로써 상기 자성 입자의 발열 특성에 의해 단시간에 향상된 소독력으로 생물막을 불활성화할 수 있다.
자성 입자, 교류 자기장, 발열, 생물막-
公开(公告)号：KR1020110052355A
公开(公告)日：2011-05-18
申请号：KR1020090109348
申请日：2009-11-12
Applicant: 서울대학교산학협력단
CPC classification number: A61L2/04 , A01N59/00 , A61L2202/13
Abstract: PURPOSE: A method of inactivating a biofilm is provided to inactivate the biofilm through improved sterilization power for a short time. CONSTITUTION: A method of inactivating a biofilm comprises: a step of preparing an object having a biofilm(5) on the surface thereof; a step of adding magnetic particles(4) to the biofilm; a step of sanctioning AC magnetic field from the outside of the object; and a step of inactivating the biofilm by generating heat from magnetic particles through the AC magnetic field applied from the outside.
Abstract translation: 目的：提供灭活生物膜的方法，以通过改善灭菌力在短时间内灭活生物膜。 构成：灭活生物膜的方法包括：在其表面上制备具有生物膜（5）的物体的步骤; 向生物膜添加磁性颗粒（4）的步骤; 从物体外部对AC磁场进行认证的步骤; 以及通过从外部施加的AC磁场产生来自磁性颗粒的热而使生物膜失活的步骤。
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公开(公告)号：KR101033023B1
公开(公告)日：2011-05-09
申请号：KR1020100085637
申请日：2010-09-01
Applicant: 주식회사 한라 , 서울대학교산학협력단 , (주)큐엔솔루션
Abstract: PURPOSE: A method and a system for processing contaminated deposit soil are provided to efficiently process the contaminated deposit soil and minimizing the burying amount of spoil soil. CONSTITUTION: Contaminated soil is classified from spoil soil(S100). The contaminated soil is mixed with processing water, and chemical and additional materials are introduced into the contaminated soil(S200). Metal materials are separated from the mixture of the contaminated soil and the water. Organic materials are oxidized(S300). Spoil soil and the processing water are processed(S400).
Abstract translation: 目的：提供一种处理污染沉积物土壤的方法和系统，以有效地处理污染的沉积物，并最大限度地减少弃土的埋藏量。 构成：污染土壤分类为破土（S100）。 受污染的土壤与加工水混合，化学和其他材料被引入污染土壤（S200）。 金属材料与污染土壤和水的混合物分离。 有机材料被氧化（S300）。 处理污水和加工水（S400）。
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公开(公告)号：KR1020100048934A
公开(公告)日：2010-05-11
申请号：KR1020090104124
申请日：2009-10-30
Applicant: 서울대학교산학협력단
IPC: C07D493/10 , C07D493/02 , A61K31/435 , A61P3/04
CPC classification number: C07D493/10
Abstract: PURPOSE: A novel compound having spiro chiral carbon skeleton is provided to suppress mastocyte differentiation and fatty acid synthesis and use in treating osteoporosis, fatty liver, and obesity. CONSTITUTION: A novel compound having spiro chiral carbon skeleton is denoted by chemical formula 1. A method for preparing the compound of chemical formula 1 comprises: a step of cutting and drying Phorbas sp. and extracting with C1-C4; a step of dividing the extracting with water and methylene chloride to remove solvent of organic layer; a step of distributing with mixture solution of normal hexane, methanol, and water; a step of removing solvent of methanol layer; and a step of performing chromatography to obtain fraction.
Abstract translation: 目的：提供一种具有螺状手性碳骨架的新型化合物，用于抑制肥大细胞分化和脂肪酸合成，并用于治疗骨质疏松症，脂肪肝和肥胖症。 构成：具有螺状手性碳骨架的新化合物由化学式1表示。化学式1化合物的制备方法包括：切割并干燥佛波斯 并用C1-C4提取; 用水和二氯甲烷分离提取物以除去有机层的溶剂的步骤; 用正己烷，甲醇和水的混合溶液分配的步骤; 去除甲醇层溶剂的步骤; 以及进行色谱以获得级分的步骤。
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