스파이로키랄 탄소 골격을 갖는 신규한 화합물, 그의 제조방법 및 그를 포함하는 약제학적 조성물
    3.
    发明公开
    스파이로키랄 탄소 골격을 갖는 신규한 화합물, 그의 제조방법 및 그를 포함하는 약제학적 조성물 有权
    具有螺旋精梳碳的新化合物,其制备方法和包含该组合物的药物组合物

    公开(公告)号:KR1020100048934A

    公开(公告)日:2010-05-11

    申请号:KR1020090104124

    申请日:2009-10-30

    CPC classification number: C07D493/10

    Abstract: PURPOSE: A novel compound having spiro chiral carbon skeleton is provided to suppress mastocyte differentiation and fatty acid synthesis and use in treating osteoporosis, fatty liver, and obesity. CONSTITUTION: A novel compound having spiro chiral carbon skeleton is denoted by chemical formula 1. A method for preparing the compound of chemical formula 1 comprises: a step of cutting and drying Phorbas sp. and extracting with C1-C4; a step of dividing the extracting with water and methylene chloride to remove solvent of organic layer; a step of distributing with mixture solution of normal hexane, methanol, and water; a step of removing solvent of methanol layer; and a step of performing chromatography to obtain fraction.

    Abstract translation: 目的:提供一种具有螺状手性碳骨架的新型化合物,用于抑制肥大细胞分化和脂肪酸合成,并用于治疗骨质疏松症,脂肪肝和肥胖症。 构成:具有螺状手性碳骨架的新化合物由化学式1表示。化学式1化合物的制备方法包括:切割并干燥佛波斯 并用C1-C4提取; 用水和二氯甲烷分离提取物以除去有机层的溶剂的步骤; 用正己烷,甲醇和水的混合溶液分配的步骤; 去除甲醇层溶剂的步骤; 以及进行色谱以获得级分的步骤。

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