公开(公告)号：KR101145751B1

公开(公告)日：2012-05-16

申请号：KR1020090098074

申请日：2009-10-15

Applicant: 유한회사한풍제약

Inventor： 조형권 ,  조성완 ,  이영재

IPC: A61K36/31 ,  A61P29/00 ,  A61P1/00

Abstract: PURPOSE: A composition containing seed of Raphanus sativus L. extract or powder is provided to treat or prevent inflammatory bowel diseases including ulcerative colitis and Crohn's disease. CONSTITUTION: A composition for treating or preventing inflammatory bowel disease contains seed of Raphanus sativus L. powder or extract. The seed of Raphanus sativus L. extract is isolated using water, methanol, ethanol, butanol, chloroform, hexane, ethylacetate, dichloromethane, or mixture solvent thereof or by supercritical extraction. The composition is manufactured in the form of medicinal product or functional food. The medicinal product or functional food additionally contains pharmaceutically acceptable excipient or additive.

公开(公告)号：KR1020050028272A

公开(公告)日：2005-03-22

申请号：KR1020030064952

申请日：2003-09-18

Applicant: 유한회사한풍제약

Inventor： 황완균 ,  조형권

IPC: A23L1/29

Abstract: Functional food containing medicinal herbs is provided, which functional food has effects on diet, anti-diabetes, anti-hyperlipemia and radical scavenging. A diet, anti-diabetic, anti-hyperlipemia and radical scavenging composition comprises 5 to 15 wt.% of Bombyx mori L., 5 to 15 wt.% of ginseng tail, 5 to 15 wt.% of Nelumbo nucifera Gaertner, 5 to 15 wt.% of root joint of Nelumbo nucifera Gaertner, 5 to 15 wt.% of Luffa cylindrica Roem, 5 to 15 wt.% of Citrus reticulata seeds, 5 to 15 wt.% of Laminaria, 5 to 15 wt.% of Platycodon grandiflorum and 5 to 15 wt.% of Lonicera japonica THUNB.

Abstract translation: 提供含有药草的功能性食品，功能食品对饮食，抗糖尿病，抗高脂血症和清除自由基有影响。 饮食，抗糖尿病，抗高脂血症和自由基清除组合物包含5至15重量％的家蚕，5至15重量％的人参尾巴，5至15重量％的Nelumbo nucifera Gaertner，5至 Nelumbo nucifera Gaertner的根接头的15重量％，5至15重量％的Luffa cylindrica Roem，5至15重量％的Citrus reticulata种子，5至15重量％的Laminaria，5至15重量％的 枸杞子和5〜15％（重量）的忍冬药THUNB。

公开(公告)号：KR100407764B1

公开(公告)日：2003-12-01

申请号：KR1020010017455

申请日：2001-04-02

Applicant: 유한회사한풍제약

Inventor： 조형권 ,  전기용 ,  조인식

IPC: C07K1/12

Abstract: PURPOSE: A method for producing silk-thread peptide is provided, thereby rapidly and cheaply producing the silk-thread peptide, which has a molecular weight of 500-10000 and 100% solubility at pH 4 to 9, in higher yield. CONSTITUTION: The method for producing silk-thread peptide comprises the steps of: inserting 1 part by weight of silk-thread protein into a solution containing 3 to 7 parts by weight of potassium chloride, 1.5 to 3.5 parts by volume(v/w) of ethanol, and 3 to 7 parts by volume(v/w) of water, and heating the solution at 85 to 95 deg. C for 1 to 3 hours to dissolve the silk-thread protein; dialyzing the silk-thread dissolved solution at 20 to 65 deg. C for 25 to 60 hours to remove salts; and adding 0.1 to 3.0%(w/v) of bromelain into 0.1 to 10.0%(w/v) of the silk-thread protein solution and reacting them at 25 to 30 deg. C for 1 to 5 hours.

Abstract translation: 目的：提供一种生产丝线肽的方法，由此以较高的收率快速和便宜地生产具有500-10000的分子量和在pH 4至9的100％溶解度的丝线肽。 构成：丝线肽的生产方法包括以下步骤：将1重量份丝线蛋白质加入含有3至7重量份氯化钾，1.5至3.5体积份（v / w） 的乙醇和3至7体积份（v / w）的水，并将溶液在85至95℃加热。 加热1至3小时以溶解丝线蛋白质; 在20至65℃下透析丝线溶解的溶液。 C 25-60小时以除去盐; 并将0.1-3.0％（w / v）菠萝蛋白酶加入0.1-10.0％（w / v）丝线蛋白质溶液中并在25-30℃下使它们反应。 C 1至5小时。

公开(公告)号：KR101528871B1

公开(公告)日：2015-06-16

申请号：KR1020120121991

申请日：2012-10-31

Applicant: 유한회사한풍제약

Inventor： 조형권 ,  박종군 ,  소윤조 ,  전기용 ,  이준경 ,  김대성 ,  변에리사 ,  유진주

IPC: A61K36/258 ,  A61K36/87 ,  A61K36/282 ,  A23L33/00

Abstract: 본발명은홍삼(Panax ginseng C.A.Meyer) 추출물; 포도(Vitis vinifera), 쑥(Artemisia), 복분자(Rubus coreanus Miquel)로이루어진군에서선택된 1 종이상의추출물;을유효성분으로함유하는세포활성화효능을갖는조성물에관한것이다. 구체적으로상기세포활성화효능은, 세포생존율, DNA 상해에대한회복, 세포고사의저해, 비주기성 DNA 합성, DNA 절단감소율, 저분자량의 DNA 함량감소, p53 단백질의발현량감소및 p53 의존성단백질의발현량감소를촉진하는기능을포함하는것을기술적특징으로하고있다.

公开(公告)号：KR101434163B1

公开(公告)日：2014-08-26

申请号：KR1020140008584

申请日：2014-01-23

Applicant: 유한회사한풍제약

Inventor： 조형권 ,  김성연 ,  한은별 ,  전기용 ,  전창현 ,  이준경 ,  김대성 ,  변에리사 ,  유진주

IPC: A61K36/488 ,  A61K8/97 ,  A61P29/00 ,  A61Q19/02 ,  A61Q19/00

CPC classification number: A61K8/97 ,  A61K36/488 ,  A61K2236/331 ,  A61Q17/00 ,  A61Q19/02 ,  A61Q19/08 ,  Y10S514/844

Abstract: The present invention relates to a composition having anti-oxidant, anti-inflammatory, and skin whitening effects and containing a kudzu aerial part extract as an active ingredient. More specifically, the present invention relates to a composition which can promote anti-oxidant, anti-inflammatory, and skin whitening effects without side effects using natural materials. The composition which can promote an anti-oxidant effect according to the present invention concentration-dependently exhibits an anti-oxidant effect as a result of a DPPH experiment. Moreover, the composition which can promote an anti-inflammatory effect according to the present invention can control the generation of NO and the expression of iNOS and COX-2. In addition, the composition which can promote a skin whitening effect according to the present invention can prevent melanin synthesis in cells, prevent melanin synthesis caused by α-MSH, inhibit melanin accumulation, control the expression of melanin synthesis enzymes and factors related to the synthesis, and improve skin whitening effect even at an in vivo level.

Abstract translation: 本发明涉及具有抗氧化剂，抗炎和皮肤美白效果的组合物，并且含有葛根部分提取物作为活性成分。 更具体地，本发明涉及一种可以使用天然材料促进抗氧化剂，抗炎和皮肤美白效果而没有副作用的组合物。 根据本发明可以促进抗氧化作用的组合物浓度依赖性地表现出作为DPPH实验的结果的抗氧化作用。 此外，根据本发明可以促进抗炎作用的组合物可以控制NO的产生和iNOS和COX-2的表达。 此外，根据本发明的能够促进皮肤美白效果的组合物可以防止细胞中的黑色素合成，防止由α-MSH引起的黑色素合成，抑制黑色素积聚，控制黑色素合成酶的表达和与合成有关的因子 ，即使在体内水平也能改善皮肤美白效果。

公开(公告)号：KR1020140056714A

公开(公告)日：2014-05-12

申请号：KR1020120121991

申请日：2012-10-31

Applicant: 유한회사한풍제약

Inventor： 조형권 ,  박종군 ,  소윤조 ,  전기용 ,  이준경 ,  김대성 ,  변에리사 ,  유진주

IPC: A61K36/258 ,  A61K36/87 ,  A61K36/282 ,  A23L33/00

CPC classification number: A61K36/258 ,  A61K36/282 ,  A61K36/87

Abstract: 본발명은홍삼(Panax ginseng C.A.Meyer) 추출물; 포도(Vitis vinifera), 쑥(Artemisia), 복분자(Rubus coreanus Miquel)로이루어진군에서선택된 1 종이상의추출물;을유효성분으로함유하는세포활성화효능을갖는조성물에관한것이다. 구체적으로상기세포활성화효능은, 세포생존율, DNA 상해에대한회복, 세포고사의저해, 비주기성 DNA 합성, DNA 절단감소율, 저분자량의 DNA 함량감소, p53 단백질의발현량감소및 p53 의존성단백질의발현량감소를촉진하는기능을포함하는것을기술적특징으로하고있다.

Abstract translation: 本发明涉及一种组合物，其包含一种或多种选自以下的提取物：人参（人参CAMeyer）提取物，葡萄（Vitis vinifera），艾蒿（艾蒿）和覆盆子（Rubus coreanus Miquel）作为活性成分， 并具有细胞活化作用。 特别地，本发明的细胞活化作用促进细胞活力; DNA损伤恢复; 抑制凋亡; 非定期DNA合成; DNA缺失率降低; 降低低分子量DNA含量; 并减少p53蛋白表达和p53依赖性蛋白表达。

公开(公告)号：KR101392715B1

公开(公告)日：2014-05-12

申请号：KR1020130021797

申请日：2013-02-28

Applicant: 유한회사한풍제약 ,  가천대학교 산학협력단

Inventor： 조형권 ,  송윤경 ,  박경무

IPC: A61K36/8994 ,  A61K36/232 ,  A61K36/17 ,  A61P3/04

CPC classification number: A61K36/8994 ,  A23L33/105 ,  A23V2200/332 ,  A23V2250/21 ,  A61K36/17 ,  A61K36/232 ,  A61K36/65 ,  A61K2236/333 ,  Y10S514/909

Abstract: The present invention relates to a composition for preventing, improving, or treating obesity and, more specifically, to a composition which contains a coicis semen complex as an active component, which is extracted by mixing 3-6 wt% of coix, 1.2-3 wt% of ma huang (ephedra), 1.2-3 wt% of angelica, 1.2-3 wt% of white atractylis, 1-2 wt% of a laurel branch, 1-2 wt% of peony, and 0.5-1 wt% of licorice. In order to prevent, improve, or treat obesity, the composition according to the present invention has effects of reducing weight, suppressing the differentiation of an adipocyte precursor cell, reducing the content of leptin in the blood, and increasing HDL cholesterol in the blood and decreasing LDL cholesterol. The composition according to the present invention has effects of suppressing an infection, decreasing blood sugar, reducing lipid content in a liver tissue, reducing the weight of organs, and removing hepatotoxicity and kidney toxicity in order to simultaneously prevent, improve, or treat chronic inflammatory conditions induced by obesity, and fat accumulation in organs, etc.

Abstract translation: 本发明涉及一种用于预防，改善或治疗肥胖的组合物，更具体地，涉及含有作为活性成分的胭脂红精液复合物的组合物，其通过混合3-6重量％的ix，，1.2-3 重量％的马黄（麻黄），1.2-3重量％的当归，1.2-3重量％的白屈肌，1-2重量％的月桂树枝，1-2重量％的牡丹和0.5-1重量％ 的甘草。 为了防止，改善或治疗肥胖症，本发明的组合物具有减轻体重，抑制脂肪细胞前体细胞分化，降低血液中瘦素含量，增加血液中HDL胆固醇的作用，以及 降低LDL胆固醇。 根据本发明的组合物具有抑制感染，降低血糖，降低肝组织中的脂质含量，降低器官重量以及除去肝毒性和肾毒性以同时预防，改善或治疗慢性炎症的作用 肥胖引起的病情，器官脂肪的积累等

公开(公告)号：KR101321754B1

公开(公告)日：2013-10-28

申请号：KR1020130034040

申请日：2013-03-29

Applicant: 유한회사한풍제약

Inventor： 조형권 ,  전기용 ,  이준경 ,  전창현 ,  김대성 ,  변에리사 ,  유진주 ,  권영배 ,  권중기 ,  김대기 ,  김세건 ,  정현주 ,  이은주

IPC: A61K36/488 ,  A61K36/732 ,  A61K36/284 ,  A61P19/02

CPC classification number: A61K36/732 ,  A61K36/185 ,  A61K36/25 ,  A61K36/284 ,  A61K36/31 ,  A61K36/714 ,  A61K2236/00 ,  A61K2300/00

Abstract: PURPOSE: A composition for prevention and treatment of rheumatoid arthritis and osteoarthritis is provided to suppress pain and inflammation of common symptoms in acute and chronic arthritis, and to improve exercise barrier which is a symptom of the chronic arthritis. CONSTITUTION: A composition for prevention and treatment of rheumatoid arthritis comprises an active ingredient mixed with: 350-450 wt% of Kalopanacis Cortex; 350-450 wt% of Chinese quince; 50-150 wt% of first extract which is extracted from Pulvis Aconiti Tuberis Purificatum; 150-250 wt% of Raphani Semen; and 50-150 wt% of second extract which is extracted from Atractylodis Rhizoma. The extract shows an effect which does not have chytotoxin to synoviocyte and chondrocyte. The extract shows effects of improving exercise barrier, and arthritic and analgesia. The extraction solvent for the first extract is 40-60 wt% of alcohol, and the extraction solvent for the second extract is water. [Reference numerals] (AA) Alleviating pain effect

Abstract translation: 目的：提供用于预防和治疗类风湿性关节炎和骨关节炎的组合物，以抑制急性和慢性关节炎中的常见症状的疼痛和炎症，并改善作为慢性关节炎症状的运动障碍。 构成：用于预防和治疗类风湿性关节炎的组合物包含与以下物质混合的活性成分：350-450重量％的卡拉帕拉西亚皮质; 中国柑橘350-450重量％ 50-150重量％的从Pulvis Aconiti Tuberis Purificatum提取的第一提取物; 150-250重量％的拉法尼精液; 和50-150重量％的从白术提取的第二提取物。 提取物显示对滑膜细胞和软骨细胞不具有chytotoxin的作用。 提取物显示改善运动障碍，关节炎和止痛的作用。 第一提取物的提取溶剂为40-60重量％的醇，第二提取物的提取溶剂为水。 （附图标记）（AA）缓解疼痛作用

公开(公告)号：KR1020110090293A

公开(公告)日：2011-08-10

申请号：KR1020100009988

申请日：2010-02-03

Applicant: 전북대학교산학협력단 ,  유한회사한풍제약

Inventor： 소윤조 ,  조형권

IPC: A61K36/718 ,  A61P1/02

CPC classification number: A61K36/718 ,  A23V2200/312 ,  A61K2236/331 ,  Y10S514/90

Abstract: PURPOSE: A composition containing Coptis japonica(Thunb.) extract is provided to reduce damage of gingival bone and to treat periodontitis. CONSTITUTION: A method for manufacturing a composition for treating periodontitis comprises: a step of extracting 100g of Coptis japonica(Thunb.) extract with 800 ml of purified water at 80-100°C for three hours; a step of filtering the extract at 200 meshes; a step of compressing under 60°C for concentration; and a step of mixing the extract, vitamin C, and vitamin E. The composition is an oral or injection formulation. The oral formulation is a granule, tablet, capsule, and liquid.

Abstract translation: 目的：提供含有黄连（Thunb。）提取物的组合物，以减少牙龈骨的损伤并治疗牙周炎。 构成：牙周炎治疗用组合物的制造方法，其特征在于，在80-100℃下，用800ml净化水提取100g黄连（Thunb。）提取物3小时; 在200目筛过滤提取物的步骤; 在60℃下压缩浓缩的步骤; 以及混合提取物，维生素C和维生素E的步骤。组合物是口服或注射制剂。 口服制剂是颗粒，片剂，胶囊和液体。

公开(公告)号：KR1020100042604A

公开(公告)日：2010-04-26

申请号：KR1020090098074

申请日：2009-10-15

Applicant: 유한회사한풍제약

Inventor： 조형권 ,  조성완 ,  이영재

IPC: A61K36/31 ,  A61P29/00 ,  A61P1/00

Abstract: PURPOSE: A composition containing seed of Raphanus sativus L. extract or powder is provided to treat or prevent inflammatory bowel diseases including ulcerative colitis and Crohn's disease. CONSTITUTION: A composition for treating or preventing inflammatory bowel disease contains seed of Raphanus sativus L. powder or extract. The seed of Raphanus sativus L. extract is isolated using water, methanol, ethanol, butanol, chloroform, hexane, ethylacetate, dichloromethane, or mixture solvent thereof or by supercritical extraction. The composition is manufactured in the form of medicinal product or functional food. The medicinal product or functional food additionally contains pharmaceutically acceptable excipient or additive.

Abstract translation: 目的：提供含有Raphanus sativus L.提取物或粉末的种子的组合物，用于治疗或预防炎症性肠病，包括溃疡性结肠炎和克罗恩病。 构成：用于治疗或预防炎性肠病的组合物含有Raphanus sativus L.粉末或提取物的种子。 使用水，甲醇，乙醇，丁醇，氯仿，己烷，乙酸乙酯，二氯甲烷或其混合溶剂或通过超临界萃取法分离us The提取物的种子。 该组合物以药用产品或功能食品的形式制造。 药用产品或功能性食品另外含有药学上可接受的赋形剂或添加剂。