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21.发明授权패혈증 비브리오균의 플라젤린과 알레르겐을 접합시켜 제조한 접합체 및 이를 유효성분으로 포함하는 점막 투여용 알레르겐-특이 면역치료제 有权通过与创伤弧菌鞭毛蛋白和变应原共轭产生的过敏原复合物，以及含有与活性成分相同的粘膜变应原特异性免疫治疗剂
公开(公告)号：KR101522280B1
公开(公告)日：2015-05-21
申请号：KR1020120107258
申请日：2012-09-26
Applicant: 전남대학교산학협력단
Abstract: 본발명은점막백신보조제와알레르겐을접합시켜제조한접합체, 및이를포함하는알레르겐-특이면역치료제에관한것으로, 보다상세하게는백신보조제이면서톨-유사수용체-5(TLR-5) 작동제인패혈증비브리오균()의플라젤린과집먼지진드기추출물을티올기(-SH)를가지고있는친수성다중결합링커를이용하여제조한접합체및 이를포함하는점막투여용알레르겐-특이면역치료제에관한것이다.
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公开(公告)号：KR1020140108801A
公开(公告)日：2014-09-15
申请号：KR1020130022161
申请日：2013-02-28
Applicant: 전남대학교산학협력단
Abstract: The present invention relates to an efficient manufacturing method of flagellin proteins (FlaB) derived from Vibrio and, more specifically, to a producing strain which can be used, when the Flab represented by the sequence 1 of amino acid is produced, in a recombinant flagellin protein, to the production of the recombinant FlaB derived from the Vibrio using the same, and a purifying process using the same.
Abstract translation: 本发明涉及一种来自弧菌属的鞭毛蛋白（FlaB）的有效制造方法，更具体地说，涉及当产生由氨基酸序列1表示的Flab时可以使用的生产菌株的重组鞭毛蛋白 蛋白质，使用其从源自弧菌的重组FlaB的生产，以及使用其的纯化方法。
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公开(公告)号：KR100997753B1
公开(公告)日：2010-12-02
申请号：KR1020100013088
申请日：2010-02-12
Applicant: 전남대학교산학협력단
IPC: C12N5/0784 , C12N5/02 , C07K14/525 , C07K14/555
CPC classification number: C12N5/0639 , C07K14/525 , C07K14/555 , C12N1/38 , C12N2501/24 , C12N2501/25 , C12N2501/998
Abstract: PURPOSE: A composition for inducing maturation of dendritic cells is provided to use as a therapeutic agent for tumor. CONSTITUTION: A composition for inducing maturation of dendritic cells contains bacteria flagellin, TNF-alpha, and interferone as active ingredients. A method for inducing maturation of immature dendritic cells comprises: a step of differentiating monocytes isolated from blood to immature dendritic cells; and a step of treating with bacteria flagellin, TNF-alpha and interferone to the immature dendtritic cells.
Abstract translation: 目的：提供一种用于诱导树突细胞成熟的组合物，用作肿瘤的治疗剂。 构成：用于诱导树突状细胞成熟的组合物含有细菌鞭毛蛋白，TNF-α和干扰素作为活性成分。 用于诱导未成熟树突状细胞成熟的方法包括：将从血液中分离的单核细胞分化成未成熟树突状细胞的步骤; 以及用细菌鞭毛蛋白，TNF-α和干扰素处理未成熟树突状细胞的步骤。
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公开(公告)号：KR1020100030729A
公开(公告)日：2010-03-19
申请号：KR1020080089581
申请日：2008-09-11
Applicant: 전남대학교산학협력단
CPC classification number: C12N1/20 , C08B37/0003 , C12P19/04
Abstract: PURPOSE: A medium for producing capsular polysaccharide is provided to optimize medium ingredient and culture condition and to enhance productivity of the polysaccharide. CONSTITUTION: A medium which produces capsular polysaccharide from streptococcus sp. contains 30g/l of carbon source selected from glucose, fructose, galactose and lactose, 5-30 g/l of yeast extract, and 2-10g/l of sodium chloride. A method for purifying capsular polysaccharide comprises: a step of adding sodium deoxycholate to culture medium of Streptococcus sp. to perform cell lysis; a step of adding chloroform-butanol solution to the cell lysate to obtain supernatant; and a step of adding ethanol to the supernatant to precipitate capsular polysaccharide.
Abstract translation: 目的：提供用于生产荚膜多糖的培养基，以优化培养基成分和培养条件，提高多糖的生产率。 构成：从链球菌生产荚膜多糖的培养基。 含有选自葡萄糖，果糖，半乳糖和乳糖的30g / l碳源，5-30g / l酵母提取物和2-10g / l氯化钠。 一种纯化荚膜多糖的方法包括：将脱氧胆酸钠加入到链球菌培养基中的步骤。 进行细胞裂解; 向细胞裂解液中加入氯仿 - 丁醇溶液以获得上清液的步骤; 以及向上清液中加入乙醇以沉淀荚膜多糖的步骤。
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公开(公告)号：KR100515767B1
公开(公告)日：2005-09-23
申请号：KR1020030026366
申请日：2003-04-25
Applicant: 전남대학교산학협력단
IPC: C12N15/63
Abstract: 본 발명은 패혈증 비브리오균(
Vibrio vulnificus )의 생체내 독력발현 조절인자인
hlyU 유전자에 관한 것으로, 보다 상세하게는 독력발현 조절인자인
hlyU 유전자를 선택적으로 결실시킨 돌연변이 균주를 제조하고, 이 돌연변이 균주를 사용하여 항 비브리오 패혈증 백신 및 치료약제를 개발하는 방법에 관한 것이다.-
Patent Agency Ranking
公开(公告)号：KR1020040092148A
公开(公告)日：2004-11-03
申请号：KR1020030026366
申请日：2003-04-25
Applicant: 전남대학교산학협력단
IPC: C12N15/63
CPC classification number: C12N15/113 , A61K39/107 , A61K2039/52 , C07K14/28
Abstract: PURPOSE: An hlyU gene as a regulator of the expression of in vivo virulence factor in Vibrio vulnificus is provided. The gene is useful for prevention and treatment of a disease caused by Vibrio vulnificus. CONSTITUTION: The hlyU gene as a regulator of the expression of in vivo virulence factor in Vibrio vulnificus has the nucleotide sequence of SEQ ID NO:1, wherein the gene hlyU encodes a protein having the amino acid sequence of SEQ ID NO:2. A vaccine for Vibrio vulnificus comprises a mutant microorganism wherein the gene hlyU is selectively deleted from the chromosome of a microorganism.
Abstract translation: 目的：提供hlyU基因作为创伤弧菌体内毒力因子表达的调节剂。 该基因可用于预防和治疗由创伤弧菌引起的疾病。 构成：作为创伤弧菌体内毒力因子表达调节剂的hlyU基因具有SEQ ID NO：1的核苷酸序列，其中，hlyU基因编码具有SEQ ID NO：2的氨基酸序列的蛋白质。 用于创伤弧菌的疫苗包含突变体微生物，其中从微生物的染色体中选择性缺失基因hlyU。
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公开(公告)号：KR101749317B1
公开(公告)日：2017-06-22
申请号：KR1020140130540
申请日：2014-09-29
Applicant: 전남대학교산학협력단
Abstract: 본발명은패혈증비브리오균()의편모구성성분인플라젤린과병원체의단백질항원을융합시킨재조합단백질을유효성분으로포함하는노화예방, 개선또는치료용조성물에관한것이다. 본발명에따르면본 발명의재조합단백질을이용하여노화에따라발생하는외적, 내적인기능을개선하고면역을강화시킬수 있는이점이있다. 또한, 본발명의조성물은점막투여를통하여손쉽게면역을할 수있다.
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公开(公告)号：KR101627285B1
公开(公告)日：2016-06-07
申请号：KR1020140068640
申请日：2014-06-05
Applicant: 한국생명공학연구원 , 전남대학교산학협력단
Abstract: 본발명은 PspA를포함하는퇴행성뇌질환의예방또는치료용약학조성물, 퇴행성뇌질환예방또는개선용식품조성물및 상기약학조성물을이용하여퇴행성뇌질환을예방또는치료하는방법에관한것이다. 본발명에서제공하는 PspA는노화에의해유발되는뇌의인지기능저하증상을부분적으로회복시킬수 있으므로, 유사한증상을나타내는퇴행성뇌질환의효과적인예방또는치료에널리활용될수 있을것이다.
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30.发明公开패혈증 비브리오균의 편모 구성성분인 플라젤린과 병원체의 항원 단백을 융합시킨 재조합 단백을 포함하는 노화 예방, 개선 또는 치료용 조성물 无效用于预防，改善和治疗包含重组融合蛋白与抗生素FLAGELLIN和致病性抗原的老化试剂的组合物
公开(公告)号：KR1020160032721A
公开(公告)日：2016-03-24
申请号：KR1020160028839
申请日：2016-03-10
Applicant: 전남대학교산학협력단
Abstract: 본발명은패혈증비브리오균()의편모구성성분인플라젤린과병원체의단백질항원을융합시킨재조합단백질을유효성분으로포함하는노화예방, 개선또는치료용조성물에관한것이다. 본발명에따르면본 발명의재조합단백질을이용하여노화에따라발생하는외적, 내적인기능을개선하고면역을강화시킬수 있는이점이있다. 또한, 본발명의조성물은점막투여를통하여손쉽게면역을할 수있다.
Abstract translation: 本发明涉及一种预防，缓解或治疗老化的组合物，其中组合物包含重组蛋白作为活性成分，其结合鞭毛蛋白，创伤弧菌的鞭毛组分和致病性抗原。 根据本发明，使用本发明的重组蛋白质的组合物具有改善由老化产生的外部和内部功能以及增强免疫力的优点。 此外，本发明的组合物可以容易地通过粘膜给药诱导免疫反应。
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