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公开(公告)号：KR100428936B1
公开(公告)日：2004-04-28
申请号：KR1019990011996
申请日：1999-04-07
Applicant: 한국과학기술연구원
IPC: A23L1/221
Abstract: PURPOSE: A condiment composition containing garlic, onion, ginger, jujubes, powder or extracts of a tangerine pericarp is provided. It has an effect of improving health through prevention of circulatory organ-related diseases when added to food. CONSTITUTION: The condiment composition contains 1 to 30% by weight of garlic, 10 to 50% by weight of onion, 0.2 to 10% by weight of ginger, 5 to 40% by weight of jujubes, tangerines, powder or extract of a tangerine pericarp and additionally 30 to 50% by weight of oatmeal powder, based on the total weight of the composition. The tangerine pericarp extract is prepared by adding 3 to 30L 20 to 95% ethanol to 1kg tangerine pericarp, extracting for 1 to 12hr at 25 to 80deg.C and then filtering.
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公开(公告)号：KR100363180B1
公开(公告)日：2003-01-24
申请号：KR1019980043909
申请日：1998-10-20
Applicant: 한국과학기술연구원
IPC: A61K31/35
Abstract: PURPOSE: A composition for increasing serum high density lipoprotein containing bioflavonoids is provided which is useful for preventing and treating diseases of cardiac circulatory organs. CONSTITUTION: The medical composition for increasing high density lipoprotein consists of(i) an effective amount of bioflavonoids of the following general formula(I) or a plant extract containing thereof, where each R¬1-R¬9 is independently hydrogen, hydroxy, alkoxy having 1-9 carbon atoms(optionally, which is able to include hydroxy, alkoxy having 1-5 carbon atoms, aryloxy or phenyl group which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido), cycloalkyloxy having 5-9 carbon atoms which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido, cycloalkylcarbonyloxy having 5-9 carbon atoms which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido, acyloxy having 2-10 or 16-18 carbon atoms(optionally, which is able to include hydroxy, alkoxy having 1-5 carbon atoms, aryloxy or phenyl group which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido), or rutinosyl, and X is either a single bond or a double bond; and (ii) a medically acceptable carrier.
Abstract translation: 目的：提供一种用于增加含血清高密度脂蛋白的生物类黄酮的组合物，其用于预防和治疗心脏循环器官疾病。 组成：用于增加高密度脂蛋白的药物组合物由（i）有效量的下列通式（I）的生物类黄酮或含有其的植物提取物组成，其中每个R 1 -R 1不是9独立地是氢，羟基， 具有1-9个碳原子的烷氧基（任选地，其能够包括羟基，具有1-5个碳原子的烷氧基，芳氧基或被1-3个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基 ），被一至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代的具有5-9个碳原子的环烷氧基，具有5-9个碳原子的环烷氧基，其被1-3个选自羟基， 烷氧基，芳氧基，卤素，硝基和酰氨基，具有2-10或16-18个碳原子的酰氧基（任选地，其可以包括羟基，具有1-5个碳原子的烷氧基，芳氧基或被取代的苯基 y选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的1至3个取代基）或芸香糖基，X为单键或双键; 和（ii）医学上可接受的载体。
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公开(公告)号：KR100314477B1
公开(公告)日：2001-11-16
申请号：KR1020000063394
申请日：2000-10-27
Applicant: 한국과학기술연구원
IPC: A61K36/725 , A61K36/752 , A61P3/06 , A61P9/12
Abstract: 본 발명은 대추 추출물 및 감귤류 과피 추출물을 포함하는 지질대사 개선 및 혈압강하용 조성물에 관한 것으로, 본 발명의 조성물은 의약용 및 식품용 조성물을 포함한다. 대추 추출물 및 감귤류 과피 추출물을 포함하는 본 발명의 조성물은, 동물에 투여되었을 때 간 질환, 고혈압증, 동맥경화증, 고지혈증 등의 성인병 및 암 예방 등의 효과를 나타낼 수 있다.
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公开(公告)号：KR100291142B1
公开(公告)日：2001-07-12
申请号：KR1019980037963
申请日：1998-09-15
Applicant: 한국과학기술연구원
Abstract: 본 발명은 네오헤스페리딘 디하이드로칼콘(neohesperidin dihydrochalcone)을 포함하는 동맥경화증, 고지혈증, 간 질환, 고혈당증의 예방 및 치료용 조성물에 관한 것으로, 본 발명의 조성물은 의약용, 식품용 및 음료용 조성물을 포함한다.
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25.发明授权네오헤스페리딘 디하이드로칼콘을 포함하는 동맥경화증,고지혈증, 간 질환, 고혈당증의 예방 및 치료용 조성물 失效用于预防和治疗动脉硬化，高脂血症，肝病，高血糖的组合物，包括新霉素二氢查耳酮
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Patent Agency Ranking
公开(公告)号：KR100291140B1
公开(公告)日：2001-05-15
申请号：KR1020000062334
申请日：2000-10-23
Applicant: 한국과학기술연구원
IPC: A61K31/366
Abstract: 본 발명은 탄닌(tannin), 또는 탄닌 유래 갈산(gallic acid) 또는 엘라그산(ellagic acid)을 포함하는 동맥경화증, 고지혈증 및 간 질환의 예방 및 치료용 조성물에 관한 것으로, 탄닌, 갈산 또는 엘라그산은 동물에게 투여되었을 때 동맥내피에 대식세포-지질 복합체가 침착되는 것을 강력히 억제할 뿐만 아니라, 동물의 혈청 GOT(glutamate-oxaloacetate transaminase), GPT(glutamate-pyruvate transaminase), γGTP(γ-glutamyl transpeptidase) 및 혈중 지질의 농도를 낮추고, 간세포의 손상 및 지방간화를 강력히 억제하므로, 본 발명의 조성물은 동맥경화증, 고지혈증 및 간 질환의 예방 및 치료제로서 유용하게 사용될 수 있다.
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公开(公告)号：KR1020010015490A
公开(公告)日：2001-02-26
申请号：KR1020000056166
申请日：2000-09-25
Applicant: 한국과학기술연구원
IPC: A23L1/29
Abstract: PURPOSE: A food or drink composition including a bioflavonoid of formula(I) or extract of vegetables or citrus fruits containing the bioflavonoid is provided. This composition prevents hypertension, arteriosclerosis and a stroke of paralysis by increasing the plasma high density lipoprotein level in the body. CONSTITUTION: The composition for increasing plasma high density lipoprotein(HDL) level comprises a bioflavonoid of formula(I), wherein i) R1 to R9 are each independently hydrogen; hydroxy group; C1-9 alkoxy group optionally substituted with one or more substituents selected from the group consisting of hydroxy, C1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C5-9 cycloalkyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; C5-9 cycloalkylcarbonyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; C2-10 or C16-18 acyloxy group optionally substituted with one or more substituents selected from the group consisting of a hydroxy, C1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen and nitro group; rutinosyl group; or rhaminosyl group, and ii) X is a single or double bond. The bioflavonoid of formula(I) or extract of vegetables or citrus fruits containing the bioflavonoid can be added to various foods or drinks.
Abstract translation: 目的：提供包含式（I）的生物类黄酮或含有生物类黄酮的蔬菜或柑橘类水果提取物的食品或饮料组合物。 该组合物通过增加体内血浆高密度脂蛋白水平来预防高血压，动脉硬化和瘫痪中风。 构成：用于增加血浆高密度脂蛋白（HDL）水平的组合物包含式（I）的生物类黄酮，其中i）R 1至R 9各自独立地为氢; 羟基; 任选地被一个或多个选自羟基，C 1-5烷氧基，芳氧基和被1至3个选自羟基，烷氧基，芳氧基，卤素取代基的取代基取代的取代基取代的C1-9烷氧基 ，硝基和酰氨基; 被1至3个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代的C5-9环烷氧基; 被1至3个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代的C 5-9环烷基羰基氧基; 任选被一个或多个选自羟基，C 1-5烷氧基，芳氧基和被1至3个选自下组取代的取代基的苯基取代的C 2-10或C16-18酰氧基：羟基， 烷氧基，芳氧基，卤素和硝基; 芸香酰基; 或rhaminosyl基，和ii）X是单键或双键。 式（I）的生物类黄酮或含有生物类黄酮的蔬菜或柑橘类水果的提取物可以添加到各种食品或饮料中。
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28.发明授权
公开(公告)号：KR100258584B1
公开(公告)日：2000-07-01
申请号：KR1019970055580
申请日：1997-10-28
Applicant: 한국과학기술연구원
IPC: A61K36/752 , A61P9/00
Abstract: PURPOSE: A composition containing orange peel extract for inhibition of acyl CoA:cholesterol-O-acyltransferase(ACAT) is provided, which is useful for preventing and treating various cardiovascular diseases by decreasing blood low density lipoprotein(LDL) cholesterol. CONSTITUTION: A process fro the preparation of composition containing orange peel extract for inhibition of acyl CoA:cholesterol-O-acyltransferase(ACAT) comprises the steps of: washing the peel of tangerine originated in Korea, and drying at normal temperature to get Aurantii Nobilis Pericarpium; adding 95% ethanol, keeping at normal temperature for 24hours, and filtering to get extract and solid residue; extracting the solid residue twice more by the same process, and gathering extracts altogether; and concentrating the extract using a rotary vacuum evaporator under decompression to get concentrated extract containing bio-flavonoids.
Abstract translation: 目的：提供含有抑制酰基CoA：胆固醇-O-酰基转移酶（ACAT）的橙皮提取物的组合物，其可用于通过降低血液低密度脂蛋白（LDL）胆固醇来预防和治疗各种心血管疾病。 构成：含有橙皮提取物抑制酰基CoA：胆固醇-O-酰基转移酶（ACAT）的组合物的制备方法包括以下步骤：洗涤起始于韩国的橘皮，并在常温下干燥以得到Aurantii Nobilis Pericarpium; 加入95％乙醇，在常温保持24小时，过滤得到提取物和固体残渣; 通过相同的方法提取固体残渣两次，并收集提取物; 并在减压下使用旋转式真空蒸发器浓缩提取物，得到含有生物黄酮的浓缩提取物。
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公开(公告)号：KR1020000019719A
公开(公告)日：2000-04-15
申请号：KR1019980037962
申请日：1998-09-15
Applicant: 한국과학기술연구원
IPC: A61K31/70
CPC classification number: A23L33/10 , A23C9/152 , A23V2002/00 , A23V2200/3262 , A61K31/7048
Abstract: PURPOSE: A pharmaceutical composition and a functional food comprising diosmin are provided, for treating and preventing hyper lipidemia and arteriosclerosis. CONSTITUTION: The pharmaceutical composition comprises diosmin in effective amount; and pharmaceutically acceptable carriers. The functional food comprises 0.01-10 wt%, preferably 0.1-5 wt% of diosmin. Diosmin inhibits HMG CoA (3-hydroxy-3-methylglutaryl coenzyme) being a reduction enzyme which relates to the biosynthesis of cholesterol and ACAT (acyl CoA; cholesterol-O-acyltransferase) which transforms cholesterol into cholesteryl ester, and reduces the concentration of cholesterol in blood and neutral lipids. Also diosmin strongly inhibits the macrophage-lipid complex from being deposited or adsorbed onto the intra trial surface.
Abstract translation: 目的：提供药物组合物和包含diosmin的功能性食品，用于治疗和预防高脂血症和动脉硬化。 构成：药物组合物含有有效量的diosmin; 和药学上可接受的载体。 功能性食品包含diosmin的0.01-10重量％，优选0.1-5重量％。 Diosmin抑制作为还原酶的HMG CoA（3-羟基-3-甲基戊二酰辅酶），其涉及将胆固醇转化为胆固醇酯的胆固醇和ACAT（酰基辅酶A;胆固醇-O-酰基转移酶）的生物合成，并降低胆固醇的浓度 在血液和中性脂质中。 此外，diosmin还强烈地抑制巨噬细胞 - 脂质复合物沉积或吸附到试验表面。
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公开(公告)号：KR1020000019717A
公开(公告)日：2000-04-15
申请号：KR1019980037959
申请日：1998-09-15
Applicant: 한국과학기술연구원
IPC: A61K31/70
CPC classification number: A23L2/52 , A21D2/14 , A23C9/13 , A23C9/152 , A23L7/109 , A23L13/428 , A23L23/00 , A23L27/63 , A61K31/70 , Y10S514/824 , A61K2300/00
Abstract: PURPOSE: A pharmaceutical composition and a functional food comprising bioflavonoids are provided, for treating and preventing hyper lipidemia, arteriosclerosis and a liver disease. CONSTITUTION: The pharmaceutical composition comprises rutin, quercetin or their mixture ineffective amount; and pharmaceutically acceptable carriers. The functional food comprises 0.01-10 wt% of rutin, quercetin or their mixture. Rutin can be obtained from a fruit, a leaf, a trunk and a flower of buck wheat and be used in the form of a powder or an extract. Rutin and quercetin being bioflavonoids inhibit HMG CoA (3-hydroxy-3-methylglutaryl coenzyme) being a reduction enzyme which relates to the biosynthesis of cholesterol and ACAT (acyl CoA; cholesterol-O-acyltransferase) which transforms cholesterol into cholesteryl ester in the body. Therefore rutin and quercetin reduce the concentration of cholesterol in blood, inhibit strongly a macrophage-lipid complex from being deposited or adsorbed onto the intra trial surface, and protect a liver.
Abstract translation: 目的：提供包含生物类黄酮的药物组合物和功能性食品，用于治疗和预防高脂血症，动脉硬化和肝脏疾病。 构成：药物组合物含有芦丁，槲皮素或其混合物无效量; 和药学上可接受的载体。 功能性食品包含0.01-10重量％的芦丁，槲皮素或其混合物。 芦丁可以从水果，叶子，树干和小麦花中获得，并以粉末或提取物的形式使用。 芦丁和槲皮素是生物类黄酮抑制作为还原酶的HMG CoA（3-羟基-3-甲基戊二酰辅酶），其涉及胆固醇和ACAT（酰基CoA;胆固醇-O-酰基转移酶）的生物合成，其将胆固醇转化为身体中的胆固醇酯 。 因此，芦丁和槲皮素降低血液中胆固醇的浓度，强烈地抑制巨噬细胞 - 脂质复合物沉积或吸附到试验表面，并保护肝脏。
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