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公开(公告)号：KR101759218B1
公开(公告)日：2017-07-31
申请号：KR1020150166704
申请日：2015-11-26
Applicant: 한국과학기술연구원
Abstract: 본발명은온도감응및 가교성포스파젠을이용하여적정온도범위에서가교결합이형성되는하이드로젤, 그의제조방법및 용도에관한것으로서, 본발명에따른가교하이드로젤은, 자외선조사가이루어져도적정온도도달시에만가교가일어나도록하여, 주입전에는용액상태로서취급및 투여가용이하며, 신체에주입후에피부에직접자외선조사를하지않아도되는생체재료용폴리포스파젠계하이드로젤, 그의제조방법및 그의용도에관한것이다.
Abstract translation: 本发明是温度敏感的，并根据制造的方法交联seongpo如，使用在适当的温度范围内形成爵交联温泉二氢，凝胶，并且使用，交联根据本发明的水凝胶，其由UV照射的也是合适的温度 用于生物材料的聚磷腈水凝胶在注射前易于处理并作为溶液给药，并且在注射到体内后不需要用紫外线直接照射紫外线， Lt。
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公开(公告)号：KR101480363B1
公开(公告)日：2015-01-09
申请号：KR1020120083104
申请日：2012-07-30
Applicant: 한국과학기술연구원
CPC classification number: C08G79/025 , A61K47/34
Abstract: 본 발명은 분해속도 조절이 가능한 이온기를 갖는 온도 감응성 포스파젠계 고분자와 그의 용도 및 그의 생리 활성 물질 전달 재료로서의 용도에 관한 것이다. 본 발명의 포스파젠계 고분자는 온도변화에 따라서 솔-젤 거동을 보이는 온도감응성을 갖기 때문에, 체내에 주입시 체온에 의하여 젤을 형성하여 약물 등의 생리 활성 물질의 방출 제어가 용이하고, 약물 등과 이온결합, 공유결합, 배위결합 등의 화학결합이 가능한 관능기를 갖고 있어서 약물 등의 담지력이 우수하다. 또한 이온기의 종류에 따라 분해속도를 조절할 수 있기 때문에 약물의 특성에 따라 선택적으로 방출시간을 조절할 수 있으며, 생체적합성도 뛰어나서 약물 등의 생리 활성 물질 전달 재료로서 매우 유용하다.
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公开(公告)号：KR1020070076386A
公开(公告)日：2007-07-24
申请号：KR1020060107230
申请日：2006-11-01
Applicant: 한국과학기술연구원
CPC classification number: A61K9/06 , A61K9/0024 , A61K9/08 , A61K47/34 , A61K47/6903 , C08G79/025
Abstract: A biodegradable and thermosensitive poly(organophosphazene) hydrogel is provided to be capable of forming a direct chemical bond or ionic bond with drugs, to release the drugs for a long time, and thus be useful as a delivery material for drugs. The phosphazene polymer represented by the following chemical formula 1 is prepared by the steps of: thermopolymerizing a phosphazene trimer to obtain a dichloro phosphazene linear polymer; reacting the dichloro phosphazene linear polymer with 0.01-1.9 equivalents of an amino acid ester or a salt thereof; reacting the product of the second step with 0-1.9 equivalents of amino acid, peptide, and depsipeptide ester, or a salt thereof; reacting the product of the third step with 0.01-1.9 equivalents of a substituent having a functional group of NH2(R6)(R7)(R8) or a salt thereof; and reacting the product of the fourth step with 0.01-1.19 equivalents of aminomethoxypolyethyleneglycol or a salt thereof.
Abstract translation: 提供可生物降解和热敏的聚（有机膦腈）水凝胶以能够与药物形成直接的化学键或离子键，长时间释放药物，因此可用作药物的递送材料。 由以下化学式1表示的磷腈聚合物是通过以下步骤制备的：使磷腈三聚体热聚合得到二氯磷腈线性聚合物; 使二氯磷腈线性聚合物与0.01-1.9当量的氨基酸酯或其盐反应; 使第二步的产物与0-1.9当量的氨基酸，肽和脱脂肽酯或其盐反应; 使第三步骤的产物与具有NH 2（R 6）（R 7）（R 8）或其盐的官能团的取代基的0.01-1.9当量反应; 并使第四步的产物与0.01-1.19当量的氨基甲氧基聚乙二醇或其盐反应。
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Patent Agency Ranking
公开(公告)号：KR1020010047025A
公开(公告)日：2001-06-15
申请号：KR1019990051049
申请日：1999-11-17
Applicant: 한국과학기술연구원
IPC: C08G79/02
CPC classification number: C08G79/025
Abstract: PURPOSE: A degradable polyphosphazene polymer having the phase transition behavior with temperature and its preparation method are provided, whose phase transition temperature and degradation velocity are controlled easily. CONSTITUTION: The polyphosphazene polymer is represented by the formula 1, wherein X represents O or N; NHR is depsipeptide and represents ethyl-2-(O-glycyl)glycolate or ethyl-2-(O-glycyl)lactate; NHR' is amino acid ethylester and represents NHCH(CH2CH2COOC2H5)COOC2H5 or phenylalanine ethylester; NHR'' represents glycine ethylester or alanine ethylester; a, b, c, d, e and f represent the mol of copolymer and are 0-1.0 and the sum of a, b, c, d, e and f is 1.0; and n represents the degree of polymerization and is 100-1,000. The method comprises the steps of reacting polydichlorophoaphazene of the formula 3 with an alkali metal salt of methoxy poly(ethylene glycol) of the formula 4 or aminomethoxy poly(ethylene glycol) of the formula 5 by the molar ratio of 1 : 0.3-1.5; reacting the product with depsipeptide (H2NR) and NH2CH(CH2CH2COOC2H5)COOC2H5 or phenylalanine ethylester (H2NR') by the molar ratio of 1 : 0.1-2 in organic solvent; and reacting the product with glycine ethylester or alanine ethylester (H2NR'') to obtain the polyphosphazene polymer of the formula 1.
Abstract translation: 目的：提供具有温度相变特性的可降解聚磷腈聚合物及其制备方法，其相变温度和降解速度易于控制。 构成：聚磷腈聚合物由式1表示，其中X表示O或N; NHR是脱肽，代表乙基-2-（O-甘氨酰）乙醇酸酯或乙基-2-（O-甘氨酰）乳酸酯; NHR'是氨基酸乙酯，代表NHCH（CH 2 CH 2 COOC 2 H 5）COOC 2 H 5或苯丙氨酸乙酯; NHR“表示甘氨酸乙酯或丙氨酸乙酯; a，b，c，d，e和f表示共聚物的摩尔数，为0-1.0，a，b，c，d，e和f的和为1.0; n表示聚合度，为100〜1,000。 该方法包括以下步骤：使式3的聚二氯代吡嗪与式4的甲氧基聚（乙二醇）的碱金属盐或式5的氨基甲氧基聚（乙二醇）摩尔比为1:0.3-1.5; 将产物与有机溶剂中的摩尔比为1：0.1-2的反式肽（H2NR）和NH2CH（CH2CH2COOC2H5）COOC2H5或苯丙氨酸乙酯（H2NR'）反应; 并使产物与甘氨酸乙酯或丙氨酸乙酯（H 2 NR“）反应，得到式1的聚磷腈聚合物。
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公开(公告)号：KR1020140016521A
公开(公告)日：2014-02-10
申请号：KR1020120083104
申请日：2012-07-30
Applicant: 한국과학기술연구원
CPC classification number: C08G79/025 , A61K47/34
Abstract: The present invention relates to a temperature-sensitive phosphazene based polymer containing a degradation-controllable ionic group, a use thereof, and a use thereof as a bioactive substance transfer material. The phosphazene based polymer of the present invention has a temperature sensitivity with a sol-gel change by the temperature change, and forms gel when the polymer is injected into the body by the body temperature for easily controlling the discharging of bioactive substances including drugs. The phosphazene based polymer has a functional group which is capable of chemically bonding including an ionic bond, a covalent bond, and a coordinate bond, and has excellent carrying power of the drugs. The degradation speed of the polymer can be controlled by the type of an ionic group for selectively controlling the discharging time by the properties of the drugs. The phosphazene based polymer has excellent biocompatibility to be used as a bioactive substance transfer material. [Reference numerals] (AA) Solution state(room temperature); (BB) Temperature is increased; (CC) Gel state(body temperature)
Abstract translation: 本发明涉及含有降解可控离子基团的温度敏感性磷腈基聚合物，其用途及其作为生物活性物质转移材料的用途。 本发明的磷腈基聚合物具有通过温度变化的溶胶 - 凝胶变化的温度敏感性，并且当聚合物通过体温注入体内以便容易地控制包括药物在内的生物活性物质的排出时，形成凝胶。 磷腈基聚合物具有能够化学键合的官能团，包括离子键，共价键和配位键，并且具有优异的药物携带能力。 聚合物的降解速度可以通过用于通过药物的性质选择性地控制放电时间的离子基团的类型来控制。 磷腈基聚合物具有优异的生物相容性，可用作生物活性物质转移材料。 （标号）（AA）溶液状态（室温） （BB）温度升高; （CC）凝胶状态（体温）
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公开(公告)号：KR101232261B1
公开(公告)日：2013-02-15
申请号：KR1020100006000
申请日：2010-01-22
Applicant: 한국과학기술연구원
Abstract: 화학적 가교결합이 가능한 포스파젠계 고분자의 생체재료로서의 용도, 생리활성물질이 공유 결합되어 있는 화학적 가교결합이 가능한 포스파젠계 고분자 및 이의 생체재료로서의 용도, 및 그 제조 방법이 제공된다. 상기 화학적 가교결합은 자외선 조사, 및/또는 가교제, 및/또는 첨가제, 및/또는 효소 및/또는, 1종 이상 고분자의 혼합에 의한 것일 수 있다.
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公开(公告)号：KR1020120002120A
公开(公告)日：2012-01-05
申请号：KR1020100062850
申请日：2010-06-30
Applicant: 한국과학기술연구원
CPC classification number: B82Y5/00 , A61K9/0009 , A61K49/1857 , B82Y15/00 , C08G79/025 , C08K3/22 , C08K2003/2265 , C08L85/02 , Y02A50/401
Abstract: PURPOSE: A biodegradable and thermosensitive poly(phosphazene)-superparamagnetic nano-particle complex is provided to have sol-gel behavior, the temperature sensibility of sol-gel behavior according to temperature change, and to improve functionality and bio-compatibility according to the purpose of a bio material. CONSTITUTION: A biodegradable and thermosensitive poly(phosphazene)-superparamagnetic nano-particle complex comprises: a polymer which has sol-gel behavior according to temperature change; and superparamagnetic ferrite nanoparticles having a structure of chemical formula 2a: Fe^(3+,T)(Fe^(2+),Fe^(3+))^0 O_4^(2-) or chemical formula 2b: Fe^(3+,T)(Me^(2+), Fe^(3+))^0 O_4^2. In the chemical formulas, Me is a transition metal selected from the group consisting of Sc, Ti, V, Cr, Mn, Co, Ni, Cu or Zn. T is tetrahedral site, I is octahedral site, δ is 0-1, as conversion ratio.
Abstract translation: 目的：提供可生物降解和热敏聚（磷腈） - 超顺磁性纳米颗粒复合物以具有溶胶 - 凝胶行为，根据温度变化的溶胶 - 凝胶行为的温度敏感性，以及根据目的改善功能性和生物相容性 的生物材料。 构成：可生物降解和热敏聚（磷腈） - 超顺磁性纳米颗粒复合物包括：根据温度变化具有溶胶 - 凝胶行为的聚合物; 具有化学式2a的结构的超顺磁铁氧体纳米颗粒：Fe 3（3 +，T）（Fe 2（+），Fe 2（3+））2 O 4（2-）或化学式2b：Fe （3 +，T）（Me ^（2+），Fe ^（3 +））^ 0 O_4 ^ 2。 在化学式中，Me是选自Sc，Ti，V，Cr，Mn，Co，Ni，Cu或Zn的过渡金属。 T为四面体位点，I为八面体位点，δ为0-1，作为转化率。
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