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21.发明公开
公开(公告)号：KR1020120061017A
公开(公告)日：2012-06-12
申请号：KR1020100109052
申请日：2010-11-04
Applicant: 한국식품연구원
Abstract: PURPOSE: A pharmaceutical composition and health functional food containing thienylbutyl isothiocyanate are provided to inhibit adipocyte differentiation. CONSTITUTION: A pharmaceutical composition for preventing and treating obesity and lipid-related metabolic disorders contains 0.1-50 wt% of thienylbutyl isothiocyanate as an active ingredient. The composition is administered in 0.01-500 mg/kg. The composition is manufactured in the form of powder, granules, tablets, capsules, suspension, emulsion, syrup, oral administration, external use formulation, suppository, or sterilized injection solution. A health functional for preventing and relieving obesity and lipid-related metabolic diseases contains the thienyl butyl isothiocyanate as an active ingredient. The health functional food is manufactured in the form of capsules, tablets, granules, powder, or beverage.
Abstract translation: 目的：提供含有噻吩基丁基异硫氰酸酯的药物组合物和保健功能食品，以抑制脂肪细胞分化。 构成：用于预防和治疗肥胖症和与脂质有关的代谢紊乱的药物组合物含有0.1-50重量％的异硫氰酸噻吩基丁酯作为活性成分。 组合物以0.01-500mg / kg施用。 组合物以粉末，颗粒，片剂，胶囊，悬浮液，乳剂，糖浆，口服给药，外用制剂，栓剂或灭菌注射液的形式制造。 用于预防和减轻肥胖症和脂质相关代谢疾病的健康功能包含异硫氰酸噻吩基丁酯作为活性成分。 保健功能食品以胶囊，片剂，颗粒，粉末或饮料的形式制造。
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公开(公告)号：KR1020120017912A
公开(公告)日：2012-02-29
申请号：KR1020100080863
申请日：2010-08-20
Applicant: 한국식품연구원
Abstract: PURPOSE: A method for detecting a marker contained in a biological sample is provided to diagnose and treat obesity or obesity-associated diseases. CONSTITUTION: A method for detecting a marker contained in a biological sample for diagnosing obesity comprises a step of detecting the concentration of arginine, tyrosine, pipecolic acid, benzoic acid, pantothenic acid, uric acid, phenyl acetamide, serotonin, L-carnitine, decanoyl carnitine, myristoyl carnitine, hexadekenoyl carnitine, linoleyl carnitien, vacenyl carnitine, stearoyl carnitine, lysoPC(C14:0), lysoPC(C15:0), lysoPC(C16:0), lysoPC(C16:1), lysoPC(C17:0), lysoPC(C17:1), lysoPC(C18:0), lysoPC(C18:1), lysoPC(C18:2), lysoPC(C18:3), lysoPC(C19:0), lysoPC(C20:1), lysoPC(C20:4), lysoPC(C20:5), lysoPE(C18:2), lysoPE(C20:4) or PCs marker in blood or glucose, glycerol, tyrosine, valine, 7-ketodeoxy cholic acid, and betain, L-carnitine, plamitic acid, linoleic acid, oleic acid, stearic acid, lysoPC(C14:0), lysoPC(C16:0), lysoPC(C16:1), lysoPC(C18:0), lysoPC(C18:3), lysoPC(C20:4), lysoPC(C22:6), or PCs in liver tissue.
Abstract translation: 目的：提供一种用于检测生物样品中包含的标记物的方法，用于诊断和治疗肥胖或肥胖相关疾病。 构成：用于检测用于诊断肥胖的生物样品中所含的标记物的方法包括检测精氨酸，酪氨酸，哌可酸，苯甲酸，泛酸，尿酸，苯乙酰胺，5-羟色胺，L-肉毒碱，癸酰基 肉毒碱，肉豆蔻肉碱，六酰基肉碱，亚油酰肉碱，肉桂碱肉碱，硬脂酰肉碱，溶血糖（C14：0），溶血卵磷脂（C15：0），溶血卵磷脂（C16：0），溶血卵磷脂（C16： ），lysoPC（C17：1），lysoPC（C18：0），lysoPC（C18：1），lysoPC（C18：1），lysoPC（C18：2），lysoPC（C18：3） ，血液或葡萄糖，甘油，酪氨酸，缬氨酸，7-酮基脱氧胆酸和甜菜碱中的溶血卵磷脂（C20：4），溶血卵磷脂（C20：5），溶血蛋白（C18：2），溶血蛋白（C20：4） ，L-carnitine，plamitic acid，亚油酸，油酸，硬脂酸，lysoPC（C14：0），lysoPC（C16：0），lysoPC（C16：1），lysoPC（C18：0），lysoPC（C18：3 ），溶血卵磷脂（C20：4），溶血卵磷脂（C22：6）或肝组织中的PC。
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公开(公告)号：KR1020120003778A
公开(公告)日：2012-01-11
申请号：KR1020100064563
申请日：2010-07-05
Applicant: 한국식품연구원
CPC classification number: A61K36/66 , A61K2236/33 , Y10S514/909
Abstract: PURPOSE: A composition containing Chelidonium majus var asiaticum extract is provided to activate AMPK(5'AMP-activated protein kinase) and to ensure antiobesity. CONSTITUTION: A composition for preventing and treating obesity contains 0.1-99.9 wt% of Chelidonium majus var asiaticum extract as an active ingredient. The composition is a pharmaceutical composition or food additive composition. The food composition for preventing and treating obesity contains the extract as an active ingredient. The extract is a hot water extract or ethanol extract. The composition is manufactured in the form of beverage, gum, tea, vitamin complex, pill, powder, granule, tablet, or capsule.
Abstract translation: 目的：提供含有Chelidonium majus var asiaticum提取物的组合物以激活AMPK（5'AMP-活化的蛋白激酶）并确保抗肥胖。 构成：用于预防和治疗肥胖症的组合物含有0.1-99.9wt％的Chelidonium majus var asiaticum提取物作为活性成分。 该组合物是药物组合物或食品添加剂组合物。 用于预防和治疗肥胖症的食物组合物含有提取物作为活性成分。 提取物是热水提取物或乙醇提取物。 该组合物以饮料，口香糖，茶叶，维生素复合物，丸剂，粉末，颗粒，片剂或胶囊的形式制成。
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公开(公告)号：KR1020110136215A
公开(公告)日：2011-12-21
申请号：KR1020100056077
申请日：2010-06-14
Applicant: 한국식품연구원
CPC classification number: A61K31/52 , A23L33/10 , Y10S514/824 , Y10S514/866 , Y10S514/909
Abstract: PURPOSE: A composition containing 3-methyladenine is provided to decompose neutral lipid into glycerol and free fatty acid and to prevent or treat obesity, diabetes, and hyperlipidemia. CONSTITUTION: A pharmaceutical composition for preventing or treating obesity contains 3-methyladenien as an active ingredient. 3-methyladenine decomposes neutral lipid into glycerol and free fatty acid. A food composition for preventing or treating obesity contains 3-methyladenine as an active ingredient. The composition is used for preventing or treating obesity-associated metabolic diseases including diabetes, arteriosclerosis, metabolic diseases, and hyperlipidemia. The pharmaceutical composition is manufactured in the form of a liquid formulation or parenteral formulation.
Abstract translation: 目的：提供含有3-甲基腺嘌呤的组合物，以将中性脂质分解为甘油和游离脂肪酸，并预防或治疗肥胖，糖尿病和高脂血症。 构成：用于预防或治疗肥胖症的药物组合物含有3-甲基腺嘌呤作为活性成分。 3-甲基腺嘌呤将中性脂质分解成甘油和游离脂肪酸。 用于预防或治疗肥胖症的食物组合物含有3-甲基腺嘌呤作为活性成分。 该组合物用于预防或治疗肥胖相关代谢疾病，包括糖尿病，动脉硬化，代谢疾病和高脂血症。 药物组合物以液体制剂或肠胃外制剂的形式制备。
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公开(公告)号：KR101089314B1
公开(公告)日：2011-12-02
申请号：KR1020100053436
申请日：2010-06-07
Applicant: 한국식품연구원
CPC classification number: A61K31/56 , A23L33/11 , A61K36/47 , Y10S514/824 , Y10S514/866 , Y10S514/909
Abstract: PURPOSE: A composition containing euphobiasteroid is provided to effectively suppress the differentiation of induced adipocytes and to prevent or treat obesity. CONSTITUTION: A pharmaceutical composition for preventing or treating obesity contains euphobiasteroid as an active ingredient. A food composition for preventing or treating obesity contains euphobiasteroid as an active ingredient. Euphobiasteroid is isolated from Euphorbiae Lathyridis semen using a solvent. The solvent is water, anhydrous or hydrous low alcohol of 1-4 carbon atoms(methanol, ethano, propanol, butanol), mixture solvent of low alcohol and water, acetone, ethyl acetate, chloroform, or 1,3-butylene glycol.
Abstract translation: 目的：提供含有对虾脂肪的组合物，以有效抑制诱导的脂肪细胞的分化和预防或治疗肥胖。 构成：用于预防或治疗肥胖症的药物组合物含有作为活性成分的兴奋石甾醇。 用于预防或治疗肥胖症的食物组合物含有作为活性成分的兴奋石甾醇。 使用溶剂从Euphorbiae Lathyridis精液中分离出Euphobiasteroid。 溶剂为1-4碳原子的水，无水或含水低级醇（甲醇，乙醇，丙醇，丁醇），低级醇和水的混合溶剂，丙酮，乙酸乙酯，氯仿或1,3-丁二醇。
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Patent Agency Ranking26.发明授权
公开(公告)号：KR101371354B1
公开(公告)日：2014-03-10
申请号：KR1020120021491
申请日：2012-02-29
Applicant: 한국식품연구원
IPC: A61K31/4745 , A61K31/475 , A61P3/04 , A61P3/00
Abstract: 본 발명은 10-히드록시캄토테신(10-Hydroxycamptothecin)을 유효성분으로 함유하는 비만 또는 지질 관련 대사성 질환의 예방 및 치료용 약학적 조성물과 건강기능식품에 관한 것으로 본 발명에 따른 10-히드록시캄토테신은 지방세포분화 저해 효과가 우수하므로, 이를 유효성분으로 함유하는 비만 또는 지질 관련 대사성 질환의 예방 및 치료용 약학적 조성물과 건강기능식품으로 사용할 수 있다.
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公开(公告)号：KR101368383B1
公开(公告)日：2014-03-03
申请号：KR1020120021490
申请日：2012-02-29
Applicant: 한국식품연구원
IPC: A61K31/122 , A61K9/16 , A61K9/20 , A61P3/04
Abstract: 본 발명은 데옥시시코닌을 유효성분으로 함유하는 비만 또는 지질 관련 대사성 질환의 예방 및 치료용 약학적 조성물과 건강기능식품에 관한 것으로 본 발명에 따른 데옥시시코닌은 지방세포분화 저해 효과가 우수하므로, 이를 유효성분으로 함유하는 비만 또는 지질 관련 대사성 질환의 예방 및 치료용 약학적 조성물과 건강기능식품으로 사용할 수 있다.
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28.发明公开
公开(公告)号：KR1020130099755A
公开(公告)日：2013-09-06
申请号：KR1020120021491
申请日：2012-02-29
Applicant: 한국식품연구원
IPC: A61K31/4745 , A61K31/475 , A61P3/04 , A61P3/00
CPC classification number: A61K31/437 , A23L33/10 , A61K9/0053 , A61K31/407 , A61K31/436 , C07D491/147 , Y10S514/909
Abstract: PURPOSE: A composition containing 10-hydroxycamptothecin for preventing and treating obesity or lipid-related metabolic diseases is provided to effectively suppress adipocyte differentiation. CONSTITUTION: A pharmaceutical composition for preventing and treating obesity or lipid-related metabolic diseases contains 10-hydroxycamptothecin as an active ingredient. The metabolic diseases are selected among diabetes, hyperlipidemia, fatty liver, arteriosclerosis, hypertension, cardiovascular diseases, and metabolic syndrome. Deoxyshikonin and 10-hydroxycamptothecin suppress adipocyte differentiation. A health food for preventing obesity or lipid-related metabolic diseases and alleviating symptoms thereof contains 10-hydroxycamptothecin as an active ingredient. [Reference numerals] (AA) Neutral lipid (absorbance); (BB) Normal; (CC) Control group; (DD) 10-hydroxycamptothecin
Abstract translation: 目的：提供含有10-羟基喜树碱的预防和治疗肥胖症或脂质代谢疾病的组合物，有效抑制脂肪细胞分化。 构成：用于预防和治疗肥胖或脂质相关代谢疾病的药物组合物含有10-羟基喜树碱作为活性成分。 代谢疾病选自糖尿病，高脂血症，脂肪肝，动脉硬化，高血压，心血管疾病和代谢综合征。 去氧喜树碱和10-羟基喜树碱抑制脂肪细胞分化。 用于预防肥胖或与脂质有关的代谢性疾病并减轻其症状的保健食品含有10-羟基喜树碱作为活性成分。 （AA）中性脂质（吸光度）; （BB）正常; （CC）对照组; （DD）10-羟基喜树碱
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29.发明授权
公开(公告)号：KR101235673B1
公开(公告)日：2013-02-21
申请号：KR1020100109052
申请日：2010-11-04
Applicant: 한국식품연구원
Abstract: 본 발명은 티에닐부틸 이소티오시아네이트를 유효성분으로 함유하는 비만 및 지질 관련 대사성 질환의 예방 및 치료용 약학적 조성물과 건강기능식품에 관한 것이다. 상기 조성물 또는 건강기능식품은 지방세포분화 저해 효능이 우수하다.
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公开(公告)号：KR101235662B1
公开(公告)日：2013-02-21
申请号：KR1020100109712
申请日：2010-11-05
Applicant: 한국식품연구원
Abstract: 본 발명은 벤질이소티오시아네이트를 유효성분으로 함유하는 비만 및 지질 관련 대사성 질환의 예방 및 치료용 약학적 조성물과 건강기능식품에 관한 것이다. 상기 조성물 또는 건강기능식품은 지방세포분화 저해 효능이 우수하다.
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