요소 분해 효소를 고정화시키는 NiO 나노 입자를 고밀도로 담지시킨 바이오 센서 및 그 제조방법
    22.
    发明公开
    요소 분해 효소를 고정화시키는 NiO 나노 입자를 고밀도로 담지시킨 바이오 센서 및 그 제조방법 审中-实审
    具有高密度支持NIO纳米粒子以进行固定化的生物传感器及其制造方法

    公开(公告)号:KR1020150092474A

    公开(公告)日:2015-08-13

    申请号:KR1020140012893

    申请日:2014-02-05

    Abstract: 본 발명은 요소 분해 능력을 개선시킨 바이오 센서의 제조방법에 관한 것으로, 상기 방법은 기판 상에 금속산화물 나노 막대를 형성하는 단계; 상기 금속산화물 나노 막대 상에 NiO 나노 입자를 부착하는 단계; 및 상기 NiO 나노 입자 상에 요소 분해 효소를 고정시키는 단계를 포함하며, 이와 같은 방법을 통해 요소분해효소를 고정화하는 NiO 나노입자를 편평한 2차원 표면보다는 3차원 구조를 가지는 금속산화물 나노막대 표면에 고정시킴으로써 단위면적 또는 단위부피 당 고정되는 요소분해효소의 양을 증가시켜 요소분해능력을 개선시킬 수 있다.

    Abstract translation: 本发明涉及提高尿素酶能力的生物传感器的制造方法。 该方法包括以下步骤:在基底上形成金属氧化物纳米棒; 将NiO纳米颗粒附着在金属氧化物纳米棒上; 并将脲酶固定在NiO纳米颗粒上。 通过将通过该方法将脲酶固定在具有三维结构而不是平面二维表面的金属氧化物纳米棒的表面上的NiO纳米颗粒固定化,可以通过增加固定脲酶的量来提高脲酶能力 单位面积或单位体积。

    전극 어레이
    23.
    发明公开
    전극 어레이 无效
    电极阵列

    公开(公告)号:KR1020140042353A

    公开(公告)日:2014-04-07

    申请号:KR1020120109029

    申请日:2012-09-28

    Abstract: An electrode array according to an embodiment of the present invention comprises: a first electrode on a substrate; a second electrode arranged on the first electrode, and having the upper side and the lower side opposed to each other; an electrode supporter coming in contact with the second electrode and having an inner surface and an outer surface perpendicular to the substrate; and a third electrode coming in contact with the upper side of the second electrode and the inner surface of the electrode supporter. The electrode array of the present invention has an improved impedance performance, and an improved interface between a biological tissue and the electrode.

    Abstract translation: 根据本发明实施例的电极阵列包括:基板上的第一电极; 布置在所述第一电极上并具有彼此相对的上侧和下侧的第二电极; 与第二电极接触并且具有垂直于衬底的内表面和外表面的电极支撑件; 以及与第二电极的上侧和电极支撑体的内表面接触的第三电极。 本发明的电极阵列具有改善的阻抗性能,以及生物组织和电极之间改进的界面。

    산화아연 나노선을 이용한 신경 전극 어레이의 표면처리방법.
    24.
    发明公开
    산화아연 나노선을 이용한 신경 전극 어레이의 표면처리방법. 无效
    使用ZNO NANOWIRE的神经电极阵列的表面处理方法

    公开(公告)号:KR1020130063777A

    公开(公告)日:2013-06-17

    申请号:KR1020110130324

    申请日:2011-12-07

    CPC classification number: A61B5/0478 B82B3/009 B82Y5/00 G03F7/20

    Abstract: PURPOSE: A surface treatment method for a neural electrode array using a zinc oxide nanowire is provided to allow the array to have surface roughness using the nanowire and to form a neuron adhesion material on the nanowire, thereby stably growing a neuron on the front surface of the array. CONSTITUTION: A surface treatment method for a neural electrode array(10) using a zinc oxide nanowire(31) includes the following steps: a step of preparing the array; a step of forming a metal seed layer on the array; a step of etching the metal seed layer; a step of growing the nanowire on the metal seed layer which is not removed in the previous step of etching; and a step of forming a neuron adhesion material(41) on the nanowire.

    Abstract translation: 目的:提供使用氧化锌纳米线的神经电极阵列的表面处理方法,以使阵列具有使用纳米线的表面粗糙度,并在纳米线上形成神经元粘附材料,从而稳定地生长在前表面上的神经元 阵列。 构成:使用氧化锌纳米线(31)的神经电极阵列(10)的表面处理方法包括以下步骤:准备阵列的步骤; 在阵列上形成金属种子层的步骤; 蚀刻金属种子层的步骤; 在前面的蚀刻步骤中在金属种子层上生长纳米线的步骤,其不被去除; 以及在纳米线上形成神经元粘附材料(41)的步骤。

    산화티타늄 막의 제조방법 및 이러한 방법에 의해 제조된 산화티타늄 막을 포함하는 신경 전극
    25.
    发明公开
    산화티타늄 막의 제조방법 및 이러한 방법에 의해 제조된 산화티타늄 막을 포함하는 신경 전극 无效
    制造氧化钛薄膜的方法和包括用该方法制造的氧化钛薄膜的神经电极

    公开(公告)号:KR1020120067087A

    公开(公告)日:2012-06-25

    申请号:KR1020100128514

    申请日:2010-12-15

    Abstract: PURPOSE: A method of manufacturing a titanium oxide film and a neural electrode including the titanium oxide film manufactured by the method are provided to produce a hierarchy structure where a micro structure and a nano structure simultaneously exist by surface-reforming a titanium oxide pattern to a nanoporous structure with an alkaline hydrothermal reaction. CONSTITUTION: A titanium oxide sol layer is formed by applying titanium oxide sol onto a substrate. A patterned titanium oxide gel layer is formed by heating the titanium oxide sol layer. The titanium oxide film having nano sized pores is formed by letting the patterned titanium oxide gel layer have hydrothermal reaction.

    Abstract translation: 目的:提供一种制造氧化钛膜的方法和包括通过该方法制造的氧化钛膜的神经电极,以通过将氧化钛图案表面重整形成为同时存在微结构和纳米结构的层次结构 纳米孔结构与碱性水热反应。 构成:通过将氧化钛溶胶施加到基材上形成氧化钛溶胶层。 通过加热氧化钛溶胶层形成图案化的氧化钛凝胶层。 通过使图案化氧化钛凝胶层具有水热反应形成具有纳米尺寸孔的氧化钛膜。

    산화아연 나노선의 패턴화된 성장 방법
    27.
    发明公开
    산화아연 나노선의 패턴화된 성장 방법 无效
    ZNO NANOWIRE的图形生长方法

    公开(公告)号:KR1020130066268A

    公开(公告)日:2013-06-20

    申请号:KR1020110133023

    申请日:2011-12-12

    Abstract: PURPOSE: A method for patterned growth of zinc oxide nanowires is provided to continuously implement a photoresist developing step and a zinc oxide seed layer etching step by using a tetramethyl ammonium hydroxide aqueous solution. CONSTITUTION: A method for patterned growth of zinc oxide nanowires includes the following steps: a zinc oxide seed layer(20) is formed on a substrate(10); a photoresist layer(30) is formed on the seed layer; the photoresist layer is patterned; the seed layer is etched and patterned by using the patterned photoresist layer; the photoresist layer is removed from the seed layer; and zinc oxide nanowires are grown on the seed layer. The patterning and etching steps are continuously implemented using tetramethyl ammonium hydroxide aqueous solution. The concentration of the tetramethyl ammonium hydroxide aqueous solution is 1-3%.

    Abstract translation: 目的:提供一种用于氧化锌纳米线图案生长的方法,通过使用四甲基氢氧化铵水溶液连续实施光致抗蚀剂显影步骤和氧化锌种子层蚀刻步骤。 构成:氧化锌纳米线图案生长的方法包括以下步骤:在衬底(10)上形成氧化锌种子层(20); 在种子层上形成光致抗蚀剂层(30) 光致抗蚀剂层被图案化; 通过使用图案化的光致抗蚀剂层来蚀刻和图案化晶种层; 从种子层除去光致抗蚀剂层; 并且在种子层上生长氧化锌纳米线。 图案化和蚀刻步骤使用四甲基氢氧化铵水溶液连续实施。 四甲基氢氧化铵水溶液的浓度为1-3%。

    신경신호 측정용 칩의 미세패턴 형성방법.
    28.
    发明公开
    신경신호 측정용 칩의 미세패턴 형성방법. 无效
    获取神经信号芯片的微型方法

    公开(公告)号:KR1020130065272A

    公开(公告)日:2013-06-19

    申请号:KR1020110132059

    申请日:2011-12-09

    Abstract: PURPOSE: A method for forming micro patterns of a neuronal signal measurement chip is provided to form the micro pattern with a desired shape and size without using a photo initiator, by forming the micro patterns of the neuronal signal measurement chip by using a photo cross linking polymer. CONSTITUTION: A substrate (10) is prepared, and surface treatment is performed with 70W plasma under Ar/N2 atmosphere for 10 minutes to form OH functional group. A bio-affinity polymer (12) of 50% is diluted to 2% density with ethanol, and the substrate where the OH functional group is formed is put into the diluted solution for 12 hours at room temperature for chemical bonding. The substrate which is chemically bonded to the bio-affinity polymer is cleaned with ethanol and is thermally-treated at 120°C for 10 minutes and then is cleaned with ultrasonic waves for 5 minutes to remove the bio-affinity polymer not bonded to the surface of the substrate. The cleaned substrate is cleaned with ethanol again and is dried with nitrogen.

    Abstract translation: 目的:提供一种形成神经元信号测量芯片的微图案的方法,通过使用光交联形成神经信号测量芯片的微图案,从而形成具有所需形状和尺寸的微图案,而不使用光引发剂 聚合物。 构成:制备基板(10),在Ar / N 2气氛下用70W等离子体进行表面处理10分钟,形成OH官能团。 将50%的生物亲和聚合物(12)用乙醇稀释至2%密度,将形成有OH官能团的基质在室温下放入稀释溶液中12小时进行化学键合。 化学键合到生物亲和聚合物上的基质用乙醇清洗,并在120℃下热处理10分钟,然后用超声波清洗5分钟以除去未结合到表面的生物亲和聚合物 的基底。 再次用乙醇清洗清洁的基材并用氮气干燥。

    전극 지지체 제조방법
    29.
    发明公开
    전극 지지체 제조방법 无效
    电极支撑的制造方法

    公开(公告)号:KR1020120133918A

    公开(公告)日:2012-12-11

    申请号:KR1020110052840

    申请日:2011-06-01

    Abstract: PURPOSE: A fabrication method of an electrode support is provided to improve adhesion with a substrate and mechanical strength of an electrode support. CONSTITUTION: A fabrication method of an electrode support comprises: a step of forming a first insulating film(30) on a conductive substrate; a step of forming an adhered film(51) on a first insulating film; a step of forming a second insulating film on the adhered film; a step of patterning the second insulating film and the adhered film; a step of patterning the second insulating film and adhered film; a step of forming a tube-type electrode support(71) on the first insulating film; and a step of heat-treating a substrate which comprises an electrode support.

    Abstract translation: 目的:提供电极支撑件的制造方法,以改善与基底的粘附和电极支撑件的机械强度。 构成:电极支撑体的制造方法包括:在导电性基板上形成第一绝缘膜(30)的工序; 在第一绝缘膜上形成粘附膜(51)的步骤; 在粘附膜上形成第二绝缘膜的步骤; 图案化第二绝缘膜和粘附膜的步骤; 图案化第二绝缘膜和粘附膜的步骤; 在所述第一绝缘膜上形成管型电极支撑件(71)的步骤; 以及对包括电极支撑体的基板进行热处理的步骤。

    RF기반 선택적 기능성 생체 이식형 뇌자극 전극 및 그 제작 방법
    30.
    发明授权
    RF기반 선택적 기능성 생체 이식형 뇌자극 전극 및 그 제작 방법 失效
    基于RF刺激的可寻址植入式功能性脑电极及其制造方法

    公开(公告)号:KR101073431B1

    公开(公告)日:2011-10-17

    申请号:KR1020080124133

    申请日:2008-12-08

    CPC classification number: A61N1/0534

    Abstract: 본발명은 RF기반선택적기능성생체이식형뇌자극전극및 그제작방법에관한것으로, 본발명의실시예에따른 RF기반선택적기능성생체이식형뇌자극전극은나노구조물로이루어진전극팁(tip); 전극팁의나노구조물을지지해주고전원을전달하는지지부; 전극팁(Tip)에전원을전달하도록전극팁및 지지부에피복된투명전도막및 지지부를외부환경에대해서절연되도록피복된절연보호막중 하나이상을포함하는코팅부; 및지지부를통해전극팁으로외부에서무선으로공급되는전원및 무선신호의주파수에따라자극을선택적으로분류하여전달하는전원부를포함하는것을특징으로한다.

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