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公开(公告)号：KR1019910005417B1
公开(公告)日：1991-07-29
申请号：KR1019890011419
申请日：1989-08-10
Applicant: 한국화학연구원
IPC: C07D285/34
Abstract: A process for preparing 1,3,5-thiadiazin-4-one derivs. of formula (I) comprises a cyclization of S-(N- alkoxycarbonyl-N-substd.)-aminomethyl isothiourea derivs. of formula (II) in the presence of an organic or inorganic base at 0-150 deg.C. In the formulas, R1,R2,R3,R4,R5 and R6 each= alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, alkoxyalkyl, cycloalkyl, cycloalkenyl, aryl, subtd. aryl, aralkyl, naphthyl, pyridyl, etc.
Abstract translation: 制备1,3,5-噻二嗪-4-酮衍生物的方法。 式（I）的化合物包括S-（N-烷氧基羰基-N-取代的） - 氨基甲基异硫脲衍生物的环化。 在有机或无机碱的存在下在0-150℃下进行。 在式中，R 1，R 2，R 3，R 4，R 5和R 6各自为烷基，烯基，炔基，卤代烷基，卤代烯基，卤代炔基，烷氧基烷基，环烷基，环烯基，芳基。 芳基，芳烷基，萘基，吡啶基等
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公开(公告)号：KR1020090024394A
公开(公告)日：2009-03-09
申请号：KR1020070089389
申请日：2007-09-04
Applicant: 한국화학연구원
CPC classification number: A01N37/52 , A01N41/12 , C07C257/12 , C07C381/06
Abstract: A derivative from fluorine-containing phenyl formamidine is provided to secure excellent insecticidal activity for prevention the breeding and extermination of harmful insects while maintaining useful plants. A derivative from fluorine-containing phenyl formamidine is represented by the formula I. In the formula 1, F is fluorine; X indicates a hydrogen atom, cyano, amino, carbo C1-C2 alkoxy, C1-C2 alkylcarbamoyl, C1-C4 alkyl or an alkoxy group; R1 shows a hydrogen atom or a C1-C4 alkyl group; Y is a C1-C8 alkyl or a dialkyl aminosulphenyl group; and n is 1,2,3 or 4. If the Y is the dialkyl aminosulphenyl group, the derivative from fluorine-containing phenyl formamidine is represented by the formula II.
Abstract translation: 提供含氟苯基甲脒的衍生物，以确保优异的杀虫活性，以防止有害昆虫的繁殖和灭绝，同时保持有用的植物。 含氟苯甲酰胺的衍生物由式I表示。在式1中，F为氟; X表示氢原子，氰基，氨基，碳C1-C2烷氧基，C1-C2烷基氨基甲酰基，C1-C4烷基或烷氧基; R1表示氢原子或C1-C4烷基; Y是C1-C8烷基或二烷基氨基磺酰基; 并且n为1,2,3或4.如果Y为二烷基氨基磺苯基，则含氟苯基甲脒的衍生物由式II表示。
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公开(公告)号：KR100750288B1
公开(公告)日：2007-08-20
申请号：KR1020060030662
申请日：2006-04-04
Applicant: 한국화학연구원 , 주식회사 디비하이텍
Abstract: Tetrahydro thiadiazolo pyridazinone derivatives having herbicidal activity are provided to control gramineous weeds and broad-leaved weeds without harmful effects on useful crops such as corn and wheat, so that the compounds are useful as nonselective herbicide used in an orchard. The Tetrahydro thiadiazolo pyridazinone derivatives represented by the formula(1) are provided, wherein X is halogen atom or cyano group; Y is oxygen or sulfur; R is hydrogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C2-C6 alkoxyalkyl group, C1-C6 hydroxyalkyl group, C2-C6 alkenyl group or C2-C6 alkynyl group; R1 is C1-C6 alkyl group, C1-C6 haloalkyl group, C2-C6 alkenyl group, C2-C6 alkynyl group, phenyl group or benzyl group; and the benzene ring of the phenyl group or benzyl group is optionally substituted by hydrogen atom, C1-C6 alkyl group, C1-C6 alkoxy group, C1-C6 haloalkyl group, C2-C4 alkenyl group or C2-C4 alkynyl group.
Abstract translation: 提供具有除草活性的四氢噻二唑并哒嗪酮衍生物以控制禾本科杂草和阔叶杂草，而对有用作物如玉米和小麦没有有害作用，从而使得该化合物可用作果园中使用的非选择性除草剂。 提供由式（1）表示的四氢噻二唑并哒嗪酮衍生物，其中X是卤素原子或氰基; Y是氧或硫; R为氢原子，C1-C6烷基，C1-C6卤代烷基，C2-C6烷氧基烷基，C1-C6羟烷基，C2-C6烯基或C2-C6炔基; R 1为C 1 -C 6烷基，C 1 -C 6卤代烷基，C 2 -C 6烯基，C 2 -C 6炔基，苯基或苄基; 并且苯基或苄基的苯环任选被氢原子，C1-C6烷基，C1-C6烷氧基，C1-C6卤代烷基，C2-C4链烯基或C2-C4炔基取代。
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公开(公告)号：KR100685473B1
公开(公告)日：2007-02-26
申请号：KR1020050118376
申请日：2005-12-06
Applicant: 한국화학연구원 , 주식회사 디비하이텍
Abstract: Hydantoin-based derivatives having herbicidal activity are provided to selectively control weeds without harmful effects to useful crops such as corn, and prevent environmental pollution by reducing the use amount of herbicides. The hydantoin-based derivatives having herbicidal activity, represented by the formula(1) are provided, wherein n is an integer from 0 to 3; R1 is hydrogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C2-C6 alkoxyalkyl group, C1-C6 hydroxyalkyl group, C2-C6 alkenyl group or C2-C6 alkynyl group; R2 is hydrogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C2-C6 alkenyl group or C2-C6 alkynyl group; and X is hydrogen atom, halogen atom, cyano group, hydroxyl group, C1-C4 alkyl group, C1-C4 alkoxy group, C2-C4 alkenyl group, C2-C4 alkynyl group, C2-C4 alkoxyalkyl group or C1-C4 hydroxyalkyl group. The hydantoin-based derivatives having herbicidal activity, represented by the formula(1) are prepared by halogenization of hydantoin carboxylic acid represented by the formula(2) to prepare compounds represented by the formula(4), and reacting the compounds represented by the formula(4) with compounds represented by the formula(3). A herbicidal composition comprises the hydantoin-based derivatives having herbicidal activity, represented by the formula(1).
Abstract translation: 提供具有除草活性的乙内酰脲类衍生物以选择性地控制杂草，而不会对有用作物例如玉米产生有害影响，并且通过减少除草剂的使用量来防止环境污染。 提供了由式（1）表示的具有除草活性的乙内酰脲类衍生物，其中n是0-3的整数; R1为氢原子，C1-C6烷基，C1-C6卤代烷基，C2-C6烷氧基烷基，C1-C6羟烷基，C2-C6烯基或C2-C6炔基; R 2为氢原子，C 1 -C 6烷基，C 1 -C 6卤代烷基，C 2 -C 6烯基或C 2 -C 6炔基; X为氢原子，卤原子，氰基，羟基，C1-C4烷基，C1-C4烷氧基，C2-C4烯基，C2-C4炔基，C2-C4烷氧基烷基或C1-C4羟烷基 。 由式（1）表示的具有除草活性的乙内酰脲类衍生物是通过将式（2）表示的乙内酰脲羧酸卤化以制备式（4）表示的化合物，然后使式 （4）所示的化合物与式（3）所示的化合物反应。 除草组合物包含由式（1）表示的具有除草活性的乙内酰脲衍生物。
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公开(公告)号：KR100597259B1
公开(公告)日：2006-07-06
申请号：KR1020040047240
申请日：2004-06-23
Applicant: 한국화학연구원
IPC: C07C67/40 , C07C69/736
CPC classification number: C07C309/73 , C07B2200/07 , C07C67/11 , C07C69/712 , C07C69/78
Abstract: 본 발명은 광학활성 (
R )-2-페녹시프로피온산 유도체의 제조방법에 관한 것으로서, 더욱 상세하게는
p- 치환된 페놀 유도체와 알킬 (
S )-2-아릴술포닐옥시프로피오네이트를 반응 원료물질로 사용하고, 이를 알칼리금속염 염기와 탄화수소 용매 존재 하에서 60 ∼ 100 ℃ 온도로 반응시켜 다음 화학식 1로 표시되는 광학활성 (
R )-2-페녹시프로피온산 유도체를 고순도로 제조하는 방법에 관한 것이다.
상기 화학식 1에서, A는 벤조일옥시(BzO)기, 아세톡시(AcO)기,
p- 톨루엔술포닐옥시(
p- TsO)기, 또는 C
1 -C
6 의 지방족 아실기를 나타내고; R은 C
1 -C
6 의 알킬기를 나타낸다.
광학활성, p-(p-톨루엔술포닐옥시)페놀, p-아실페놀, p-벤조일옥시페놀, p-아세톡시페놀, 알킬 (S)-2-(p-톨루엔술포닐옥시)프로피오네이트, (R)-2-(p-아세틸페녹시)프로피온산(에스터), (R)-2-(p-아세틸옥시페녹시)프로피온산(에스터), (R)-2-(p-하이드록시페녹시)프로피온산(에스터)-
Patent Agency Ranking
公开(公告)号：KR100531119B1
公开(公告)日：2005-11-28
申请号：KR1020030044300
申请日：2003-07-01
Applicant: 한국화학연구원
IPC: C07D263/58
Abstract: 본 발명은 2-머캅토벤즈아졸 유도체의 개선된 제조방법에 관한 것으로서, 보다 상세하게는 2-아미노페놀 유도체 또는 1,2-페닐렌디아민 유도체를 원료물질로 사용하여 유황(S
8 ) 및 디클로로메탄과의 고리화 반응을 수행함에 있어, 상기한 고리화 반응을 알칼리금속의 무기염기, 특정 촉매 및 알콜용매를 사용하는 최적의 조건하에서 수행하여 고수율 및 고순도로 다음 화학식 1로 표시되는 2-머캅토벤즈아졸 유도체를 제조하는 방법에 관한 것이다.
상기 화학식 1에서, X는 O 또는 NH를 나타내며, R은 할로겐원자, 니트로기, 니트릴기, C
1-6 알킬기 또는 C
1-6 알콕시기를 나타낸다.-
公开(公告)号：KR1020050005276A
公开(公告)日：2005-01-13
申请号：KR1020030044300
申请日：2003-07-01
Applicant: 한국화학연구원
IPC: C07D263/58
Abstract: PURPOSE: A method for preparing 2-Mercaptobenzazole derivatives is provided, thereby improving the purity and yield of 2-Mercaptobenzazole derivatives by limiting the reaction condition. CONSTITUTION: The method for preparing 2-Mercaptobenzazole derivatives represented by formula (1) comprises cyclization of 2-aminophenol derivatives or 1,2-phenylenediamine derivatives of formula (2) using sulfur(S8) and dichloromethane(CH2Cl2) in the presence of a catalyst selected from an inorganic base of alkali metal, quaternary ammonium salt and alkali metal salt iodide in alcohol solvent at 60 to 100 deg. C, wherein X is O or NH; and R is halogen atom, nitro, nitrile, C1-6 alkyl or C1-6 alkoxy, wherein the alkali metal base is potassium carbonate; and the alcohol solvent is isopropanol solvent.
Abstract translation: 目的：提供2-巯基吲唑衍生物的制备方法，通过限制反应条件提高2-巯基吲唑衍生物的纯度和产率。 构成：由式（1）表示的2-巯基吲唑衍生物的制备方法包括使用硫（S8）和二氯甲烷（CH 2 Cl 2）在存在下使式（2）的2-氨基苯酚衍生物或式（2）的1,2-苯二胺衍生物 催化剂选自碱金属的无机碱，季铵盐和碱金属盐碘化物，在醇溶剂中，在60-100℃。 C，其中X是O或NH; 并且R是卤素原子，硝基，腈，C 1-6烷基或C 1-6烷氧基，其中碱金属碱是碳酸钾; 醇溶剂为异丙醇溶剂。
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公开(公告)号：KR1020040091318A
公开(公告)日：2004-10-28
申请号：KR1020030025121
申请日：2003-04-21
Applicant: 한국화학연구원
IPC: C07D263/58
Abstract: PURPOSE: A manufacturing process of 6-chlorobenzoxazol-2-one is provided, thereby improving purity of 6-chlorobenzoxazol-2-one and manufacturing yield. CONSTITUTION: The manufacturing process of 6-chlorobenzoxazol-2-one comprises reacting benzoxazol-2-one with chlorine gas(Cl2) in protic organic solvent at -70 to 20 deg. C, preferably -20 to -5 deg. C, wherein the protic organic solvent is selected from methanol, ethanol, formic acid and acetic acid, preferably methanol.
Abstract translation: 目的：提供6-氯苯并恶唑-2-酮的制备方法，从而提高6-氯苯并恶唑-2-酮的纯度和制备产率。 构成：6-氯苯并恶唑-2-酮的制备方法包括在-70至20℃下将苯并恶唑-2-酮与质子有机溶剂中的氯气（Cl2）反应。 优选-20至-5℃。 其中质子有机溶剂选自甲醇，乙醇，甲酸和乙酸，优选甲醇。
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公开(公告)号：KR1020040002510A
公开(公告)日：2004-01-07
申请号：KR1020030028254
申请日：2003-05-02
Applicant: 한국화학연구원
IPC: C07D263/58
CPC classification number: C07D213/643 , C07B2200/07 , C07C67/31 , C07C253/30 , C07D241/44 , C07D263/58 , C07C69/712 , C07C255/55
Abstract: PURPOSE: Provided is a process for manufacturing (R)-aryloxypropionic acid ester derivatives using substituted phenol derivative and (S)-alkyl O-arylsulfonyl lactate. CONSTITUTION: A process for manufacturing (R)-aryloxypropionic acid ester derivatives of the formula(1) is characterized by reacting a phenol derivative of the formula(2) and (S)-alkyl O-arylsulfonyl lactate of the formula(3) in the presence of alkali metal carbonate, using aliphatic or aromatic hydrocarbon at 60-100 deg.C.
Abstract translation: 目的：提供使用取代的苯酚衍生物和（S） - 烷基O-芳基磺酰基乳酸盐制备（R） - 丙氧基丙酸酯衍生物的方法。 构成：式（1）的（R） - 芳氧基丙酸酯衍生物的制备方法的特征在于使式（2）的苯酚衍生物与（S） - 式（3）的O-芳基磺酰基烷基烷基酯在 在60-100℃下使用脂族或芳族烃的碱金属碳酸盐的存在。
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公开(公告)号：KR1020000026668A
公开(公告)日：2000-05-15
申请号：KR1019980044313
申请日：1998-10-22
Applicant: 한국화학연구원
Abstract: PURPOSE: 2-phenyl alkanoic acid are prepared from 5,6-dihydro-2(4H)-benzofuranone in the presence of organic acid metal salt catalyst. CONSTITUTION: 5,6-Dihydro-2(4H)-benzofuranone of formula 2(R1 is H, C1-C6 alkyl, phenyl, benzoyl, phenoxy, furoyl or thenoyl; R2 is H, C1-C6 alkyl or phenyl; R3 is H, C1-C6 alkyl, phenyl, pyridyl, naphthyl or thiophenyl group) is reacted at 150-250°C in the presence of 0.01-5 equivalent weight of organic metal salt such as R-CO2M(R is H, C1-C13 alkyl, C1-C13 alkene, C1-C13 alkyne, C1-C13 alkoxyalkyl, C3-C6 cycloalkyl or A-(CH2)n; A is aryl group such as phenyl, naphthyl, pyridyl, quinolyl and thiophenyl group; n= 0-4; Mis alkali metal atom or under the structure) to give 2-phenyl alkanoic acid of formula 1.
Abstract translation: 目的：在有机酸金属盐催化剂存在下，从5,6-二氢-2（4H） - 苯并呋喃酮制备2-苯基链烷酸。 构成：式2的5,6-二氢-2（4H） - 苯并呋喃酮（R 1是H，C 1 -C 6烷基，苯基，苯甲酰基，苯氧基，糠基或后酰基; R 2是H，C 1 -C 6烷基或苯基; R 3是 H，C 1 -C 6烷基，苯基，吡啶基，萘基或噻吩基）在0.01-5当量有机金属盐如R-CO 2 M（R为H，C 1 -C 13）的存在下，在150-250℃下反应 烷基，C1-C13烯烃，C1-C13炔烃，C1-C13烷氧基烷基，C3-C6环烷基或A-（CH2）n; A是芳基如苯基，萘基，吡啶基，喹啉基和噻吩基; n = 4;错碱金属原子或结构下），得到式1的2-苯基链烷酸。
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