公开(公告)号：DE3686116T2

公开(公告)日：1993-01-28

申请号：DE3686116

申请日：1986-10-03

Applicant: ABBOTT LAB

Inventor： BROWN III WILLIAM E ,  DEVEREAUX SHARON M ,  KNIGGE KEVIN M ,  CLEMENS JOHN M ,  HOFLER JOHN G ,  SAFFORD SARAH E

IPC: G01N33/548 ,  G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/546 ,  G01N33/569 ,  G01N33/576 ,  G01N33/76

Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens or antibodies, is disclosed. The material comprises a porous matrix of fibers and a plurality of substantially spherical, solid particles having an average diameter of from about 0.1 to about 5 microns. The particles are retained and immobilized upon the fibers of the matrix. Preferably, the particles have on their surfaces a substance capable of reaction with the analyte in the sample, and the average diameter of the particles is less than the average pore size of the matrix. The device, in a preferred embodiment, comprises a substantially planar layer of the described material.

公开(公告)号：AT83325T

公开(公告)日：1992-12-15

申请号：AT90109680

申请日：1990-05-22

Applicant: ABBOTT LAB

Inventor： BROWN WILLIAM E III ,  DEVEREAUX SHARON M ,  KNIGGE KEVIN M ,  CLEMENS JOHN M ,  HOFLER JOHN G ,  SAFFORD SARAH E

IPC: G01N33/548 ,  G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/546 ,  G01N33/569 ,  G01N33/576 ,  G01N33/76

Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens or antibodies, is disclosed. The material comprises a porous matrix of fibers and a plurality of substantially spherical, solid particles having an average diameter of from about 0.1 to about 5 microns. The particles are retained and immobilized upon the fibers of the matrix. Preferably, the particles have on their surfaces a substance capable of reaction with the analyte in the sample, and the average diameter of the particles is less than the average pore size of the matrix. The device, in a preferred embodiment, comprises a substantially planar layer of the described material.

公开(公告)号：AU593285B2

公开(公告)日：1990-02-08

申请号：AU6350286

申请日：1986-10-03

Applicant: ABBOTT LAB

Inventor： BROWN WILLIAM E III ,  CLEMENS JOHN M ,  DEVEREAUX SHARON M ,  HOFLER JOHN G ,  KNIGGE KEVIN M ,  SAFFORD SARAH E

IPC: G01N33/548 ,  G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/546 ,  G01N33/569 ,  G01N33/576 ,  G01N33/76 ,  G01N33/545

Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens or antibodies, is disclosed. The material comprises a porous matrix of fibers and a plurality of substantially spherical, solid particles having an average diameter of from about 0.1 to about 5 microns. The particles are retained and immobilized upon the fibers of the matrix. Preferably, the particles have on their surfaces a substance capable of reaction with the analyte in the sample, and the average diameter of the particles is less than the average pore size of the matrix. The device, in a preferred embodiment, comprises a substantially planar layer of the described material.