公开(公告)号：DE68926941T2

公开(公告)日：1997-03-20

申请号：DE68926941

申请日：1989-09-21

Applicant: ABBOTT LAB

Inventor： CHU DANIEL TIM-WO ,  HALLAS ROBERT

IPC: A61K31/00 ,  A61K31/435 ,  A61K31/47 ,  A61K38/00 ,  A61P31/00 ,  A61P31/04 ,  C07D401/04 ,  C07D471/04 ,  C07K1/113 ,  C07K5/06 ,  C07K5/08 ,  C07K5/10 ,  C07K5/04

Abstract: 7-(3-A-amino-1-pyrrolidinyl) substituted naphthyridine and quinoline compounds wherein A is a solubilizing group selected from an amino acid residue or polypeptide chain.

公开(公告)号：ES2092991T3

公开(公告)日：1996-12-16

申请号：ES89117428

申请日：1989-09-21

Applicant: ABBOTT LAB

Inventor： CHU DANIEL TIM-WO ,  HALLAS ROBERT

IPC: A61K31/00 ,  A61K31/435 ,  A61K31/47 ,  A61K38/00 ,  A61P31/00 ,  A61P31/04 ,  C07D401/04 ,  C07D471/04 ,  C07K1/113 ,  C07K5/06 ,  C07K5/08 ,  C07K5/10 ,  C07K5/04

Abstract: 7-(3-A-amino-1-pyrrolidinyl) substituted naphthyridine and quinoline compounds wherein A is a solubilizing group selected from an amino acid residue or polypeptide chain.

公开(公告)号：DE68926941D1

公开(公告)日：1996-09-19

申请号：DE68926941

申请日：1989-09-21

Applicant: ABBOTT LAB

Inventor： CHU DANIEL TIM-WO ,  HALLAS ROBERT

IPC: A61K31/00 ,  A61K31/435 ,  A61K31/47 ,  A61K38/00 ,  A61P31/00 ,  A61P31/04 ,  C07D401/04 ,  C07D471/04 ,  C07K1/113 ,  C07K5/06 ,  C07K5/08 ,  C07K5/10 ,  C07K5/04

Abstract: 7-(3-A-amino-1-pyrrolidinyl) substituted naphthyridine and quinoline compounds wherein A is a solubilizing group selected from an amino acid residue or polypeptide chain.

公开(公告)号：AU3780393A

公开(公告)日：1993-09-13

申请号：AU3780393

申请日：1993-02-26

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  PLATTNER JACOB J ,  HALLAS ROBERT

IPC: C07D471/04 ,  A61K31/435 ,  A61K31/535 ,  A61K31/54 ,  A61P35/00 ,  C07D455/03 ,  C07D471/06 ,  C07D498/04 ,  C07D498/06 ,  C07D498/16 ,  C07D513/04 ,  C07D513/06 ,  A61K37/02 ,  C07K15/12

公开(公告)号：GB2118179A

公开(公告)日：1983-10-26

申请号：GB8308760

申请日：1983-03-30

Applicant: ABBOTT LAB

Inventor： TADANIER JOHN SOLOMAN ,  HALLAS ROBERT

IPC: A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61P31/04 ,  C07H15/224 ,  C07H15/22

Abstract: 2-Deoxy-3-demethoxyfortimicin A and B and related compounds have antibiotic activity and can be incorporated into pharmaceutical compositions.

公开(公告)号：FR2524892A1

公开(公告)日：1983-10-14

申请号：FR8305783

申请日：1983-04-08

Applicant: ABBOTT LAB

Inventor： TADANIER JOHN SOLOMAN ,  HALLAS ROBERT

IPC: A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61P31/04 ,  C07H15/224 ,  C07H15/22 ,  A61L2/16

公开(公告)号：AU6790774A

公开(公告)日：1975-10-16

申请号：AU6790774

申请日：1974-04-16

Applicant: ABBOTT LAB

Inventor： HALLAS ROBERT ,  TADANIER JOHN SOLOMAN ,  MARTIN JERRY ROY

IPC: A61K31/335 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07D9/00 ,  A61K21/00

Abstract: 1467296 Erythromycin derivatives ABBOTT LABORATORIES 1 May 1974 [4 May 1973] 19163/74 Heading C2C Novel erythromycin derivatives of the general formula wherein R is a C 1-6 alkyl, C 2-6 alkenyl, or optionally nuclear substituted aryl, benzyl or aroxyalkyl group, R 1 is a hydrogen atom or methyl group, R 2 is a hydrogen atom or C 1-6 alkanoyl group and R 3 is a hydrogen atom or hydroxyl group, provided that R 1 and R 3 are not simultaneously a hydrogen atom and the nuclear substituent is nitro, alkyl or halogen are prepared by reacting the corresponding compound in which the -OSO 2 R group is replaced by -OH with RSO 2 Cl (when R is vinyl in the product, R may be 2-bromoethyl in the starting material), followed optionally by hydrolysis or alcoholysis when R 2 is a C 1-6 alkanoyl group to give the corresponding product wherein R 2 is a hydrogen atom. Pharmaceutical compositions having antibiotic activity comprise, as active ingredient, an erythromycin derivative of the above general formula, together with an appropriate carrier.

公开(公告)号：CA2235942C

公开(公告)日：2005-12-06

申请号：CA2235942

申请日：1996-10-17

Applicant: ABBOTT LAB

Inventor： PHAN LY TAM ,  ELLIOTT RICHARD L ,  CHU DANIEL T ,  HALLAS ROBERT ,  OR YAT SUN ,  SPINA KENNETH P

IPC: A61K31/70 ,  C07H17/08 ,  C07H23/00

Abstract: Compounds, or pharmaceutically acceptable salts and esters thereof, of formulae (I); (II); (III) or (IV) wherein A, B, D and E, R1, R2 and Z are specificall y defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of antibacterial infections with such compositions, and processes for the preparation of the compounds.

公开(公告)号：PT876388E

公开(公告)日：2004-07-30

申请号：PT96936579

申请日：1996-10-17

Applicant: ABBOTT LAB

Inventor： SPINA KENNETH P ,  HALLAS ROBERT ,  EDELSON RICHARD L ,  CHU DANIEL T ,  OR YAT SUN ,  PHAN LY TAM

IPC: C07H17/00 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08

Abstract: Compounds, or pharmaceutically acceptable salts and esters thereof, of formulae (I); (II); (III) or (IV) wherein A, B, D and E, R , R and Z are specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of antibacterial infections with such compositions, and processes for the preparation of the compounds.

公开(公告)号：CZ9902315A3

公开(公告)日：1999-12-15

申请号：CZ231599

申请日：1997-04-07

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  PHAN LY TAM ,  CHU DANIAL T ,  SPINA KENNATH P ,  HALLAS ROBERT ,  ELLIOTT RICHARD L ,  TUFANO MICHAEL

IPC: C07H17/00 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08 ,  A61K31/71

CPC classification number: C07H17/08 ,  C07H17/00