Abstract:
An automated, continuous and random access analytical system, having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample (26), reagents (30) to a reaction vessel (34) without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable (34) to a process work station, whereby a mixture of the unit dose disposable reagents and sample (34) are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.
Abstract:
An automated, continuous and random access analytical system (18), having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system (18) capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample (26) and reagents (30) to a reaction vessel (34) without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable to a processing workstation (52), whereby a mixture of the unit dose disposable reagents and sample (34) are achieved during incubation. The system (18) is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system (18) is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.
Abstract:
A method for verifying that an assay methodology is properly performed that assay reagents employed possess the necessary potency for accurately performing such assay methodology, and whether or not test samples or assay reagents have been tampered with or are adulterated, is described. The method is performed by employing an assay verification sample, comprising a positive analyte component and the test sample under analysis, wherein the assay verification sample is analyzed employing the same assay reagents and essentially the same assay methodology employed to analyze the test sample. The method is particularly useful for performing heterogeneous immunoassays on an automated continuous and random access analytical system.
Abstract:
A plastic assay cuvette (506) having the desired optical properties for the analysis of a test sample or reaction mixture thereof, and a method for making such a plastic assay cuvette (506), are described. The optical properties of the plastic assay cuvette (506) are substantially the same as the optical properties of glass wherein low birefringence throughout the optical read region (516) thereof is provided. When used for the analysis of a test sample or reaction mixture thereof, such as in fluorescence polarization assays and absorbance assays, the plastic assay cuvette (506) provides accurate and reproducible disposable assay cuvette which can be used in place of conventional glass assay cuvettes.
Abstract:
SE PRESENTA UN SISTEMA ANALITICO AUTOMATICO DE ACCESO CONTINUO Y ALEATORIO, QUE TIENE UN APARATO Y UNA METODOLOGIA CAPACES DE REALIZAR SIMULTANEAMENTE ANALISIS MULTIPLES DE MUESTRAS DE LIQUIDOS UTILIZANDO DIFERENTES METODOLOGIAS DE ANALISIS, Y SUMINISTRANDO UN ACCESO CONTINUO Y ALEATORIO MIENTRAS QUE REALIZA UNA PLURALIDAD DE ANALISIS SOBRE LA MISMA O DIFERENTES MUESTRAS DURANTE EL MISMO PERIODO DE TIEMPO. TAMBIEN SE PRESENTA UN METODO PARA UTILIZAR UN SISTEMA ANALITICO AUTOMATICO DE ACCESO CONTINUO Y ALEATORIO CAPAZ DE EFECTUAR SIMULTANEAMENTE ANALISIS MULTIPLES DE UNA PLURALIDAD DE MUESTRAS DE LIQUIDO EN DONDE LA CATALOGACION DE LOS DIFERENTES ANALISIS DE LA PLURALIDAD DE MUESTRAS DE LIQUIDO SE SIGUE CREANDO UNA DOSIS UNITARIA DESECHABLE Y SEPARADAMENTE TRANSFIRIENDO UNA PRIMERA MUESTRA DE LIQUIDO (26), REACTIVOS (30) A UN VASO DE REACCION (34) SIN LA INICIALIZACION DE UNA SECUENCIA DE REACCION DE ANALISIS, SIGUIENDO CON LA TRANSFERENCIA FISICA DE LA DOSIS UNITARIA DESECHABLE (34) A UNA ESTACION DE TRABAJO DE PROCESAMIENTO, EN DONDE SE CONSIGUE UNA MEZCLA DE LA DOSIS UNITARIA DESECHABLE, LOS REACTIVOS Y LA MUESTRA (34) DURANTE LA INCUBACION. EL SISTEMA ES CAPAZ DE REALIZAR MAS DE UN ANALISIS CATALOGADO EN CUALQUIER ORDEN, Y LOS ANALISIS EN LOS QUE ESTAN PRESENTES MAS DE UN ANALISIS PROGRAMADO. EL SISTEMA ANALITICO AUTOMATICO, DE ACCESO CONTINUO Y ALEATORIO ES TAMBIEN CAPAZ DE ANALIZAR LAS MEZCLAS DE REACCION INCUBADAS INDEPENDIENTEMENTE E INDIVIDUALMENTE MEDIANTE AL MENOS DOS PROCEDIMIENTOS DE ENSAYO.
Abstract:
An automated, continuous and random access analytical system, having apparat us and methodology capable of simultaneously performing multiple assays of liqu id samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of vario us assays of the plurality of liquid samples is followed by creating a unit dose disposab le and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reaction sequence, followed by physical transfer of t he unit dose disposable to a processing workstation, whereby a mixture of the unit dose disposable reagents and sample are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtur es independently and individually by atleast two assay procedures.
Abstract:
The invention relates to an automated liquid level sensing system for detecting the presence of liquid in a container, said liquid level sensing system comprising: a vertically oriented, electrically conductive probe positioned above said container; means for vertically moving said probe into and out of said container; a signal source electrically connected to said probe, said signal source energizing said probe with an electrical signal and causing said probe to transmit said electrical signal; a receiving antenna positioned below said container for receiving said transmitted electrical signal; means for analyzing said received electrical signal for indications that said probe has contacted liquid in said container; means for transferring said received electrical signal from said receiving antenna to said analyzing means; and means for indicating that liquid has been detected. Further, the invention also provides for a method for automatically detecting the presence of liquid in a container, said method comprising the steps of: vertically positioning an electrically conductive probe above said container; vertically moving said probe into and out of said container; electrically connecting a signal source to said probe, said signal source energizing said probe with an electrical signal and causing said probe to transmit said electrical signal; positioning a receiving antenna below said container for receiving said transmitted electrical signal; analyzing said received electrical signal for indications that said probe has contacted liquid in said container; transferring said received electrical signal from said receiving antenna to said analyzing means; and indicating that liquid has been detected.
Abstract:
The invention relates to an automated liquid level sensing system for detecting the presence of liquid in a container, said liquid level sensing system comprising: a vertically oriented, electrically conductive probe positioned above said container; means for vertically moving said probe into and out of said container; a signal source electrically connected to said probe, said signal source energizing said probe with an electrical signal and causing said probe to transmit said electrical signal; a receiving antenna positioned below said container for receiving said transmitted electrical signal; means for analyzing said received electrical signal for indications that said probe has contacted liquid in said container; means for transferring said received electrical signal from said receiving antenna to said analyzing means; and means for indicating that liquid has been detected. Further, the invention also provides for a method for automatically detecting the presence of liquid in a container, said method comprising the steps of: vertically positioning an electrically conductive probe above said container; vertically moving said probe into and out of said container; electrically connecting a signal source to said probe, said signal source energizing said probe with an electrical signal and causing said probe to transmit said electrical signal; positioning a receiving antenna below said container for receiving said transmitted electrical signal; analyzing said received electrical signal for indications that said probe has contacted liquid in said container; transferring said received electrical signal from said receiving antenna to said analyzing means; and indicating that liquid has been detected.