公开(公告)号：CA2367431C

公开(公告)日：2008-06-10

申请号：CA2367431

申请日：2000-03-08

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  CLARK RICHARD F ,  RUPP MICHAEL J ,  MA ZHENKUN

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04

Abstract: The instant invention provides novel macrolide compounds and compositions useful in treating bacterial infections. Also provided are processes for preparing same. These macrolides are substituted on the 6- O- position with X'-Y'-Z', wherein X' is selected from the group consisting of C1-C10 alkyl, C3-C10 alkenyl, and C3-C10 alkynyl; Y' and Z' are independently selected from the group consisting of: (c) optionally substituted aryl, and (d) optionally substituted heteroaryl, with the proviso that both Y' and Z' are not both phenyl, and with the further proviso that Y' is not isoxazole when Z' is thiophenyl.

公开(公告)号：SI1161438T1

公开(公告)日：2004-12-31

申请号：SI200030438

申请日：2000-03-08

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  CLARK RICHARD F ,  MA ZHENKUN ,  RUPP MICHAEL J

IPC: A61K31/70 ,  C07H17/08

公开(公告)号：NZ513206A

公开(公告)日：2004-02-27

申请号：NZ51320600

申请日：2000-03-08

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  CLARK RICHARD F ,  MA ZHENKUN ,  RUPP MICHAEL J

IPC: A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

Abstract: The instant invention provides novel macrolide compounds and compositions useful in treating bacterial infections. Also provided are processes for preparing same. These macrolides are substituted on the 6-O-position with X'-Y'-Z', wherein X' is selected from the group consisting of C1-C10 alkyl, C3-C10 alkenyl, and C3-C10 alkynyl; Y' and Z' are independently selected from the group consisting of: (c) optionally substituted aryl, and (d) optionally substituted heteroaryl, with the proviso that both Y' and Z' are not both phenyl, and with the further proviso that Y' is not isoxazole when Z' is thiophenyl.

公开(公告)号：BR0008731A

公开(公告)日：2002-09-24

申请号：BR0008731

申请日：2000-03-08

Applicant: ABBOTT LAB

Inventor： OR YAN SUN ,  CLARK RICHARD F ,  MA ZHENKUN ,  RUPP MICHAEL J

IPC: A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

Abstract: The instant invention provides novel macrolide compounds and compositions useful in treating bacterial infections. Also provided are processes for preparing same. These macrolides are substituted on the 6-O-position with X'-Y'-Z', wherein X' is selected from the group consisting of C1-C10 alkyl, C3-C10 alkenyl, and C3-C10 alkynyl; Y' and Z' are independently selected from the group consisting of: (c) optionally substituted aryl, and (d) optionally substituted heteroaryl, with the proviso that both Y' and Z' are not both phenyl, and with the further proviso that Y' is not isoxazole when Z' is thiophenyl.

公开(公告)号：HU0201067A2

公开(公告)日：2002-08-28

申请号：HU0201067

申请日：2000-03-08

Applicant: ABBOTT LAB

Inventor： CLARK RICHARD F ,  MA ZHENKUN ,  OR YAT SUN ,  RUPP MICHAEL J

IPC: A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: The instant invention provides novel macrolide compounds and compositions useful in treating bacterial infections. Also provided are processes for preparing same. These macrolides are substituted on the 6-O-position with X'-Y'-Z', wherein X' is selected from the group consisting of C1-C10 alkyl, C3-C10 alkenyl, and C3-C10 alkynyl; Y' and Z' are independently selected from the group consisting of: (c) optionally substituted aryl, and (d) optionally substituted heteroaryl, with the proviso that both Y' and Z' are not both phenyl, and with the further proviso that Y' is not isoxazole when Z' is thiophenyl.

公开(公告)号：CZ20013223A3

公开(公告)日：2002-01-16

申请号：CZ20013223

申请日：2000-03-08

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  CLARK RICHARD F ,  MA ZHENKUN ,  RUPP MICHAEL J

IPC: A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: The instant invention provides novel macrolide compounds and compositions useful in treating bacterial infections. Also provided are processes for preparing same. These macrolides are substituted on the 6-O-position with X'-Y'-Z', wherein X' is selected from the group consisting of C1-C10 alkyl, C3-C10 alkenyl, and C3-C10 alkynyl; Y' and Z' are independently selected from the group consisting of: (c) optionally substituted aryl, and (d) optionally substituted heteroaryl, with the proviso that both Y' and Z' are not both phenyl, and with the further proviso that Y' is not isoxazole when Z' is thiophenyl.

公开(公告)号：NO20014380L

公开(公告)日：2001-09-10

申请号：NO20014380

申请日：2001-09-10

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  CLARK RICHARD F ,  MA ZHENKUN ,  RUPP MICHAEL J

IPC: A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

Abstract: The instant invention provides novel macrolide compounds and compositions useful in treating bacterial infections. Also provided are processes for preparing same. These macrolides are substituted on the 6-O-position with X'-Y'-Z', wherein X' is selected from the group consisting of C1-C10 alkyl, C3-C10 alkenyl, and C3-C10 alkynyl; Y' and Z' are independently selected from the group consisting of: (c) optionally substituted aryl, and (d) optionally substituted heteroaryl, with the proviso that both Y' and Z' are not both phenyl, and with the further proviso that Y' is not isoxazole when Z' is thiophenyl.

公开(公告)号：NO20014380A

公开(公告)日：2001-09-10

申请号：NO20014380

申请日：2001-09-10

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  CLARK RICHARD F ,  MA ZHENKUN ,  RUPP MICHAEL J

IPC: A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08

公开(公告)号：ZA987689B

公开(公告)日：1999-02-24

申请号：ZA987689

申请日：1998-08-25

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  LI LEPING ,  RUPP MICHAEL J ,  CHU DANIEL T

IPC: A61K31/7042 ,  A61K31/7048 ,  A61K31/7056 ,  A61P31/04 ,  C07H17/08 ,  C07D ,  A61K ,  C07F