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    3-DESCLADINOSE 6-O-SUBSTITUDED ERYTHROMYCIN DERIVATIVES
    1.
    发明申请
    3-DESCLADINOSE 6-O-SUBSTITUDED ERYTHROMYCIN DERIVATIVES 审中-公开
    3-DESCLADINOSE 6-O-取代的红霉素衍生物

    公开(公告)号：WO9911651A3

    公开(公告)日：1999-05-06

    申请号：PCT/US9818125

    申请日：1998-09-01

    Applicant: ABBOTT LAB

    Inventor： OR YAT SUN ,  LI LEPING ,  RUPP MICHAEL J ,  CHU DANIEL T

    IPC: A61K31/7042 ,  A61K31/7048 ,  A61K31/7056 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

    CPC classification number: C07H17/08

    Abstract: Novel multicyclic erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having a formula selected from the group consisting of (I), (II), (III), (IV) and (V), compositions comprising a therapeutically eff ective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically effective amount of a compound of formulas (I)-(V).

    Abstract translation: 具有选自（I），（II），（III），（IV）和（V）组的式的具有抗菌活性的新型多环红霉素化合物及其药学上可接受的盐和酯包含治疗有效量 的本发明化合物与药学上可接受的载体的组合，以及通过向哺乳动物施用含有治疗有效量的式（I） - （V）化合物的药物组合物来治疗细菌感染的方法。

    MACROLIDOS SUSTITUIDOS EN 6-O CON UNA ACTIVIDAD ANTIBACTERIANA.
    2.
    发明专利
    MACROLIDOS SUSTITUIDOS EN 6-O CON UNA ACTIVIDAD ANTIBACTERIANA. 未知

    公开(公告)号：ES2222189T3

    公开(公告)日：2005-02-01

    申请号：ES00913805

    申请日：2000-03-08

    Applicant: ABBOTT LAB

    Inventor： OR YAT SUN ,  CLARK RICHARD F ,  MA ZHENKUN ,  RUPP MICHAEL J

    IPC: A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

    Abstract: Un compuesto seleccionado del grupo formado por un compuesto de **fórmula** o una sal, solvato, éster o profármaco del mismo farmacéuticamente aceptable, donde o bien: (a) Y y Z tomados juntos definen un grupo X, y X se selecciona del grupo formado por (1) =O, (2) =N-OH, (3) =N-O-R1 donde R1 se selecciona del grupo formado por (a) alquilo C1-C12 no sustituido, (b) alquilo C1-C12 sustituido con arilo, (c) alquilo C1-C12 sustituido con arilo sustituido, (d) alquilo C1-C12 sustituido con heteroarilo, (e) alquilo C1-C12 sustituido con heteroarilo sustituido, (f) cicloalquilo C3-C12, y (g) -Si-(R2)(R3)(R4) donde R2, R3 y R4 se seleccionan cada uno independientemente entre alquilo C1- C12 y arilo; o cualquier par de sustituyentes, que consta de AB, AD, AE, BD, BE o DE, se toma junto con el átomo o átomos a los que están anclados para formar un anillo de 3 a 7 miembros que contiene opcionalmente una heterofunción seleccionada del grupo formado por -O-, -NH-, -N(alquilo C1-C6-)-, -N(arilalquilo C1-C6-)-, -N(arilalquilo C1-C6 sustituido-)-, -N(heteroarilalquilo C1-C6-)-, -N(heteroarilaquilo C1-C6 sustituido-)-, -S- o -S(O)n-, donde n es 1 o 2, -C(O)-NH, -C(O)-NR12-, donde R12 se selecciona del grupo formado hidrógeno, alquilo C1-C3, alquilo C1-C3 sustituido con arilo, arilo sustituido, heteroarilo, o heteroarilo sustituido, -NH-C(O)-, y -NR12-C(O)-.

    3.
    发明专利
    未知

    公开(公告)号：AT266036T

    公开(公告)日：2004-05-15

    申请号：AT00913805

    申请日：2000-03-08

    Applicant: ABBOTT LAB

    Inventor： OR YAT SUN ,  CLARK RICHARD F ,  MA ZHENKUN ,  RUPP MICHAEL J

    IPC: A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

    Abstract: The instant invention provides novel macrolide compounds and compositions useful in treating bacterial infections. Also provided are processes for preparing same. These macrolides are substituted on the 6-O-position with X'-Y'-Z', wherein X' is selected from the group consisting of C1-C10 alkyl, C3-C10 alkenyl, and C3-C10 alkynyl; Y' and Z' are independently selected from the group consisting of: (c) optionally substituted aryl, and (d) optionally substituted heteroaryl, with the proviso that both Y' and Z' are not both phenyl, and with the further proviso that Y' is not isoxazole when Z' is thiophenyl.

    6-O-substituted macrolides having antibacterial acitivity.
    9.
    发明专利
    6-O-substituted macrolides having antibacterial acitivity. 未知

    公开(公告)号：ZA200106181B

    公开(公告)日：2002-10-26

    申请号：ZA200106181

    申请日：2001-07-26

    Applicant: ABBOTT LAB

    Inventor： OR YAT SUN ,  MA ZHENKUN ,  CLARK RICHARD F ,  RUPP MICHAEL J

    IPC: A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07H ,  A61K

    Abstract: The instant invention provides novel macrolide compounds and compositions useful in treating bacterial infections. Also provided are processes for preparing same. These macrolides are substituted on the 6-O-position with X'-Y'-Z', wherein X' is selected from the group consisting of C1-C10 alkyl, C3-C10 alkenyl, and C3-C10 alkynyl; Y' and Z' are independently selected from the group consisting of: (c) optionally substituted aryl, and (d) optionally substituted heteroaryl, with the proviso that both Y' and Z' are not both phenyl, and with the further proviso that Y' is not isoxazole when Z' is thiophenyl.

    6-O-SUBSTITUTED MACROLIDES HAVING ANTIBACTERIAL ACTIVITY
    10.
    发明专利
    6-O-SUBSTITUTED MACROLIDES HAVING ANTIBACTERIAL ACTIVITY 未知

    公开(公告)号：BG105865A

    公开(公告)日：2002-05-31

    申请号：BG10586501

    申请日：2001-09-01

    Applicant: ABBOTT LAB

    Inventor： OR YAT S ,  CLARK RICHARD F ,  MA ZHENKUN ,  RUPP MICHAEL J

    IPC: A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

    Abstract: The instant invention provides novel macrolide compounds and compositions useful in treating bacterial infections. Also provided are processes for preparing same. These macrolides are substituted on the 6-O-position with X'-Y'-Z', wherein X' is selected from the group consisting of C1-C10 alkyl, C3-C10 alkenyl, and C3-C10 alkynyl; Y' and Z' are independently selected from the group consisting of: (c) optionally substituted aryl, and (d) optionally substituted heteroaryl, with the proviso that both Y' and Z' are not both phenyl, and with the further proviso that Y' is not isoxazole when Z' is thiophenyl. 14 claims

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