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    3-DESCLADINOSE 6-O-SUBSTITUDED ERYTHROMYCIN DERIVATIVES
    2.
    发明申请
    3-DESCLADINOSE 6-O-SUBSTITUDED ERYTHROMYCIN DERIVATIVES 审中-公开
    3-DESCLADINOSE 6-O-取代的红霉素衍生物

    公开(公告)号：WO9911651A3

    公开(公告)日：1999-05-06

    申请号：PCT/US9818125

    申请日：1998-09-01

    Applicant: ABBOTT LAB

    Inventor： OR YAT SUN ,  LI LEPING ,  RUPP MICHAEL J ,  CHU DANIEL T

    IPC: A61K31/7042 ,  A61K31/7048 ,  A61K31/7056 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

    CPC classification number: C07H17/08

    Abstract: Novel multicyclic erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having a formula selected from the group consisting of (I), (II), (III), (IV) and (V), compositions comprising a therapeutically eff ective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically effective amount of a compound of formulas (I)-(V).

    Abstract translation: 具有选自（I），（II），（III），（IV）和（V）组的式的具有抗菌活性的新型多环红霉素化合物及其药学上可接受的盐和酯包含治疗有效量 的本发明化合物与药学上可接受的载体的组合，以及通过向哺乳动物施用含有治疗有效量的式（I） - （V）化合物的药物组合物来治疗细菌感染的方法。

    COMPUESTOS A BASE DE ERITROMICINA 6-0 SUSTITUIDA Y TECNICA DE PRODUCCION.
    4.
    发明专利
    COMPUESTOS A BASE DE ERITROMICINA 6-0 SUSTITUIDA Y TECNICA DE PRODUCCION. 未知

    公开(公告)号：ES2252784T3

    公开(公告)日：2006-05-16

    申请号：ES97924605

    申请日：1997-05-06

    Applicant: ABBOTT LAB

    Inventor： OR YAT SUN ,  CLARK RICHARD F ,  MA ZHENKUN ,  GRIESGRABER GEORGE ,  LI LEPING ,  CHU DANIEL T

    IPC: C07H17/08 ,  A61K31/70

    Abstract: Un compuesto que tiene la fórmula o una sal farmacéuticamente aceptable del mismo, en la que X es =O, Ra es hidroxi; Rb es hidrógeno; Rc es hidrógeno y Rd es hidroxi; Re es metoxi; Rf es hidrógeno; y R se selecciona entre el grupo compuesto por (2) alquilo C2-C10 sustituido con uno o más sustituyentes seleccionados entre el grupo compuesto por (a) halógeno, (b) hidroxi, (c) alcoxi C1-C3, (d) alcoxi C1-C3-alcoxi C1-C3, (e) oxo, (f) -N3, (g) -CHO, (h) O-SO2-(alquilo C1-C6 sustituido), (i) -NR15R16 en la que R15 y R16 se seleccionan entre el grupo compuesto por (i) hidrógeno, (ii) alquilo C1-C12, (iii) alquilo C1-C12 sustituido, (iv) alquenilo C1-C12, (v) alquenilo C1-C12 sustituido, (vi) alquinilo C1-C12, (vii) alquinilo C1-C12 sustituido, (viii) arilo, (ix) cicloalquilo C3-C8, (x) cicloalquilo C3-C8 sustituido, (xi) arilo sustituido, (xii) heterocicloalquilo, (xiii) heterocicloalquilo sustituido, (xiv) alquilo C1-C12 sustituido con arilo, (xv) alquilo C1-C12 sustituido con arilo sustituido,(xvi) alquilo C1-C12 sustituido con heterocicloalquilo, (xvii) alquilo C1-C12 sustituido con sustituido heterocicloalquilo, (xviii) alquilo C1-C12 sustituido con cicloalquilo C3-C8, (xix) alquilo C1-C12 sustituido con cicloalquilo C3-C8 sustituido, (xx) heteroarilo, (xxi) sustituido heteroarilo, (xxii) alquilo C1-C12 sustituido con heteroarilo, y (xxiii) alquilo C1-C12 sustituido con heteroarilo sustituido, o R15 y R16 tomados junto con el átomo al que están unidos forman morfolinilo; (3) alquenilo C4-C10; y (4) alquinilo C3-C10.

    6.
    发明专利
    未知

    公开(公告)号：ES2198766T3

    公开(公告)日：2004-02-01

    申请号：ES98956314

    申请日：1998-10-29

    Applicant: ABBOTT LAB

    Inventor： OR YAT SUN ,  GRIESGRABER GEORGE ,  LI LEPING ,  CHU DANIEL T

    IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07H17/00 ,  A61K31/70

    Abstract: Novel 6,11-bridged erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II); compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier; a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention; and processes for their preparation.

    7.
    发明专利
    未知

    公开(公告)号：PT1027361E

    公开(公告)日：2003-09-30

    申请号：PT98956314

    申请日：1998-10-29

    Applicant: ABBOTT LAB

    Inventor： OR YAT SUN ,  LI LEPING ,  CHU DANIEL T ,  GRIESGRABER GEORGE

    IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07H17/00 ,  A61K31/70

    Abstract: Novel 6,11-bridged erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II); compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier; a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention; and processes for their preparation.

    6,11-bridged erythromycin derivatives
    10.
    发明专利
    6,11-bridged erythromycin derivatives 未知

    公开(公告)号：AU1286799A

    公开(公告)日：1999-05-17

    申请号：AU1286799

    申请日：1998-10-29

    Applicant: ABBOTT LAB

    Inventor： OR YAT SUN ,  GRIESGRABER GEORGE ,  LI LEPING ,  CHU DANIEL T

    IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07H17/00 ,  A61K31/70

    Abstract: Novel 6,11-bridged erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II); compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier; a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention; and processes for their preparation.

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