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21.发明公开APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权细胞凋亡诱导剂用于癌症和免疫球蛋白和自身免疫性疾病的治疗
公开(公告)号：EP2435432A2
公开(公告)日：2012-04-04
申请号：EP10721246.6
申请日：2010-05-26
Applicant: Abbott Laboratories
Inventor： BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd M.
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D491/052 , C07D519/00
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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Patent Agency Ranking22.发明公开APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开细胞凋亡诱导剂治疗癌症和免疫及自身免疫疾病
公开(公告)号：EP2387560A2
公开(公告)日：2011-11-23
申请号：EP10701083.7
申请日：2010-01-15
Applicant: Abbott Laboratories
Inventor： HEXAMER, Laura , DING, Hong , ELMORE, Steven, W. , KUNZER, Aaron, R. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard, M. , TAO, Zhi-fu , WENDT, Michael, D.
IPC: C07D209/08 , C07D311/14 , C07D295/155 , A61P35/00 , A61K31/635 , C07D213/71 , C07D231/56 , C07D235/04 , C07D265/02 , C07D285/14
CPC classification number: C07D295/155 , C07D209/08 , C07D213/71 , C07D231/56 , C07D235/04 , C07D265/02 , C07D285/14 , C07D311/14
Abstract: Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白质活性的式（I）化合物，含有该化合物的组合物和治疗表达抗凋亡Bcl-2蛋白质的疾病的方法。
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23.发明公开SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES 有权磺胺ALS BCL-2选择性诱导细胞凋亡的手段治疗癌症和免疫系统疾病的
公开(公告)号：EP2376480A2
公开(公告)日：2011-10-19
申请号：EP09795606.4
申请日：2009-12-04
Applicant: Abbott Laboratories
Inventor： BRUNCKO, Milan , DING, Hong , DOHERTY, George, A. , ELMORE, Steven, W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron, R. , MANTEI, Robert, A. , MCCLELLAN, William, J. , PARK, Chang, H. , PARK, Cheol-min , PETROS, Andrew, M. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard, M. , TAO, Zhi-fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael, D.
IPC: C07D405/12 , A61K31/404 , A61P35/00
CPC classification number: C07D405/12 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12 , C07D417/12
Abstract: Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic BcI -2 or BcI -xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti -aooptotic Bcl-2 protein.
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24.发明公开APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权APOPTOSE-INDUZIERENDE MITTEL ZUR BEHANDLUNG VON KREBS UND INMMUN- UND AUTOIMMUNKRANKHEITEN
公开(公告)号：EP2376197A2
公开(公告)日：2011-10-19
申请号：EP09768289.2
申请日：2009-12-04
Applicant: Abbott Laboratories
Inventor： BRUNCKO, Milan , DAI, Yujia , DING, Hong , DOHERTY, George, A. , ELMORE, Steven, W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron, R. , MANTEI, Robert, A. , MCCLELLAN, William, J. , PARK, Chang, H. , PARK, Cheol-Min , PETROS, Andrew, M. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard, M. , TAO, Zhi-Fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael, D.
IPC: A61P35/00 , A61K31/496 , C07D403/12
CPC classification number: C07D405/12 , C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗其中表达抗凋亡Bcl-2蛋白的疾病的方法。
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公开(公告)号：EP2134685A1
公开(公告)日：2009-12-23
申请号：EP08745934.3
申请日：2008-04-16
Applicant: Abbott Laboratories
Inventor： BRUNCKO, Milan , SONG, Xiaohong , DING, Hong , TAO, Zhi-fu , KUNZER, Aaron R , ELMORE, Steven, W. , PARK, Cheol-Min , MADAR, David , WANG, Xilu , SOUERS, Andrew, J.
IPC: C07D209/42 , C07D403/04 , A61K31/404 , A61K31/405 , A61P35/00
CPC classification number: C07D209/42 , C07D403/04
Abstract: Compounds of formula (I) which inhibit the activity of anti-apoptotic Mcl-1 protein, compositins containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
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公开(公告)号：EP1318978A2
公开(公告)日：2003-06-18
申请号：EP01971244.7
申请日：2001-09-20
Applicant: Abbott Laboratories
Inventor： MCCLELLAN, William , OOST, Thorsten , BRUNCKO, Milan , WANG, Xilu , AUGERI, David, J. , BAUMEISTER, Steven, A. , DICKMAN, Daniel, A. , DING, Hong , DINGES, Jurgen , FESIK, Stephen, W. , HAJDUK, Philip, J. , KUNZER, Aaron, R. , NETTESHEIM, David, G. , PETROS, Andrew, M. , ROSENBERG, Saul, H. , SHEN, Wang , THOMAS, Sheela, A. , WENDT, Michael, D.
IPC: C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/58 , C07C323/60
CPC classification number: C07D207/404 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/58 , C07C323/60 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/28 , C07C2602/42 , C07C2602/44 , C07C2603/74 , C07D203/10 , C07D205/12 , C07D207/24 , C07D209/08 , C07D209/96 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/61 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/227 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D235/08 , C07D235/26 , C07D241/16 , C07D249/04 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D401/06 , C07D401/12 , C07D405/04 , C07D417/12 , C07D451/02
Abstract: N-Benzoyl arylsulfonamides having the formula (I) are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.
Abstract translation: 具有式（I）的N-苯甲酰基芳基磺酰胺是BCL-X1抑制剂，可用于促进凋亡。 还公开了BCL-X1抑制组合物和促进哺乳动物细胞凋亡的方法。
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