公开(公告)号：WO2012045196A1

公开(公告)日：2012-04-12

申请号：PCT/CN2010/001579

申请日：2010-10-09

Applicant: ABBOTT LABORATORIES ,  ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD. ,  XU, Xiangdong ,  DINGES, Jurgent ,  HASVOLD, Lisa ,  LONGENECKER, Kenton, L.

Inventor： XU, Xiangdong ,  DINGES, Jurgent ,  HASVOLD, Lisa ,  LONGENECKER, Kenton, L.

IPC: C07D241/44 ,  A61K31/498 ,  A61P35/00

CPC classification number: C07D241/44 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D413/04

Abstract: Disclosed are compounds of formula (I) or pharmaceutical acceptable salts thereof, wherein R 1 , R 2 , R 3 and R 4 are as defined in the description. Disclosed are also the methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as phosphoglycerate kinase.

Abstract translation: 公开了式（I）化合物或其药学上可接受的盐，其中R 1，R 2，R 3和R 4如说明书中所定义。 还公开了制备所述化合物的方法，以及含有可用于抑制磷酸甘油酸激酶等激酶的所述化合物的组合物。

公开(公告)号：WO2013097601A1

公开(公告)日：2013-07-04

申请号：PCT/CN2012/086357

申请日：2012-12-11

Applicant: ABBVIE INC. ,  ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.

Inventor： WANG, Le ,  PRATT, John K. ,  MCDANIEL, Keith F. ,  DAI, Yujia ,  FIDANZE, Steven D. ,  HASVOLD, Lisa ,  HOLMS, James H. ,  KATI, Warren M. ,  LIU, Dachun ,  MANTEI, Robert A. ,  MCCLELLAN, William J ,  SHEPPARD, George S. ,  WADA, Carol K.

IPC: C07D471/04 ,  A61K31/407 ,  A61P35/00 ,  A61P31/18 ,  A61P13/12 ,  A61P3/10

CPC classification number: A61K31/541 ,  A61K31/437 ,  A61K31/5025 ,  A61K31/5377 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention provides for compounds of formula (I) wherein A 1 , A 2 , A 3 , A 4 , X 1 , X 2 , Y 1 , L 1 , G 1 , R x , and R y have any of the values defined thereof in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

Abstract translation: 本发明提供式（I）化合物，其中A1，A2，A3，A4，X1，X2，Y1，L1，G1，Rx和Ry具有说明书中定义的任何值及其药学上可接受的盐 ，其作为治疗疾病和病症（包括炎性疾病，癌症和AIDS）的药剂是有用的。 还提供了包含一种或多种式（I）化合物的药物组合物。

公开(公告)号：WO2011149492A1

公开(公告)日：2011-12-01

申请号：PCT/US2010/057587

申请日：2010-11-22

Applicant: ABBOTT LABORATORIES ,  BRUNCKO, Milan ,  DING, Hong ,  DOHERTY, George ,  ELMORE, Steven ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron R. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard ,  TAO, Zhi-Fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael ,  MANTEI, Robert ,  HANSEN, Todd, M.

Inventor： BRUNCKO, Milan ,  DING, Hong ,  DOHERTY, George ,  ELMORE, Steven ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron R. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard ,  TAO, Zhi-Fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael ,  MANTEI, Robert ,  HANSEN, Todd, M.

IPC: C07D471/04 ,  A61K31/437 ,  A61K35/00

CPC classification number: C07D401/12 ,  A61K31/496 ,  C07D209/82 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D519/00 ,  Y02A50/463

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：WO2011068561A1

公开(公告)日：2011-06-09

申请号：PCT/US2010/036919

申请日：2010-06-01

Applicant: ABBOTT LABORATORIES ,  BRUNCKO, Milan ,  DING, Hong ,  DOHERTY, George A. ,  ELMORE, Steven, W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron ,  MANTEI, Robert, A. ,  McCLELLAN, William, J. ,  PARK, Chang, H. ,  PARK, Cheol-Min ,  PETROS, Andrew, M. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-Fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael, D. ,  HANSEN, Todd, M.

Inventor： BRUNCKO, Milan ,  DING, Hong ,  DOHERTY, George A. ,  ELMORE, Steven, W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron ,  MANTEI, Robert, A. ,  McCLELLAN, William, J. ,  PARK, Chang, H. ,  PARK, Cheol-Min ,  PETROS, Andrew, M. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-Fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael, D. ,  HANSEN, Todd, M.

IPC: C07D405/12 ,  A61K31/404 ,  A61P35/00 ,  C07D209/32 ,  C07D211/96 ,  C07D213/64 ,  C07D215/20 ,  C07D217/16 ,  C07D235/26 ,  C07D249/04 ,  C07D295/14 ,  C07D309/14 ,  C07D401/12 ,  C07D295/125 ,  C07D231/56 ,  C07D405/14

CPC classification number: C07D401/12 ,  A61K31/407 ,  A61K31/495 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5377 ,  A61K45/06 ,  C07D209/08 ,  C07D209/32 ,  C07D211/58 ,  C07D211/96 ,  C07D213/64 ,  C07D215/20 ,  C07D217/16 ,  C07D231/56 ,  C07D235/26 ,  C07D241/04 ,  C07D249/04 ,  C07D295/125 ,  C07D295/14 ,  C07D295/155 ,  C07D309/04 ,  C07D309/14 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

Abstract: Disclosed are compounds (I) which inhibit the activity of anti-apoptotic Bc1-2 or Bc1 xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti apoptotic Bc1-2 protein.

Abstract translation: 公开了抑制抗凋亡Bc1-2或Bc1 xL蛋白活性的化合物（I），含有该化合物的组合物和治疗其中表达抗凋亡Bc1-2蛋白的疾病的方法。

公开(公告)号：WO2010138588A2

公开(公告)日：2010-12-02

申请号：PCT/US2010/036198

申请日：2010-05-26

Applicant: ABBOTT LABORATORIES ,  BRUNCKO, Milan ,  DING, Hong ,  DOHERTY, George ,  ELMORE, Steven ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron R. ,  SONG, Xiaohong ,  SOUERS, Andrew J. ,  SULLIVAN, Gerard ,  TAO, Zhi-Fu ,  WANG, Gary T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael ,  MANTEI, Robert ,  HANSEN, Todd M.

Inventor： BRUNCKO, Milan ,  DING, Hong ,  DOHERTY, George ,  ELMORE, Steven ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron R. ,  SONG, Xiaohong ,  SOUERS, Andrew J. ,  SULLIVAN, Gerard ,  TAO, Zhi-Fu ,  WANG, Gary T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael ,  MANTEI, Robert ,  HANSEN, Todd M.

IPC: C07D471/04

CPC classification number: C07D471/04 ,  C07D491/052 ,  C07D519/00

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有该化合物的组合物和治疗表达抗凋亡Bcl-2蛋白的疾病的方法。

公开(公告)号：WO2011068560A1

公开(公告)日：2011-06-09

申请号：PCT/US2010/036844

申请日：2010-06-01

Applicant: ABBOTT LABORATORIES ,  BRUNCKO, Milan ,  DAI, Yujia ,  DING, Hong ,  DOHERTY, George A. ,  ELMORE, Steven W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron ,  MANTEI, Robert A. ,  McCLELLAN, William J. ,  PARK, Chang H. ,  PARK, Cheol-Min ,  PETROS, Andrew M. ,  SONG, Xiaohong ,  SOUERS, Andrew J. ,  SULLIVAN, Gerard M. ,  TAO, Zhi-Fu ,  WANG, Gary T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael D. ,  HANSEN, Todd M.

Inventor： BRUNCKO, Milan ,  DAI, Yujia ,  DING, Hong ,  DOHERTY, George A. ,  ELMORE, Steven W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron ,  MANTEI, Robert A. ,  McCLELLAN, William J. ,  PARK, Chang H. ,  PARK, Cheol-Min ,  PETROS, Andrew M. ,  SONG, Xiaohong ,  SOUERS, Andrew J. ,  SULLIVAN, Gerard M. ,  TAO, Zhi-Fu ,  WANG, Gary T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael D. ,  HANSEN, Todd M.

IPC: C07D209/08 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D309/04 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

CPC classification number: C07D209/08 ,  A61K31/635 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D295/30 ,  C07D309/04 ,  C07D309/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：WO2010065865A2

公开(公告)日：2010-06-10

申请号：PCT/US2009/066790

申请日：2009-12-04

Applicant: ABBOTT LABORATORIES ,  BRUNCKO, Milan ,  DING, Hong ,  DOHERTY, George, A. ,  ELMORE, Steven, W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron, R. ,  MANTEI, Robert, A. ,  MCCLELLAN, William, J. ,  PARK, Chang, H. ,  PARK, Cheol-min ,  PETROS, Andrew, M. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael, D.

Inventor： BRUNCKO, Milan ,  DING, Hong ,  DOHERTY, George, A. ,  ELMORE, Steven, W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron, R. ,  MANTEI, Robert, A. ,  MCCLELLAN, William, J. ,  PARK, Chang, H. ,  PARK, Cheol-min ,  PETROS, Andrew, M. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael, D.

IPC: C07D405/12 ,  A61K31/404 ,  A61P35/00

CPC classification number: C07D405/12 ,  C07D209/32 ,  C07D211/96 ,  C07D213/64 ,  C07D215/20 ,  C07D217/16 ,  C07D231/56 ,  C07D235/26 ,  C07D249/04 ,  C07D295/125 ,  C07D295/14 ,  C07D309/14 ,  C07D401/12 ,  C07D417/12

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

Abstract translation: 公开了抑制抗凋亡Bcl-2或Bcl-xL蛋白的活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。

公开(公告)号：WO2010065824A2

公开(公告)日：2010-06-10

申请号：PCT/US2009/066722

申请日：2009-12-04

Applicant: ABBOTT LABORATORIES ,  BRUNCKO, Milan ,  DAI, Yujia ,  DING, Hong ,  DOHERTY, George, A. ,  ELMORE, Steven, W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron, R. ,  MANTEI, Robert, A. ,  MCCLELLAN, William, J. ,  PARK, Chang, H. ,  PARK, Cheol-Min ,  PETROS, Andrew, M. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-Fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael, D.

Inventor： BRUNCKO, Milan ,  DAI, Yujia ,  DING, Hong ,  DOHERTY, George, A. ,  ELMORE, Steven, W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron, R. ,  MANTEI, Robert, A. ,  MCCLELLAN, William, J. ,  PARK, Chang, H. ,  PARK, Cheol-Min ,  PETROS, Andrew, M. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-Fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael, D.

IPC: A61P35/00 ,  A61K31/496 ,  C07D403/12

CPC classification number: C07D405/12 ,  C07D209/08 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D295/30 ,  C07D309/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。

公开(公告)号：EP2507211A1

公开(公告)日：2012-10-10

申请号：EP10722500.5

申请日：2010-06-01

Applicant: Abbott Laboratories

Inventor： BRUNCKO, Milan ,  DAI, Yujia ,  DING, Hong ,  DOHERTY, George A. ,  ELMORE, Steven W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron ,  MANTEI, Robert A. ,  McCLELLAN, William J. ,  PARK, Chang H. ,  PARK, Cheol-Min ,  PETROS, Andrew M. ,  SONG, Xiaohong ,  SOUERS, Andrew J. ,  SULLIVAN, Gerard M. ,  TAO, Zhi-Fu ,  WANG, Gary T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael D. ,  HANSEN, Todd M.

IPC: C07D209/08 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D309/04 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

CPC classification number: C07D209/08 ,  A61K31/635 ,  C07D211/58 ,  C07D213/74 ,  C07D213/84 ,  C07D231/56 ,  C07D235/06 ,  C07D277/24 ,  C07D295/30 ,  C07D309/04 ,  C07D309/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有该化合物的组合物和治疗表达抗凋亡Bcl-2蛋白的疾病的方法。

公开(公告)号：EP2507229A1

公开(公告)日：2012-10-10

申请号：EP10727241.1

申请日：2010-06-01

Applicant: Abbott Laboratories

Inventor： PARK, Chang, H. ,  BRUNCKO, Milan ,  DING, Hong ,  DOHERTY, George A. ,  ELMORE, Steven, W. ,  HASVOLD, Lisa ,  HEXAMER, Laura ,  KUNZER, Aaron ,  MANTEI, Robert, A. ,  McCLELLAN, William, J. ,  PARK, Cheol-Min ,  PETROS, Andrew, M. ,  SONG, Xiaohong ,  SOUERS, Andrew, J. ,  SULLIVAN, Gerard, M. ,  TAO, Zhi-Fu ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WENDT, Michael, D. ,  HANSEN, Todd, M.

IPC: C07D405/12 ,  A61K31/404 ,  A61P35/00 ,  C07D209/32 ,  C07D211/96 ,  C07D213/64 ,  C07D215/20 ,  C07D217/16 ,  C07D235/26 ,  C07D249/04 ,  C07D295/14 ,  C07D309/14 ,  C07D401/12 ,  C07D295/125 ,  C07D231/56 ,  C07D405/14

CPC classification number: C07D401/12 ,  A61K31/407 ,  A61K31/495 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5377 ,  A61K45/06 ,  C07D209/08 ,  C07D209/32 ,  C07D211/58 ,  C07D211/96 ,  C07D213/64 ,  C07D215/20 ,  C07D217/16 ,  C07D231/56 ,  C07D235/26 ,  C07D241/04 ,  C07D249/04 ,  C07D295/125 ,  C07D295/14 ,  C07D295/155 ,  C07D309/04 ,  C07D309/14 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

Abstract: Disclosed are compounds (I) which inhibit the activity of anti-apoptotic Bc1-2 or Bc1 xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti apoptotic Bc1-2 protein.