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1.发明申请
公开(公告)号：WO2011150016A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/037849
申请日：2011-05-25
Applicant: ABBOTT LABORATORIES , TAO, Zhi-Fu , WANG, Xilu , SOUERS, Andrew J. , CATRON, Nathaniel D. , SULLIVAN, Gerard
Inventor： TAO, Zhi-Fu , WANG, Xilu , SOUERS, Andrew J. , CATRON, Nathaniel D. , SULLIVAN, Gerard
CPC classification number: C07D471/04 , A61K31/18 , A61K31/44 , A61K31/496 , A61P35/00 , C07F9/65616 , Y02A50/385 , Y02A50/401 , Y02A50/411 , Y02A50/463
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：WO2008067257A8
公开(公告)日：2008-06-05
申请号：PCT/US2007/085543
申请日：2007-11-26
Applicant: ABBOTT LABORATORIES , SOUERS, Andrew J. , GAO, Ju , HANSEN, Todd Matthew , IYENGAR, Rajesh R. , KYM, Philip R. , LIU, Bo X , PEI, Zhonghua , YEH, Vince , ZHAO, Gang
Inventor： SOUERS, Andrew J. , GAO, Ju , HANSEN, Todd Matthew , IYENGAR, Rajesh R. , KYM, Philip R. , LIU, Bo X , PEI, Zhonghua , YEH, Vince , ZHAO, Gang
IPC: A61K31/17 , C07C229/40 , A61P1/16 , A61P3/00
Abstract: Compounds of formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Pharmaceutical compositions of formula (I) and related methods for treating or preventing metabolic diseases or conditions.
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公开(公告)号：WO2008067257A3
公开(公告)日：2008-06-05
申请号：PCT/US2007/085543
申请日：2007-11-26
Applicant: ABBOTT LABORATORIES , SOUERS, Andrew J. , GAO, Ju , HANSEN, Todd Matthew , IYENGAR, Rajesh R. , KYM, Philip R. , LIU, Bo X , PEI, Zhonghua , YEH, Vince , ZHAO, Gang
Inventor： SOUERS, Andrew J. , GAO, Ju , HANSEN, Todd Matthew , IYENGAR, Rajesh R. , KYM, Philip R. , LIU, Bo X , PEI, Zhonghua , YEH, Vince , ZHAO, Gang
IPC: A61K31/17 , C07C229/40 , A61P1/16 , A61P3/00
Abstract: Compounds of formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Pharmaceutical compositions of formula (I) and related methods for treating or preventing metabolic diseases or conditions.
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4.发明申请APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开细胞凋亡诱导剂治疗癌症和免疫及自身免疫疾病
公开(公告)号：WO2010138588A2
公开(公告)日：2010-12-02
申请号：PCT/US2010/036198
申请日：2010-05-26
Applicant: ABBOTT LABORATORIES , BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd M.
Inventor： BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd M.
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D491/052 , C07D519/00
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有该化合物的组合物和治疗表达抗凋亡Bcl-2蛋白的疾病的方法。
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5.发明申请
公开(公告)号：WO2011068560A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/036844
申请日：2010-06-01
Applicant: ABBOTT LABORATORIES , BRUNCKO, Milan , DAI, Yujia , DING, Hong , DOHERTY, George A. , ELMORE, Steven W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron , MANTEI, Robert A. , McCLELLAN, William J. , PARK, Chang H. , PARK, Cheol-Min , PETROS, Andrew M. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard M. , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael D. , HANSEN, Todd M.
Inventor： BRUNCKO, Milan , DAI, Yujia , DING, Hong , DOHERTY, George A. , ELMORE, Steven W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron , MANTEI, Robert A. , McCLELLAN, William J. , PARK, Chang H. , PARK, Cheol-Min , PETROS, Andrew M. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard M. , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael D. , HANSEN, Todd M.
IPC: C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D309/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
CPC classification number: C07D209/08 , A61K31/635 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D309/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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Patent Agency Ranking
公开(公告)号：WO2008067257A2
公开(公告)日：2008-06-05
申请号：PCT/US2007/085543
申请日：2007-11-26
Applicant: ABBOTT LABORATORIES , SOUERS, Andrew J. , GAO, Ju , HANSEN, Todd Matthew , IYENGAR, Rajesh R. , KYM, Philip R. , LIU, Bo X , PEI, Zhonghua , YEH, Vince , ZHAO, Gang
Inventor： SOUERS, Andrew J. , GAO, Ju , HANSEN, Todd Matthew , IYENGAR, Rajesh R. , KYM, Philip R. , LIU, Bo X , PEI, Zhonghua , YEH, Vince , ZHAO, Gang
IPC: A61K31/415
CPC classification number: C07D487/04 , C07C59/54 , C07C275/42 , C07D211/60 , C07D231/12 , C07D231/20 , C07D249/08 , C07D263/48 , C07D277/40 , C07D401/04 , C07D407/12 , C07D407/14 , C07D413/12 , C07D413/14
Abstract: Compounds of formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Pharmaceutical compositions of formula (I) and related methods for treating or preventing metabolic diseases or conditions.
Abstract translation: 式（I）化合物或其药学上可接受的盐，前药，前药的盐或其组合。 式（I）的药物组合物和用于治疗或预防代谢疾病或病症的相关方法。
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7.发明公开APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权细胞凋亡诱导剂治疗癌症和免疫及自身免疫疾病
公开(公告)号：EP2507211A1
公开(公告)日：2012-10-10
申请号：EP10722500.5
申请日：2010-06-01
Applicant: Abbott Laboratories
Inventor： BRUNCKO, Milan , DAI, Yujia , DING, Hong , DOHERTY, George A. , ELMORE, Steven W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron , MANTEI, Robert A. , McCLELLAN, William J. , PARK, Chang H. , PARK, Cheol-Min , PETROS, Andrew M. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard M. , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael D. , HANSEN, Todd M.
IPC: C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D309/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
CPC classification number: C07D209/08 , A61K31/635 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D309/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有该化合物的组合物和治疗表达抗凋亡Bcl-2蛋白的疾病的方法。
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8.发明公开APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权细胞凋亡诱导剂用于癌症和免疫球蛋白和自身免疫性疾病的治疗
公开(公告)号：EP2435432A2
公开(公告)日：2012-04-04
申请号：EP10721246.6
申请日：2010-05-26
Applicant: Abbott Laboratories
Inventor： BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd M.
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D491/052 , C07D519/00
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：EP2117526A2
公开(公告)日：2009-11-18
申请号：EP07854765.0
申请日：2007-11-26
Applicant: Abbott Laboratories
Inventor： SOUERS, Andrew J. , GAO, Ju , HANSEN, Todd Matthew , IYENGAR, Rajesh R. , KYM, Philip R. , LIU, Bo X , PEI, Zhonghua , YEH, Vince , ZHAO, Gang , XIN, Zhili
IPC: A61K31/17 , C07C229/40 , A61P1/16 , A61P3/00
CPC classification number: C07D487/04 , C07C59/54 , C07C275/42 , C07D211/60 , C07D231/12 , C07D231/20 , C07D249/08 , C07D263/48 , C07D277/40 , C07D401/04 , C07D407/12 , C07D407/14 , C07D413/12 , C07D413/14
Abstract: Compounds of formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Pharmaceutical compositions of formula (I) and related methods for treating or preventing metabolic diseases or conditions.
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公开(公告)号：EP2117526B1
公开(公告)日：2013-04-03
申请号：EP07854765.0
申请日：2007-11-26
Applicant: Abbott Laboratories
Inventor： SOUERS, Andrew J. , GAO, Ju , HANSEN, Todd Matthew , IYENGAR, Rajesh R. , KYM, Philip R. , LIU, Bo X , PEI, Zhonghua , YEH, Vince , ZHAO, Gang , XIN, Zhili
IPC: A61K31/17 , C07C229/40 , A61P1/16 , A61P3/00 , C07D231/20 , C07D263/48 , C07D277/38 , C07D403/04 , C07D487/04 , C07D405/04
CPC classification number: C07D487/04 , C07C59/54 , C07C275/42 , C07D211/60 , C07D231/12 , C07D231/20 , C07D249/08 , C07D263/48 , C07D277/40 , C07D401/04 , C07D407/12 , C07D407/14 , C07D413/12 , C07D413/14
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