公开(公告)号：WO2008144360A1

公开(公告)日：2008-11-27

申请号：PCT/US2008/063648

申请日：2008-05-15

Applicant: ABBOTT LABORATORIES ,  DART, Michael, J. ,  CARROLL, William, A. ,  PEREZ-MEDRANO, Arturo ,  PEDDI, Sridhar ,  FROST, Jennifer, M.

Inventor： DART, Michael, J. ,  CARROLL, William, A. ,  PEREZ-MEDRANO, Arturo ,  PEDDI, Sridhar ,  FROST, Jennifer, M.

IPC: C07D513/04 ,  A61K31/429 ,  A61P29/00 ,  A61P37/00

CPC classification number: A61K31/429 ,  C07D513/04

Abstract: The present application relates to thiazolylidene containing compounds of formula (I) wherein R 1 , R 2 , R 3 , and R 4 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract translation: 本申请涉及式（I）的含噻唑基的化合物，其中R 1，R 2，R 3和R 4如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。

公开(公告)号：WO2007140439A2

公开(公告)日：2007-12-06

申请号：PCT/US2007/070029

申请日：2007-05-31

Applicant: ABBOTT LABORATORIES ,  DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie

Inventor： DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie

IPC: C07D277/46 ,  C07D277/48 ,  C07D277/82 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D493/08 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61P29/00

CPC classification number: C07D277/46 ,  A61K31/429 ,  C07D277/48 ,  C07D277/82 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D493/08 ,  C07D513/04

Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R 1 , R 2 , R 3 , R 4 , and L 2 , are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，前体药物，前药盐或其组合，其中R 1，R 2，R 2， 在本说明书中定义了含有这些化合物的组合物，以及使用这些化合物治疗病症和障碍的方法，其中，R 3，R 4， 和组合物。

公开(公告)号：EP2334646A2

公开(公告)日：2011-06-22

申请号：EP09792591.1

申请日：2009-09-16

Applicant: Abbott Laboratories

Inventor： CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  PEDDI, Sridhar ,  LIU, Bo ,  PEREZ-MEDRANO, Arturo ,  PATEL, Meena ,  WANG, Xueqing ,  NELSON, Derek W.

IPC: C07D231/40 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

CPC classification number: C07D405/12 ,  C07D231/40 ,  C07D285/135 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I), wherein A
1 , A
5 , R
x , X
4 , and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

公开(公告)号：EP2146973A2

公开(公告)日：2010-01-27

申请号：EP08745908.7

申请日：2008-04-16

Applicant: Abbott Laboratories

Inventor： CARROLL, William A ,  DART, Michael, J. ,  PEDDI, Sridhar ,  PATEL, Meena, V. ,  NELSON, Derek, W. ,  LI, Tongmei ,  WANG, Xueqing ,  KOLASA, Teodozyj ,  PEREZ-MEDRANO, Arturo

IPC: C07D275/02 ,  C07D275/04 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04 ,  C07D513/10 ,  A61K31/425 ,  A61P9/00 ,  A61P11/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

CPC classification number: A61K31/425 ,  A61K31/427 ,  A61K31/429 ,  A61K31/4436 ,  A61K31/4725 ,  A61K31/5377 ,  C07D275/02 ,  C07D275/04 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04 ,  C07D513/10 ,  Y02P20/582

Abstract: The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract translation: 本申请涉及其中R 1，R 2，R 3，R 4和L如说明书中所定义的式（I）的含异噻唑亚基的化合物，包含此类化合物的组合物，以及使用此类化合物和组合物治疗病症和病症的方法。

公开(公告)号：EP2504317A1

公开(公告)日：2012-10-03

申请号：EP10784389.8

申请日：2010-11-18

Applicant: Abbott Laboratories

Inventor： BROWN, Brian, S. ,  LI, Tongmei ,  PEREZ-MEDRANO, Arturo ,  PEDDI, Sridhar

IPC: C07D237/24 ,  C07D401/12 ,  C07D405/04 ,  C07D471/04 ,  C07D495/04 ,  A61K31/502 ,  A61P29/00

CPC classification number: C07D237/24 ,  C07D401/12 ,  C07D405/04 ,  C07D471/04 ,  C07D495/04

Abstract: Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein ring Z
1 , R
1 , p, R
3 , and R
4 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.

公开(公告)号：EP2344463A2

公开(公告)日：2011-07-20

申请号：EP09752053.0

申请日：2009-11-04

Applicant: Abbott Laboratories

Inventor： CARROLL, William, A. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  NELSON, Derek, W. ,  PATEL, Meena, V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  WANG, Xuequing

IPC: C07D275/02 ,  C07D275/04 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04 ,  C07D513/10 ,  A61K31/425 ,  A61P9/00 ,  A61P11/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

CPC classification number: C07D275/02 ,  C07D275/04 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04 ,  C07D513/10 ,  Y02P20/582

Abstract: The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R
1 , R
2 , R
3 , R
4 , and L are as defined in the specification, compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions.

公开(公告)号：EP2160393A1

公开(公告)日：2010-03-10

申请号：EP08755491.1

申请日：2008-05-15

Applicant: Abbott Laboratories

Inventor： DART, Michael, J. ,  CARROLL, William, A. ,  PEREZ-MEDRANO, Arturo ,  PEDDI, Sridhar ,  FROST, Jennifer, M.

IPC: C07D513/04 ,  A61K31/429 ,  A61P29/00 ,  A61P37/00

CPC classification number: A61K31/429 ,  C07D513/04

Abstract: The present application relates to thiazolylidene containing compounds of formula (I) wherein R1, R2, R3, and R4 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：EP2411382A1

公开(公告)日：2012-02-01

申请号：EP10724166.3

申请日：2010-03-26

Applicant: Abbott Laboratories

Inventor： CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  LI, Tongmei ,  LIU, Bo ,  PEDDI, Sridhar ,  WANG, Xueqing ,  KOLASA, Teodozyj ,  NELSON, Derek W. ,  PEREZ-MEDRANO, Arturo

IPC: C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  A61K31/433 ,  A61P25/04

CPC classification number: C07D417/06 ,  C07D405/06 ,  C07D413/06

Abstract: Disclosed herein are compounds of formula (I) wherein Ring A and R
1 are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and pharmaceutical compositions are also disclosed.

公开(公告)号：EP2142522A1

公开(公告)日：2010-01-13

申请号：EP08732454.7

申请日：2008-03-19

Applicant: ABBOTT LABORATORIES

Inventor： CARROLL, William A ,  KOLASA, Teodozyi ,  FROST, Jennifer M ,  DART, Michael J ,  PATEL, Meena V ,  LATSHAW, Steven P ,  PEREZ-MEDRANO, Arturo ,  WANG, Xueqing ,  PEDDI, Sridhar

IPC: C07D277/46 ,  A61K31/426 ,  A61K31/427 ,  A61K31/429 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04

CPC classification number: C07D277/46 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04 ,  Y02P20/582

Abstract: The present application relates to thiazolylidene containing compounds of formula (I) wherein R1, R2, R3, R4, L2 and A are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

公开(公告)号：EP2024349A2

公开(公告)日：2009-02-18

申请号：EP07797908.6

申请日：2007-05-31

Applicant: ABBOTT LABORATORIES

Inventor： DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie

IPC: C07D277/46 ,  C07D277/48 ,  C07D277/82 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D493/08 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61P29/00

CPC classification number: C07D277/46 ,  A61K31/429 ,  C07D277/48 ,  C07D277/82 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D493/08 ,  C07D513/04

Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L2, are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，前药，前药的盐或其组合，其中R 1，R 2，R 3，R 4和L 2在说明书中定义，包含此类化合物的组合物， 以及使用这样的化合物和组合物治疗病症和障碍的方法。