公开(公告)号：WO2007140439A2

公开(公告)日：2007-12-06

申请号：PCT/US2007/070029

申请日：2007-05-31

Applicant: ABBOTT LABORATORIES ,  DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie

Inventor： DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie

IPC: C07D277/46 ,  C07D277/48 ,  C07D277/82 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D493/08 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61P29/00

CPC classification number: C07D277/46 ,  A61K31/429 ,  C07D277/48 ,  C07D277/82 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D493/08 ,  C07D513/04

Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R 1 , R 2 , R 3 , R 4 , and L 2 , are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，前体药物，前药盐或其组合，其中R 1，R 2，R 2， 在本说明书中定义了含有这些化合物的组合物，以及使用这些化合物治疗病症和障碍的方法，其中，R 3，R 4， 和组合物。

公开(公告)号：WO2011133388A1

公开(公告)日：2011-10-27

申请号：PCT/US2011/032464

申请日：2011-04-14

Applicant: ABBOTT LABORATORIES ,  PENNING, Thomas D. ,  WOODS, Keith W. ,  LAI, Chunqiu ,  FLORJANCIC, Alan S. ,  TONG, Yungsong

Inventor： PENNING, Thomas D. ,  WOODS, Keith W. ,  LAI, Chunqiu ,  FLORJANCIC, Alan S. ,  TONG, Yungsong

IPC: C07D471/04 ,  A61K31/513 ,  A61K31/444 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, Formula (I) wherein R 1a , R 1b , R 1c , X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，式（I）其中R 1a，R 1b，R 1c，X和Y在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。

公开(公告)号：WO2007140385A3

公开(公告)日：2007-12-06

申请号：PCT/US2007/069921

申请日：2007-05-30

Applicant: ABBOTT LABORATORIES ,  DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie ,  KOLASA, Teodozyj

Inventor： DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie ,  KOLASA, Teodozyj

IPC: C07D277/46 ,  C07D277/48 ,  C07D277/60 ,  C07D277/82 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/429 ,  A61P29/00

Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：EP1579864A1

公开(公告)日：2005-09-28

申请号：EP05104506.0

申请日：2003-04-23

Applicant: ABBOTT LABORATORIES

Inventor： MA, Zhenkun ,  DJURIC, Stevan ,  FLORJANCIC, Alan S. ,  YONG, Hong ,  GU, Yugui

IPC: A61K31/7048 ,  C07H17/08

CPC classification number: C07H17/08

Abstract: Antibacterial compounds having formula (II), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates employed in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections in a fish or a mammal using the compounds are disclosed.

公开(公告)号：EP2024349A2

公开(公告)日：2009-02-18

申请号：EP07797908.6

申请日：2007-05-31

Applicant: ABBOTT LABORATORIES

Inventor： DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie

IPC: C07D277/46 ,  C07D277/48 ,  C07D277/82 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D493/08 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61P29/00

CPC classification number: C07D277/46 ,  A61K31/429 ,  C07D277/48 ,  C07D277/82 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D493/08 ,  C07D513/04

Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L2, are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，前药，前药的盐或其组合，其中R 1，R 2，R 3，R 4和L 2在说明书中定义，包含此类化合物的组合物， 以及使用这样的化合物和组合物治疗病症和障碍的方法。

公开(公告)号：EP2038266A2

公开(公告)日：2009-03-25

申请号：EP07797862.5

申请日：2007-05-30

Applicant: ABBOTT LABORATORIES

Inventor： DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie ,  KOLASA, Teodozyj

IPC: C07D277/46 ,  C07D277/48 ,  C07D277/60 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/429 ,  A61P29/00

CPC classification number: C07D277/82 ,  C07D277/46 ,  C07D277/48 ,  C07D277/60 ,  C07D417/06 ,  C07D417/12 ,  C07D477/14 ,  C07D513/04

Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.