公开(公告)号：WO2008063781A3

公开(公告)日：2008-05-29

申请号：PCT/US2007/081263

申请日：2007-10-12

Applicant: ABBOTT LABORATORIES ,  CARROLL, William A. ,  DART, Michael J. ,  KOLASA, Teodozyj ,  MEYER, Michael D. ,  PATEL, Meena V. ,  WANG, Xueqing

Inventor： CARROLL, William A. ,  DART, Michael J. ,  KOLASA, Teodozyj ,  MEYER, Michael D. ,  PATEL, Meena V. ,  WANG, Xueqing

IPC: C07D277/26 ,  C07D277/30 ,  C07D277/64 ,  C07D417/06 ,  C07D277/60 ,  C07D277/56 ,  C07D285/12 ,  C07D513/04 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/429 ,  A61K31/433 ,  A61P25/00 ,  A61P29/00

Abstract: The present invention relates to compounds of formula (I), wherein A, E, L2, R1, R3, R4 and R5 are as defined in the herein, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：WO2010033543A2

公开(公告)日：2010-03-25

申请号：PCT/US2009/057088

申请日：2009-09-16

Applicant: ABBOTT LABORATORIES ,  CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  KOLASA, Teodozyi ,  LI, Tongmei ,  PEDDI, Sridhar ,  LIU, Bo ,  PEREZ-MEDRANO, Arturo ,  PATEL, Meena ,  WANG, Xueqing ,  NELSON, Derek W.

Inventor： CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  KOLASA, Teodozyi ,  LI, Tongmei ,  PEDDI, Sridhar ,  LIU, Bo ,  PEREZ-MEDRANO, Arturo ,  PATEL, Meena ,  WANG, Xueqing ,  NELSON, Derek W.

IPC: C07D231/40 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

CPC classification number: C07D405/12 ,  C07D231/40 ,  C07D285/135 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I), wherein A 1 , A 5 , R x , X 4 , and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本文公开了式（I）的大麻素受体配体，其中A1，A5，Rx，X4和z如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。

公开(公告)号：WO2007140439A2

公开(公告)日：2007-12-06

申请号：PCT/US2007/070029

申请日：2007-05-31

Applicant: ABBOTT LABORATORIES ,  DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie

Inventor： DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie

IPC: C07D277/46 ,  C07D277/48 ,  C07D277/82 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D493/08 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61P29/00

CPC classification number: C07D277/46 ,  A61K31/429 ,  C07D277/48 ,  C07D277/82 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D493/08 ,  C07D513/04

Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R 1 , R 2 , R 3 , R 4 , and L 2 , are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，前体药物，前药盐或其组合，其中R 1，R 2，R 2， 在本说明书中定义了含有这些化合物的组合物，以及使用这些化合物治疗病症和障碍的方法，其中，R 3，R 4， 和组合物。

公开(公告)号：WO2010111572A1

公开(公告)日：2010-09-30

申请号：PCT/US2010/028790

申请日：2010-03-26

Applicant: ABBOTT LABORATORIES ,  CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  LI, Tongmei ,  LIU, Bo ,  PEDDI, Sridhar ,  WANG, Xueqing ,  KOLASA, Teodozyi ,  NELSON, Derek W. ,  PEREZ-MEDRANO, Arturo

Inventor： CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  LI, Tongmei ,  LIU, Bo ,  PEDDI, Sridhar ,  WANG, Xueqing ,  KOLASA, Teodozyi ,  NELSON, Derek W. ,  PEREZ-MEDRANO, Arturo

IPC: C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  A61K31/433 ,  A61P25/04

CPC classification number: C07D417/06 ,  C07D405/06 ,  C07D413/06

Abstract: Disclosed herein are compounds of formula (I) wherein Ring A and R 1 are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and pharmaceutical compositions are also disclosed.

Abstract translation: 本文公开了式（I）的化合物，其中环A和R 1如说明书中所定义。 还公开了包含这些化合物的药物组合物，以及使用这些化合物和药物组合物治疗病症和障碍的方法。

公开(公告)号：WO2009048936A1

公开(公告)日：2009-04-16

申请号：PCT/US2008/079182

申请日：2008-10-08

Applicant: ABBOTT LABORATORIES ,  CARROLL, William A. ,  MEYER, Michael D. ,  PEREZ-MEDRANO, Arturo ,  DART, Michael J. ,  NELSON, Derek W.

Inventor： CARROLL, William A. ,  MEYER, Michael D. ,  PEREZ-MEDRANO, Arturo ,  DART, Michael J. ,  NELSON, Derek W.

IPC: A61K31/015 ,  A61P43/00

CPC classification number: C07D405/06 ,  C07D405/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14

Abstract: The present invention relates compounds of formula (I), as defined in the specification, pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions.

Abstract translation: 本发明涉及如说明书中定义的式（I）化合物，包含这些化合物的药物组合物，以及使用这些化合物和药物组合物治疗病症和障碍的方法。

公开(公告)号：WO2007140385A3

公开(公告)日：2007-12-06

申请号：PCT/US2007/069921

申请日：2007-05-30

Applicant: ABBOTT LABORATORIES ,  DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie ,  KOLASA, Teodozyj

Inventor： DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie ,  KOLASA, Teodozyj

IPC: C07D277/46 ,  C07D277/48 ,  C07D277/60 ,  C07D277/82 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/429 ,  A61P29/00

Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：EP2334646A2

公开(公告)日：2011-06-22

申请号：EP09792591.1

申请日：2009-09-16

Applicant: Abbott Laboratories

Inventor： CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  PEDDI, Sridhar ,  LIU, Bo ,  PEREZ-MEDRANO, Arturo ,  PATEL, Meena ,  WANG, Xueqing ,  NELSON, Derek W.

IPC: C07D231/40 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

CPC classification number: C07D405/12 ,  C07D231/40 ,  C07D285/135 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I), wherein A
1 , A
5 , R
x , X
4 , and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

公开(公告)号：EP2411382A1

公开(公告)日：2012-02-01

申请号：EP10724166.3

申请日：2010-03-26

Applicant: Abbott Laboratories

Inventor： CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  LI, Tongmei ,  LIU, Bo ,  PEDDI, Sridhar ,  WANG, Xueqing ,  KOLASA, Teodozyj ,  NELSON, Derek W. ,  PEREZ-MEDRANO, Arturo

IPC: C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  A61K31/433 ,  A61P25/04

CPC classification number: C07D417/06 ,  C07D405/06 ,  C07D413/06

Abstract: Disclosed herein are compounds of formula (I) wherein Ring A and R
1 are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and pharmaceutical compositions are also disclosed.

公开(公告)号：EP2024349A2

公开(公告)日：2009-02-18

申请号：EP07797908.6

申请日：2007-05-31

Applicant: ABBOTT LABORATORIES

Inventor： DART, Michael J. ,  CARROLL, William A. ,  FLORJANCIC, Alan S. ,  FROST, Jennifer M. ,  GALLAGHER, Megan E. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  NELSON, Derek W. ,  PATEL, Meena V. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  RYTHER, Keith B. ,  TIETJE, Karin Rosemarie

IPC: C07D277/46 ,  C07D277/48 ,  C07D277/82 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D493/08 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61P29/00

CPC classification number: C07D277/46 ,  A61K31/429 ,  C07D277/48 ,  C07D277/82 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D493/08 ,  C07D513/04

Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L2, are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，前药，前药的盐或其组合，其中R 1，R 2，R 3，R 4和L 2在说明书中定义，包含此类化合物的组合物， 以及使用这样的化合物和组合物治疗病症和障碍的方法。

公开(公告)号：EP2219629A1

公开(公告)日：2010-08-25

申请号：EP08837396.4

申请日：2008-10-08

Applicant: Abbott Laboratories

Inventor： CARROLL, William A. ,  PEDDI, Sridhar ,  PEREZ-MEDRANO, Arturo ,  DART, Michael J. ,  NELSON, Derek W. ,  LI, Tongmei ,  LIU, Bo ,  KOLASA, Teodozyj ,  FROST, Jennifer ,  WANG, Xueqing ,  LATSHAW, Steven, P.

IPC: A61K31/015 ,  A61P43/00

CPC classification number: C07D405/06 ,  C07D405/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14

Abstract: The present invention relates compounds of formula (I), as defined in the specification, pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions.

Abstract translation: 本发明涉及如说明书中所定义的式（I）化合物，包含此类化合物的药物组合物，以及使用此类化合物和药物组合物治疗病症和障碍的方法。