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21.发明申请METHODS FOR INCREASING SKELETAL MUSCLE PROTEIN SYNTHESIS USING GREEN TEA EXTRACT 审中-公开使用绿茶提取物增加骨骼肌蛋白合成的方法
公开(公告)号：WO2015094772A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/069126
申请日：2014-12-08
Applicant: ABBOTT LABORATORIES
Inventor： MEADOR, Benjamin , PEREIRA, Suzette , EDENS, Neile , TISDALE, Michael
IPC: A23L1/30 , A23L1/29 , A61K31/353 , A61P21/00
CPC classification number: A61K31/353 , A23L33/105 , A23L33/115 , A23L33/125 , A23L33/17 , A23L33/30 , A23V2002/00 , A23V2200/316 , A23V2250/214 , A61K9/0053 , A61K31/19 , A61K36/82 , A61K45/06 , A61K2300/00
Abstract: Methods of increasing skeletal muscle protein synthesis in a subject are provided. Methods of increasing or maintaining mammalian target of rapamycin (mTOR) activation are also provided. Such methods include a step of administering at least one serving per day of a composition including 20 to 2,000 mg of a green tea extract per serving to the subject.
Abstract translation: 提供了在受试者中增加骨骼肌蛋白质合成的方法。 还提供了增加或维持哺乳动物雷帕霉素靶标（mTOR）活化的方法。 这样的方法包括每天给予至少一份服用组合物的步骤，其包含20至2,000mg每份一份绿茶提取物。
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22.发明申请SHELF-STABLE, CLEAR LIQUID NUTRITIONAL COMPOSITIONS COMPRISING EPIGALLOCATECHIN GALLATE (EGCG) AND METHODS FOR PREPARING THE SAME 审中-公开包含EPIGOCOCCHIN GALLATE（EGCG）的清晰液体营养组合物及其制备方法
公开(公告)号：WO2014055830A1
公开(公告)日：2014-04-10
申请号：PCT/US2013/063394
申请日：2013-10-04
Applicant: ABBOTT LABORATORIES
Inventor： PATEL, Gaurav , JOHNS, Paul , DEWILLE, Normanella , PEREIRA, Suzette
CPC classification number: A23L2/52 , A23L2/46 , A23L2/66 , A23L33/105 , A23L33/17 , A23L33/40 , A23V2002/00 , A23V2200/00 , A61K36/82 , A23V2250/214 , A23V2250/5424 , A23V2250/54244
Abstract: Disclosed herein are shelf-stable, clear liquid nutritional compositions having a pH ranging from 2.5 to 4.6 and comprising water; at least one source of EGCg in an amount sufficient to provide 200-1700 mg/L of EGCg; and at least one source of protein in an amount sufficient to provide 25-45 g/L of total protein. The shelf-stable, clear liquid nutritional compositions lose no more than 20% by weight solids of the EGCg content present in the initial formulation of the compositions to epimerization, degradation, or both epimerization and degradation during heat sterilization. In certain embodiments, the loss of EGCg is exhibited by the amount of epimerization product GCg present in the shelf-stable, clear liquid nutritional composition following heat sterilization. Methods for preparing the shelf-stable, clear liquid nutritional compositions are also disclosed herein.
Abstract translation: 本文公开了具有pH范围为2.5至4.6并且包含水的储存稳定的透明液体营养组合物; 至少一种EGCg来源，其量足以提供200-1700mg / L的EGCg; 和至少一种蛋白质来源，其量足以提供25-45g / L的总蛋白质。 货架稳定的透明液体营养组合物在组合物的初始配方中不超过20重量％固体的EGCg含量，在加热灭菌期间差向异构化，降解或差向异构化和降解均失去。 在某些实施方案中，EGCg的损失由加热灭菌后储存稳定的透明液体营养组合物中存在的差向异构化产物GCg的量显示。 制备储存稳定的透明液体营养组合物的方法也在本文中公开。
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公开(公告)号：WO2010126653A1
公开(公告)日：2010-11-04
申请号：PCT/US2010/027085
申请日：2010-03-12
Applicant: ABBOTT LABORATORIES , PEREIRA, Suzette , KRISHNAN, Padmavathy , DAS, Tapas , MUKERJI, Pradip
Inventor： PEREIRA, Suzette , KRISHNAN, Padmavathy , DAS, Tapas , MUKERJI, Pradip
CPC classification number: C07K16/14 , C07K16/40 , C07K2319/23
Abstract: Disclosed are antibodies that specifically recognize Δ5-desaturase, methods of producing the antibodies, nucleotides and polypeptides for producing the antibodies, and methods of using the antibodies. The Δ5-desaturase-specific antibodies provide improved methods of detecting Δ5- desaturase in a sample.
Abstract translation: 公开了特异性识别α5-去饱和酶的抗体，产生抗体的方法，用于产生抗体的核苷酸和多肽，以及使用该抗体的方法。 α5-去饱和酶特异性抗体提供了在样品中检测α5去饱和酶的改进方法。
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24.发明公开
公开(公告)号：EP2358869A1
公开(公告)日：2011-08-24
申请号：EP09793321.2
申请日：2009-10-06
Applicant: Abbott Laboratories
Inventor： DAS, Tapas , MUKERJI, Pradip , PEREIRA, Suzette , KRISHNAN, Padmavathy
IPC: C12N9/02
CPC classification number: C12N15/8247 , C12N9/0083 , C12P7/6427
Abstract: The present invention is related to isolated polynucleotides encoding a delta-8 desaturase, delta-8 desaturases encoded by the isolated polynucleotides, expression vectors containing the isolated polynucleotides, host cells containing the expression vectors and methods for producing delta-8 desaturases and polyunsaturated fatty acids.
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25.发明授权SHELF-STABLE, CLEAR LIQUID NUTRITIONAL COMPOSITIONS COMPRISING EPIGALLOCATECHIN GALLATE (EGCG) AND PROTEINS 有权包含表没食子儿茶素（EGCG）和蛋白质的贮存稳定，澄清的液体营养组合物
公开(公告)号：EP2903459B1
公开(公告)日：2017-09-06
申请号：EP13779683.5
申请日：2013-10-04
Applicant: ABBOTT LABORATORIES
Inventor： PATEL, Gaurav , JOHNS, Paul , DEWILLE, Normanella , PEREIRA, Suzette
CPC classification number: A23L2/52 , A23L2/46 , A23L2/66 , A23L33/105 , A23L33/17 , A23L33/40 , A23V2002/00 , A23V2200/00 , A61K36/82 , A23V2250/214 , A23V2250/5424 , A23V2250/54244
Abstract: Disclosed herein are shelf-stable, clear liquid nutritional compositions having a pH ranging from 2.5 to 4.6 and comprising water; at least one source of EGCg in an amount sufficient to provide 200-1700 mg/L of EGCg; and at least one source of protein in an amount sufficient to provide 25-45 g/L of total protein. The shelf-stable, clear liquid nutritional compositions lose no more than 20% by weight solids of the EGCg content present in the initial formulation of the compositions to epimerization, degradation, or both epimerization and degradation during heat sterilization. In certain embodiments, the loss of EGCg is exhibited by the amount of epimerization product GCg present in the shelf-stable, clear liquid nutritional composition following heat sterilization. Methods for preparing the shelf-stable, clear liquid nutritional compositions are also disclosed herein.
Abstract translation: 本文公开了具有2.5至4.6的pH且包含水的耐贮存，清澈的液体营养组合物; 至少一种EGCg源，其量足以提供200-1700mg / L的EGCg; 和至少一种蛋白质来源，其量足以提供25-45g / L的总蛋白质。 贮存稳定的透明液体营养组合物在加热消毒过程中失去不超过组合物初始配方中存在的EGCg含量的20重量％至差向异构化，降解或二者的差向异构化和降解。 在某些实施方案中，EGCg的损失由加热消毒后储存稳定的透明液体营养组合物中存在的差向异构化产物GCg的量表现。 本文还公开了制备货架稳定的透明液体营养组合物的方法。
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Patent Agency Ranking26.发明公开METHODS FOR ENHANCING THE EFFECT OF EGCG ON MITIGATING SKELETAL MUSCLE LOSS 有权用于增加EGCG的有效方法，以减少骨骼肌萎缩
公开(公告)号：EP2903458A1
公开(公告)日：2015-08-12
申请号：EP13776697.8
申请日：2013-10-04
Applicant: ABBOTT LABORATORIES
Inventor： PEREIRA, Suzette , GARVEY, Sean , EDENS, Neile
CPC classification number: A61K33/30 , A23L2/66 , A23L33/105 , A23L33/16 , A23L33/17 , A23L33/175 , A23L33/19 , A23L33/195 , A23L33/40 , A23V2002/00 , A61K9/0095 , A61K31/353 , A61K35/20 , A61K36/48 , A61K36/82 , A61K38/011 , A61K38/018 , A61K38/39 , A61K2300/00
Abstract: Disclosed herein are methods for enhancing the efficacy of epigallocatechin gallate (“EGCg”) in mitigating skeletal muscle loss in a subject. Providing EGCg to a subject in a nutritional composition reduces muscle protein degradation, thereby mitigating skeletal muscle loss in the subject. The combination of EGCg with zinc in a nutritional composition enhances the mitigating effect that EGCg has on muscle loss. Specifically, when used in combination, a nutritional composition containing both EGCg and zinc requires less EGCg to obtain the same mitigating effect that occurs in the same nutritional composition containing EGCg but no zinc.
Abstract translation: 公开在用于增强儿茶素的在受试者减轻骨骼肌损失效力（“EGCG”）的方法。 提供了EGCG以营养组合物的受试者减少肌肉蛋白降解，从而减轻受试者的骨骼肌损失。 EGCG与营养组合物的锌结合提高的减轻作用做了EGCG对肌肉损失。 具体而言，当组合使用时，营养组合物含有EGCG和锌需要较少的EGCG以获得相同的减轻作用做了发生在相同的营养组合物含有EGCG但不含锌。
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27.发明公开NOVEL 9-ELONGASE FOR PRODUCTION OF POLYUNSATURATED FATTY ACID-ENRICHED OILS 审中-公开全新的9 ELONGASE与多不饱和脂肪酸富硒产油
公开(公告)号：EP2454365A2
公开(公告)日：2012-05-23
申请号：EP10737154.4
申请日：2010-07-17
Applicant: Abbott Laboratories
Inventor： PEREIRA, Suzette , DAS, Tapas , KRISHNAN, Padmavathy , MUKERJI, Pradip
CPC classification number: C12N9/0071 , C12N9/93 , C12N15/8247
Abstract: The present disclosure relates to isolated polynucleotides encoding a delta 9-elongase, delta 9-elongases encoded by the isolated polynucleotides, expression vectors comprising the isolated polynucleotides, host cells comprising the expression vectors, and methods for producing delta 9-elongase and polyunsaturated fatty acids.
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28.发明公开METHODS FOR INCREASING SKELETAL MUSCLE PROTEIN SYNTHESIS USING GREEN TEA EXTRACT 审中-公开法提高骨骼肌肉蛋白质的合成和绿茶的提取物
公开(公告)号：EP3091859A1
公开(公告)日：2016-11-16
申请号：EP14821389.5
申请日：2014-12-08
Applicant: Abbott Laboratories
Inventor： MEADOR, Benjamin , PEREIRA, Suzette , EDENS, Neile , TISDALE, Michael
IPC: A23L33/00 , A23L33/10 , A61K31/353 , A61P21/00
CPC classification number: A61K31/353 , A23L33/105 , A23L33/115 , A23L33/125 , A23L33/17 , A23L33/30 , A23V2002/00 , A23V2200/316 , A23V2250/214 , A61K9/0053 , A61K31/19 , A61K36/82 , A61K45/06 , A61K2300/00
Abstract: Methods of increasing skeletal muscle protein synthesis in a subject are provided. Methods of increasing or maintaining mammalian target of rapamycin (mTOR) activation are also provided. Such methods include a step of administering at least one serving per day of a composition including 20 to 2,000 mg of a green tea extract per serving to the subject.
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29.发明公开METHODS OF MAINTAINING AND IMPROVING MUSCLE FUNCTION 审中-公开VERFAHREN ZUR BEWAHRUNG UND VERBESSERUNG DER MUSKELFUNKTION
公开(公告)号：EP2986158A1
公开(公告)日：2016-02-24
申请号：EP14719586.1
申请日：2014-03-14
Applicant: ABBOTT LABORATORIES
Inventor： GARVEY, Sean , PEREIRA, Suzette , EDENS, Neile
CPC classification number: A61K31/353 , A23L2/50 , A23L33/105 , A23V2002/00 , A23V2200/316 , A61K9/0053 , A23V2250/214
Abstract: Methods of decreasing muscle function decline and improving muscle function in a subject are provided. The methods utilize an effective amount of epigallocatechin-3-gallate (EGCg) to increase the level of muscle vascular endothelial growth factor A (VEGF), to decrease myostatin levels, or both, and thereby decrease muscle function decline or improve muscle function. The EGCg may be provided as part of a nutritional composition.
Abstract translation: 提供减少肌肉功能下降和改善受试者肌肉功能的方法。 该方法利用有效量的表没食子儿茶素-3-没食子酸酯（EGCg）来增加肌肉血管内皮生长因子A（VEGF）的水平，降低肌生成抑制素水平或两者，从而减少肌肉功能下降或改善肌肉功能。 EGCg可以作为营养组合物的一部分提供。
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30.发明公开
公开(公告)号：EP4284355A1
公开(公告)日：2023-12-06
申请号：EP22704098.7
申请日：2022-01-21
Applicant: ABBOTT LABORATORIES
IPC: A61K31/19 , A61K31/352 , A61K31/7048 , A61P21/00
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