公开(公告)号：WO2014055830A1

公开(公告)日：2014-04-10

申请号：PCT/US2013/063394

申请日：2013-10-04

Applicant: ABBOTT LABORATORIES

Inventor： PATEL, Gaurav ,  JOHNS, Paul ,  DEWILLE, Normanella ,  PEREIRA, Suzette

IPC: A23L1/30 ,  A23L2/52 ,  A23L2/66 ,  A61K36/82

CPC classification number: A23L2/52 ,  A23L2/46 ,  A23L2/66 ,  A23L33/105 ,  A23L33/17 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/00 ,  A61K36/82 ,  A23V2250/214 ,  A23V2250/5424 ,  A23V2250/54244

Abstract: Disclosed herein are shelf-stable, clear liquid nutritional compositions having a pH ranging from 2.5 to 4.6 and comprising water; at least one source of EGCg in an amount sufficient to provide 200-1700 mg/L of EGCg; and at least one source of protein in an amount sufficient to provide 25-45 g/L of total protein. The shelf-stable, clear liquid nutritional compositions lose no more than 20% by weight solids of the EGCg content present in the initial formulation of the compositions to epimerization, degradation, or both epimerization and degradation during heat sterilization. In certain embodiments, the loss of EGCg is exhibited by the amount of epimerization product GCg present in the shelf-stable, clear liquid nutritional composition following heat sterilization. Methods for preparing the shelf-stable, clear liquid nutritional compositions are also disclosed herein.

Abstract translation: 本文公开了具有pH范围为2.5至4.6并且包含水的储存稳定的透明液体营养组合物; 至少一种EGCg来源，其量足以提供200-1700mg / L的EGCg; 和至少一种蛋白质来源，其量足以提供25-45g / L的总蛋白质。 货架稳定的透明液体营养组合物在组合物的初始配方中不超过20重量％固体的EGCg含量，在加热灭菌期间差向异构化，降解或差向异构化和降解均失去。 在某些实施方案中，EGCg的损失由加热灭菌后储存稳定的透明液体营养组合物中存在的差向异构化产物GCg的量显示。 制备储存稳定的透明液体营养组合物的方法也在本文中公开。

公开(公告)号：WO2017117121A1

公开(公告)日：2017-07-06

申请号：PCT/US2016/068701

申请日：2016-12-27

Applicant: ABBOTT LABORATORIES

Inventor： DAS, Tas ,  VURMA, Mustafa ,  LAI, Chron-Si ,  JOHNS, Paul

IPC: A23L33/00 ,  A61K31/575 ,  A23L33/12 ,  A23L33/19 ,  A61P25/28 ,  A61P29/00 ,  A61P43/00 ,  A61K31/685 ,  A61K38/01 ,  A23J3/34

CPC classification number: A23L33/40 ,  A23J3/343 ,  A23J3/344 ,  A23L33/115 ,  A23L33/12 ,  A23L33/125 ,  A23L33/18 ,  A23L33/19 ,  A23V2002/00 ,  A61K31/575 ,  A61K31/685 ,  A61K38/018 ,  A23V2200/322 ,  A23V2250/1578 ,  A23V2250/16 ,  A23V2250/161 ,  A23V2250/1614 ,  A23V2250/1842 ,  A23V2250/186 ,  A23V2250/1862 ,  A23V2250/1868 ,  A23V2250/192 ,  A23V2250/211 ,  A23V2250/304 ,  A23V2250/5054 ,  A23V2250/5114 ,  A23V2250/5118 ,  A23V2250/54246 ,  A23V2250/702 ,  A23V2250/708 ,  A23V2250/71 ,  A23V2250/712 ,  A23V2250/714 ,  A61K2300/00

Abstract: Disclosed embodiments provide nutritional compositions and methods of enhancing maturation of an infant's brain. The methods include the step of administering to the infant a nutritional composition comprising a protein with a degree of hydrolysis of 10% to 75% in combination with at least one of a monoglyceride, a free fatty acid, a salt of a free fatty acid, a phospholipid, and cholesterol.

Abstract translation: 所公开的实施方案提供了增强婴儿脑部成熟的营养组合物和方法。 所述方法包括向婴儿施用营养组合物的步骤，所述营养组合物包含水解度为10％至75％的蛋白质与甘油单酯，游离脂肪酸，游离脂肪酸的盐， 磷脂和胆固醇。

公开(公告)号：WO2017044601A1

公开(公告)日：2017-03-16

申请号：PCT/US2016/050739

申请日：2016-09-08

Applicant: ABBOTT LABORATORIES

Inventor： CORDLE, Christopher ,  TYRE, Roger ,  JOHNS, Paul ,  GARVEY, Sean ,  TORGERSON, Eric

IPC: A23L33/175 ,  A23L2/39 ,  A23L27/30 ,  A23L33/18 ,  A61K31/198

CPC classification number: A23L33/175 ,  A23L2/39 ,  A23L33/125 ,  A23L33/18 ,  A23V2002/00 ,  A23V2200/316 ,  A23V2250/0626 ,  A23V2250/0628 ,  A23V2250/0654 ,  A23V2250/64

Abstract: Powdered nutritional products containing branched-chain amino acids and a sugar alcohol are provided. The branched-chain amino acids in the powdered nutritional product exhibit improved solubility and thus improved dissolution upon reconstitution of the powdered nutritional product.

Abstract translation: 提供含有支链氨基酸和糖醇的粉状营养产品。 粉状营养产品中的支链氨基酸表现出改善的溶解性，从而改善了粉末营养产品重建时的溶解度。

公开(公告)号：WO2015089009A1

公开(公告)日：2015-06-18

申请号：PCT/US2014/069215

申请日：2014-12-09

Applicant: ABBOTT LABORATORIES

Inventor： WEARLY, Douglas ,  JOHNS, Paul ,  DEWILLE, Normanella ,  BLUMBERG, Rachel ,  BAXTER, Jeffrey

IPC: A23L1/305 ,  A23C9/156 ,  A23L2/39 ,  A23L2/66 ,  A23L1/00 ,  A23L1/29

CPC classification number: A23L2/66 ,  A23L2/52 ,  A23L33/115 ,  A23L33/125 ,  A23L33/185 ,  A23L33/19 ,  A23L33/40 ,  A23V2002/00

Abstract: The combination of potato protein, intact rice protein and hydrolyzed rice protein, replaces a portion of the vegetable protein in a nutrition shake or other nutritional composition intended for oral consumption. By suitable selection of the types and amounts of these proteins the overall cost of manufacturing the nutritional composition can be reduce without adversely affecting its other desirable properties such as nutritional value, stability, taste and mouthfeel.

Abstract translation: 马铃薯蛋白质，完整的米蛋白质和水解的蛋白质的组合替代了用于口服消费的营养摇动剂或其它营养组合物中的一部分植物蛋白质。 通过适当选择这些蛋白质的类型和量，可以减少营养组合物的总体成本，而不会不利地影响其它所需的性质，例如营养价值，稳定性，味觉和口感。

公开(公告)号：WO2015031657A1

公开(公告)日：2015-03-05

申请号：PCT/US2014/053230

申请日：2014-08-28

Applicant: ABBOTT LABORATORIES

Inventor： JOHNS, Paul ,  VURMA, Mustafa ,  ALBRECHT, Daniel ,  DEMICHELE, Stephen ,  KATZ, Gary ,  REDDY, Todime

IPC: A23L1/30 ,  A23L1/302 ,  A23C9/20 ,  A23L1/29

CPC classification number: A23L33/115 ,  A23C9/1526 ,  A23C9/1528 ,  A23L33/15 ,  A23L33/155 ,  A23L33/17 ,  A23L33/19 ,  A23L33/40 ,  A23V2002/00 ,  A23V2250/182 ,  A23V2250/192 ,  A23V2250/211 ,  A23V2250/71

Abstract: Disclosed herein is a nutritional composition having at least one protein, at least one fat, and at least one lipophilic compound, the composition comprising at least one assembly comprising at least one hydrophobic protein, monoglycerides and diglycerides ("MDG") and at least one lipophilic compound, wherein at least 1% of the total MDG in the nutritional composition remains in the aqueous phase after centrifugation at 100,000 x g for 1 hour at 20°C.

Abstract translation: 本文公开了具有至少一种蛋白质，至少一种脂肪和至少一种亲脂性化合物的营养组合物，所述组合物包含至少一种包含至少一种疏水蛋白，单酸甘油酯和甘油二酯（“MDG”）的组合物和至少一种 亲脂性化合物，其中营养组合物中总MDG的至少1％在20℃下以100,000×g离心1小时后保持在水相中。

公开(公告)号：WO2014160261A1

公开(公告)日：2014-10-02

申请号：PCT/US2014/026188

申请日：2014-03-13

Applicant: ABBOTT LABORATORIES

Inventor： JOHNS, Paul ,  PATEL, Gaurav ,  FAWCETT, Susan

IPC: A23L1/305 ,  A23L1/30 ,  A23L1/29 ,  A23C9/20

CPC classification number: A23C11/06 ,  A23C11/02 ,  A23L33/12 ,  A23L33/185 ,  A23L33/19 ,  A23L33/40

Abstract: A nutritional composition in the form of an oil-in-water emulsion contains about 0.5 to 50 wt.% protein, about 0.1 to 25 wt.% fat, about 0.1 to 50 wt.% carbohydrate, and about 50 to 95 wt.% water. At least 40 wt.% of the protein in the composition is cold water soluble. In addition, at least 50 wt.% of the cold water soluble protein in the composition is derived from a cold water soluble milk protein concentrate containing at least 50 wt.% cold water soluble protein.

Abstract translation: 水包油乳液形式的营养组合物包含约0.5至50重量％的蛋白质，约0.1至25重量％的脂肪，约0.1至50重量％的碳水化合物和约50至95重量％ 水。 组合物中至少40重量％的蛋白质是冷水溶解的。 此外，组合物中至少50重量％的冷水可溶性蛋白质来自含有至少50重量％冷水可溶性蛋白质的冷水可溶性乳蛋白浓缩物。

公开(公告)号：WO2022115669A1

公开(公告)日：2022-06-02

申请号：PCT/US2021/060921

申请日：2021-11-29

Applicant: ABBOTT LABORATORIES

Inventor： PHAM, Quang Son ,  PEREIRA, Suzette ,  JOHNS, Paul ,  WANG, Susan ,  TERP, Megan ,  RUEDA CABRERA, Ricardo

IPC: A23L33/105 ,  A23L33/185 ,  A23L33/19 ,  A23C9/20 ,  A61K36/605 ,  A61K36/87 ,  A61K36/752

Abstract: A method of forming a heat-treated liquid nutritional composition having a neutral pH and comprising a water-insoluble plant flavonoid comprises providing an aqueous liquid nutritional composition having a pH of from about 6 to about 7.5 and comprising protein, fat, carbohydrate, and water-insoluble plant flavonoid, homogenizing the liquid nutritional composition at a pressure of at least about 2000 psi, and heat treating the liquid nutritional composition. A heat-treated liquid nutritional composition having a pH of from about 6 to about 7.5 comprises a water-insoluble plant flavonoid, protein, fat and carbohydrate. At least about 75 wt % of the water-insoluble plant flavonoid remains suspended throughout the liquid nutritional composition after two months of storage at room temperature.

公开(公告)号：WO2017116800A1

公开(公告)日：2017-07-06

申请号：PCT/US2016/067539

申请日：2016-12-19

Applicant: ABBOTT LABORATORIES

Inventor： LOWE, Kelley ,  CHAPMAN, Timothy ,  DEWILLE, Normanella ,  JOHNS, Paul

IPC: A23L33/00 ,  A23L33/185 ,  A23L33/19

CPC classification number: A23L33/40 ,  A23L33/185 ,  A23L33/19 ,  A23V2002/00 ,  A23V2200/33 ,  A23V2250/00 ,  A23V2200/244 ,  A23V2250/5424 ,  A23V2250/5488

Abstract: Liquid nutritional compositions including both soy protein and dairy protein demonstrate enhanced rheological properties. By suitable selection of the types and amounts of these proteins, high caloric density products can be obtained without adversely affecting other desirable properties such as nutritional value, stability, taste, and mouthfeel.

Abstract translation: 包含大豆蛋白质和乳蛋白质的液体营养组合物表现出增强的流变性质。 通过适当选择这些蛋白质的类型和数量，可以获得高热量密度产品而不会不利地影响诸如营养价值，稳定性，味道和口感的其它所需特性。

公开(公告)号：WO2016057818A1

公开(公告)日：2016-04-14

申请号：PCT/US2015/054744

申请日：2015-10-08

Applicant: ABBOTT LABORATORIES

Inventor： TERP, Megan ,  HEO, Youngsuk ,  DEWILLE, Normanella ,  JOHNS, Paul ,  ATNIP, Allison

IPC: A61K36/53 ,  A23L3/3472 ,  A23L5/20 ,  A23L33/105 ,  A23L33/115 ,  A23L33/12

CPC classification number: A23L5/20 ,  A23L3/3472 ,  A23L33/105 ,  A23L33/115 ,  A23L33/40 ,  A23V2002/00 ,  A61K36/53 ,  A61K36/534 ,  A61K2236/00 ,  C08L5/00 ,  A23V2200/02 ,  A23V2200/15 ,  A23V2200/16 ,  A23V2250/156 ,  A23V2250/1882 ,  A23V2250/21 ,  A23V2250/2116 ,  A23V2250/5046 ,  A23V2250/5114 ,  A23V2250/54246 ,  A23V2250/54252 ,  A23V2250/70 ,  A23V2250/712

Abstract: A nutritional composition including an oxidizable component and a water-soluble plant extract is provided. The water-soluble plant extract includes rosmarinic acid and has a total phenolic content, such that a ratio of the total phenolic content to the rosmarinic acid is between about 1.1:1 to about 3.5:1. A method of reducing off-flavors and aromas in a nutritional composition having an oxidizable component is also provided.

Abstract translation: 提供了包含可氧化成分和水溶性植物提取物的营养组合物。 水溶性植物提取物包括迷迭香酸，并且具有总酚含量，使得总酚含量与迷迭香酸的比例在约1.1:1至约3.5:1之间。 还提供了减少具有可氧化成分的营养组合物中的异味和香味的方法。

公开(公告)号：WO2016007515A1

公开(公告)日：2016-01-14

申请号：PCT/US2015/039381

申请日：2015-07-07

Applicant: ABBOTT LABORATORIES

Inventor： BLUMBERG, Rachel ,  DEWILLE, Normanella ,  WEARLY, Douglas ,  JOHNS, Paul

IPC: A23L1/305 ,  A23L2/66 ,  A23L1/304

CPC classification number: A23L33/19 ,  A23L33/16 ,  A23L33/175 ,  A23L33/185 ,  A23V2002/00 ,  A23V2200/00 ,  A23V2250/1578 ,  A23V2250/1592 ,  A23V2250/1642 ,  A23V2250/54246 ,  A23V2250/548

Abstract: A nutrient delivery system includes a protein system, calcium, zinc, and iron. The protein system includes a calcium binding protein in an amount of 40% to 75% by weight of the protein system, a zinc binding protein in an amount of 10% to 30% by weight of the protein system, and an iron binding protein in an amount of 10% to 30% by weight of the protein system. The calcium binding protein and the calcium are present in a weight ratio of 13:1 to 25:1, the zinc binding protein and the zinc are present in a weight ratio of 6:1 to 900:1, and the iron binding protein and the iron are present in a weight ratio of 5.4:1 to 800:1.

Abstract translation: 营养输送系统包括蛋白质系统，钙，锌和铁。 蛋白质系统包括蛋白质体系重量的40〜75重量％的钙结合蛋白，蛋白质体系的10〜30重量％的锌结合蛋白，以及铁蛋白结合蛋白 其量为蛋白质体系重量的10％至30％。 钙结合蛋白和钙以13:1至25:1的重量比存在，锌结合蛋白和锌以6:1至900:1的重量比存在，铁结合蛋白和 铁以5.4:1至800:1的重量比存在。