公开(公告)号：WO2021183740A1

公开(公告)日：2021-09-16

申请号：PCT/US2021/021864

申请日：2021-03-11

Applicant: ABBOTT LABORATORIES

Inventor： PEREIRA, Suzette ,  RUEDA, Ricardo ,  GANAPATHY, Vadivel

IPC: A61K31/19 ,  A61P1/12 ,  A61P1/00 ,  A61P37/02 ,  A61P35/00 ,  A23L33/00 ,  A61K9/00 ,  A61P1/04

Abstract: A method of treating diarrhea or an inflammatory condition of the gut in a subject comprises administering a therapeutically effective amount of beta-hydroxy-beta-methylbutyrate (HMB) or a salt thereof to a subject in need thereof. A method of treating secretory diarrhea in a subject comprises administering a therapeutically effective amount of HMB or a salt thereof to a subject exhibiting one or more of the following symptoms: loss of fluids from the gut, loss of electrolytes from the gut, dehydration, or inflammation of the intestinal tract.

公开(公告)号：WO2015094767A1

公开(公告)日：2015-06-25

申请号：PCT/US2014/069092

申请日：2014-12-08

Applicant: ABBOTT LABORATORIES

Inventor： PEREIRA, Suzette ,  MEADOR, Benjamin ,  EDENS, Neile ,  PATEL, Gaurav

IPC: A23L1/30 ,  A61P3/00 ,  A61K31/353

CPC classification number: A61K31/353 ,  A23L33/105 ,  A61K35/20 ,  A61K36/28 ,  A61K36/82 ,  A61K36/889 ,  A61K36/899 ,  A61K38/018 ,  A61K2300/00

Abstract: Methods for maintaining or increasing bodyweight in a subject susceptible to unintentional weight loss are provided. The methods include a step of administering at least one serving per day of a composition including 20 to 2000 mg of a decaffeinated green tea extract per serving to the subject.

Abstract translation: 提供了在易受无意减肥的受试者中维持或增加体重的方法。 所述方法包括每天至少一次服用包含20至2000mg每份一次的脱咖啡因绿茶提取物的组合物的步骤。

公开(公告)号：WO2015073843A1

公开(公告)日：2015-05-21

申请号：PCT/US2014/065732

申请日：2014-11-14

Applicant: ABBOTT LABORATORIES

Inventor： JOHNS, Paul ,  LASEKAN, John ,  PATEL, Gaurav ,  ZEITLER, Wilson George ,  PEREIRA, Suzette

IPC: A23L1/29 ,  A23L2/10 ,  A23L2/39 ,  A23L1/00

CPC classification number: A23L33/40 ,  A23L2/102 ,  A23L2/39 ,  A23L2/56 ,  A23L2/66 ,  A23L33/185 ,  A23P10/40 ,  A23V2002/00 ,  A23V2200/00 ,  A23V2250/0632 ,  A23V2250/1592 ,  A23V2250/1642 ,  A23V2250/5488

Abstract: Nutritional powder products exhibiting better taste and bioavailability of micronutrients are produced by avoiding certain ingredient combinations in the blended liquid mixture which is spray dried during manufacture. Particular ingredients which are omitted from this blended liquid mixture so as to avoid these combinations are added back by dry blending these omitted ingredients with the base powder produced by spray drying.

Abstract translation: 通过避免在制造过程中喷雾干燥的混合液体混合物中的某些成分组合，产生表现出更好的微量营养素的味道和生物利用度的营养粉末产品。 通过将这些省略的成分与通过喷雾干燥制备的基础粉末干混而将这些混合的液体混合物中省略的避免这些组合的特定成分加入。

公开(公告)号：WO2014144458A1

公开(公告)日：2014-09-18

申请号：PCT/US2014/028879

申请日：2014-03-14

Applicant: ABBOTT LABORATORIES

Inventor： GARVEY, Sean ,  PEREIRA, Suzette ,  EDENS, Neile

IPC: A23L1/30 ,  A23L2/50

CPC classification number: A61K31/353 ,  A23L2/50 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/316 ,  A61K9/0053 ,  A23V2250/214

Abstract: Methods of decreasing muscle function decline and improving muscle function in a subject are provided. The methods utilize an effective amount of epigallocatechin-3-gallate (EGCg) to increase the level of muscle vascular endothelial growth factor A (VEGF), to decrease myostatin levels, or both, and thereby decrease muscle function decline or improve muscle function. The EGCg may be provided as part of a nutritional composition.

Abstract translation: 提供减少肌肉功能下降和改善受试者肌肉功能的方法。 该方法利用有效量的表没食子儿茶素-3-没食子酸酯（EGCg）来增加肌肉血管内皮生长因子A（VEGF）的水平，降低肌生成抑制素水平或两者，从而降低肌肉功能下降或改善肌肉功能。 EGCg可以作为营养组合物的一部分提供。

公开(公告)号：WO2022115669A1

公开(公告)日：2022-06-02

申请号：PCT/US2021/060921

申请日：2021-11-29

Applicant: ABBOTT LABORATORIES

Inventor： PHAM, Quang Son ,  PEREIRA, Suzette ,  JOHNS, Paul ,  WANG, Susan ,  TERP, Megan ,  RUEDA CABRERA, Ricardo

IPC: A23L33/105 ,  A23L33/185 ,  A23L33/19 ,  A23C9/20 ,  A61K36/605 ,  A61K36/87 ,  A61K36/752

Abstract: A method of forming a heat-treated liquid nutritional composition having a neutral pH and comprising a water-insoluble plant flavonoid comprises providing an aqueous liquid nutritional composition having a pH of from about 6 to about 7.5 and comprising protein, fat, carbohydrate, and water-insoluble plant flavonoid, homogenizing the liquid nutritional composition at a pressure of at least about 2000 psi, and heat treating the liquid nutritional composition. A heat-treated liquid nutritional composition having a pH of from about 6 to about 7.5 comprises a water-insoluble plant flavonoid, protein, fat and carbohydrate. At least about 75 wt % of the water-insoluble plant flavonoid remains suspended throughout the liquid nutritional composition after two months of storage at room temperature.

公开(公告)号：WO2014179526A1

公开(公告)日：2014-11-06

申请号：PCT/US2014/036297

申请日：2014-05-01

Applicant: ABBOTT LABORATORIES

Inventor： GARVEY, Sean ,  PEREIRA, Suzette ,  EDENS, Neile

IPC: A23L1/30 ,  A23L1/305 ,  A23L1/29 ,  A61K31/353

CPC classification number: A23L1/3002 ,  A23L33/105 ,  A23L33/15 ,  A23L33/17 ,  A23L33/175 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/19 ,  A61K31/353 ,  A23V2200/316 ,  A61K2300/00

Abstract: Compositions and methods for enhancing the regenerative capacity of an individual are provided. The compositions include, and the methods provide, a combination of an effective amount of epigallocatechin-3-gallate (EGCg) and an effective amount of beta-hydroxy-beta-methylbutyrate (HMB) to decrease the level of intramuscular FGF2, to enhance the regenerative capacity of muscle, or both.

Abstract translation: 提供了增强个人再生能力的组合物和方法。 组合物包括并且该方法提供有效量的表没食子儿茶-3-没食子酸酯（EGCg）和有效量的β-羟基-β-甲基丁酸酯（HMB）的组合以降低肌内FGF2的水平，以增强 肌肉的再生能力，或两者。

公开(公告)号：WO2014152606A2

公开(公告)日：2014-09-25

申请号：PCT/US2014/027524

申请日：2014-03-14

Applicant: ABBOTT LABORATORIES

Inventor： LUO, Menghua ,  PEREIRA, Suzette ,  EDENS, Neile ,  DAVIS, Gerard ,  GAWEL, Susan ,  CHANDRAN, Raj

IPC: A61K31/19

CPC classification number: A61K31/19 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2333/4704 ,  G01N2333/575 ,  G01N2800/52

Abstract: Insulin resistance biomarkers and related methods of using the biomarkers are provided. The biomarkers may be blood biomarkers and include C-peptide, Insulin-Like Growth Factor- Binding Protein 2 (IGFBP-2), and Leptin. Also provided is a method of reducing the effect of prolonged physical inactivity on insulin resistance in a subject who is experiencing prolonged physical inactivity, or who is expected to experience prolonged physical inactivity in the near future.

Abstract translation: 提供了使用生物标志物的胰岛素抵抗生物标志物和相关方法。 生物标志物可以是血液生物标志物，包括C肽，胰岛素样生长因子结合蛋白2（IGFBP-2）和瘦蛋白。 还提供了一种减少长期身体不活动对经历长时间身体不活动的受试者或预期在不久的将来会经历长时间身体不活动的受试者的胰岛素抵抗的影响的方法。

公开(公告)号：WO2014028607A1

公开(公告)日：2014-02-20

申请号：PCT/US2013/054925

申请日：2013-08-14

Applicant: ABBOTT LABORATORIES

Inventor： PEREIRA, Suzette ,  KRISHNAN DESAI, Padmavathy ,  EDENS, Neile

IPC: A61K31/122 ,  A61P3/02 ,  A61K36/00

CPC classification number: A61K31/12 ,  A61K36/9066 ,  A61K31/353 ,  A61K2300/00

Abstract: Nutritional compositions that include a combination of Curcumin and epigallocatechin gallate (EGCg) are provided. The nutritional compositions may be formulated as low glycemic index nutritional compositions. The nutritional compositions may be administered to an individual, particularly an insulin resistant, pre-diabetic, or diabetic individual, to preserve muscle mass and decrease fat deposition, thereby improving overall body composition leading to increased strength and functionality as well as improved blood glucose control and insulin sensitivity.

Abstract translation: 提供了包含姜黄素和表没食子儿茶素没食子酸酯（EGCg）的组合的营养组合物。 营养组合物可以配制成低血糖指数营养组合物。 营养组合物可以施用于个体，特别是胰岛素抵抗，糖尿病前期或糖尿病个体，以保持肌肉质量并减少脂肪沉积，从而改善整体身体组成，从而提高强度和功能，以及改善血糖控制 和胰岛素敏感性。

公开(公告)号：WO2016044272A1

公开(公告)日：2016-03-24

申请号：PCT/US2015/050179

申请日：2015-09-15

Applicant: ABBOTT LABORATORIES

Inventor： PEREIRA, Suzette ,  EDENS, Neile

IPC: A61K36/82 ,  A61K31/19 ,  A61K31/198 ,  A61K31/353 ,  A61P21/06

CPC classification number: A61K31/19 ,  A61K31/198 ,  A61K31/353 ,  A61K36/82 ,  A61K2300/00

Abstract: Methods of preserving muscle strength in a subject during a period of muscle disuse are provided. Methods of preserving muscle strength in a subject during a period of muscle disuse and a subsequent period of muscle recovery are also provided. The methods include administering a composition including β-hydroxy-β-methylbutyrate and green tea extract to the subject during at least a portion of the period of muscle disuse and, optionally, during at least a portion of the period of muscle recovery. The composition may also include leucine or another leucine metabolite, such as α-ketoisocaproic acid or α-hydroxyisocaproic acid.

Abstract translation: 提供在肌肉消除期间保持受试者肌肉力量的方法。 还提供了在肌肉消除期间和随后的肌肉恢复期间保持受试者肌肉力量的方法。 所述方法包括在至少一段时间的肌肉消除期间和任选地在至少一部分肌肉恢复期间内向受试者施用包含β-羟基-β-甲基丁酸酯和绿茶提取物的组合物。 组合物还可以包括亮氨酸或另一亮氨酸代谢物，例如α-酮异己酸或α-羟基异己酸。

公开(公告)号：WO2015126716A1

公开(公告)日：2015-08-27

申请号：PCT/US2015/015566

申请日：2015-02-12

Applicant: ABBOTT LABORATORIES

Inventor： MEADOR, Benjamin ,  PEREIRA, Suzette ,  EDENS, Neile ,  PATEL, Gaurav

IPC: A23L1/30 ,  A23L1/305 ,  A23L2/52 ,  A23L2/66

CPC classification number: A23L2/52 ,  A23L2/66 ,  A23L33/10 ,  A23L33/105 ,  A23L33/17

Abstract: A liquid nutritional composition includes a source of epigallocatechin gallate and at least one of a source of protein, a source of carbohydrate, and a source of fat. The liquid nutritional composition includes gallocatechin gallate and epigallocatechin gallate in a ratio of about 1:20 to about 1:0.60. At least a portion of the gallocatechin gallate is formed by epimerization of the epigallocatechin gallate as a result of application of heat to the liquid nutritional composition. Methods of making the liquid nutritional composition are also provided.

Abstract translation: 液体营养组合物包括表没食子儿茶素没食子酸酯的来源和蛋白质来源，碳水化合物源和脂肪源中的至少一种。 液体营养组合物包含比例为约1:20至约1:0.60的没食子儿茶素没食子酸酯和表没食子儿茶素没食子酸酯。 通过向液体营养组合物施加热量，表儿茶素没食子酸酯的至少一部分由表没食子儿茶素没食子酸酯的差向异构化形成。 还提供了制备液体营养组合物的方法。