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公开(公告)号：JPH01149751A
公开(公告)日：1989-06-12
申请号：JP31026887
申请日：1987-12-08
Applicant: AGENCY IND SCIENCE TECHN
Inventor： KAMATA TOSHIHIRO , ISHIGAMI YUTAKA , WASADA NOBUHIDE
Abstract: NEW MATERIAL:A compound shown by formula I (OR is hydroxyl or alcohol residue). USE:An immunoactivator having weak toxicity and strongly activating action on cell. Since the compound has two chain aliphatic groups, the compound is useful as a raw material for biodegradable surfactant having balanced hydrophilic and lipophilic nature. PREPARATION:The ketone group of a 2-n-hexyl-3-oxo-n-decanoic acid ester shown by formula II is reduced to give a 2-n-hexyl-3-hydroxy-n-decanoic acid ester shown by formula 1. Then this ester is treated with an alkali and the ester group is hydrolyzed to give 2-n-hexyl-3-hydroxy-n-decanoic acid. The compound shown by formula II is obtained by condensing an octanoic acid ester in xylene in the presence of sodium hydride under heating.
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公开(公告)号：JPS63182029A
公开(公告)日：1988-07-27
申请号：JP1312287
申请日：1987-01-22
Applicant: AGENCY IND SCIENCE TECHN , SHINETSU CHEMICAL CO
Inventor： ISHIGAMI YUTAKA , GAMA YASUO , NAGAHORA HITOSHI , MOTOMIYA TATSUHIKO , YAMAGUCHI MUNEO
IPC: C12N15/09 , A61K8/14 , A61K8/60 , A61K9/127 , A61Q19/00 , B01J13/02 , C07H15/10 , C12N1/00 , C12N15/00 , C12P19/44
Abstract: PURPOSE:To obtain liposome which is fine, stable and capable of use for biological applications by forming a wall film consisting of substance selected from among rhamnolipid A, rhamnolipid B and their neutral salts. CONSTITUTION:Rhamnolipid A and rhamnolipid B shown in a formula I and a formula II are a microbe-derived biosurfactant and are one kind of glycolipids. These perform the conversion of a molecular association type reversible among micell-droplet-lamella-vehicle (closed follicle) which is dependent on pH. In other words, a micell is formed at pH not less than 6.8 (complete neutral salt) and a lamella-shape is formed at 6.5-6.0pH and they are converted into a vehicle at 5.8-4.3pH. Liposome is formed from rhamnolipid A and rhamnolipid B by a well-known method by utilizing these properties. The obtained liposome is fine and stable and can be used for biological applications.
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公开(公告)号：JPS61146330A
公开(公告)日：1986-07-04
申请号：JP26597884
申请日：1984-12-17
Applicant: AGENCY IND SCIENCE TECHN
Inventor： ISHIGAMI YUTAKA , YAMAZAKI SHINSUKE , GAMA YASUO
IPC: B01F17/42 , B01F17/44 , C07C69/675 , C07C235/06
Abstract: PURPOSE:To improve solubilizing power and emulsifying and dispersing effects for solid fine powder and several substances by prepg. a surface active agent from at least one compd. selected from three kinds of compds. expressed by the specified general formulas. CONSTITUTION:The surface active agent is prepd. from at least one compd. selected from compds. expressed by formula I (wherein X and X are polyoxyalkylene group, alkylamino group, alkoxy group, etc.; one of X and X is polyoxyalkylene group), from compds. expressed by formula II (wherein Y , Y and Y are polyoxyalkylene group, alkylamino group, etc.; at least one of the three is polyoxyalkylene group), and from compds. expressed by formula III (wherein Z , Z and Z are polyoxyalkylene group, alkylamino group, etc.; at least one of the three is polyoxyalkylene group).
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公开(公告)号：JP2000087006A
公开(公告)日：2000-03-28
申请号：JP25962898
申请日：1998-09-14
Applicant: AGENCY IND SCIENCE TECHN
Inventor： ISHIGAMI YUTAKA , SAKAGUCHI HIROSHI , MASUDA TAKASHI , ITO SHOJI , UCHIYAMA HIROO , CHO YAKUGUN
IPC: C09K3/00
Abstract: PROBLEM TO BE SOLVED: To obtain a gelatinizer having biodegradability and high safety to living organism by reacting spiculisporic acid with a basic compound to produce a neutral salt. SOLUTION: This gelatinizer comprises a compound represented by the formula (wherein X is mutually same or different from each other and a metal atom or a group selected from the group consisting of an alkaline earth metal, Li, Al and an arginine residue; and (n) is 1 or 2). The galatinizer is usually used as an aqueous solution. The concentration of the compound of the formula in the aqueous solution is preferably 20 wt.% or below, more preferably 0.5-10 wt.%. To spiculisporic acid [(4S,5S)-4,5-dicarboxyl-4-pentadecanolide] is added an aqueous solution of a basic compound in excess of a calculated amount, and the resulting product is heated to obtain the compound of the formula which has the structure of ring operating of a lactone ring. An oil phase component and alcohol capable of gelation using this gelatinizer are monovalent alcohol, polyvalent alcohol, oil such as hydrocarbons, or the like.
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25.发明专利
公开(公告)号：JP2000086541A
公开(公告)日：2000-03-28
申请号：JP25792898
申请日：1998-09-11
Applicant: AGENCY IND SCIENCE TECHN
Inventor： SAKAGUCHI HIROSHI , KAKU TAMAHO , ISHIGAMI YUTAKA , MASUDA TAKASHI
Abstract: PROBLEM TO BE SOLVED: To provide a method for making a liquid or gas state organic compound as a solid state material, and a method for taking the organic material out as an original state from the above solid state material. SOLUTION: This method for solidifying a hydrocarbon is provided by bringing an aliphatic saturated carboxylic acid metal salt dissolved emulsified or suspended in water in contact with an organic compound to form a solid state aggregate with the organic compound. The method for regenerating the organic compound is provided by heating the above solid state aggregate for decomposition to obtain the organic compound.
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Patent Agency Ranking
公开(公告)号：JPH06100581A
公开(公告)日：1994-04-12
申请号：JP27956192
申请日：1992-09-24
Applicant: AGENCY IND SCIENCE TECHN
Inventor： ISHIGAMI YUTAKA , GAMA YASUO , KITAMOTO MASARU
Abstract: PURPOSE:To provide the subject new compound useful as a water-soluble or oil-soluble surfactant or gelling agent etc. CONSTITUTION:The objective compound of formula I (R is H or acetyl; R is H, aliphatic group or aromatic group), e.g. sophorolipid benzylamide. The compound of the formula I can be obtained, for example, by reaction of (A) an acid-type sophorolipid of formula II produced by an established culture method with (B) an amine compound of formula R NH2 in a methylene chloride solvent in the presence of N-methyl-2-chloro-pyridinium iodide and tributylamine. The compound of the formula II can, in turn, be obtained, for example, by culture of Candida bombicola ATCC 22214 strain using, as carbon source, a saccharide like glucose and a natural oil like sunflower oil.
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公开(公告)号：JPH03143540A
公开(公告)日：1991-06-19
申请号：JP27703989
申请日：1989-10-26
Applicant: AGENCY IND SCIENCE TECHN , ISHIHARA CHEMICAL CO LTD
Inventor： ISHIGAMI YUTAKA , GAMA YASUO , KAWAGUCHI YOSHIHIRO , MATSUKAWA KURAYA
Abstract: PURPOSE:To perform satisfactory emulsification with an emulsifier derived from a living body and to simultaneously stabilize an emulsified compsn. by using specified hyaluronic acid derivs. as an emulsification stabilizer. CONSTITUTION:Hyaluronic acid derivs. represented by general formulae I, II (where R is acyl, R is hydroxyl, -OM (M is an alkali metal atom) or -NH2 and n is an integer of >=2) are used as an emulsification stabilizer having high safety derived from a living body. Since this stabilizer has hydroxyl groups in the molecule, an emulsified compsn. having high stability is obtd. without using alcohol. The viscosity of the emulsified compsn. can be regulated according to the mol.wts. of the hyaluronic acid derivs. This stabilizer has numerous uses for cosmetics, pharmaceuticals, etc.
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公开(公告)号：JPH01247088A
公开(公告)日：1989-10-02
申请号：JP7516088
申请日：1988-03-29
Applicant: AGENCY IND SCIENCE TECHN
Inventor： MASUDA HITOSHI , ISHIGAMI YUTAKA
Abstract: PURPOSE:To supply sufficient nutrient and oxygen to a biocatalyst and to enable the repeated use of the catalyst over a long period in the production of a substance with an immobilized biocatalyst, by supporting a biocatalyst on a wall membrane composed of a polymer membrane having a pore diameter of =1hr. Microbial cells are put into the bag and the opening of the bag is sealed. The bag is put into a wide-mouthed bottle containing an unsterilized medium and the microorganism is cultured under aeration. The microbial cells are attached to both surfaces of the nonwoven cloth in the form of films by this culture process. There is not proliferation of sundry germs in the culture liquid outside of the membrane. The immobilized catalyst has high durability and productivity and can be used without sterilizing the culture liquid or necessitating the troublesome operation of the gel preparation because the microorganisms are present in the membrane.
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公开(公告)号：JPH01157931A
公开(公告)日：1989-06-21
申请号：JP31439887
申请日：1987-12-11
Applicant: AGENCY IND SCIENCE TECHN
Inventor： KAMATA TOSHIHIRO , ISHIGAMI YUTAKA , WASADA NOBUHIDE
Abstract: NEW MATERIAL:2-n-Dodecyl-3-hydroxy-n-hexadecanoic acid of formula I (OR is hydroxyl or alcohol residue) or its ester. EXAMPLE:anti-2-n-Dodecyl-3-hydroxy-n-hexadecanoic acid methyl ester. USE:An immunoactivator. A raw material for a bio-degradable surfactant having balanced lipophilic and hydrophilic properties. PREPARATION:The objective compound of formula I can be produced by adding sodium hydride to a tetradecanoic acid ester in xylene, subjecting to thermal condensation reaction, reducing the ketone group of the resultant 2-n-dodecyl-3- oxo-n-hexadecanoic acid ester of formula II and subjecting the obtained compound of formula III to hydrolysis and, as necessary, esterification.
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公开(公告)号：JPH01107837A
公开(公告)日：1989-04-25
申请号：JP26337287
申请日：1987-10-19
Applicant: AGENCY IND SCIENCE TECHN
Inventor： KAMATA TOSHIHIRO , GAMA YASUO , ISHIGAMI YUTAKA
Abstract: PURPOSE:To improve the emulsion dispersibility of a surfactant in an oily or aq. base and the penetrating property by preparing 2-n-alkyl-3-hydroxy-long chain fatty acid represented by a specified general formula or a salt thereof as the surfactant. CONSTITUTION:Long or medium chain fatty acid ester is mixed with sodium hydride in xylene and heated to obtain 2-n-alkyl-3-hydroxy-long chain fatty acid ester represented by formula I (where -OR is an alcohol residue and each of n and m is an integer of 4-20, preferably 6-16). The ester is converted into 2-n-alkyl-3-hydroxy-long chain fatty acid represented by formula II (where -OR, n and m are -OR, n and m in the formula I) by reducing the ketone group of the ester. The hydroxy-fatty acid is further treated with alkali to obtain 2-n-alkyl-3-hydroxy-long chain fatty acid represented by formula III (where each of n and m is an integer of 6-20) or a salt thereof.
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