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21.发明申请
公开(公告)号：WO1989009057A1
公开(公告)日：1989-10-05
申请号：PCT/US1989000952
申请日：1989-03-09
Applicant: ALCON LABORATORIES, INC.
Inventor： ALCON LABORATORIES, INC. , CAGLE, Gerald, D. , MCDONALD, Thomas, O. , ROSENTHAL, Allan, L.
IPC: A61K31/74
CPC classification number: A61K31/70 , A61K31/57 , A61K2300/00
Abstract: Disclosed are pharmaceutical compositions comprising tobramycin and a steroid such as dexamethasone or fluorometholone for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for infection and control of inflammatory response for optimal wound healing and normalization of the eye of a human or animal.
Abstract translation: 公开了包含妥布霉素和类固醇例如地塞米松或氟替米隆用于局部眼科递送的药物组合物，以及一种治疗方法，包括当指示感染时施用所述组合物，并控制炎症反应以获得最佳伤口愈合和人或动物眼睛的归一化 。
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22.发明申请USE OF ALDOSE REDUCTASE INHIBITORS TO ENHANCE INSULIN SENSITIVITY IN DIABETES MELLITUS 审中-公开使用降糖抑制剂来增强糖尿病胰岛素敏感性
公开(公告)号：WO1988006887A1
公开(公告)日：1988-09-22
申请号：PCT/US1988000814
申请日：1988-03-18
Applicant: ALCON LABORATORIES, INC.
Inventor： ALCON LABORATORIES, INC. , YORK, Billie, M., Jr.
IPC: A61K31/50
CPC classification number: A61K31/415 , A61K31/195 , A61K31/40 , A61K31/42 , A61K31/44 , A61K31/50
Abstract: A method of enhancing insulin sensitivity in mammals (e.g. humans) is described. The method is based on the use of aldose reductase inhibitors to restore and preserve intracellular reduced glutathione levels, thereby enhancing the formation of insulin receptor-mixed disulfide bonds.
Abstract translation: 描述了在哺乳动物（例如人）中增强胰岛素敏感性的方法。 该方法基于使用醛糖还原酶抑制剂来恢复和保持细胞内还原型谷胱甘肽水平，从而增强胰岛素受体 - 混合二硫键的形成。
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公开(公告)号：WO1983003542A1
公开(公告)日：1983-10-27
申请号：PCT/US1983000545
申请日：1983-04-11
Applicant: ALCON LABORATORIES, INC.
Inventor： ALCON LABORATORIES, INC. , YORK, Jr., Billie, Murray
IPC: A61K31/415
CPC classification number: C07D491/10 , C07C323/00 , C07D311/22 , Y10S514/866
Abstract: 6-méthylthio et 6-méthylsulfinyl spiro-chromanimidazolidine diones sont utiles pour traiter les complications dues au diabète sucré. L'activité des composés est surprenante lorsque l'on compare la grandeur des substituants en position 6 par rapport aux composés de l'art antérieur.
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公开(公告)号：WO1983001003A1
公开(公告)日：1983-03-31
申请号：PCT/US1982001333
申请日：1982-09-27
Applicant: ALCON LABORATORIES, INC.
Inventor： ALCON LABORATORIES, INC. , STARK, Raymond, LLoyd
IPC: A61K31/74
CPC classification number: A61L12/145 , A61K9/0048 , A61K31/785 , Y02A50/395
Abstract: This invention relates to the quaternary ammonium salt, alpha -4-[-tris (2-hydroxyethyl) ammonium chloride-2-butenyl] poly[1-dimethyl ammonium chloride-2-butenyl]-w-tris (2-hydroxyethyl) ammonium chloride, providing aqueous disinfecting solutions for contact lenses as well as a preservative for ocular solutions including contact lens treating solutions.
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25.发明申请
公开(公告)号：WO1998025649A1
公开(公告)日：1998-06-18
申请号：PCT/US1997020826
申请日：1997-11-17
Applicant: ALCON LABORATORIES, INC. , ASGHARIAN, Bahram
Inventor： ALCON LABORATORIES, INC.
IPC: A61K47/18
CPC classification number: A61K33/22 , A61K9/0048 , A61K31/13 , A61K31/138 , A61K47/18 , A61L12/147 , Y10S514/839 , Y10S514/84 , Y10S514/912 , A61K2300/00
Abstract: The use of low molecular weight amino alcohols in ophthalmic compositions is described. These compounds have been found to enhance the efficacy of anti-microbial preservatives. Particularly preferred amino alcohols are 2-amino-2-methyl-1-propanol (AMP), 2-dimethylamino-2-methyl-1-propanediol (DMAMP), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2-amino-2-methyl-1,3-propanediol (AMPD), and 2-amino-1-butanol (AB). The ophthalmic compositions further optionally comprise a borate/polyol buffer system and an alkylamine.
Abstract translation: 描述了在眼用组合物中使用低分子量氨基醇。 已经发现这些化合物增强了抗微生物防腐剂的功效。 特别优选的氨基醇是2-氨基-2-甲基-1-丙醇（AMP），2-二甲基氨基-2-甲基-1-丙二醇（DMAMP），2-氨基-2-乙基-1,3-丙二醇（AEPD ），2-氨基-2-甲基-1,3-丙二醇（AMPD）和2-氨基-1-丁醇（AB）。 眼用组合物还任选地包含硼酸盐/多元醇缓冲体系和烷基胺。
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Patent Agency Ranking
公开(公告)号：WO1998025620A1
公开(公告)日：1998-06-18
申请号：PCT/US1997015727
申请日：1997-09-05
Applicant: ALCON LABORATORIES, INC.
Inventor： ALCON LABORATORIES, INC. , ALI, Yusuf , BECK, Robert, E. , SPORT, Rex, C.
IPC: A61K31/54
CPC classification number: A61K31/542 , A61K9/0048 , A61K31/77 , Y10S514/912 , A61K2300/00
Abstract: Ophthalmic suspensions containing brinzolamide or brinzolamide and a beta-blocker and processes for manufacturing the suspensions are disclosed. The use of Tyloxapol or Triton X-100 avoids chrystallization of brinzolamide after autoclaving.
Abstract translation: 公开了含有brinzolamide或brinzolamide和β-阻滞剂的眼用悬浮液和制备悬浮液的方法。 Tyloxapol或Triton X-100的使用避免了高压灭菌后呋喃唑胺的结晶。
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27.发明申请
公开(公告)号：WO1998021181A2
公开(公告)日：1998-05-22
申请号：PCT/US1997020671
申请日：1997-11-07
Applicant: ALCON LABORATORIES, INC. , KLIMKO, Peter, G. , HELLBERG, Mark, R. , ZINKE, Paul, W.
Inventor： ALCON LABORATORIES, INC.
IPC: C07C405/00
CPC classification number: A61K31/5575 , C07C405/00
Abstract: 15-fluoro substituted analogs of PGF2 alpha and methods of their use in treating glaucoma and ocular hypertension are disclosed.
Abstract translation: 公开了PGF2α的15-氟取代类似物及其用于治疗青光眼和高眼压症的方法。
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28.发明申请11-HALO PROSTAGLANDINS FOR THE TREATMENT OF GLAUCOMA OR OCULAR HYPERTENSION 审中-公开用于治疗玻璃体积或高血压的11-HALO前列腺素
公开(公告)号：WO1998020880A2
公开(公告)日：1998-05-22
申请号：PCT/US1997020672
申请日：1997-11-07
Applicant: ALCON LABORATORIES, INC. , SALLEE, Verney, L. , HELLBERG, Mark, R. , KLIMKO, Peter, G. , ZINKE, Paul, W.
Inventor： ALCON LABORATORIES, INC.
IPC: A61K31/557
CPC classification number: C07C405/0016 , A61K31/5575 , C07C405/00
Abstract: 11-Halo substituted analogs of PGF2 alpha and methods of their use in treating glaucoma and ocular hypertension are disclosed.
Abstract translation: 公开了1-卤代取代的PGF2α类似物及其用于治疗青光眼和高眼压症的方法。
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29.发明申请USE OF A COMBINATION OF CARBONIC ANHYDRASE INHIBITORS AND PROSTAGLANDINS FOR TREATING GLAUCOMA 审中-公开碳氢化合物抑制剂和前列腺素联合治疗玻璃体的应用
公开(公告)号：WO1998019680A1
公开(公告)日：1998-05-14
申请号：PCT/US1997015793
申请日：1997-09-05
Applicant: ALCON LABORATORIES, INC. , DEAN, Thomas, R. , MAY, Jesse, A.
Inventor： ALCON LABORATORIES, INC.
IPC: A61K31/557
CPC classification number: A61K31/557 , A61K31/54 , A61K2300/00
Abstract: Compositions and methods for treating persons suffering from glaucoma or ocular hypertension are disclosed. In particular, the persons are treated with prostaglandins and carbonic anhydrase inhibitors to control their intraocular pressure.
Abstract translation: 公开了治疗患有青光眼或高眼压症的人的组合物和方法。 特别地，这些人用前列腺素和碳酸酐酶抑制剂治疗以控制其眼内压。
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30.发明申请
公开(公告)号：WO1998019678A1
公开(公告)日：1998-05-14
申请号：PCT/US1996017686
申请日：1996-11-06
Applicant: ALCON LABORATORIES, INC. , DeSANTIS, Louis, Jr. , KAPIN, Michael, A.
Inventor： ALCON LABORATORIES, INC.
IPC: A61K31/445
CPC classification number: A61K9/0048 , A61K31/445
Abstract: Pharmaceutical compositions useful in ophthalmic surgery are described. The compositions include one or more polyamine antagonists, and are useful for preventing or treating excitotoxicity associated with ophthalmic surgery. Methods of using the compositions in connection with ophthalmic surgical procedures are also described.
Abstract translation: 描述了可用于眼科手术的药物组合物。 组合物包括一种或多种多胺拮抗剂，并且可用于预防或治疗与眼科手术相关的兴奋性毒性。 还描述了使用组合物与眼科外科手术相关的方法。
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