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    23.
    发明专利
    未知

    公开(公告)号：DE69809161D1

    公开(公告)日：2002-12-12

    申请号：DE69809161

    申请日：1998-08-24

    Applicant: APPLIED SPECTRAL IMAGING LTD

    Inventor： KATZIR NIR ,  GARINI YUVAL ,  WINE DAVID ,  CABIB DARIO

    IPC: G01N21/64 ,  G01N15/14 ,  G01N21/78 ,  G01N33/533 ,  G01N33/566 ,  G01N33/58 ,  G02B21/06 ,  G01J3/28

    Abstract: Classification of pixels into groups of pixels according to their association with a single fluorophore or a combination of fluorophores, comprises: (a) providing a number of wide-band emission filters; (b) for each of the pixels, recording emitted light intensity as retrieved after passing through each one of the emission filters, such that each of the pixels is representable by a vector of a number of dimensions equal to the number of wide-band emission filters; and (c) using an algorithm for evaluating the presence of each of the fluorophores associated with each of the pixels, thus classifying each of the pixels into a group of pixels according to its association with the fluorophores. Each fluorophore has a characterising emission spectrum and a specifying emission peak.

    Method of and composite for fluorescent (in situ) hybridization
    26.
    发明专利
    Method of and composite for fluorescent (in situ) hybridization 未知

    公开(公告)号：AU5123599A

    公开(公告)日：2000-02-21

    申请号：AU5123599

    申请日：1999-07-23

    Applicant: APPLIED SPECTRAL IMAGING LTD

    Inventor： BAR-AM IRIT ,  JANISH CATHY ,  GARINI YUVAL ,  CABIB DARIO ,  BUCKWALD ROBERT A

    IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/6841 ,  G01N33/533 ,  G01N33/566 ,  C07H21/04

    Abstract: A fluorescent in situ hybridization method including the steps of (a) obtaining a chromosome spread of a species; (b) preparing a hybridization composite containing a plurality of chromosomal paints each of the plurality of chromosomal paints being labeled with a different fluorophore-or-combination-of-fluorophores, such that an averaged specific activity of highly repetitive sequences in the hybridization composite substantially equals an averaged specific activity of unique sequences in the hybridization composite; (c) denaturing the hybridization composite and subjecting the hybridization composite to conditions for allowing at least a part of the highly repetitive sequences in the hybridization composite to reanneal while at least a part of the unique sequences in the hybridization composite remaining single stranded; (d) contacting under hybridization conditions the hybridization composite with the chromosome spread; (e) washing away excess of the hybridization composite; and (d) analyzing and presenting images of the now hybridized chromosome spread.

    Method for chromosomes classification
    27.
    发明专利
    Method for chromosomes classification 未知

    公开(公告)号：AU6774398A

    公开(公告)日：1998-11-13

    申请号：AU6774398

    申请日：1998-03-27

    Applicant: APPLIED SPECTRAL IMAGING LTD

    Inventor： GARINI YUVAL ,  KATZIR NIR ,  WINE DAVID ,  CABIB DARIO

    IPC: G01N33/48 ,  C12M1/00 ,  C12M3/00 ,  C12N15/09 ,  C12N15/11 ,  C12Q1/68 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/453 ,  G01N1/28 ,  G01N21/64 ,  G01N21/75 ,  G01N33/483 ,  G01N33/50 ,  G01N33/52 ,  G01N33/569 ,  G01N33/58 ,  G01N37/00 ,  G02B21/00 ,  G02B21/16 ,  G06K9/00 ,  G06K9/76 ,  G02B21/18

    Abstract: A method for finding L internal reference vectors for classification of L chromosomes or portions of chromosomes of a cell, the L chromosomes or portions of chromosomes being painted with K different fluorophores or combinations thereof, wherein K basic chromosomes or portions of chromosomes of the L chromosomes or portions of chromosomes are each painted with only one of the K different fluorophores, whereas the other L-K of the L chromosomes or portions of chromosomes are each painted with a different combination of the K different fluorophores, the method comprising the steps of (a) using a multi-band collection device for measuring a first vector for each pixel of each of the L chromosomes or portions of chromosomes; (b) identifying pixels belonging to each of the K basic chromosomes or portions of chromosomes and defining the pixels as basic pixels, so as to obtain K basic classes of basic pixels; (c) using at least one basic pixel from each of the K basic classes for obtaining K basic vectors, the K basic vectors being K internal reference vectors; (d) using the K basic vectors for identifying pixels belonging to the other L-K chromosomes or portions of chromosomes; and (e) using the pixels belonging to the other L-K chromosomes or portions of chromosomes for calculating the other L-K internal reference vectors, thereby finding all of the L internal reference vectors. A method for classification of L chromosomes or portions of chromosomes of a cell similarly painted using the above method for finding L internal reference vectors, and using the L reference vectors for classification of each of the pixels into one of L classification classes. And, images presenting color chromosomes.

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