公开(公告)号：SG178561A1

公开(公告)日：2012-03-29

申请号：SG2012013116

申请日：2010-08-27

Applicant: ARRAY BIOPHARMA INC ,  GENENTECH INC

Inventor： GRADL STEFAN ,  LAIRD ELLEN ,  MORENO DAVID ,  REN LI ,  WENGLOWSKY STEVEN MARK

Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. [FORMULA I]

公开(公告)号：SG178534A1

公开(公告)日：2012-03-29

申请号：SG2012012407

申请日：2010-08-27

Applicant: ARRAY BIOPHARMA INC ,  GENENTECH INC

Inventor： ALIAGAS IGNACIO ,  GRADL STEFAN ,  GUNZNER JANET ,  MATHIEU SIMON ,  PULK REBECCA ,  RUDOLPH JOACHIM ,  WEN ZHAOYANG ,  GRINA JONAS ,  HANSEN JOSHUA D ,  LAIRD ELLEN ,  MORENO DAVID ,  REN LI ,  WENGLOWSKY STEVEN MARK

Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：PT1809280E

公开(公告)日：2011-11-15

申请号：PT05819172

申请日：2005-10-18

Applicant: ARRAY BIOPHARMA INC

Inventor： LYSSIKATOS JOSEPH P ,  WALLACE ELI M ,  ZHAO QIAN ,  HANS JEREMY ,  AICHER TOM ,  LAIRD ELLEN ,  ALLEN SHELLEY

IPC: A61K31/4245 ,  C07D413/00 ,  C07D417/00

公开(公告)号：BRPI0707401A2

公开(公告)日：2011-05-03

申请号：BRPI0707401

申请日：2007-01-26

Applicant: ARRAY BIOPHARMA INC

Inventor： GRONEBERG ROBERT D ,  BURGESS LAURENCE E ,  HARVEY DARREN ,  LAIRD ELLEN ,  MUNSON MARK ,  RIZZI JAMES ,  RODRIGUEZ MARTHA ,  EARY CHARLES TODD ,  WATSON DANIEL J

IPC: C07D231/40 ,  A61K31/416 ,  A61P29/00 ,  C07D231/56

Abstract: The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.

公开(公告)号：HK1123548A1

公开(公告)日：2009-06-19

申请号：HK09100807

申请日：2009-01-23

Applicant: ARRAY BIOPHARMA INC

Inventor： GRONEBERG ROBERT ,  BURGESS LAURENCE E ,  HARVEY DARREN ,  LAIRD ELLEN ,  MUNSON MARK ,  RIZZI JAMES ,  RODRIGUEZ MARTHA ,  EARY CHARLES TODD ,  WATSON DANIEL

IPC: A61K20060101 ,  A61P20060101 ,  C07D20060101

Abstract: The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.

公开(公告)号：HK1115376A1

公开(公告)日：2008-11-28

申请号：HK08105389

申请日：2008-05-15

Applicant: ARRAY BIOPHARMA INC

Inventor： HANS JEREMY ,  WALLACE ELI M ,  ZHAO QIAN ,  ALLEN SHELLEY ,  LAIRD ELLEN ,  LYSSIKATOS JOSEPH P ,  ROBINSON JOHN E ,  CORRETTE CHRISTOPHER P ,  DELISLE ROBERT KIRK ,  VOEGTLI WALTER CHARLES

IPC: C07D20060101

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

公开(公告)号：BRPI0518228A

公开(公告)日：2008-11-04

申请号：BRPI0518228

申请日：2005-10-18

Applicant: ARRAY BIOPHARMA INC

Inventor： HANS JEREMY ,  WALLACE ELI M ,  ZHAO QIAN ,  LYSSIKATOS JOSEPH P ,  AICHER TOM ,  LAIRD ELLEN ,  ROBINSON JOHN ,  ALLEN SHELLEY

IPC: A61K31/4245 ,  C07D413/00 ,  C07D417/00

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

公开(公告)号：HK1106131A1

公开(公告)日：2008-03-07

申请号：HK07111370

申请日：2007-10-22

Applicant: ARRAY BIOPHARMA INC

Inventor： HANS JEREMY ,  WALLACE ELI M ,  ZHAO QIAN ,  LYSSIKATOS JOSEPH P ,  AICHER TOM ,  LAIRD ELLEN ,  ROBINSON JOHN ,  ALLEN SHELLEY

IPC: A61K20060101 ,  C07D20060101

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

公开(公告)号：MX2007013539A

公开(公告)日：2008-01-24

申请号：MX2007013539

申请日：2006-05-01

Applicant: ARRAY BIOPHARMA INC

Inventor： ZHAO QIAN ,  WALLACE ELI M ,  LYSSIKATOS JOSEPH P ,  ROBINSON JOHN E ,  HANS JEREMY ,  LAIRD ELLEN ,  ALLEN SHELLEY ,  CORRETTE CHRISTOPHER P ,  DELISLE ROBERT KIRK ,  VOEGTLI WALTER CHARLES

IPC: C07D417/04

Abstract: Esta invencion se relaciona a inhibidores de cinesinas mitoticas, particularmente KSP, y metodos para producir estos inhibidores. La invencion tambien proporciona composiciones farmaceuticas las cuales comprenden los inhibidores de la invencion y metodos para utilizar los inhibidores y composiciones farmaceuticas en el tratamiento y prevencion de varios desordenes.

公开(公告)号：AU2007210073A1

公开(公告)日：2007-08-09

申请号：AU2007210073

申请日：2007-01-26

Applicant: ARRAY BIOPHARMA INC

Inventor： RODRIGUEZ MARTHA ,  BURGESS LAURENCE E ,  MUNSON MARK ,  LAIRD ELLEN ,  GRONEBERG ROBERT ,  EARY CHARLES TODD ,  RIZZI JAMES ,  WATSON DANIEL ,  HARVEY DARREN

IPC: C07D231/40 ,  A61K31/416 ,  A61P29/00 ,  C07D231/56

Abstract: The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.