中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

49 records (took 0.04 seconds)

    HETEROARYLMETHOXYPHENYLTHIOALKYL CARBOXYLATES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS
    22.
    发明申请
    HETEROARYLMETHOXYPHENYLTHIOALKYL CARBOXYLATES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS 审中-公开
    作为紫杉醇生物合成酶的抑制剂的二异丙氧基甲基邻氨基甲酸酯

    公开(公告)号：WO1998014429A1

    公开(公告)日：1998-04-09

    申请号：PCT/US1997017265

    申请日：1997-09-26

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  KOLASA, Teodozyj ,  BROOKS, C., D., W. ,  GUNN, David, E.

    IPC: C07D215/14

    CPC classification number: C07D405/14 ,  C07D215/14 ,  C07D409/12 ,  C07D409/14 ,  C07D417/14

    Abstract: Compounds having formula (I), wherein W and W are independently selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted naphthyl; R anb R are independently selected from hydrogen, alkyl, halolalkyl, alkoxy, halogen; R is selected from thienyl, furyl, phenyl, naphthyl, benzo[b]thienyl, alkyl, hydroxyl, and hydrogen; Y an alkylene of one to six carbon atoms; and M is selected from (a) a pharmaceutically acceptable metabolically cleavable group, (b) -OR , (c) -NR R , (d) -NR SO2R (e) -NH-Tetrazolyl, and (f) glycinyl; inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method of inhibiting leukotriene biosynthesis.

    Abstract translation: 具有式（I）的化合物，其中W 1和W 2独立地选自任选取代的喹啉基，任选取代的苯并噻唑基，任选取代的苯并恶唑基，任选取代的苯并咪唑基，任选取代的喹喔啉基，任选取代的萘基; R 1和R 2独立地选自氢，烷基，卤代烷基，烷氧基，卤素; R 3选自噻吩基，呋喃基，苯基，萘基，苯并[b]噻吩基，烷基，羟基和氢; Y为1至6个碳原子的亚烷基; 并且M选自（a）药学上可接受的代谢可裂解基团，（b）-OR 4，（c）-NR 5 R 6，（d）-NR 4 SO 2 R 7 e）-NH-四唑基，和（f）甘氨酰; 抑制白细胞三烯生物合成，可用于治疗过敏性和炎性疾病状态。 还公开了白三烯生物合成抑制组合物和抑制白三烯生物合成的方法。

    BIS-(HETEROARYLMETHOXYPHENYL)CYCLOALKYL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF LEUKOTRIENE BIOSYTHESIS
    23.
    发明申请
    BIS-(HETEROARYLMETHOXYPHENYL)CYCLOALKYL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF LEUKOTRIENE BIOSYTHESIS 审中-公开
    BIS-（异邻甲氧基苯基）环烷基衍生物，其制备及其作为紫杉醇生物合成抑制剂的用途

    公开(公告)号：WO1997029090A1

    公开(公告)日：1997-08-14

    申请号：PCT/US1997001953

    申请日：1997-02-06

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  KOLASA, Teodozyj ,  GUNN, David, E. ,  BROOKS, Clint, D., W.

    IPC: C07D215/14

    CPC classification number: C07D215/18 ,  C07D215/14 ,  C07D241/42 ,  C07D277/64

    Abstract: Compounds having structure (I), where m is an integer of from one to nine; n is an integer of from one to four; W is selected from unsubstituted quinolyl, benzothiazolyl, or quinoxalyl, or quinolyl, benzothiazolyl, or quinoxalyl substituted with one, two or three substituents selected from the group consisting of halogen, C1-6 alkyl, and C1-6 alkoxy; X is absent or is selected from the group consisting of (a) C1-6 alkylene; (b) C1-6 alkenylene; and (c) C1-6 alkynylene; Y is one to four substituents independently selected from halogen, C1-6 alkyl, and C1-6 alkoxy; Z is selected from the group consisting of (a) COB; (b) C(R )2-O-N=A-COB; and (c) C(R )=N-O-A-COB where A is C1-6 alkylene, and B is selected from the group consisting of (a) -OH; (b) -O M where M is a pharmaceutically acceptable cation; (c) -OR where R is hydrogen or alkyl of one to six carbon atoms; (d) -NR R where R is as previously defined and R is selected from the group consisting of hydrogen, alkyl of one to six carbon atoms, hydroxy, and alkoxy of from one to six carbon atoms, or R and R , together with the atom to which they are attached, form a ring of five to eight members containing one optional heteratom selected from N, O and S; and (e) -O-D where D is a metabolically cleavable group, are inhibitors of leukotriene biosynthesis.

    Abstract translation: 具有结构（I）的化合物，其中m是1至9的整数; n是1到4的整数; W选自未取代的喹啉基，苯并噻唑基或喹喔啉基，或喹啉基，苯并噻唑基或喹喔啉基，其被一个，两个或三个选自卤素，C 1-6烷基和C 1-6烷氧基的取代基取代; X不存在或选自（a）C 1-6亚烷基; （b）C 1-6亚烯基; 和（c）C1-6亚炔基; Y是一至四个独立地选自卤素，C 1-6烷基和C 1-6烷氧基的取代基; Z选自（a）COB; （b）C（R 2）2 -O-N = A-COB; 和（c）C（R 2）= N-O-A-COB，其中A是C 1-6亚烷基，B选自（a）-OH; （b）-O - M +，其中M是药学上可接受的阳离子; （c）-OR 6其中R 6为氢或1至6个碳原子的烷基; （d）-NR 6 R 7，其中R 6如前所定义，R 7选自氢，1至6个碳原子的烷基，羟基和1位的烷氧基 至6个碳原子，或R 6和R 7与它们所连接的原子一起形成含有一个任选的选自N，O和S的杂原子的五至八个成员的环; 和（e）-O-D，其中D是代谢可裂解基团，是白三烯生物合成的抑制剂。

Patent Agency Ranking