公开(公告)号：EP2237779A1

公开(公告)日：2010-10-13

申请号：EP08867156.5

申请日：2008-12-18

Applicant: Abbott Laboratories

Inventor： BLACK, Lawrence A. ,  COWART, Marlon D. ,  GFESSER, Gregory A. ,  WAKEFIELD, Brian D. ,  ALTENBACH, Robert J. ,  LIU, Huaqing ,  ZHAO, Chen ,  HSIEH, Gin C.

IPC: A61K31/423 ,  A61K31/428 ,  C07D413/14 ,  C07D417/14 ,  A61P25/00 ,  A61P3/10

CPC classification number: C07D417/14 ,  C07D413/04 ,  C07D417/04

Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.

公开(公告)号：EP1751130A2

公开(公告)日：2007-02-14

申请号：EP05763655.7

申请日：2005-04-29

Applicant: ABBOTT LABORATORIES

Inventor： ALTENBACH, Robert, J. ,  BLACK, Lawrence, A. ,  CHANG, Sou-jen ,  COWART, Marlon, D. ,  FAGHIH, Ramin ,  GFESSER, Gregory, A. ,  KU, Yi-yin ,  LIU, Huaqing ,  LUKIN, Kirill, A. ,  NERSESIAN, Diana, L. ,  PU, Yu-ming ,  CURTIS, Michael, P.

IPC: C07D401/00

CPC classification number: C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

Abstract: Compounds of formula (I) wherein R1 or R2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R1, R2, R3, R3a, R3b, R4, R5, L, X, X', Y, Y', Z, and Z' are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

公开(公告)号：EP1124804A1

公开(公告)日：2001-08-22

申请号：EP99953259.1

申请日：1999-10-27

Applicant: ABBOTT LABORATORIES

Inventor： BLACK, Lawrence, A. ,  BASHA, Anwer ,  KOLASA, Teodozyj ,  KORT, Michael, E. ,  LIU, Huaqing ,  MCCARTY, Catherine, M. ,  PATEL, Meena, V. ,  ROHDE, Jeffrey, J. ,  COGHLAN, Michael, J. ,  STEWART, Andrew, O.

IPC: C07D237/14 ,  A61K31/50 ,  C07D405/04 ,  C07D409/04

CPC classification number: C07D405/04 ,  C07D237/14 ,  C07D409/04

Abstract: The present invention describes pyridazinone compounds of formula (I) which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important 'housekeeping' enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectively of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).

公开(公告)号：EP2231631A1

公开(公告)日：2010-09-29

申请号：EP08861197.5

申请日：2008-12-05

Applicant: Abbott Laboratories

Inventor： LIU, Huaqing ,  BLACK, Lawrence A. ,  BENNANI, Youssef L. ,  COWART, Marlon D. ,  TIAN, Zhenping ,  BRACKEMEYER, Paul J.

IPC: C07D295/14 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  A61K31/40 ,  A61K31/41 ,  A61K31/44 ,  A61P25/00

CPC classification number: C07D401/12 ,  C07D207/06 ,  C07D207/08 ,  C07D207/12 ,  C07D213/82 ,  C07D295/14 ,  C07D295/155 ,  C07D401/10 ,  C07D403/10 ,  C07D403/12 ,  C07D417/10 ,  C07D417/12 ,  C07D495/04

Abstract: Compounds of formula (I) wherein R1, R2, R3, R3a, R3b, R4, and R5 are defined in the description, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

Abstract translation: 其中R 1，R 2，R 3，R 3a，R 3b，R 4和R 5在说明书中定义的式（I）化合物可用于治疗由组胺-3受体配体阻止或缓解的病症或障碍。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法以及制备式（I）范围内的化合物的方法。

公开(公告)号：EP2188288A1

公开(公告)日：2010-05-26

申请号：EP08830602.2

申请日：2008-09-11

Applicant: Abbott Laboratories

Inventor： COWART, Marlon D ,  MARSH, Kennan C ,  LIU, Huaqing ,  LEE, Jae Yong ,  BECONI, Maria G ,  WETTER, Jill M ,  BLACK, Lawrence A ,  CUSTER, Thomas C

IPC: C07D487/04 ,  A61K31/501 ,  A61P25/00

CPC classification number: C07D487/04

Abstract: The invention relates to octahydro-pyrrolo[3,4-b]pyrrole N-oxides as prodrugs of CNS-active compounds, compositions comprising such compounds, methods for making the compounds, salts, and polymorphs, and methods of treating conditions and disorders using such compounds and compositions. Octahydro-pyrrolo[3,4-b]pyrrole N-oxides of formula (I) are prodrugs of histamine-3 antagonists, and are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole N-oxide compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.

公开(公告)号：EP1569637A1

公开(公告)日：2005-09-07

申请号：EP03768721.7

申请日：2003-11-05

Applicant: ABBOTT LABORATORIES

Inventor： ALTENBACH, Robert, J. ,  BLACK, Lawrence, A. ,  CHANG, Sou-Jen ,  COWART, Marlon, D. ,  FAGHIH, Ramin ,  GFESSER, Gregory, A.; ,  KU, Yi-Yin ,  LIU, Huaqing ,  LUKIN, Kirill, A. ,  NERSESIAN, Diana, L. ,  PU, Yu-ming ,  SHARMA, Padam, N. ,  BENNANI, Youssef, L. ,  CURTIS, Michael, P.

IPC: A61K31/40 ,  C07D295/155 ,  C07D295/116 ,  A61P25/00 ,  A61P3/00 ,  C07D261/08 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07C255/58 ,  C07D295/088 ,  C07D207/20 ,  C07D215/12 ,  C07D215/14 ,  C07D217/14

CPC classification number: C07C255/58 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D207/20 ,  C07D213/30 ,  C07D213/38 ,  C07D213/61 ,  C07D213/64 ,  C07D213/85 ,  C07D215/12 ,  C07D215/14 ,  C07D215/20 ,  C07D217/14 ,  C07D237/12 ,  C07D237/14 ,  C07D237/28 ,  C07D239/26 ,  C07D239/28 ,  C07D239/42 ,  C07D239/52 ,  C07D241/12 ,  C07D241/42 ,  C07D263/32 ,  C07D277/28 ,  C07D295/073 ,  C07D295/088 ,  C07D295/096 ,  C07D295/112 ,  C07D295/135 ,  C07D295/155 ,  C07D401/04 ,  C07D401/10 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04

Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

公开(公告)号：EP1007515A1

公开(公告)日：2000-06-14

申请号：EP98938451.6

申请日：1998-08-10

Applicant: Abbott Laboratories

Inventor： BLACK, Lawrence, A. ,  BASHA, Anwer ,  KOLASA, Teodozyj ,  KORT, Michael, E. ,  LIU, Huaqing ,  McCARTY, Catherine, M. ,  PATEL, Meena, V. ,  ROHDE, Jeffrey, J.

IPC: C07D237/14 ,  C07D401/06 ,  C07D403/06 ,  C07D237/18 ,  C07D409/06 ,  C07D413/06 ,  C07D405/06 ,  A61K31/50 ,  C07F11/00

CPC classification number: C07D401/06 ,  C07D237/14 ,  C07D237/18 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D409/06 ,  C07D409/12 ,  C07D417/06

Abstract: The present invention describes pyridazinone compounds which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX/2), COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important 'housekeeping' enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectivity of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).