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公开(公告)号：DE19534164A1
公开(公告)日：1996-04-25
申请号：DE19534164
申请日：1995-09-15
Applicant: BASF AG
Inventor： ALBRECHT HANS-PETER , BOEHM HANS-JOACHIM , BRADY KENNETH DALE , ECKARD PETER , KARDORFF UWE , MEYER NORBERT , SCHIRMER ULRICH , TALANIAN ROBERT VINCENT , WALKER NIGEL P C
IPC: A61K31/53 , A61K31/5377 , C07D487/04
Abstract: Pyrimido(5,4-e)-as-triazine-5,7(6H,8H)-dione derivs. of formula (I) and their acid addn. salts are claimed for use in combatting diseases. R , R = H, alkyl, 3-6C cycloalkyl, 2-8C alkenyl, phenyl or benzyl; R = H, halogen or NO2; 1-8C alkyl (opt. substd. by 1-3 of OH, halogen, alkoxy, alkyl, (1-4C)alkoxy(1-4C)alkoxy, 2-6C alkenyl, alkylthio, phenyl and benzyl); 2-6C alkenyl or -phenylalkenyl; 3-6C cycloalkyl (opt. substd. by one to three 1-4C alkyl gps.); 5- or 6-membered heterocycle contg. 1 or 2 of O, S, NR and N as ring members; COR or COOR ; phenyl or monocyclic heteroaryl (both opt. substd. by 1-3 of halogen, NO2, alkyl, 2-6C alkenyl, alkoxy and NR R ); or -ZR ; R , R = H or alkyl; Z = O, S or NR ; R = H or alkyl; or phenyl or benzyl (both opt. ring-substd. by 1-3 of alkyl, alkoxy and halogen); R = H or alkyl; or NR R = 5- or 6-membered ring (opt. interrupted by O); n = 0 or 1; alkyl moieties have 1-6C unless specified otherwise. (I) are known cpds., described in EP407888.
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公开(公告)号：MX9203910A
公开(公告)日：1993-01-01
申请号：MX9203910
申请日：1992-07-02
Applicant: BASF AG
Inventor： MACK HELMUT , PFEIFFER THOMAS , HOEFFKERN HANS WOLFGANG , BOEHM HANS-JOACHIM , HORNBERGER WILFRIED
IPC: A61K38/00 , A61K38/55 , A61K38/05 , A61P7/02 , C07K1/113 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/078 , C07C257/18
Abstract: PCT No. PCT/EP92/01411 Sec. 371 Date Dec. 28, 1993 Sec. 102(e) Date Dec. 28, 1993 PCT Filed Jun. 23, 1992 PCT Pub. No. WO93/01208 PCT Pub. Date Jan. 21, 1993.2-Substituted 3-(4-amidinophenyl)propionic acid derivatives of the formula in which A, Ar and B have the meanings stated in the description, and the preparation thereof are described. The compounds are suitable for controlling diseases.
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公开(公告)号：CA2005281A1
公开(公告)日：1990-06-12
申请号：CA2005281
申请日：1989-12-12
Applicant: BASF AG
Inventor： BOEHM HANS-JOACHIM , DAUM LOTHAR , HAUPT ANDREAS , SCHMIED BERNHARD , WALKER NIGEL , ZECHEL JOHANN-CHRISTIAN
IPC: A61K38/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07K1/04 , C07K7/06 , C07K7/08 , C07K7/56 , C07K7/64 , C07K14/52 , C07K14/525 , A61K38/02 , A61K38/08
Abstract: - 33 - O. Z . 0050/40383 Peptides of the formula X-A-Asn-B-Y, where A, B, X and Y are defined in the description, and the preparation thereof are described. The novel peptides are suitable for controlling diseases.
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公开(公告)号：CA2005051A1
公开(公告)日：1990-06-12
申请号：CA2005051
申请日：1989-12-11
Applicant: BASF AG
Inventor： BOEHM HANS-JOACHIM , DAUM LOTHAR , HAUPT ANDREAS , SCHMIED BERNHARD , WALKER NIGEL , ZECHEL JOHANN-CHRISTIAN
IPC: A61K38/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07K1/04 , C07K7/06 , C07K7/08 , C07K7/56 , C07K7/64 , C07K14/52 , C07K14/525 , A61K38/08 , A61K38/10 , A61K38/12 , A61K38/19 , C07K7/50
Abstract: Peptides of the formula X-A-Gly-B-Y, where A, B, X and Y are defined in the description, and the preparation thereof are described. The novel peptides are suitable for controlling diseases.
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公开(公告)号：HRP960075B1
公开(公告)日：2004-10-31
申请号：HRP960075
申请日：1996-02-15
Applicant: BASF AG
Inventor： BOEHM HANS-JOACHIM , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS
IPC: A61K31/00 , A61K38/55 , A61P7/02 , C07D205/04 , C07D207/16 , C07D213/53 , C07D213/63 , C07D213/72 , C07D213/78 , C07D213/79 , C07D239/28 , C07D241/14 , C07D241/24 , C07D401/12 , C07K5/06 , C07K5/062 , C07K5/078 , A61K31/40 , A61K31/445 , A61K31/495
Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R 1 , R 2 , A, B, C and D have the meanings described in the specification.
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Patent Agency Ranking
公开(公告)号：DE59510645D1
公开(公告)日：2003-05-22
申请号：DE59510645
申请日：1995-06-06
Applicant: BASF AG
Inventor： BOEHM HANS-JOACHIM , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , HOEFFKEN WOLFGANG , HORNBERGER WILFRIED
IPC: A61K31/40 , A61K38/00 , A61K38/05 , A61K38/55 , A61K47/48 , A61P7/02 , C07C279/00 , C07D205/04 , C07D207/06 , C07D207/16 , C07D207/48 , C07D211/60 , C07K5/06 , C07K5/065 , C07K5/072 , C07K5/078
Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.
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公开(公告)号：HU9800634A2
公开(公告)日：1999-06-28
申请号：HU9800634
申请日：1996-02-06
Applicant: BASF AG
Inventor： BOEHM HANS-JOACHIM , HORNBERGER WILFRIED , HOEFFKEN HANS WOLFGANG , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS
Abstract: PCT No. PCT/EP96/00472 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 6, 1996 PCT Pub. No. WO96/24609 PCT Pub. Date Aug. 15, 1996Thrombin inhibitors of the formula where R1, A, B and D have the meaning indicated in the description, and intermediates for the preparation thereof are described. The compounds I are suitable for controlling diseases.
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公开(公告)号：HU9800263A2
公开(公告)日：1998-06-29
申请号：HU9800263
申请日：1996-02-12
Applicant: BASF AG
Inventor： BOEHM HANS-JOACHIM , HORNBERGER WILFRIED , HOEFFKEN HANS WOLFGANG , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS
IPC: A61K31/00 , A61K38/55 , A61P7/02 , C07D205/04 , C07D207/16 , C07D213/53 , C07D213/63 , C07D213/72 , C07D213/78 , C07D213/79 , C07D239/28 , C07D241/14 , C07D241/24 , C07D401/12 , C07K5/06 , C07K5/062 , C07K5/078 , A61K31/40 , A61K31/445 , A61K31/495
Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R 1 , R 2 , A, B, C and D have the meanings described in the specification.
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公开(公告)号：SI9620037A
公开(公告)日：1998-02-28
申请号：SI9620037
申请日：1996-02-12
Applicant: BASF AG
Inventor： BOEHM HANS-JOACHIM , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS
IPC: A61K31/00 , A61K38/55 , A61P7/02 , C07D205/04 , C07D207/16 , C07D213/53 , C07D213/63 , C07D213/72 , C07D213/78 , C07D213/79 , C07D239/28 , C07D241/14 , C07D241/24 , C07D401/12 , C07K5/06 , C07K5/062 , C07K5/078 , A61K31/40 , A61K31/445 , A61K31/495
Abstract: The description relates to compounds of formula (I) in which A, B, D, R1 and R2 have the meanings given in the specification. The compounds are suitable for the treatment of diseases. The novel compounds are produced via compounds of the formula H2N-CH2-G-M in which G and M have the meanings given in claim 4.
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公开(公告)号：PL321759A1
公开(公告)日：1997-12-22
申请号：PL32175996
申请日：1996-02-12
Applicant: BASF AG
Inventor： BOEHM HANS-JOACHIM , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED , KOSER STEFAN , MACK HELMUT , PFFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS
IPC: A61K31/00 , A61K38/55 , A61P7/02 , C07D205/04 , C07D207/16 , C07D213/53 , C07D213/63 , C07D213/72 , C07D213/78 , C07D213/79 , C07D239/28 , C07D241/14 , C07D241/24 , C07D401/12 , C07K5/06 , C07K5/062 , C07K5/078 , A61K31/40 , A61K31/445 , A61K31/495
Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R 1 , R 2 , A, B, C and D have the meanings described in the specification.
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